{"id":"https://openalex.org/W2028344932","doi":null,"title":"The role of the laboratory mouse in the human genome project.","display_name":"The role of the laboratory mouse in the human genome project.","publication_year":1996,"publication_date":"1996-10-01","ids":{"openalex":"https://openalex.org/W2028344932","mag":"2028344932","pmid":"https://pubmed.ncbi.nlm.nih.gov/8808590","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1914805"},"language":"en","primary_location":{"id":"pmid:8808590","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8808590","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of human genetics","raw_type":"Journal Article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1914805/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070868538","display_name":"Miriam H. Meisler","orcid":"https://orcid.org/0000-0001-9107-706X","observed_orcids":["https://orcid.org/0000-0001-9107-706X"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M H Meisler","raw_affiliation_strings":["Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor, USA. meislerm@umich.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor, USA. meislerm@umich.edu","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5070868538"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"],"apc_list":null,"apc_paid":null,"fwci":0.6672,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.52291105,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"59","issue":"4","first_page":"764","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.47440001368522644,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.47440001368522644,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.14309999346733093,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.058800000697374344,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/laboratory-mice","display_name":"laboratory mice","score":0.9679999947547913},{"id":"https://openalex.org/keywords/human-genome-project","display_name":"Human Genome Project","score":0.7649999856948853},{"id":"https://openalex.org/keywords/gene-function","display_name":"gene function","score":0.9070000052452087},{"id":"https://openalex.org/keywords/positional-cloning","display_name":"positional cloning","score":0.9350000023841858},{"id":"https://openalex.org/keywords/mouse-mutants","display_name":"mouse mutants","score":0.7039999961853027},{"id":"https://openalex.org/keywords/chemical-mutagenesis","display_name":"chemical mutagenesis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/targeted-mutations","display_name":"targeted mutations","score":0.7680000066757202},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.9919999837875366},{"id":"https://openalex.org/keywords/polygenic-traits","display_name":"polygenic traits","score":0.9829999804496765},{"id":"https://openalex.org/keywords/comparative-mapping","display_name":"comparative mapping","score":0.8240000009536743},{"id":"https://openalex.org/keywords/gene-discovery","display_name":"gene discovery","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7251046895980835},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7218661308288574},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.6703979969024658},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6279006004333496},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6002137660980225},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.5649439096450806},{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.5494049787521362},{"id":"https://openalex.org/C25365240","wikidata":"https://www.wikidata.org/wiki/Q1897151","display_name":"Reverse genetics","level":4,"score":0.5198096036911011},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.5117056369781494},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.4746941924095154},{"id":"https://openalex.org/C3020804800","wikidata":"https://www.wikidata.org/wiki/Q5050812","display_name":"Positional cloning","level":4,"score":0.47424688935279846},{"id":"https://openalex.org/C134486438","wikidata":"https://www.wikidata.org/wiki/Q3123214","display_name":"Forward genetics","level":4,"score":0.44547557830810547},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.43603166937828064},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4331430196762085},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4150317311286926}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016045","descriptor_name":"Human Genome Project","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:8808590","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8808590","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of human genetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1914805","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1914805/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Hum