{"id":"https://openalex.org/W2028809014","doi":"https://doi.org/10.1016/s0022-5193(05)80143-2","title":"Mathematical model of antiviral immune response. II. Parameters identification for acute viral hepatitis B","display_name":"Mathematical model of antiviral immune response. II. Parameters identification for acute viral hepatitis B","publication_year":1991,"publication_date":"1991-07-01","ids":{"openalex":"https://openalex.org/W2028809014","doi":"https://doi.org/10.1016/s0022-5193(05)80143-2","mag":"2028809014","pmid":"https://pubmed.ncbi.nlm.nih.gov/1943137"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-5193(05)80143-2","doi":"https://doi.org/10.1016/s0022-5193(05)80143-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5193(05)80143-2","pdf_url":null,"source":{"id":"https://openalex.org/S109682412","display_name":"Journal of Theoretical Biology","issn_l":"0022-5193","issn":["0022-5193","1095-8541"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Theoretical Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111459554","display_name":"Gurii Ivanovich Marchuk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210086928","display_name":"Institute of Numerical Mathematics","ror":"https://ror.org/00520ey40","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210086928","https://openalex.org/I4210124601"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"G.I. Marchuk","raw_affiliation_strings":["Department of Numerical Mathematics U.S.S.R. Academy of Sciences, Moscow","Department of Numerical Mathematics U.S.S.R. Academy of Sciences, Leninsky Prospect 32-A, 117334 Moscow, U.S.S.R"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Numerical Mathematics U.S.S.R. Academy of Sciences, Moscow","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210086928"]},{"raw_affiliation_string":"Department of Numerical Mathematics U.S.S.R. Academy of Sciences, Leninsky Prospect 32-A, 117334 Moscow, U.S.S.R","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210086928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014803626","display_name":"Alexei Alexeevich Romanyukha","orcid":"https://orcid.org/0000-0002-9122-7045","observed_orcids":["https://orcid.org/0000-0002-9122-7045"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210086928","display_name":"Institute of Numerical Mathematics","ror":"https://ror.org/00520ey40","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210086928","https://openalex.org/I4210124601"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"A.A. Romanyukha","raw_affiliation_strings":["Department of Numerical Mathematics U.S.S.R. Academy of Sciences, Leninsky Prospect 32-A, 117334, Moscow, U.S.S.R"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Numerical Mathematics U.S.S.R. Academy of Sciences, Leninsky Prospect 32-A, 117334, Moscow, U.S.S.R","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210086928"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032433442","display_name":"Gennady Alekseevich Bocharov","orcid":"https://orcid.org/0000-0002-5049-0656","observed_orcids":["https://orcid.org/0000-0002-5049-0656"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210086928","display_name":"Institute of Numerical Mathematics","ror":"https://ror.org/00520ey40","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210086928","https://openalex.org/I4210124601"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"G.A. Bocharov","raw_affiliation_strings":["Department of Numerical Mathematics U.S.S.R. Academy of Sciences, Leninsky Prospect 32-A, 117334, Moscow, U.S.S.R"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Numerical Mathematics U.S.S.R. Academy of Sciences, Leninsky Prospect 32-A, 117334, Moscow, U.S.S.R","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210086928"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014803626"],"corresponding_institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210086928"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":null,"fwci":1.8097,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.82798472,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"151","issue":"1","first_page":"41","last_page":"69"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/2604","display_name":"Applied Mathematics"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiviral-immunity","display_name":"antiviral immunity","score":0.878000020980835},{"id":"https://openalex.org/keywords/acute-hepatitis-b","display_name":"acute hepatitis B","score":0.9620000123977661},{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.8610000014305115},{"id":"https://openalex.org/keywords/parameter-estimation","display_name":"parameter estimation","score":0.796999990940094},{"id":"https://openalex.org/keywords/model-fitting","display_name":"model