{"id":"https://openalex.org/W2028318441","doi":"https://doi.org/10.1139/y90-116","title":"Characterization and regulation of sex-specific mouse steroid hydroxylase genes","display_name":"Characterization and regulation of sex-specific mouse steroid hydroxylase genes","publication_year":1990,"publication_date":"1990-06-01","ids":{"openalex":"https://openalex.org/W2028318441","doi":"https://doi.org/10.1139/y90-116","mag":"2028318441","pmid":"https://pubmed.ncbi.nlm.nih.gov/2372744"},"language":"en","primary_location":{"id":"doi:10.1139/y90-116","doi":"https://doi.org/10.1139/y90-116","is_oa":false,"landing_page_url":"https://doi.org/10.1139/y90-116","pdf_url":null,"source":{"id":"https://openalex.org/S82722058","display_name":"Canadian Journal of Physiology and Pharmacology","issn_l":"0008-4212","issn":["0008-4212","1205-7541"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Physiology and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110775065","display_name":"Hidefumi Yoshioka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hidefumi Yoshioka","raw_affiliation_strings":["Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073096423","display_name":"Raija L.P. Lindberg","orcid":"https://orcid.org/0000-0003-3349-314X","observed_orcids":["https://orcid.org/0000-0003-3349-314X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raija Lindberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063000955","display_name":"Garry Wong","orcid":"https://orcid.org/0000-0003-4566-9958","observed_orcids":["https://orcid.org/0000-0003-4566-9958"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Garry Wong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Takeshi Ichikawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takeshi Ichikawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059875004","display_name":"Takao Itakura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takao Itakura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062920765","display_name":"Barbara A. Burkhart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbara Burkhart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5089629096","display_name":"Masahiko Negishi","orcid":"https://orcid.org/0000-0002-2076-8928","observed_orcids":["https://orcid.org/0000-0002-2076-8928"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masahiko Negishi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2335,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.77226796,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"68","issue":"6","first_page":"754","last_page":"761"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.024399999529123306,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sex-specific-gene-expression","display_name":"sex-specific gene expression","score":0.9039999842643738},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/gene-duplication","display_name":"gene duplication","score":0.8629999756813049},{"id":"https://openalex.org/keywords/coumarin-7-hydroxylase","display_name":"coumarin 7-hydroxylase","score":0.972000002861023},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.33799999952316284}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7068036794662476},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6323409080505371},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.5978449583053589},{"id":"https://openalex.org/C159167319","wikidata":"https://www.wikidata.org/wiki/Q420766","display_name":"Tyrosine hydroxylase","level":3,"score":0.573167085647583},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.5359400510787964},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5271812677383423},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.4929006099700928},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.44959983229637146},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.41664573550224304},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2983861565589905},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.27761489152908325},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.08215385675430298}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001189","descriptor_name":"Aryl Hydrocarbon Hydroxylases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003374","descriptor_name":"Coumarins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013250","descriptor_name":"Steroid Hydroxylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013250","descriptor_name":"Steroid Hydroxylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065637","descriptor_name":"Cytochrome P-450 CYP2A6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1139/y90-116","doi":"https://doi.org/10.1139/y90-116","is_oa":false,"landing_page_url":"https://doi.org/10.1139/y90-116","pdf_url":null,"source":{"id":"https://openalex.org/S82722058","display_name":"Canadian Journal of Physiology and Pharmacology","issn_l":"0008-4212","issn":["0008-4212","1205-7541"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Physiology and Pharmacology","raw_type":"journal-article"},{"id":"pmid:2372744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2372744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian journal of physiology and pharmacology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1508994608","https://openalex.org/W1552736699","https://openalex.org/W1971807649","https://openalex.org/W2032006109","https://openalex.org/W2150946709"],"related_works":["https://openalex.org/W1648138277","https://openalex.org/W1563156812","https://openalex.org/W1949456489","https://openalex.org/W2051449793","https://openalex.org/W2032006109","https://openalex.org/W3164431077","https://openalex.org/W2000069123","https://openalex.org/W1857592341","https://openalex.org/W2009427123","https://openalex.org/W2030277270"],"abstract_inverted_index":{"We":[0],"characterized":[1],"the":[2,5,14,30,37,40,47,52,60,101,127],"genes":[3,42],"of":[4,29,39],"male-specific":[6],"mouse":[7,16,102],"steroid":[8,17,68,80,94],"16":[9],"alpha-hydroxylase":[10,19,82],"(C-P-45016":[11],"alpha)":[12,21],"and":[13,110],"female-specific":[15],"15":[18,81],"(P-45015":[20],"within":[22,34],"two":[23],"distinct":[24],"gene":[25,104,108,128],"families.":[26],"In":[27],"spite":[28],"high":[31],"structural":[32],"identities":[33],"each":[35],"family,":[36],"expression":[38],"hydroxylase":[41,69,95],"is":[43],"uniquely":[44],"regulated.":[45],"Moreover,":[46],"other":[48],"family":[49],"members":[50],"encode":[51],"P-450s":[53,116],"which":[54,88],"are":[55,63],"structurally":[56,117],"very":[57],"similar":[58],"to":[59,66,113,121],"hydroxylases":[61],"but":[62,92],"not":[64],"able":[65],"catalyze":[67],"activities.":[70],"For":[71],"example,":[72],"only":[73],"a":[74],"single":[75],"amino":[76],"acid":[77],"substitution":[78],"creates":[79],"activity":[83],"in":[84],"another":[85],"family-member":[86],"P-450coh,":[87],"catalyzes":[89],"coumarin":[90],"7-hydroxylase":[91],"little":[93],"activity.":[96],"It":[97],"appears,":[98],"therefore,":[99],"that":[100],"P-450":[103],"families":[105],"evolved":[106],"through":[107],"duplication":[109],"selective":[111],"mutation":[112],"create":[114],"new":[115],"as":[118,120],"well":[119],"establish":[122],"novel":[123],"regulatory":[124],"elements":[125],"for":[126],"expressions.":[129]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
