{"id":"https://openalex.org/W2028465837","doi":"https://doi.org/10.1073/pnas.0803934105","title":"Integrins \u03b11\u03b21 and \u03b12\u03b21 are receptors for the rotavirus enterotoxin","display_name":"Integrins \u03b11\u03b21 and \u03b12\u03b21 are receptors for the rotavirus enterotoxin","publication_year":2008,"publication_date":"2008-06-27","ids":{"openalex":"https://openalex.org/W2028465837","doi":"https://doi.org/10.1073/pnas.0803934105","mag":"2028465837","pmid":"https://pubmed.ncbi.nlm.nih.gov/18587047","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3021436"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0803934105","doi":"https://doi.org/10.1073/pnas.0803934105","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0803934105","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3021436","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069530678","display_name":"Neung\u2010Seon Seo","orcid":"https://orcid.org/0000-0001-7308-3191","observed_orcids":["https://orcid.org/0000-0001-7308-3191"]},"institutions":[{"id":"https://openalex.org/I173268674","display_name":"Texas A&M University System","ror":"https://ror.org/0034eay46","country_code":"US","type":"education","lineage":["https://openalex.org/I173268674"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neung-Seon Seo","raw_affiliation_strings":["*Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, TX 77030; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, TX 77030; and","institution_ids":["https://openalex.org/I173268674","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110198270","display_name":"Carl Q.\u2010Y. Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl Q.-Y. Zeng","raw_affiliation_strings":["Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034229449","display_name":"Joseph M. Hyser","orcid":"https://orcid.org/0000-0001-5249-3482","observed_orcids":["https://orcid.org/0000-0001-5249-3482"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph M. Hyser","raw_affiliation_strings":["Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083005456","display_name":"Budi Utama","orcid":"https://orcid.org/0000-0002-6247-4426","observed_orcids":["https://orcid.org/0000-0002-6247-4426"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Budi Utama","raw_affiliation_strings":["Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012500318","display_name":"Sue E. Crawford","orcid":"https://orcid.org/0000-0001-8113-3806","observed_orcids":["https://orcid.org/0000-0001-8113-3806"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sue E. Crawford","raw_affiliation_strings":["Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003191411","display_name":"Kate J. Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173268674","display_name":"Texas A&M University System","ror":"https://ror.org/0034eay46","country_code":"US","type":"education","lineage":["https://openalex.org/I173268674"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kate J. Kim","raw_affiliation_strings":["*Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, TX 77030; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, TX 77030; and","institution_ids":["https://openalex.org/I173268674","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110274784","display_name":"Magnus H\u00f6\u00f6k","orcid":"https://orcid.org/0000-0003-2703-0309","observed_orcids":["https://orcid.org/0000-0003-2703-0309"]},"institutions":[{"id":"https://openalex.org/I173268674","display_name":"Texas A&M University System","ror":"https://ror.org/0034eay46","country_code":"US","type":"education","lineage":["https://openalex.org/I173268674"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Magnus H\u00f6\u00f6k","raw_affiliation_strings":["*Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, TX 77030; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, TX 77030; and","institution_ids":["https://openalex.org/I173268674","https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087604589","display_name":"Mary Kolb Estes","orcid":"https://orcid.org/0000-0002-4813-4249","observed_orcids":["https://orcid.org/0000-0002-4813-4249"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary K. Estes","raw_affiliation_strings":["Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.8179,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.94965572,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"105","issue":"26","first_page":"8811","last_page":"8818"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":0.6259999871253967,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":0.6259999871253967,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.3700999915599823,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11855","display_name":"Gastrointestinal disorders and treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rotavirus","display_name":"rotavirus","score":0.8209999799728394},{"id":"https://openalex.org/keywords/nsp4","display_name":"NSP4","score":0.9559999704360962},{"id":"https://openalex.org/keywords/integrin-alpha1beta1","display_name":"alpha1beta1 integrin","score":0.9390000104904175},{"id":"https://openalex.org/keywords/integrin-alpha2beta1","display_name":"alpha2beta1 integrin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/integrin-i-domain","display_name":"integrin I domain","score":0.7990000247955322},{"id":"https://openalex.org/keywords/metal-ion-dependent-adhesion-site","display_name":"metal ion-dependent adhesion site","score":0.8859999775886536},{"id":"https://openalex.org/keywords/receptor-binding","display_name":"receptor