{"id":"https://openalex.org/W2028397449","doi":"https://doi.org/10.3109/03639045.2015.1014374","title":"Development and optimization of press coated tablets of release engineered valsartan for pulsatile delivery","display_name":"Development and optimization of press coated tablets of release engineered valsartan for pulsatile delivery","publication_year":2015,"publication_date":"2015-02-27","ids":{"openalex":"https://openalex.org/W2028397449","doi":"https://doi.org/10.3109/03639045.2015.1014374","mag":"2028397449","pmid":"https://pubmed.ncbi.nlm.nih.gov/25721985"},"language":"en","primary_location":{"id":"doi:10.3109/03639045.2015.1014374","doi":"https://doi.org/10.3109/03639045.2015.1014374","is_oa":false,"landing_page_url":"https://doi.org/10.3109/03639045.2015.1014374","pdf_url":null,"source":{"id":"https://openalex.org/S162444473","display_name":"Drug Development and Industrial Pharmacy","issn_l":"0363-9045","issn":["0363-9045","1520-5762"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Development and Industrial Pharmacy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051079557","display_name":"Sunny R. Shah","orcid":"https://orcid.org/0000-0002-0828-8059","observed_orcids":["https://orcid.org/0000-0002-0828-8059"]},"institutions":[{"id":"https://openalex.org/I4387153807","display_name":"B. K. Mody Government Pharmacy College","ror":"https://ror.org/00k7kt283","country_code":"IN","type":"education","lineage":["https://openalex.org/I4387153807"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sunny Shah","raw_affiliation_strings":["a Department of Pharmaceutics , B. K. Mody Government Pharmacy College, Government Polytechnic Campus , Rajkot , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Department of Pharmaceutics , B. K. Mody Government Pharmacy College, Government Polytechnic Campus , Rajkot , India","institution_ids":["https://openalex.org/I4387153807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037375610","display_name":"Romik Patel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153807","display_name":"B. K. Mody Government Pharmacy College","ror":"https://ror.org/00k7kt283","country_code":"IN","type":"education","lineage":["https://openalex.org/I4387153807"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Romik Patel","raw_affiliation_strings":["a Department of Pharmaceutics , B. K. Mody Government Pharmacy College, Government Polytechnic Campus , Rajkot , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Department of Pharmaceutics , B. K. Mody Government Pharmacy College, Government Polytechnic Campus , Rajkot , India","institution_ids":["https://openalex.org/I4387153807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015346091","display_name":"Moinuddin M. Soniwala","orcid":"https://orcid.org/0000-0001-5976-7255","observed_orcids":["https://orcid.org/0000-0001-5976-7255"]},"institutions":[{"id":"https://openalex.org/I4387153807","display_name":"B. K. Mody Government Pharmacy College","ror":"https://ror.org/00k7kt283","country_code":"IN","type":"education","lineage":["https://openalex.org/I4387153807"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Moinuddin Soniwala","raw_affiliation_strings":["a Department of Pharmaceutics , B. K. Mody Government Pharmacy College, Government Polytechnic Campus , Rajkot , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Department of Pharmaceutics , B. K. Mody Government Pharmacy College, Government Polytechnic Campus , Rajkot , India","institution_ids":["https://openalex.org/I4387153807"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006277448","display_name":"Jayant R. Chavda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153807","display_name":"B. K. Mody Government Pharmacy College","ror":"https://ror.org/00k7kt283","country_code":"IN","type":"education","lineage":["https://openalex.org/I4387153807"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jayant Chavda","raw_affiliation_strings":["a Department of Pharmaceutics , B. K. Mody Government Pharmacy College, Government Polytechnic Campus , Rajkot , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Department of Pharmaceutics , B. K. Mody Government Pharmacy College, Government Polytechnic Campus , Rajkot , India","institution_ids":["https://openalex.org/I4387153807"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5051079557"],"corresponding_institution_ids":["https://openalex.org/I4387153807"],"apc_list":null,"apc_paid":null,"fwci":0.9331,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.65196548,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"41","issue":"11","first_page":"1835","last_page":"1846"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/valsartan","display_name":"valsartan","score":1.0},{"id":"https://openalex.org/keywords/pulsatile-drug-delivery","display_name":"pulsatile