fitting","score":0.7540000081062317},{"id":"https://openalex.org/keywords/sequential-parameter-estimation","display_name":"sequential parameter estimation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/hepatitis-b-vaccination","display_name":"hepatitis B vaccination","score":0.8180000185966492},{"id":"https://openalex.org/keywords/incubation-time","display_name":"incubation time","score":0.8130000233650208},{"id":"https://openalex.org/keywords/sensitivity-analysis","display_name":"sensitivity analysis","score":0.6990000009536743},{"id":"https://openalex.org/keywords/viral-dose","display_name":"viral dose","score":0.38499999046325684}],"concepts":[{"id":"https://openalex.org/C2777410769","wikidata":"https://www.wikidata.org/wiki/Q2282887","display_name":"HBsAg","level":4,"score":0.7687589526176453},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5995916128158569},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5905444622039795},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.5406453609466553},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.5166457295417786},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5045260190963745},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.47245410084724426},{"id":"https://openalex.org/C3020505244","wikidata":"https://www.wikidata.org/wiki/Q846227","display_name":"Antiviral treatment","level":4,"score":0.4579119086265564},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.44521552324295044},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4332500100135803},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36699509620666504},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33602333068847656},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3201390504837036},{"id":"https://openalex.org/C3020491458","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Chronic hepatitis","level":3,"score":0.154166579246521},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006514","descriptor_name":"Hepatitis B Surface Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0022-5193(05)80143-2","doi":"https://doi.org/10.1016/s0022-5193(05)80143-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5193(05)80143-2","pdf_url":null,"source":{"id":"https://openalex.org/S109682412","display_name":"Journal of Theoretical Biology","issn_l":"0022-5193","issn":["0022-5193","1095-8541"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Theoretical Biology","raw_type":"journal-article"},{"id":"pmid:1943137","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1943137","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of theoretical biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W87159398","https://openalex.org/W99790034","https://openalex.org/W115457706","https://openalex.org/W234332593","https://openalex.org/W291003596","https://openalex.org/W1485579322","https://openalex.org/W1501399145","https://openalex.org/W1515410113","https://openalex.org/W1527920117","https://openalex.org/W1540986790","https://openalex.org/W1679923858","https://openalex.org/W1946724793","https://openalex.org/W1968685925","https://openalex.org/W1968890997","https://openalex.org/W1972462008","https://openalex.org/W1973247949","https://openalex.org/W1974823531","https://openalex.org/W1983420763","https://openalex.org/W1983527377","https://openalex.org/W1994638450","https://openalex.org/W1995658901","https://openalex.org/W2002451611","https://openalex.org/W2006492421","https://openalex.org/W2011684625","https://openalex.org/W2011760528","https://openalex.org/W2026836745","https://openalex.org/W2032315442","https://openalex.org/W2035141712","https://openalex.org/W2041491028","https://openalex.org/W2048052465","https://openalex.org/W2063695143","https://openalex.org/W2073816666","https://openalex.org/W2078409719","https://openalex.org/W2080532202","https://openalex.org/W2100078961","https://openalex.org/W2117397815","https://openalex.org/W2138220015","https://openalex.org/W2154876043","https://openalex.org/W2161146662","https://openalex.org/W2171074980","https://openalex.org/W2319885746","https://openalex.org/W2414269515","https://openalex.org/W2414992652","https://openalex.org/W2418880088","https://openalex.org/W2506991716","https://openalex.org/W2611132655","https://openalex.org/W2970517232","https://openalex.org/W3022936315","https://openalex.org/W3156466618","https://openalex.org/W4230115272","https://openalex.org/W4238502811","https://openalex.org/W4313310723","https://openalex.org/W6603560536"],"related_works":["https://openalex.org/W1974823531","https://openalex.org/W2418699250","https://openalex.org/W2314684226","https://openalex.org/W2168003330","https://openalex.org/W7096532712","https://openalex.org/W2462784957","https://openalex.org/W4394622738","https://openalex.org/W4417308252","https://openalex.org/W2052712728","https://openalex.org/W7097644260"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}