binding","score":0.6710000038146973},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.5170000195503235},{"id":"https://openalex.org/keywords/cell-spreading","display_name":"cell spreading","score":0.42399999499320984},{"id":"https://openalex.org/keywords/c2c12-myoblasts","display_name":"C2C12 myoblasts","score":0.7760000228881836},{"id":"https://openalex.org/keywords/viral-virulence-factors","display_name":"viral virulence factors","score":0.597000002861023},{"id":"https://openalex.org/keywords/rotavirus-pathogenesis","display_name":"rotavirus pathogenesis","score":0.7829999923706055}],"concepts":[{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.7725428938865662},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6184271574020386},{"id":"https://openalex.org/C156585808","wikidata":"https://www.wikidata.org/wiki/Q18028043","display_name":"Integrin, beta 6","level":4,"score":0.5667144060134888},{"id":"https://openalex.org/C66999527","wikidata":"https://www.wikidata.org/wiki/Q421978","display_name":"Enterotoxin","level":4,"score":0.5179051756858826},{"id":"https://openalex.org/C171779818","wikidata":"https://www.wikidata.org/wiki/Q3799301","display_name":"Integrin alpha M","level":3,"score":0.48654118180274963},{"id":"https://openalex.org/C4894155","wikidata":"https://www.wikidata.org/wiki/Q4201950","display_name":"CD49c","level":5,"score":0.4767899513244629},{"id":"https://openalex.org/C119524353","wikidata":"https://www.wikidata.org/wiki/Q5145908","display_name":"Collagen receptor","level":4,"score":0.4447074830532074},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.43314486742019653},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43236833810806274},{"id":"https://openalex.org/C2779358239","wikidata":"https://www.wikidata.org/wiki/Q2124191","display_name":"RGD motif","level":4,"score":0.4136843979358673},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39935725927352905},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.215518057346344},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08731302618980408},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077191","descriptor_name":"Wortmannin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000730","descriptor_name":"Androstadienes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004768","descriptor_name":"Enterotoxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004768","descriptor_name":"Enterotoxins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004963","descriptor_name":"Estrenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011760","descriptor_name":"Pyrrolidinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012401","descriptor_name":"Rotavirus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012401","descriptor_name":"Rotavirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014118","descriptor_name":"Toxins, Biological","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014118","descriptor_name":"Toxins, Biological","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020349","descriptor_name":"Surface Plasmon Resonance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D038982","descriptor_name":"Integrin alpha2beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D038982","descriptor_name":"Integrin alpha2beta1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D039222","descriptor_name":"Integrin alpha1beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D039222","descriptor_name":"Integrin alpha1beta1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.0803934105","doi":"https://doi.org/10.1073/pnas.0803934105","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0803934105","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2000156","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3021436","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3021436","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3021436","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:18587047","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18587047","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2000156","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3021436","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1848797220","display_name":"MOLECULAR BIOLOGY OF THE ROTAVIRUSES","funder_award_id":"R01DK030144","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1937313886","display_name":null,"funder_award_id":"AI20624","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2999623016","display_name":"Analysis of Staphylococcus Aureus Host Interactions","funder_award_id":"R56AI020624","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4740606549","display_name":"Molecular Biology of the Rotaviruses","funder_award_id":"R56DK030144","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5316166300","display_name":"Analysis of Staphylococcus Aureus Host Interactions.","funder_award_id":"R01AI020624","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8906397878","display_name":"Research Training Program in Molecular Virology","funder_award_id":"T32AI007471","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000079273","display_name":null,"funder_award_id":"DK-56338","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000341266","display_name":null,"funder_award_id":"AI20624","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000890444","display_name":"Regulation of Rotavirus Replication","funder_award_id":"R01AI080656","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000893404","display_name":"Texas Medical Center Digestive Diseases