{"id":"https://openalex.org/W2028328261","doi":"https://doi.org/10.1111/j.1530-0277.1980.tb04835.x","title":"Methanol Toxicity: Treatment With Folic Acid and 5\u2010Formyl Tetrahydrofolic Acid","display_name":"Methanol Toxicity: Treatment With Folic Acid and 5\u2010Formyl Tetrahydrofolic Acid","publication_year":1980,"publication_date":"1980-10-01","ids":{"openalex":"https://openalex.org/W2028328261","doi":"https://doi.org/10.1111/j.1530-0277.1980.tb04835.x","mag":"2028328261","pmid":"https://pubmed.ncbi.nlm.nih.gov/7004236"},"language":"en","primary_location":{"id":"doi:10.1111/j.1530-0277.1980.tb04835.x","doi":"https://doi.org/10.1111/j.1530-0277.1980.tb04835.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1530-0277.1980.tb04835.x","pdf_url":null,"source":{"id":"https://openalex.org/S115510430","display_name":"Alcoholism Clinical and Experimental Research","issn_l":"0145-6008","issn":["0145-6008","1530-0277","2993-7175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism: Clinical and Experimental Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113646181","display_name":"P. E. Noker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. E. Noker","raw_affiliation_strings":["Toxicology Center, Department of Pharmacology, University of Iowa, Iowa City, Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toxicology Center, Department of Pharmacology, University of Iowa, Iowa City, Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028127515","display_name":"Janis Thane Eells","orcid":"https://orcid.org/0000-0002-4857-4746","observed_orcids":["https://orcid.org/0000-0002-4857-4746"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. T. Eells","raw_affiliation_strings":["Toxicology Center, Department of Pharmacology, University of Iowa, Iowa City, Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toxicology Center, Department of Pharmacology, University of Iowa, Iowa City, Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002630064","display_name":"Thomas R. Tephly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"T. R. Tephly","raw_affiliation_strings":["Toxicology Center, Department of Pharmacology, University of Iowa, Iowa City, Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toxicology Center, Department of Pharmacology, University of Iowa, Iowa City, Iowa","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002630064"],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":{"value":4110,"currency":"USD","value_usd":4110},"apc_paid":null,"fwci":5.0,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.94798387,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"4","issue":"4","first_page":"378","last_page":"383"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.0284000001847744,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methanol-poisoning","display_name":"methanol poisoning","score":0.8870000243186951},{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":0.9380000233650208},{"id":"https://openalex.org/keywords/formate-accumulation","display_name":"formate accumulation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/metabolic-acidosis","display_name":"metabolic acidosis","score":0.8889999985694885},{"id":"https://openalex.org/keywords/blood-bicarbonate","display_name":"blood bicarbonate","score":0.7820000052452087},{"id":"https://openalex.org/keywords/formate-oxidation","display_name":"formate oxidation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/monkeys","display_name":"monkeys","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C2779607525","wikidata":"https://www.wikidata.org/wiki/Q14982","display_name":"Methanol","level":2,"score":0.8616459369659424},{"id":"https://openalex.org/C2780178953","wikidata":"https://www.wikidata.org/wiki/Q2001841","display_name":"Formate","level":3,"score":0.8012710809707642},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7472301721572876},{"id":"https://openalex.org/C2909879501","wikidata":"https://www.wikidata.org/wiki/Q3631225","display_name":"Methanol poisoning","level":3,"score":0.7466577887535095},{"id":"https://openalex.org/C2779246250","wikidata":"https://www.wikidata.org/wiki/Q1598200","display_name":"Metabolic acidosis","level":2,"score":0.6792890429496765},{"id":"https://openalex.org/C2776420369","wikidata":"https://www.wikidata.org/wiki/Q179731","display_name":"Sodium bicarbonate","level":2,"score":0.6618646383285522},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6361255645751953},{"id":"https://openalex.org/C2781112554","wikidata":"https://www.wikidata.org/wiki/Q409202","display_name":"Bicarbonate","level":2,"score":0.5956873297691345},{"id":"https://openalex.org/C2778553927","wikidata":"https://www.wikidata.org/wiki/Q185089","display_name":"Acidosis","level":2,"score":0.5735554695129395},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5348756313323975},{"id":"https://openalex.org/C2992130864","wikidata":"https://www.wikidata.org/wiki/Q127060","display_name":"Folic