drug delivery","score":0.890999972820282},{"id":"https://openalex.org/keywords/press-coated-tablets","display_name":"press-coated tablets","score":0.8040000200271606},{"id":"https://openalex.org/keywords/beta-cyclodextrin-inclusion-complex","display_name":"\u03b2-cyclodextrin inclusion complex","score":0.8840000033378601},{"id":"https://openalex.org/keywords/drug-solubility-enhancement","display_name":"drug solubility enhancement","score":0.7599999904632568},{"id":"https://openalex.org/keywords/time-delay","display_name":"time delay","score":0.6029999852180481},{"id":"https://openalex.org/keywords/hpmc-k4m","display_name":"HPMC K4M","score":0.8730000257492065},{"id":"https://openalex.org/keywords/ethylcellulose","display_name":"ethyl cellulose","score":0.9700000286102295},{"id":"https://openalex.org/keywords/controlled-release","display_name":"controlled release","score":0.43700000643730164},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.7850000262260437},{"id":"https://openalex.org/keywords/plackett-burman-design","display_name":"Plackett-Burman design","score":0.7990000247955322},{"id":"https://openalex.org/keywords/full-factorial-design","display_name":"full factorial design","score":0.7200000286102295},{"id":"https://openalex.org/keywords/desirability-function","display_name":"desirability function","score":0.9670000076293945}],"concepts":[{"id":"https://openalex.org/C2777387769","wikidata":"https://www.wikidata.org/wiki/Q155472","display_name":"Valsartan","level":3,"score":0.7536262273788452},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.7161866426467896},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6307344436645508},{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.6109969615936279},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5649827718734741},{"id":"https://openalex.org/C2993377847","wikidata":"https://www.wikidata.org/wiki/Q1771903","display_name":"Lag time","level":2,"score":0.5360422730445862},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.5313644409179688},{"id":"https://openalex.org/C169222746","wikidata":"https://www.wikidata.org/wiki/Q4116558","display_name":"Factorial experiment","level":2,"score":0.5187113881111145},{"id":"https://openalex.org/C79191276","wikidata":"https://www.wikidata.org/wiki/Q7259620","display_name":"Pulsatile flow","level":2,"score":0.5185056924819946},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.45218318700790405},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.43486836552619934},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.4266948401927948},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4255010187625885},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.27769291400909424},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.26019227504730225},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.14122968912124634},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1263420283794403},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07834693789482117},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068756","descriptor_name":"Valsartan","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000068756","descriptor_name":"Valsartan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002152","descriptor_name":"Calorimetry, Differential Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002482","descriptor_name":"Cellulose","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002482","descriptor_name":"Cellulose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005079","descriptor_name":"Excipients","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013607","descriptor_name":"Tablets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017550","descriptor_name":"Spectroscopy, Fourier Transform Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020551","descriptor_name":"Pulse Therapy, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047228","descriptor_name":"Angiotensin II Type 1 Receptor Blockers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D047228","descriptor_name":"Angiotensin II Type 1 Receptor Blockers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047392","descriptor_name":"beta-Cyclodextrins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D065347","descriptor_name":"Hypromellose Derivatives","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D065546","descriptor_name":"Drug