{"id":"https://openalex.org/W2028367236","doi":"https://doi.org/10.1179/016164109x12478302362536","title":"Prognostic and predictive value of p53 in low MGMT expressing glioblastoma treated with surgery, radiation and adjuvant temozolomide chemotherapy","display_name":"Prognostic and predictive value of p53 in low MGMT expressing glioblastoma treated with surgery, radiation and adjuvant temozolomide chemotherapy","publication_year":2009,"publication_date":"2009-08-24","ids":{"openalex":"https://openalex.org/W2028367236","doi":"https://doi.org/10.1179/016164109x12478302362536","mag":"2028367236","pmid":"https://pubmed.ncbi.nlm.nih.gov/19703338"},"language":"en","primary_location":{"id":"doi:10.1179/016164109x12478302362536","doi":"https://doi.org/10.1179/016164109x12478302362536","is_oa":false,"landing_page_url":"https://doi.org/10.1179/016164109x12478302362536","pdf_url":null,"source":{"id":"https://openalex.org/S187584928","display_name":"Neurological Research","issn_l":"0161-6412","issn":["0161-6412","1743-1328"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurological Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020997966","display_name":"Shouwei Li","orcid":"https://orcid.org/0000-0003-3320-2517","observed_orcids":["https://orcid.org/0000-0003-3320-2517"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210087691","display_name":"Beijing Tian Tan Hospital","ror":"https://ror.org/003regz62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087691"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shouwei Li","raw_affiliation_strings":["Glioma Treatment Center Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing, China; Beijing Neurosurgical Institute, Beijing, China","Beijing Neurosurgical Institute, Beijing, China","Glioma Treatment Center Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glioma Treatment Center Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing, China; Beijing Neurosurgical Institute, Beijing, China","institution_ids":["https://openalex.org/I4210087691"]},{"raw_affiliation_string":"Beijing Neurosurgical Institute, Beijing, China","institution_ids":[]},{"raw_affiliation_string":"Glioma Treatment Center Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210087691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100441502","display_name":"Wei Zhang","orcid":"https://orcid.org/0000-0001-7800-3189","observed_orcids":["https://orcid.org/0000-0001-7800-3189","https://orcid.org/0000-0002-4700-1276","https://orcid.org/0000-0001-5576-6108","https://orcid.org/0000-0003-4783-876X","https://orcid.org/0000-0001-5362-7569","https://orcid.org/0000-0002-5314-9904","https://orcid.org/0000-0001-6518-4152","https://orcid.org/0000-0001-7799-833X","https://orcid.org/0000-0001-8799-1182","https://orcid.org/0000-0002-0223-1924","https://orcid.org/0000-0002-4771-7573","https://orcid.org/0000-0002-7513-2185","https://orcid.org/0000-0002-7532-5550","https://orcid.org/0000-0001-6389-8274","https://orcid.org/0000-0001-6850-4027","https://orcid.org/0000-0001-6958-2342","https://orcid.org/0000-0001-7730-9274","https://orcid.org/0000-0001-8742-8736","https://orcid.org/0000-0002-0378-9946","https://orcid.org/0000-0002-0958-6349","https://orcid.org/0000-0002-2301-147X","https://orcid.org/0000-0002-2637-6001","https://orcid.org/0000-0002-3339-8751","https://orcid.org/0000-0002-3493-6064","https://orcid.org/0000-0002-3575-6225","https://orcid.org/0000-0002-4646-1991","https://orcid.org/0000-0002-5413-2442","https://orcid.org/0000-0002-6781-2826","https://orcid.org/0000-0003-2708-2221","https://orcid.org/0000-0003-2951-4833","https://orcid.org/0009-0002-2478-982X","https://orcid.org/0009-0006-1427-475X","https://orcid.org/0009-0007-0791-3186","https://orcid.org/0009-0007-8571-8044","https://orcid.org/0009-0008-9912-0649","https://orcid.org/0000-0001-5778-9936","https://orcid.org/0000-0001-5972-6744","https://orcid.org/0000-0001-6118-3136","https://orcid.org/0000-0001-6597-4103","https://orcid.org/0000-0001-6670-3057","https://orcid.org/0000-0001-7538-8570","https://orcid.org/0000-0001-7764-1613","https://orcid.org/0000-0001-7792-3389","https://orcid.org/0000-0001-7849-0255","https://orcid.org/0000-0001-8077-3019","https://orcid.org/0000-0001-8369-9264","https://orcid.org/0000-0001-8690-2838","https://orcid.org/0000-0001-9449-6673","https://orcid.org/0000-0001-9755-4402","https://orcid.org/0000-0001-9820-9600","https://orcid.org/0000-0002-0487-4659","https://orcid.org/0000-0002-0534-0974","https://orcid.org/0000-0002-1678-7683","https://orcid.org/0000-0002-1833-8152","https://orcid.org/0000-0002-3088-8931","https://orcid.org/0000-0002-3933-0109","https://orcid.org/0000-0002-4177