{"id":"https://openalex.org/W2028554205","doi":"https://doi.org/10.1034/j.1600-0609.2000.065004272.x","title":"Improvement of extrathymic T cell type of large granular lymphocyte (LGL) leukemia by cyclosporin A: the serum level of Fas ligand is a marker of LGL leukemia activity","display_name":"Improvement of extrathymic T cell type of large granular lymphocyte (LGL) leukemia by cyclosporin A: the serum level of Fas ligand is a marker of LGL leukemia activity","publication_year":2000,"publication_date":"2000-10-01","ids":{"openalex":"https://openalex.org/W2028554205","doi":"https://doi.org/10.1034/j.1600-0609.2000.065004272.x","mag":"2028554205","pmid":"https://pubmed.ncbi.nlm.nih.gov/11073168"},"language":"en","primary_location":{"id":"doi:10.1034/j.1600-0609.2000.065004272.x","doi":"https://doi.org/10.1034/j.1600-0609.2000.065004272.x","is_oa":false,"landing_page_url":"https://doi.org/10.1034/j.1600-0609.2000.065004272.x","pdf_url":null,"source":{"id":"https://openalex.org/S159715054","display_name":"European Journal Of Haematology","issn_l":"0902-4441","issn":["0902-4441","1600-0609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081426498","display_name":"Takayuki Saitoh","orcid":"https://orcid.org/0000-0001-5524-7455","observed_orcids":["https://orcid.org/0000-0001-5524-7455"]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]},{"id":"https://openalex.org/I4210164827","display_name":"Gunma University Hospital","ror":"https://ror.org/05kq1z994","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210164827"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Saitoh","raw_affiliation_strings":["Third Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan","Third Department of Internal Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan","institution_ids":["https://openalex.org/I165735259","https://openalex.org/I4210164827"]},{"raw_affiliation_string":"Third Department of Internal Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109572726","display_name":"Masamitsu Karasawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]},{"id":"https://openalex.org/I4210164827","display_name":"Gunma University Hospital","ror":"https://ror.org/05kq1z994","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210164827"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masamitsu Karasawa","raw_affiliation_strings":["Division of Blood Transfusion Service, Gunma University School of Medicine, Maebashi, Gunma, Japan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Blood Transfusion Service, Gunma University School of Medicine, Maebashi, Gunma, Japan,","institution_ids":["https://openalex.org/I165735259","https://openalex.org/I4210164827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038493520","display_name":"Masataka Sakuraya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masataka Sakuraya","raw_affiliation_strings":["Third Department of Internal Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nakamura Norio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165085132","display_name":"Mochida Pharmaceutical (Japan)","ror":"https://ror.org/045p8e908","country_code":"JP","type":"company","lineage":["https://openalex.org/I165085132"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nakamura Norio","raw_affiliation_strings":["Biosciences Research Laboratory, Mochida Pharmacehtical Co., Ltd., Tokyo, Japan, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biosciences Research Laboratory, Mochida Pharmacehtical Co., Ltd., Tokyo, Japan, and","institution_ids":["https://openalex.org/I165085132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053341947","display_name":"Junko Tohma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165085132","display_name":"Mochida Pharmaceutical (Japan)","ror":"https://ror.org/045p8e908","country_code":"JP","type":"company","lineage":["https://openalex.org/I165085132"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tohma Junko","raw_affiliation_strings":["Biosciences Research Laboratory, Mochida Pharmacehtical Co., Ltd., Tokyo, Japan, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biosciences Research Laboratory, Mochida Pharmacehtical Co., Ltd., Tokyo, Japan, and","institution_ids":["https://openalex.org/I165085132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113606884","display_name":"Kamon Shirakawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165085132","display_name":"Mochida Pharmaceutical (Japan)","ror":"https://ror.org/045p8e908","country_code":"JP","type":"company","lineage":["https://openalex.org/I165085132"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kamon Shirakawa","raw_affiliation_strings":["Biosciences Research Laboratory, Mochida Pharmacehtical Co., Ltd., Tokyo, Japan, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biosciences Research Laboratory, Mochida Pharmacehtical Co., Ltd., Tokyo, Japan, and","institution_ids":["https://openalex.org/I165085132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110466824","display_name":"Takafumi Matsushima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takafumi Matsushima","raw_affiliation_strings":["Third Department of Internal Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111764986","display_name":"Norifumi Tsukamoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Norifumi Tsukamoto","raw_affiliation_strings":["Third Department of Internal Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025593969","display_name":"Jun\u2010ichi Tamura","orcid":"https://orcid.org/0000-0002-3957-0479","observed_orcids":["https://orcid.org/0000-0002-3957-0479"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun'ichi Tamura","raw_affiliation_strings":["Third Department of Internal Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015137708","display_name":"Takuji Naruse","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takuji Naruse","raw_affiliation_strings":["Third Department of Internal Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042551306","display_name":"Hirokazu Murakami","orcid":"https://orcid.org/0000-0003-1766-4615","observed_orcids":["https://orcid.org/0000-0003-1766-4615"]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hirokazu Murakami","raw_affiliation_strings":["School of Health Science, Facaulty of Medicine, Gunma University, Maebashi, Gunma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Health Science, Facaulty of Medicine, Gunma University, Maebashi, Gunma, Japan","institution_ids":["https://openalex.org/I165735259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5042551306"],"corresponding_institution_ids":["https://openalex.org/I165735259"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":1.6282,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.82694927,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"65","issue":"4","first_page":"272","last_page":"275"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.6410999894142151,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.6410999894142151,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.08649999648332596,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.08399999886751175,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/large-granular-lymphocytic-leukemia","display_name":"large