Liberation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/03639045.2015.1014374","doi":"https://doi.org/10.3109/03639045.2015.1014374","is_oa":false,"landing_page_url":"https://doi.org/10.3109/03639045.2015.1014374","pdf_url":null,"source":{"id":"https://openalex.org/S162444473","display_name":"Drug Development and Industrial Pharmacy","issn_l":"0363-9045","issn":["0363-9045","1520-5762"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Development and Industrial Pharmacy","raw_type":"journal-article"},{"id":"pmid:25721985","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25721985","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug development and industrial pharmacy","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1493552329","https://openalex.org/W1970231235","https://openalex.org/W1987986548","https://openalex.org/W1991302292","https://openalex.org/W1992793444","https://openalex.org/W1995108089","https://openalex.org/W1997361375","https://openalex.org/W2002185000","https://openalex.org/W2012064271","https://openalex.org/W2013065334","https://openalex.org/W2029584395","https://openalex.org/W2029986982","https://openalex.org/W2030565144","https://openalex.org/W2041110213","https://openalex.org/W2041606511","https://openalex.org/W2053019592","https://openalex.org/W2054139139","https://openalex.org/W2055663558","https://openalex.org/W2058063692","https://openalex.org/W2058702090","https://openalex.org/W2058852128","https://openalex.org/W2066291670","https://openalex.org/W2067557011","https://openalex.org/W2067914352","https://openalex.org/W2073440492","https://openalex.org/W2077879461","https://openalex.org/W2083233337","https://openalex.org/W2086812070","https://openalex.org/W2090319255","https://openalex.org/W2096197056","https://openalex.org/W2113002163","https://openalex.org/W2114501722","https://openalex.org/W2120777811","https://openalex.org/W2128708327","https://openalex.org/W2153774773","https://openalex.org/W2154357108","https://openalex.org/W2317091093","https://openalex.org/W2322397021","https://openalex.org/W2333826222","https://openalex.org/W3021261631"],"related_works":["https://openalex.org/W7105810904","https://openalex.org/W7211901169","https://openalex.org/W2110959815","https://openalex.org/W2769805085","https://openalex.org/W4402540129","https://openalex.org/W7219391712","https://openalex.org/W2294609210","https://openalex.org/W4360619156","https://openalex.org/W2010282462","https://openalex.org/W2515253499"],"abstract_inverted_index":{"The":[0,63,177],"present":[1],"work":[2],"is":[3],"aimed":[4],"to":[5,19,51,75,82,115,157,182],"develop":[6],"and":[7,39,60,92,131,142,164,169,197,211,218],"optimize":[8],"pulsatile":[9],"delivery":[10],"during":[11],"dissolution":[12,69],"of":[13,17,37,49,85,101,123,133,161,194,199,209],"an":[14],"improved":[15],"formulation":[16],"valsartan":[18,38,50,104,124],"coordinate":[20],"the":[21,35,83,134,159,183,187],"drug":[22,102,174],"release":[23,175],"with":[24,206],"circadian":[25],"rhythm.":[26],"Preliminary":[27],"studies":[28,59,97],"suggested":[29],"that":[30,99,139],"\u03b2":[31,52,105,125],"cyclodextrin":[32,53,106,126],"could":[33,79],"improve":[34],"solubility":[36,43,58],"showed":[40,66,144],"AL":[41],"type":[42],"curve.":[44],"A":[45,150],"1:1":[46],"stoichiometric":[47],"ratio":[48,205],"was":[54,108,155],"revealed":[55,89,98,138,212],"from":[56,90,103,186],"phase":[57],"Job's":[61],"plot.":[62],"prepared":[64,130,180],"complex":[65,87,107,127],"significantly":[67,109],"better":[68],"efficiency":[70],"(p":[71,111],"<":[72,112],"0.05)":[73,113],"compared":[74,114],"pure":[76,116],"drug,":[77,117],"which":[78],"be":[80],"due":[81],"formation":[84],"inclusion":[86],"as":[88],"FTIR":[91],"DSC":[93],"studies.":[94],"Continuous":[95],"dissolution-absorption":[96],"absorption":[100],"higher":[110],"in":[118,202],"second":[119],"part":[120],"press-coated":[121],"tablets":[122],"were":[128],"subsequently":[129],"application":[132],"Plackett-Burman":[135],"screening":[136],"design":[137,154],"HPMC":[140,162,200],"K4M":[141,163],"EC":[143,165],"significant":[145],"effect":[146],"on":[147,166],"lag":[148,167,192],"time.":[149],"3(2)":[151],"full":[152],"factorial":[153],"used":[156],"measure":[158],"response":[160],"time":[168,170,193],"taken":[171],"for":[172],"90%":[173],"(T90).":[176],"optimized":[178],"batch":[179],"according":[181],"levels":[184],"obtained":[185],"desirability":[188],"function":[189],"had":[190],"a":[191,203,213],"6":[195],"h":[196],"consisted":[198],"K4M:ethylcellulose":[201],"1:1.5":[204],"180":[207],"mg":[208],"coating":[210],"close":[214],"agreement":[215],"between":[216],"observed":[217],"predicted":[219],"value":[220],"(R(2":[221],")=":[222],"0.9694).":[223]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