-5991","https://orcid.org/0000-0002-5111-4951","https://orcid.org/0000-0002-5822-9970","https://orcid.org/0000-0002-6633-1801","https://orcid.org/0000-0002-8305-1465","https://orcid.org/0000-0002-8636-2816","https://orcid.org/0000-0002-9056-5675","https://orcid.org/0000-0002-9939-6978","https://orcid.org/0000-0003-0146-3552","https://orcid.org/0000-0003-0192-5956","https://orcid.org/0000-0003-0275-7376","https://orcid.org/0000-0003-0710-1966","https://orcid.org/0000-0003-1229-4782","https://orcid.org/0000-0003-1380-8482","https://orcid.org/0000-0003-1547-8907","https://orcid.org/0000-0003-2962-0847","https://orcid.org/0000-0003-3208-1039","https://orcid.org/0000-0003-4680-2992","https://orcid.org/0009-0000-1533-0959","https://orcid.org/0009-0000-1704-6855","https://orcid.org/0009-0000-5413-0650","https://orcid.org/0009-0000-6636-2299","https://orcid.org/0009-0000-7139-9678","https://orcid.org/0009-0000-8916-6944","https://orcid.org/0009-0001-0397-966X","https://orcid.org/0009-0001-0861-0271","https://orcid.org/0009-0001-1834-7884","https://orcid.org/0009-0001-6561-8616","https://orcid.org/0009-0001-8040-9708","https://orcid.org/0009-0001-9053-4633","https://orcid.org/0009-0001-9192-3323","https://orcid.org/0009-0002-0014-9182","https://orcid.org/0009-0002-1413-6024","https://orcid.org/0009-0002-2343-340X","https://orcid.org/0009-0002-4769-4372","https://orcid.org/0009-0002-4792-852X","https://orcid.org/0009-0002-6269-707X","https://orcid.org/0009-0002-6500-6895","https://orcid.org/0009-0002-9810-6745","https://orcid.org/0009-0003-1136-5160","https://orcid.org/0009-0003-4076-6422","https://orcid.org/0009-0003-5785-7363","https://orcid.org/0009-0003-8041-8676","https://orcid.org/0009-0003-8191-2422","https://orcid.org/0009-0003-9626-5790","https://orcid.org/0009-0004-0357-2212","https://orcid.org/0009-0004-2127-0285","https://orcid.org/0009-0004-4494-6014","https://orcid.org/0009-0004-6787-8990","https://orcid.org/0009-0004-7102-906X","https://orcid.org/0009-0005-1531-4445","https://orcid.org/0009-0005-1978-8285","https://orcid.org/0009-0005-5940-1997","https://orcid.org/0009-0005-8820-1206","https://orcid.org/0009-0005-9317-6797","https://orcid.org/0009-0006-0341-4243","https://orcid.org/0009-0006-1801-2175","https://orcid.org/0009-0006-3425-895X","https://orcid.org/0009-0006-3504-9041","https://orcid.org/0009-0006-6384-9142","https://orcid.org/0009-0006-6856-5034","https://orcid.org/0009-0007-2635-6469","https://orcid.org/0009-0007-2828-2686","https://orcid.org/0009-0007-4467-5906","https://orcid.org/0009-0007-6425-0374","https://orcid.org/0009-0007-7226-4928","https://orcid.org/0009-0007-8877-8077","https://orcid.org/0009-0007-9343-755X","https://orcid.org/0009-0007-9913-9107","https://orcid.org/0009-0008-1719-2287","https://orcid.org/0009-0008-3319-942X","https://orcid.org/0009-0008-3420-6919","https://orcid.org/0009-0008-4852-3018","https://orcid.org/0009-0008-5114-0595","https://orcid.org/0009-0008-6872-612X","https://orcid.org/0009-0008-7164-8927","https://orcid.org/0009-0008-9897-8416","https://orcid.org/0009-0009-3917-2460","https://orcid.org/0009-0009-4149-8136","https://orcid.org/0009-0009-4338-2313","https://orcid.org/0009-0009-5446-6205","https://orcid.org/0009-0009-6166-0858","https://orcid.org/0009-0009-6476-5524","https://orcid.org/0000-0002-9212-3010","https://orcid.org/0009-0006-6429-5962"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210087691","display_name":"Beijing Tian Tan Hospital","ror":"https://ror.org/003regz62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087691"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["Glioma Treatment Center Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glioma Treatment Center Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210087691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084796751","display_name":"Baoshi Chen","orcid":"https://orcid.org/0000-0002-3436-9557","observed_orcids":["https://orcid.org/0000-0002-3436-9557"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210087691","display_name":"Beijing Tian Tan Hospital","ror":"https://ror.org/003regz62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087691"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baoshi Chen","raw_affiliation_strings":["Glioma Treatment Center Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glioma Treatment Center Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210087691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070697945","display_name":"Tao Jiang","orcid":"https://orcid.org/0000-0002-7008-6351","observed_orcids":["https://orcid.org/0000-0002-7008-6351","https://orcid.org/0009-0004-6284-9162"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210087691","display_name":"Beijing