granular lymphocyte leukemia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/gamma-delta-t-cells","display_name":"\u03b3\u03b4 T cells","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.968999981880188},{"id":"https://openalex.org/keywords/soluble-fas-ligand","display_name":"soluble Fas ligand","score":0.8899999856948853},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.6970000267028809},{"id":"https://openalex.org/keywords/disease-activity-markers","display_name":"disease activity markers","score":0.7419999837875366},{"id":"https://openalex.org/keywords/non-mhc-restricted-cytotoxicity","display_name":"non-MHC-restricted cytotoxicity","score":0.8939999938011169},{"id":"https://openalex.org/keywords/thrombocytosis","display_name":"thrombocytosis","score":0.7950000166893005},{"id":"https://openalex.org/keywords/pure-red-cell-aplasia","display_name":"pure red cell aplasia","score":0.8659999966621399},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.6399999856948853},{"id":"https://openalex.org/keywords/extrathymic-t-cells","display_name":"extrathymic T cells","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C66008609","wikidata":"https://www.wikidata.org/wiki/Q14866113","display_name":"Fas ligand","level":4,"score":0.6942293643951416},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.608985185623169},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5974611043930054},{"id":"https://openalex.org/C2777422296","wikidata":"https://www.wikidata.org/wiki/Q751631","display_name":"Pure red cell aplasia","level":3,"score":0.51875901222229},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5015199184417725},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.484797865152359},{"id":"https://openalex.org/C2777863708","wikidata":"https://www.wikidata.org/wiki/Q424519","display_name":"Thrombopoietin","level":4,"score":0.47102007269859314},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.44717052578926086},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4383953809738159},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.4243868291378021},{"id":"https://openalex.org/C2779788118","wikidata":"https://www.wikidata.org/wiki/Q1542410","display_name":"Thrombocytosis","level":3,"score":0.4139050841331482},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40107646584510803},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37648922204971313},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.37537747621536255},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.22837001085281372},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.18980970978736877},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.17843759059906006},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.17081031203269958},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.16028758883476257},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.11170119047164917},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.07622876763343811},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007945","descriptor_name":"Leukemia, Lymphoid","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007945","descriptor_name":"Leukemia, Lymphoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012010","descriptor_name":"Red-Cell Aplasia, Pure","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012010","descriptor_name":"Red-Cell Aplasia, Pure","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D013922","descriptor_name":"Thrombocytosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013922","descriptor_name":"Thrombocytosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D015458","descriptor_name":"Leukemia, T-Cell","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D015458","descriptor_name":"Leukemia, T-Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016692","descriptor_name":"Receptors, Antigen, T-Cell, gamma-delta","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1034/j.1600-0609.2000.065004272.x","doi":"https://doi.org/10.1034/j.1600-0609.2000.065004272.x","is_oa":false,"landing_page_url":"https://doi.org/10.1034/j.1600-0609.2000.065004272.x","pdf_url":null,"source":{"id":"https://openalex.org/S159715054","display_name":"European Journal Of Haematology","issn_l":"0902-4441","issn":["0902-4441","1600-0609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:11073168","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11073168","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of haematology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2092226795","https://openalex.org/W2008057516","https://openalex.org/W2039852679","https://openalex.org/W2059552299","https://openalex.org/W2574398068","https://openalex.org/W2039011374","https://openalex.org/W1989555905","https://openalex.org/W2026910508","https://openalex.org/W4238490177","https://openalex.org/W2059045334"],"abstract_inverted_index":{"We":[0],"report":[1],"a":[2,117],"case":[3],"of":[4,32,63,73,122,126,136],"gammadelta":[5],"T-cell-type":[6],"large":[7],"granular":[8,51],"lymphocyte":[9],"(LGL)":[10],"leukemia":[11],"(CD3":[12],"+,CD8":[13],"+,":[14],"CD57":[15],"+,TCR":[16],"gammadelta+),":[17],"which":[18],"was":[19,66],"accompanied":[20],"by":[21],"pure":[22],"red":[23],"cell":[24],"aplasia,":[25],"neutropenia":[26],"and":[27,87,97,101,103,129],"thrombocytosis.":[28],"Southern":[29],"blotting":[30],"analysis":[31],"the":[33,39,70,104,120,123],"T-cell":[34],"receptor":[35],"beta":[36,83],"gene":[37],"showed":[38],"germline":[40],"configuration,":[41],"but":[42],"clonal":[43],"TCR":[44],"J":[45],"gamma":[46,80],"rearrangements":[47],"were":[48,89,99],"identified.":[49],"These":[50,109],"lymphocytes":[52],"demonstrated":[53],"non-major":[54],"histocompatibility":[55],"complex-restricted":[56],"cytotoxicitity.":[57],"The":[58],"serum-soluble":[59],"FasL":[60,113],"(sFasL)":[61],"concentration":[62,107],"this":[64,127],"patient":[65,128],"very":[67],"high,":[68],"whereas":[69],"serum":[71],"levels":[72],"tumor":[74],"necrosis":[75],"factor":[76],"alpha":[77],"(TNF-alpha),":[78],"interferon":[79],"(IFN-gamma),":[81],"interleukin-1":[82],"(IL-1beta),":[84],"interleukin-2":[85],"(IL-2)":[86],"thrombopoietin":[88],"normal.":[90],"After":[91],"treatment":[92],"with":[93],"cyclosporin":[94],"A,":[95],"anemia":[96],"thrombocytosis":[98],"improved,":[100],"LGL":[102],"elevated":[105],"sFasL":[106],"decreased.":[108],"observations":[110],"suggested":[111],"that":[112],"may":[114],"have":[115],"played":[116],"role":[118],"in":[119],"establishment":[121],"clinical":[124],"symptoms":[125],"could":[130],"be":[131],"useful":[132],"as":[133],"an":[134],"indicator":[135],"disease":[137],"activity.":[138]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}