{"id":"https://openalex.org/W2028294800","doi":"https://doi.org/10.1159/000049396","title":"Modulation of Atopy Patch Test Reactions by Topical Treatment of Human Skin with a Fatty Acid-Rich Emollient","display_name":"Modulation of Atopy Patch Test Reactions by Topical Treatment of Human Skin with a Fatty Acid-Rich Emollient","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2028294800","doi":"https://doi.org/10.1159/000049396","mag":"2028294800","pmid":"https://pubmed.ncbi.nlm.nih.gov/11867966"},"language":"en","primary_location":{"id":"doi:10.1159/000049396","doi":"https://doi.org/10.1159/000049396","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000049396","pdf_url":null,"source":{"id":"https://openalex.org/S2715032","display_name":"Skin Pharmacology and Physiology","issn_l":"1422-2868","issn":["1422-2868","1422-2906","1660-5527","1660-5535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Skin Pharmacology and Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088372218","display_name":"Claudia Billmann-Eberwein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. Billmann-Eberwein","raw_affiliation_strings":["Clinical and Experimental Photodermatology, Department of Dermatology, University of D\u00fcsseldorf, 40225, Germany","Clinical and Experimental Photodermatology, Department of Dermatology, University of D\u00fcsseldorf,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical and Experimental Photodermatology, Department of Dermatology, University of D\u00fcsseldorf, 40225, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Clinical and Experimental Photodermatology, Department of Dermatology, University of D\u00fcsseldorf,","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071896738","display_name":"Frank Rippke","orcid":"https://orcid.org/0000-0002-8917-1177","observed_orcids":["https://orcid.org/0000-0002-8917-1177"]},"institutions":[{"id":"https://openalex.org/I106618798","display_name":"Beiersdorf (Germany)","ror":"https://ror.org/04aqg9s78","country_code":"DE","type":"company","lineage":["https://openalex.org/I106618798"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F. Rippke","raw_affiliation_strings":["Beiersdorf AG, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beiersdorf AG, Hamburg, Germany","institution_ids":["https://openalex.org/I106618798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111684140","display_name":"Thomas Ruzicka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. Ruzicka","raw_affiliation_strings":["Clinical and Experimental Photodermatology, Department of Dermatology, University of D\u00fcsseldorf,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical and Experimental Photodermatology, Department of Dermatology, University of D\u00fcsseldorf,","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071887916","display_name":"Jean Krutmann","orcid":"https://orcid.org/0000-0001-8433-1517","observed_orcids":["https://orcid.org/0000-0001-8433-1517"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Krutmann","raw_affiliation_strings":["Clinical and Experimental Photodermatology, Department of Dermatology, University of D\u00fcsseldorf,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical and Experimental Photodermatology, Department of Dermatology, University of D\u00fcsseldorf,","institution_ids":["https://openalex.org/I44260953"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6935,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.67730971,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"15","issue":"2","first_page":"100","last_page":"104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/atopy-patch-test","display_name":"atopy patch test","score":0.8069999814033508},{"id":"https://openalex.org/keywords/skin-barrier-function","display_name":"skin barrier function","score":0.8619999885559082},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.8429999947547913},{"id":"https://openalex.org/keywords/non-lesional-skin","display_name":"non-lesional skin","score":0.8220000267028809},{"id":"https://openalex.org/keywords/eczema-prevention","display_name":"eczema prevention","score":0.7580000162124634},{"id":"https://openalex.org/keywords/topical-therapy","display_name":"topical treatment","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C2777697326","wikidata":"https://www.wikidata.org/wiki/Q757678","display_name":"Atopy","level":3,"score":0.9451384544372559},{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.8076925873756409},{"id":"https://openalex.org/C140764562","wikidata":"https://www.wikidata.org/wiki/Q2056643","display_name":"Patch test","level":3,"score":0.6687993407249451},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5287002325057983},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5174327492713928},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.45066913962364197},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3539767265319824}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D004643","descriptor_name":"Emollients","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004643","descriptor_name":"Emollients","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009823","descriptor_name":"Ointment Bases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009823","descriptor_name":"Ointment Bases","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012882","descriptor_name":"Skin Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000049396","doi":"https://doi.org/10.1159/000049396","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000049396","pdf_url":null,"source":{"id":"https://openalex.org/S2715032","display_name":"Skin Pharmacology and Physiology","issn_l":"1422-2868","issn":["1422-2868","1422-2906","1660-5527","1660-5535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Skin Pharmacology and Physiology","raw_type":"journal-article"},{"id":"pmid:11867966","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11867966","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Skin pharmacology and applied skin physiology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W146662650","https://openalex.org/W1900907547","https://openalex.org/W1991195369","https://openalex.org/W1994339135","https://openalex.org/W2015941743","https://openalex.org/W2021041399","https://openalex.org/W2026990074","https://openalex.org/W2072288364","https://openalex.org/W2091060798","https://openalex.org/W2143138262","https://openalex.org/W2410761200","https://openalex.org/W2597829800","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W4394575240","https://openalex.org/W7164893356","https://openalex.org/W3132137273","https://openalex.org/W3201142073","https://openalex.org/W2298157494","https://openalex.org/W2011671705","https://openalex.org/W4409138277","https://openalex.org/W2147401052","https://openalex.org/W4412602099","https://openalex.org/W4240890327"],"abstract_inverted_index":{"Measures":[0],"directed":[1],"at":[2],"improving":[3],"the":[4,32,35,46,90,102,112,119,128,137],"skin":[5,60],"barrier":[6],"function":[7],"are":[8],"thought":[9],"to":[10,54,135,143],"be":[11,133],"effective":[12],"in":[13,52,73,101,147],"preventing":[14],"reexacerbation":[15],"of":[16,22,26,49,58,79,92,114,121,139],"atopic":[17,50,76,122],"dermatitis,":[18],"but":[19],"direct":[20],"proof":[21],"a":[23,43,62,70,140],"prophylactic":[24,71,145],"effect":[25,72],"emollients":[27,117],"has":[28,39,69],"been":[29,40],"elusive.":[30],"In":[31],"present":[33],"study,":[34],"atopy":[36,129],"patch":[37,130],"test":[38,80,99,131],"employed":[41],"as":[42,94],"model":[44],"for":[45],"initiation":[47],"phase":[48],"dermatitis":[51],"order":[53],"assess":[55,136],"whether":[56],"pretreatment":[57],"non-lesional":[59],"with":[61,75,82,96],"fatty":[63,115],"acid-rich":[64,116],"emollient":[65],"(Eucerin":[66],"Omega":[67,84],"Creme)":[68],"patients":[74,104],"dermatitis.":[77],"Pretreatment":[78],"sites":[81,100],"Eucerin":[83],"Creme":[85],"either":[86],"prevented":[87],"or":[88],"diminished":[89],"development":[91,120],"eczema,":[93],"compared":[95],"untreated":[97],"control":[98],"same":[103],"(n":[105],"=":[106],"38).":[107],"These":[108],"studies":[109],"indicate":[110],"that":[111,127],"use":[113],"prevents":[118],"eczema.":[123],"They":[124],"also":[125],"demonstrate":[126],"can":[132],"used":[134],"capacity":[138],"given":[141],"regimen":[142],"exert":[144],"effects":[146],"this":[148],"disease.":[149]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}