acid","level":2,"score":0.4353176951408386},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40885403752326965},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3825964331626892},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.19205957651138306},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18024751543998718},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1719701886177063},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.06130009889602661}],"mesh":[{"descriptor_ui":"D000432","descriptor_name":"Methanol","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000432","descriptor_name":"Methanol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000432","descriptor_name":"Methanol","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005561","descriptor_name":"Formates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008252","descriptor_name":"Macaca fascicularis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1530-0277.1980.tb04835.x","doi":"https://doi.org/10.1111/j.1530-0277.1980.tb04835.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1530-0277.1980.tb04835.x","pdf_url":null,"source":{"id":"https://openalex.org/S115510430","display_name":"Alcoholism Clinical and Experimental Research","issn_l":"0145-6008","issn":["0145-6008","1530-0277","2993-7175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism: Clinical and Experimental Research","raw_type":"journal-article"},{"id":"pmid:7004236","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7004236","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism, clinical and experimental research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1810620222","https://openalex.org/W1970480086","https://openalex.org/W1988966336","https://openalex.org/W2003189563","https://openalex.org/W2011242734","https://openalex.org/W2018188476","https://openalex.org/W2019039571","https://openalex.org/W2019434502","https://openalex.org/W2032319980","https://openalex.org/W2056779274","https://openalex.org/W2076183022","https://openalex.org/W2082513483","https://openalex.org/W2090306342","https://openalex.org/W2140703352","https://openalex.org/W2227741897","https://openalex.org/W2270599964","https://openalex.org/W2334503167","https://openalex.org/W2418758442","https://openalex.org/W2472461560","https://openalex.org/W2755423457","https://openalex.org/W4407022330"],"related_works":["https://openalex.org/W144632747","https://openalex.org/W1970480086","https://openalex.org/W2004894766","https://openalex.org/W7100357853","https://openalex.org/W2080847007","https://openalex.org/W2019434502","https://openalex.org/W3213434585","https://openalex.org/W2950255986","https://openalex.org/W2083466785","https://openalex.org/W1519469564"],"abstract_inverted_index":{"After":[0],"methanol":[1,51,114,121,140,162],"administration":[2,49],"to":[3,72],"monkeys,":[4],"an":[5,102],"accumulation":[6,138],"of":[7,16,22,41,56,61,98,104,110,157,160],"formate":[8,100,137,143],"in":[9,27,91,95,127,154],"blood":[10,23,99,111],"occurs":[11],"coincident":[12],"with":[13,58],"the":[14,39,96,128,155],"development":[15],"metabolic":[17,106],"acidosis":[18,107],"and":[19,31,45,68,85,101,108,147],"a":[20,35,92,149],"depletion":[21,109],"bicarbonate.":[24],"Formate":[25],"metabolism":[26],"monkeys":[28,57],"depends":[29],"upon":[30],"is":[32],"regulated":[33],"by":[34,141],"folate-dependent":[36],"system;":[37],"therefore,":[38],"effect":[40],"folic":[42],"acid":[43,48,77,119],"pretreatment":[44],"5-formyl":[46,75,117],"tetrahydrofolic":[47,76,118],"on":[50],"toxicity":[52,122],"was":[53,125],"investigated.":[54],"Treatment":[55],"repetitive":[59],"doses":[60],"either":[62],"sodium":[63],"folate":[64,134],"(48,":[65],"24,":[66],"12,":[67,84],"4":[69],"hr":[70,87],"prior":[71],"methanol)":[73,89],"or":[74,145],"(2":[78],"mg/kg":[79],"at":[80],"0,":[81],"4,":[82],"8,":[83],"18":[86],"after":[88,139],"resulted":[90],"marked":[93],"decrease":[94,136],"levels":[97],"absence":[103],"both":[105],"bicarbonate":[112],"following":[113],"administration.":[115],"Also,":[116],"reversed":[120],"once":[123],"it":[124],"established":[126],"monkey.":[129],"The":[130],"results":[131],"indicate":[132],"that":[133],"compounds":[135],"stimulating":[142],"oxidation":[144],"utilization":[146],"suggest":[148],"possible":[150],"use":[151],"for":[152],"folates":[153],"treatment":[156],"certain":[158],"cases":[159],"human":[161],"poisoning.":[163]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