Center","funder_award_id":"P30DK056338","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G921446284","display_name":null,"funder_award_id":"DK-30144","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W1494085200","https://openalex.org/W1530895186","https://openalex.org/W1576773659","https://openalex.org/W1819797284","https://openalex.org/W1837209866","https://openalex.org/W1967525449","https://openalex.org/W1971875616","https://openalex.org/W1974250799","https://openalex.org/W1980495742","https://openalex.org/W1981284849","https://openalex.org/W1989038840","https://openalex.org/W1990876250","https://openalex.org/W1991546772","https://openalex.org/W1996141909","https://openalex.org/W2003111769","https://openalex.org/W2006551247","https://openalex.org/W2009045275","https://openalex.org/W2015641127","https://openalex.org/W2019086026","https://openalex.org/W2020265941","https://openalex.org/W2020624113","https://openalex.org/W2020733401","https://openalex.org/W2021900417","https://openalex.org/W2021968896","https://openalex.org/W2022026033","https://openalex.org/W2027371568","https://openalex.org/W2027856974","https://openalex.org/W2029231027","https://openalex.org/W2037503395","https://openalex.org/W2039052448","https://openalex.org/W2045238641","https://openalex.org/W2046428666","https://openalex.org/W2047204461","https://openalex.org/W2048846997","https://openalex.org/W2055692179","https://openalex.org/W2055925640","https://openalex.org/W2058013542","https://openalex.org/W2058166542","https://openalex.org/W2063559096","https://openalex.org/W2064384823","https://openalex.org/W2070185260","https://openalex.org/W2070509942","https://openalex.org/W2072376558","https://openalex.org/W2074353579","https://openalex.org/W2076397950","https://openalex.org/W2077493156","https://openalex.org/W2099097747","https://openalex.org/W2100071111","https://openalex.org/W2101772576","https://openalex.org/W2104124112","https://openalex.org/W2104366664","https://openalex.org/W2106333878","https://openalex.org/W2109960999","https://openalex.org/W2111924954","https://openalex.org/W2113801524","https://openalex.org/W2120975539","https://openalex.org/W2126606502","https://openalex.org/W2134445527","https://openalex.org/W2137134545","https://openalex.org/W2137464792","https://openalex.org/W2144750575","https://openalex.org/W2146604114","https://openalex.org/W2150862362","https://openalex.org/W2159874398","https://openalex.org/W2162814300","https://openalex.org/W2164841306","https://openalex.org/W2170584552","https://openalex.org/W2170877356","https://openalex.org/W4213141530"],"related_works":["https://openalex.org/W2027371568","https://openalex.org/W1967279658","https://openalex.org/W2148462836","https://openalex.org/W2055925640","https://openalex.org/W2899771630","https://openalex.org/W2147052881","https://openalex.org/W2112196702","https://openalex.org/W2121576794","https://openalex.org/W1974250799","https://openalex.org/W2258151631"],"abstract_inverted_index":{"Rotavirus":[0],"NSP4":[1,22,51,89,100,107,120,134,170,192,215],"is":[2,15,68,83,222],"a":[3,32],"viral":[4,235],"enterotoxin":[5,227],"capable":[6],"of":[7,20,125,157,179,226],"causing":[8],"diarrhea":[9,206],"in":[10,205,208],"neonatal":[11,209],"mice.":[12,210],"This":[13],"process":[14],"initiated":[16],"by":[17,70],"the":[18,27,42,55,71,116,126,142,146,155,166,176],"binding":[19,114,124,144],"extracellular":[21],"to":[23,36,54,94,115,131,145,154,196],"target":[24],"molecule(s)":[25],"on":[26,175],"cell":[28],"surface":[29,178],"that":[30,41,152,194,214],"triggers":[31],"signaling":[33,151],"cascade":[34],"leading":[35],"diarrhea.":[37],"We":[38],"now":[39],"report":[40],"integrins":[43],"alpha1beta1":[44],"and":[45,57,87,119,220,229],"alpha2beta1":[46],"are":[47,111,138],"receptors":[48],"for":[49,113],"NSP4.":[50],"specifically":[52],"binds":[53],"alpha1":[56,219],"alpha2":[58,96,168,174,202,221],"I":[59,72,98,117,147],"domains":[60],"with":[61,85,141,172,217],"apparent":[62],"K(d)":[63],"=":[64],"1-2.7":[65],"muM.":[66],"Binding":[67],"mediated":[69],"domain":[73],"metal":[74],"ion-dependent":[75],"adhesion":[76],"site":[77],"motif,":[78],"requires":[79],"Mg(2+)":[80],"or":[81,198],"Mn(2+),":[82],"abolished":[84],"EDTA,":[86],"an":[88,223],"point":[90],"mutant,":[91],"E(120)A,":[92],"fails":[93],"bind":[95,197],"integrin":[97,104,132,173,201,218],"domain.":[99],"has":[101],"two":[102],"distinct":[103],"interaction":[105,216],"domains.":[106],"amino":[108,135],"acids":[109,136],"114-130":[110],"essential":[112],"domain,":[118,148],"peptide":[121],"114-135":[122],"blocks":[123],"natural":[127],"ligand,":[128],"collagen":[129],"I,":[130],"alpha2.":[133],"131-140":[137],"not":[139],"associated":[140],"initial":[143],"but":[149],"elicit":[150],"leads":[153],"spreading":[156],"attached":[158],"C2C12-alpha2":[159],"cells,":[160],"mouse":[161],"myoblast":[162],"cells":[163,185],"stably":[164],"expressing":[165],"human":[167],"integrin.":[169],"colocalizes":[171],"basolateral":[177],"rotavirus-infected":[180],"polarized":[181],"intestinal":[182],"epithelial":[183],"(Caco-2)":[184],"as":[186,188],"well":[187],"surrounding":[189],"noninfected":[190],"cells.":[191],"mutants":[193],"fail":[195],"signal":[199],"through":[200],"were":[203],"attenuated":[204],"induction":[207],"These":[211],"results":[212],"indicate":[213],"important":[224],"component":[225],"function":[228],"rotavirus":[230],"pathogenesis,":[231],"further":[232],"distinguishing":[233],"this":[234],"virulence":[236],"factor":[237],"from":[238],"other":[239],"microbial":[240],"enterotoxins.":[241]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}