Tian Tan Hospital","ror":"https://ror.org/003regz62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087691"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Jiang","raw_affiliation_strings":["Glioma Treatment Center Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing 100050, China; Beijing Neurosurgical Institute, Beijing, China; Email: taojiang1964@yahoo.com.cn","Beijing Neurosurgical Institute, Beijing, China","Glioma Treatment Center Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glioma Treatment Center Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing 100050, China; Beijing Neurosurgical Institute, Beijing, China; Email: taojiang1964@yahoo.com.cn","institution_ids":["https://openalex.org/I4210087691"]},{"raw_affiliation_string":"Beijing Neurosurgical Institute, Beijing, China","institution_ids":[]},{"raw_affiliation_string":"Glioma Treatment Center Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing 100050, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210087691"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101501945","display_name":"Zhongcheng Wang","orcid":"https://orcid.org/0000-0001-8971-7742","observed_orcids":["https://orcid.org/0000-0001-8971-7742"]},"institutions":[{"id":"https://openalex.org/I4210113914","display_name":"Beijing Institute of Neurosurgery","ror":"https://ror.org/01xbd6g65","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210113914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongcheng Wang","raw_affiliation_strings":["Beijing Neurosurgical Institute Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Neurosurgical Institute Beijing, China","institution_ids":["https://openalex.org/I4210113914"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8693,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.75695403,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"32","issue":"7","first_page":"690","last_page":"694"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53-expression","display_name":"p53 expression","score":0.8489999771118164},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9639999866485596},{"id":"https://openalex.org/keywords/mgmt-promoter-methylation","display_name":"MGMT promoter methylation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8270000219345093},{"id":"https://openalex.org/keywords/temozolomide-chemotherapy","display_name":"temozolomide chemotherapy","score":0.7940000295639038},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.7559999823570251},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.6740000247955322},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9990000128746033},{"id":"https://openalex.org/keywords/karnofsky-performance-status","display_name":"Karnofsky performance status","score":0.9810000061988831},{"id":"https://openalex.org/keywords/extent-of-resection","display_name":"extent of resection","score":0.7620000243186951},{"id":"https://openalex.org/keywords/patient-stratification","display_name":"patient stratification","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.9642249345779419},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.7912094593048096},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7585481405258179},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6697203516960144},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5698884129524231},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.5551832318305969},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5530949234962463},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.48480287194252014},{"id":"https://openalex.org/C2780964509","wikidata":"https://www.wikidata.org/wiki/Q416975","display_name":"Dacarbazine","level":3,"score":0.4699335992336273},{"id":"https://openalex.org/C3018227240","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant chemotherapy","level":4,"score":0.45532137155532837},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44925838708877563},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.348215788602829},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2822389006614685},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22343513369560242},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077204","descriptor_name":"Temozolomide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003606","descriptor_name":"Dacarbazine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003606","descriptor_name":"Dacarbazine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015254","descriptor_name":"DNA Modification Methylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045643","descriptor_name":"DNA Repair Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1179/016164109x12478302362536","doi":"https://doi.org/10.1179/016164109x12478302362536","is_oa":false,"landing_page_url":"https://doi.org/10.1179/016164109x12478302362536","pdf_url":null,"source":{"id":"https://openalex.org/S187584928","display_name":"Neurological Research","issn_l":"0161-6412","issn":["0161-6412","1743-1328"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurological Research","raw_type":"journal-article"},{"id":"pmid:19703338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19703338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurological research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1507460734","https://openalex.org/W1650797637","https://openalex.org/W1959628099","https://openalex.org/W1968601707","https://openalex.org/W1971620542","https://openalex.org/W1972546051","https://openalex.org/W1975608733","https://openalex.org/W1993745984","https://openalex.org/W2008854570","https://openalex.org/W2019300898","https://openalex.org/W2036560693","https://openalex.org/W2041538681","https://openalex.org/W2049852204","https://openalex.org/W2050686338","https://openalex.org/W2050771499","https://openalex.org/W2055629756","https://openalex.org/W2059624809","https://openalex.org/W2063299309","https://openalex.org/W2067104522","https://openalex.org/W2087904586","https://openalex.org/W2088925558","https://openalex.org/W2095443177","https://openalex.org/W2096287682","https://openalex.org/W2100312975","https://openalex.org/W2105100844","https://openalex.org/W2109557450","https://openalex.org/W2114012083","https://openalex.org/W2120610071","https://openalex.org/W2123730023","https://openalex.org/W2125464483","https://openalex.org/W2136527161","https://openalex.org/W2138545604","https://openalex.org/W2138800281","https://openalex.org/W2138837018","https://openalex.org/W2138946288","https://openalex.org/W2139008103","https://openalex.org/W2154968799","https://openalex.org/W2157270051","https://openalex.org/W2157836985","https://openalex.org/W2158370459","https://openalex.org/W2164774264","https://openalex.org/W2167288010","https://openalex.org/W2168656682","https://openalex.org/W2168877357","https://openalex.org/W2512906422"],"related_works":["https://openalex.org/W2067104522","https://openalex.org/W2225092011","https://openalex.org/W3135393711","https://openalex.org/W2563789939","https://openalex.org/W2000039301","https://openalex.org/W1554631561","https://openalex.org/W2620622663","https://openalex.org/W2016760158","https://openalex.org/W2129558754","https://openalex.org/W3120996230"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"assess":[2],"the":[3,29,170],"prognostic":[4,106,129,152],"and":[5,46,54,61,80,94,121,157],"predictive":[6],"significance":[7],"of":[8,32],"p53":[9,51,69,98,122,145,163],"protein":[10],"expression":[11,52,70,99,123,146],"in":[12,169],"low":[13,34,68,97,136,144],"O6-methylguanine-DNA":[14],"methyltransferase":[15],"(MGMT)":[16],"expressing":[17,36,138],"glioblastoma":[18],"multiform":[19],"(GBM)":[20],"treated":[21],"with":[22,59,67,88,141],"combined":[23,142],"therapy.":[24],"METHODS:":[25],"The":[26],"authors":[27],"reviewed":[28],"clinical":[30,55],"outcomes":[31,56],"46":[33],"MGMT":[35,137],"GBM":[37,139],"patients":[38,140],"who":[39],"had":[40,71],"undergone":[41],"surgery,":[42],"conventional":[43],"local":[44],"radiotherapy":[45],"temozolomide":[47],"chemotherapy.":[48],"Correlation":[49],"between":[50],"level":[53,124],"were":[57,126],"analysed":[58],"univariate":[60,93],"multivariate":[62,95],"Cox":[63],"model.":[64],"RESULTS:":[65],"Patients":[66],"a":[72,102,148],"significantly":[73],"improved":[74],"progression":[75],"free":[76],"survival":[77,82],"(PFS)":[78],"(p=0.015)":[79],"overall":[81],"(OS)":[83],"(p=0.047)":[84],"compared":[85],"to":[86,161],"those":[87],"high":[89],"expression.":[90],"On":[91],"both":[92,155],"analyses,":[96],"persisted":[100],"as":[101],"significant":[103,127,149],"independent":[104,128,150],"favorable":[105,151],"factor":[107,153],"for":[108,131,154],"PFS":[109,156],"(p=0.017).":[110],"Pre-operative":[111],"Karnofsky":[112],"performance":[113],"status":[114],"score":[115],"(p=0.029),":[116],"tumor":[117],"resection":[118],"extent":[119],"(p=0.045)":[120],"(p=0.038)":[125],"factors":[130],"OS.":[132,158],"CONCLUSION:":[133],"In":[134,159],"these":[135],"treatment,":[143],"was":[147],"addition":[160],"MGMT,":[162],"may":[164],"be":[165],"another":[166],"stratification":[167],"variable":[168],"future":[171],"therapeutic":[172],"trials.":[173]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}