{"id":"https://openalex.org/W2028445408","doi":"https://doi.org/10.1073/pnas.75.7.3244","title":"Disulfide-linked high molecular weight protein associated with human cataract.","display_name":"Disulfide-linked high molecular weight protein associated with human cataract.","publication_year":1978,"publication_date":"1978-07-01","ids":{"openalex":"https://openalex.org/W2028445408","doi":"https://doi.org/10.1073/pnas.75.7.3244","mag":"2028445408","pmid":"https://pubmed.ncbi.nlm.nih.gov/277922","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/392751"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.75.7.3244","doi":"https://doi.org/10.1073/pnas.75.7.3244","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.75.7.3244","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC392751","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112028763","display_name":"Abraham Spector","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Spector","raw_affiliation_strings":["Biochemistry and Molecular Biology Laboratory, Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York, New York 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology Laboratory, Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York, New York 10032","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012942768","display_name":"Debdutta Roy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Roy","raw_affiliation_strings":["Biochemistry and Molecular Biology Laboratory, Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York, New York 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology Laboratory, Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York, New York 10032","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":3.193,"has_fulltext":false,"cited_by_count":156,"citation_normalized_percentile":{"value":0.92573527,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"75","issue":"7","first_page":"3244","last_page":"3248"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cataract","display_name":"cataract","score":0.8519999980926514},{"id":"https://openalex.org/keywords/lens-proteins","display_name":"lens proteins","score":0.7990000247955322},{"id":"https://openalex.org/keywords/high-molecular-weight-proteins","display_name":"high molecular weight proteins","score":0.8320000171661377},{"id":"https://openalex.org/keywords/sulfhydryl-groups","display_name":"sulfhydryl groups","score":0.8550000190734863},{"id":"https://openalex.org/keywords/protein-reduction","display_name":"protein reduction","score":0.7089999914169312},{"id":"https://openalex.org/keywords/lens-aging","display_name":"lens aging","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C27256138","wikidata":"https://www.wikidata.org/wiki/Q1230226","display_name":"Disulfide bond","level":2,"score":0.7339355945587158},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7199402451515198},{"id":"https://openalex.org/C7263354","wikidata":"https://www.wikidata.org/wiki/Q2992167","display_name":"Crystallin","level":2,"score":0.6065248250961304},{"id":"https://openalex.org/C149629883","wikidata":"https://www.wikidata.org/wiki/Q660926","display_name":"Fraction (chemistry)","level":2,"score":0.5640400648117065},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45829471945762634},{"id":"https://openalex.org/C58121356","wikidata":"https://www.wikidata.org/wiki/Q182854","display_name":"Molecular mass","level":3,"score":0.4522190988063812},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.29593223333358765},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2156502902507782}],"mesh":[{"descriptor_ui":"D002386","descriptor_name":"Cataract","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003459","descriptor_name":"Crystallins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003459","descriptor_name":"Crystallins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004220","descriptor_name":"Disulfides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.75.7.3244","doi":"https://doi.org/10.1073/pnas.75.7.3244","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.75.7.3244","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:64563","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC392751","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:392751","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/392751","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:277922","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/277922","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:64563","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC392751","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W73256791","https://openalex.org/W148976868","https://openalex.org/W1514987858","https://openalex.org/W1625660792","https://openalex.org/W1971496802","https://openalex.org/W1983055388","https://openalex.org/W1984707567","https://openalex.org/W1991310329","https://openalex.org/W1997951802","https://openalex.org/W2001702012","https://openalex.org/W2006972270","https://openalex.org/W2011520923","https://openalex.org/W2024120301","https://openalex.org/W2035333976","https://openalex.org/W2046363984","https://openalex.org/W2046661478","https://openalex.org/W2048877651","https://openalex.org/W2064283501","https://openalex.org/W2066415161","https://openalex.org/W2087709897","https://openalex.org/W2395795515"],"related_works":["https://openalex.org/W2066415161","https://openalex.org/W2035334721","https://openalex.org/W2053495306","https://openalex.org/W2000704611","https://openalex.org/W2417135033","https://openalex.org/W7139171061","https://openalex.org/W19562346","https://openalex.org/W2070130191","https://openalex.org/W1974940412","https://openalex.org/W2035333976"],"abstract_inverted_index":{"A":[0],"major":[1,103,130],"high":[2,138],"molecular":[3,41,139],"weight":[4,140],"disulfide-linked":[5,78,134],"protein":[6,20,79],"has":[7,24],"been":[8,26,62],"isolated":[9],"from":[10],"cataractous":[11,73],"lenses.":[12,74],"It":[13],"is":[14,109,136],"only":[15,129],"present":[16,146],"in":[17,28,64,69,90,97,105,147],"the":[18,77,86,91,98,101,106,128,137,144,148],"water-insoluble":[19,107],"fractions.":[21],"This":[22],"species":[23,55,141],"not":[25],"found":[27,63,117],"normal":[29,71],"lenses":[30],"of":[31,36,43,76,85,100],"comparable":[32],"age.":[33],"Upon":[34],"reduction":[35],"this":[37],"fraction,":[38],"polypeptides":[39,60,104,157],"having":[40],"weights":[42],"approximately":[44,83],"60,000,":[45],"43,000,":[46],"and":[47,72,142],"20,000":[48],"as":[49,51],"well":[50],"a":[52],"noncharacterized":[53],"heterogeneous":[54],"are":[56,89,151],"released.":[57],"Similar":[58],"sized":[59],"have":[61],"various":[65],"noncovalently":[66],"linked":[67],"aggregates":[68],"both":[70],"Examination":[75],"fraction":[80,108,132],"indicates":[81],"that":[82,127,143],"70%":[84],"sulfhydryl":[87],"groups":[88],"oxidized":[92],"state.":[93],"Although":[94],"little":[95],"change":[96],"sizes":[99],"other":[102],"observed":[110],"upon":[111],"reduction,":[112],"these":[113],"components":[114],"were":[115],"also":[116],"to":[118,158],"contain":[119],"an":[120],"appreciable":[121],"disulfide":[122],"content.":[123],"Such":[124],"results":[125],"indicate":[126],"lens":[131],"containing":[133],"polypeptide":[135],"disulfides":[145,154],"remaining":[149],"fractions":[150],"either":[152],"intrachain":[153],"or":[155],"link":[156],"small":[159],"peptides.":[160]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
