{"id":"https://openalex.org/W2028310348","doi":"https://doi.org/10.1016/s0022-2836(02)00366-2","title":"Human Genome Search in Celiac Disease: Mutated Gliadin T-cell-like Epitope in Two Human Proteins Promotes T-cell Activation","display_name":"Human Genome Search in Celiac Disease: Mutated Gliadin T-cell-like Epitope in Two Human Proteins Promotes T-cell Activation","publication_year":2002,"publication_date":"2002-06-01","ids":{"openalex":"https://openalex.org/W2028310348","doi":"https://doi.org/10.1016/s0022-2836(02)00366-2","mag":"2028310348","pmid":"https://pubmed.ncbi.nlm.nih.gov/12054857"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-2836(02)00366-2","doi":"https://doi.org/10.1016/s0022-2836(02)00366-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-2836(02)00366-2","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100648315","display_name":"Rajesh Kumar","orcid":"https://orcid.org/0000-0003-4478-1518","observed_orcids":["https://orcid.org/0000-0003-4478-1518"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajesh Kumar","raw_affiliation_strings":["Department of Cell Biology, University of Virginia, Charlottesville, VA 22908-0732, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Virginia, Charlottesville, VA 22908-0732, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075804482","display_name":"Amy L. Eastwood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy L Eastwood","raw_affiliation_strings":["Department of Chemistry, University of Virginia, Charlottesville, VA 22908-0732, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Virginia, Charlottesville, VA 22908-0732, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019326307","display_name":"Milton L. Brown","orcid":"https://orcid.org/0000-0003-1253-8505","observed_orcids":["https://orcid.org/0000-0003-1253-8505"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Milton L Brown","raw_affiliation_strings":["Department of Chemistry, University of Virginia, Charlottesville, VA 22908-0732, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Virginia, Charlottesville, VA 22908-0732, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073294634","display_name":"Gordon W. Laurie","orcid":"https://orcid.org/0000-0002-5311-2650","observed_orcids":["https://orcid.org/0000-0002-5311-2650"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gordon W Laurie","raw_affiliation_strings":["Department of Cell Biology, University of Virginia, Charlottesville, VA 22908-0732, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Virginia, Charlottesville, VA 22908-0732, USA","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5073294634"],"corresponding_institution_ids":["https://openalex.org/I51556381"],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":1.2596,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.81098825,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"319","issue":"3","first_page":"593","last_page":"602"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11348","display_name":"Celiac Disease Research and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11348","display_name":"Celiac Disease Research and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10733","display_name":"Wheat and Barley Genetics and Pathology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/celiac-disease","display_name":"celiac disease","score":0.8659999966621399},{"id":"https://openalex.org/keywords/tfiia","display_name":"TFIIA","score":0.796999990940094},{"id":"https://openalex.org/keywords/non-hla-genes","display_name":"non-HLA genes","score":0.6019999980926514},{"id":"https://openalex.org/keywords/mhc-class-ii-restriction","display_name":"MHC class II restriction","score":0.6539999842643738},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.6389999985694885},{"id":"https://openalex.org/keywords/phlda1","display_name":"PHLDA1","score":0.6140000224113464},{"id":"https://openalex.org/keywords/igd","display_name":"IgD","score":0.6290000081062317},{"id":"https://openalex.org/keywords/il-2-release","display_name":"IL-2 release","score":0.5410000085830688},{"id":"https://openalex.org/keywords/wheat-gliadin","display_name":"wheat gliadin","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C2780092158","wikidata":"https://www.wikidata.org/wiki/Q279074","display_name":"Gliadin","level":3,"score":0.8767437934875488},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.7902501821517944},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5987968444824219},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5045956373214722},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.49619394540786743},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4252042770385742},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4243502616882324},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.42069536447525024},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30937838554382324},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.29024460911750793},{"id":"https://openalex.org/C2776336767","wikidata":"https://www.wikidata.org/wiki/Q188251","display_name":"Gluten","level":2,"score":0.2713295817375183}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002446","descriptor_name":"Celiac Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002446","descriptor_name":"Celiac Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005903","descriptor_name":"Gliadin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005903","descriptor_name":"Gliadin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006683","descriptor_name":"HLA-DQ Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017385","descriptor_name":"Sequence Homology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019992","descriptor_name":"Databases as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035561","descriptor_name":"Transcription Factor TFIIA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0022-2836(02)00366-2","doi":"https://doi.org/10.1016/s0022-2836(02)00366-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-2836(02)00366-2","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},{"id":"pmid:12054857","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12054857","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G374311122","display_name":null,"funder_award_id":"EY09747","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G4075441951","display_name":"OCULAR TEAR SECRETION BY THE LACRIMAL GLAND","funder_award_id":"R01EY009747","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W5861652","https://openalex.org/W136910319","https://openalex.org/W1525478170","https://openalex.org/W1811817270","https://openalex.org/W1967131476","https://openalex.org/W1971424198","https://openalex.org/W1971857925","https://openalex.org/W1972187865","https://openalex.org/W1979217451","https://openalex.org/W1984339309","https://openalex.org/W1985046231","https://openalex.org/W1990569913","https://openalex.org/W1993708940","https://openalex.org/W1997300911","https://openalex.org/W2002180660","https://openalex.org/W2004267701","https://openalex.org/W2006424562","https://openalex.org/W2015292449","https://openalex.org/W2020626950","https://openalex.org/W2028222510","https://openalex.org/W2036052530","https://openalex.org/W2043856196","https://openalex.org/W2049615365","https://openalex.org/W2051788484","https://openalex.org/W2051967381","https://openalex.org/W2059754738","https://openalex.org/W2061777334","https://openalex.org/W2063084183","https://openalex.org/W2066237821","https://openalex.org/W2066932270","https://openalex.org/W2073255828","https://openalex.org/W2080891856","https://openalex.org/W2084439623","https://openalex.org/W2085350060","https://openalex.org/W2088189141","https://openalex.org/W2097430118","https://openalex.org/W2105673186","https://openalex.org/W2106856156","https://openalex.org/W2113819336","https://openalex.org/W2117235976","https://openalex.org/W2118160482","https://openalex.org/W2124378624","https://openalex.org/W2135926596","https://openalex.org/W2141692304","https://openalex.org/W2143210482","https://openalex.org/W2145314352","https://openalex.org/W2148682967","https://openalex.org/W2155234131","https://openalex.org/W2158499654","https://openalex.org/W2159429023","https://openalex.org/W2162143225","https://openalex.org/W2169580132","https://openalex.org/W2405730962"],"related_works":["https://openalex.org/W2986583802","https://openalex.org/W2038911754","https://openalex.org/W2076389815","https://openalex.org/W7101122250","https://openalex.org/W1695894247","https://openalex.org/W2035683776","https://openalex.org/W2125509340","https://openalex.org/W2113819336","https://openalex.org/W1811817270","https://openalex.org/W2111006781"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}