Genet","raw_type":"Text"},{"id":"mag:2028344932","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8808590","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1914805","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1914805/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Hum Genet","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G312593855","display_name":"Gene Interaction in Development and Disease","funder_award_id":"R01GM024872","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3891256672","display_name":"CONFERENCE--THIRTEENTH AND FOURTEENTH  MOUSE GENOME MEET","funder_award_id":"R13HG000756","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1493943318","https://openalex.org/W1540446015","https://openalex.org/W1770702054","https://openalex.org/W1892495821","https://openalex.org/W1969117394","https://openalex.org/W1969717268","https://openalex.org/W1973487567","https://openalex.org/W1981149320","https://openalex.org/W1987828155","https://openalex.org/W1989223654","https://openalex.org/W1991765418","https://openalex.org/W1992494470","https://openalex.org/W2000130011","https://openalex.org/W2005932739","https://openalex.org/W2008787085","https://openalex.org/W2012329129","https://openalex.org/W2018774900","https://openalex.org/W2023326751","https://openalex.org/W2030209823","https://openalex.org/W2036055802","https://openalex.org/W2039060713","https://openalex.org/W2039298424","https://openalex.org/W2041407230","https://openalex.org/W2043508769","https://openalex.org/W2049761547","https://openalex.org/W2050213225","https://openalex.org/W2054429098","https://openalex.org/W2055525504","https://openalex.org/W2060319335","https://openalex.org/W2065975305","https://openalex.org/W2066188549","https://openalex.org/W2070956299","https://openalex.org/W2071313290","https://openalex.org/W2075296925","https://openalex.org/W2078210518","https://openalex.org/W2086508545","https://openalex.org/W2090072184","https://openalex.org/W2092670526","https://openalex.org/W2093285783","https://openalex.org/W2094194370","https://openalex.org/W2094197485","https://openalex.org/W2098959714","https://openalex.org/W2101013701","https://openalex.org/W2105004499","https://openalex.org/W2106253081","https://openalex.org/W2112704054","https://openalex.org/W2116365881","https://openalex.org/W2122699096","https://openalex.org/W2169845675","https://openalex.org/W2468313363","https://openalex.org/W4250796669","https://openalex.org/W7097599086"],"related_works":["https://openalex.org/W4210882715","https://openalex.org/W2093307033","https://openalex.org/W2403449881","https://openalex.org/W4366987167","https://openalex.org/W2152146604","https://openalex.org/W1983913203","https://openalex.org/W1981572467","https://openalex.org/W1880270016","https://openalex.org/W2122250955","https://openalex.org/W2158900896"],"abstract_inverted_index":{"The":[0,25,124],"long-term":[1],"goal":[2],"of":[3,15,17,28,37,61,68,87,90,95,103,112,118,126,129,154,163,175],"the":[4,13,18,23,29,43,50,53,59,62,77,85,119,130,140,152,173],"human":[5,120,155,170],"genome":[6],"project":[7,30],"is":[8,31,49],"to":[9,65,76,143,169],"identify":[10],"and":[11,39,71,115,121,137,147,172],"establish":[12],"function":[14,70],"each":[16],"estimated":[19],"100,000":[20],"genes":[21,48,105,146],"in":[22,84],"genome.":[24],"gene-discovery":[26],"phase":[27],"proceeding":[32],"rapidly,":[33],"via":[34],"large-scale":[35],"sequencing":[36],"genomic":[38],"cDNA":[40],"clones.":[41],"Establishing":[42],"functional":[44],"roles":[45],"for":[46,52,110],"these":[47],"challenge":[51],"future.":[54],"New":[55],"methods":[56],"have":[57,72],"improved":[58],"power":[60],"laboratory":[63],"mouse":[64,92,122,145,148],"address":[66],"questions":[67],"gene":[69,176],"attracted":[73],"many":[74],"investigators":[75],"field.":[78],"There":[79],"has":[80],"been":[81],"dramatic":[82],"progress":[83],"efficiency":[86],"positional":[88],"cloning":[89],"mutant":[91],"genes,":[93],"induction":[94],"new":[96],"mutants":[97,149],"by":[98,106],"chemical":[99],"mutagenesis,":[100],"targeted":[101],"mutation":[102],"cloned":[104],"homologous":[107],"recombination,":[108],"strategies":[109],"analysis":[111,174],"polygenic":[113],"traits,":[114],"comparative":[116],"mapping":[117],"chromosomes.":[123],"contents":[125],"recent":[127,164],"issues":[128],"journals":[131],"Human":[132],"Molecular":[133],"Genetics,":[134,136],"Nature":[135],"Genomics":[138],"demonstrate":[139],"striking":[141],"extent":[142],"which":[144],"now":[150],"occupy":[151],"attention":[153],"geneticists.":[156],"This":[157],"paper":[158],"provides":[159],"a":[160],"brief":[161],"survey":[162],"developments":[165],"with":[166],"particular":[167],"relevance":[168],"genetics":[171],"function.":[177],"56":[178],"refs.,":[179],"2":[180],"figs.,":[181],"4":[182],"tabs.":[183]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
