{"id":"https://openalex.org/W2028273635","doi":"https://doi.org/10.1158/1538-7445.am2012-2070","title":"Abstract 2070: Obesity, p53 and increased oxidative stress: The role of TXNIP","display_name":"Abstract 2070: Obesity, p53 and increased oxidative stress: The role of TXNIP","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W2028273635","doi":"https://doi.org/10.1158/1538-7445.am2012-2070","mag":"2028273635"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2012-2070","doi":"https://doi.org/10.1158/1538-7445.am2012-2070","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-2070","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113536753","display_name":"Karrie W. Wheatley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karrie Wheatley","raw_affiliation_strings":["1UT MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036400845","display_name":"Stephen David Hursting","orcid":"https://orcid.org/0000-0003-3605-2833","observed_orcids":["https://orcid.org/0000-0003-3605-2833"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen D. Hursting","raw_affiliation_strings":["2University of Texas, Austin, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Texas, Austin, TX","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"8_Supplement","first_page":"2070","last_page":"2070"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.3441999852657318,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.3441999852657318,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.2434999942779541,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.17820000648498535,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9610000252723694},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.7739999890327454},{"id":"https://openalex.org/keywords/txnip","display_name":"TXNIP","score":0.9940000176429749},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9940000176429749},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9440000057220459},{"id":"https://openalex.org/keywords/mammary-fat-pad","display_name":"mammary fat pad","score":0.8180000185966492},{"id":"https://openalex.org/keywords/postmenopausal-breast-cancer","display_name":"postmenopausal breast cancer","score":0.8889999985694885},{"id":"https://openalex.org/keywords/estrogen-receptor-negative-breast-cancer","display_name":"estrogen receptor-negative breast cancer","score":0.7860000133514404},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.5730000138282776},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.42899999022483826},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.8579999804496765},{"id":"https://openalex.org/keywords/high-glucose","display_name":"high glucose","score":0.41999998688697815},{"id":"https://openalex.org/keywords/shrna-knockdown","display_name":"shRNA knockdown","score":0.6769999861717224},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.8899999856948853},{"id":"https://openalex.org/keywords/redox-signaling","display_name":"redox signaling","score":0.574999988079071},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.3919999897480011}],"concepts":[{"id":"https://openalex.org/C2779076967","wikidata":"https://www.wikidata.org/wiki/Q21122281","display_name":"TXNIP","level":4,"score":0.9722065925598145},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6719403266906738},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6678588390350342},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6582698822021484},{"id":"https://openalex.org/C2908690268","wikidata":"https://www.wikidata.org/wiki/Q21122281","display_name":"Thioredoxin-Interacting Protein","level":5,"score":0.6535606384277344},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5955968499183655},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4645889103412628},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41817614436149597},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.381062775850296},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3349851369857788},{"id":"https://openalex.org/C3623737","wikidata":"https://www.wikidata.org/wiki/Q421219","display_name":"Thioredoxin","level":3,"score":0.31863856315612793}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2012-2070","doi":"https://doi.org/10.1158/1538-7445.am2012-2070","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-2070","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1831306379","https://openalex.org/W2120112210","https://openalex.org/W2097337288","https://openalex.org/W3176400937","https://openalex.org/W6906640269","https://openalex.org/W2948861400","https://openalex.org/W4409624382","https://openalex.org/W7167853747","https://openalex.org/W1972759576","https://openalex.org/W4393071999"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Although":[2],"epidemiological":[3],"studies":[4],"show":[5],"a":[6,130,310,352,383],"strong":[7],"association":[8],"between":[9],"increased":[10,164,202,226,392],"BMI":[11],"and":[12,31,69,79,109,125,144,195,240,302,348,378,395,412],"heightened":[13],"risk":[14],"of":[15,48,62,66,72,87,97,121,137,157,171,210,238,253,333,339,345,375,437,442],"postmenopausal":[16],"breast":[17,26,42,256,405],"cancer,":[18],"the":[19,73,95,117,135,158,208,251,398,438,443],"underlying":[20],"mechanisms":[21],"by":[22,37,151,165,203,337,393,420],"which":[23,38],"obesity":[24,39,106,394,419],"influences":[25],"cancer":[27,43,257,406],"susceptibility":[28],"are":[29,82],"multivariate":[30],"poorly":[32],"characterized.":[33],"One":[34],"potential":[35],"mechanism":[36],"contributes":[40],"to":[41,101,107,141,178,216,229,321,425],"initiation":[44],"is":[45,53,225,241,391],"through":[46,60,236],"induction":[47,61],"oxidative":[49,110,142,376,415],"stress.":[50,111],"Oxidative":[51],"burden":[52],"strongly":[54],"implicated":[55],"in":[56,91,169,207,227,243,255,275,313,317,324,351,355,361,386,397],"tumor":[57,74],"initiating":[58],"events":[59],"chromosome":[63],"instability,":[64],"dysregulation":[65],"proapoptotic":[67],"signaling,":[68],"redox":[70],"modulation":[71,237],"suppressor":[75],"gene,":[76],"TP53.":[77],"Obesity":[78],"p53":[80,108,123,174,181,212,218,349],"mutations":[81],"both":[83,346],"associated":[84,365,417],"with":[85,264,306,366,418],"development":[86],"aggressive,":[88],"ER-negative":[89],"disease":[90],"younger":[92],"women.":[93],"Therefore,":[94],"goal":[96],"this":[98,187],"study":[99],"was":[100,163,200,335,364,382],"identify":[102],"genes":[103,139],"that":[104,148,197],"link":[105],"Results:":[112],"We":[113,185],"isolated":[114],"mRNA":[115,199],"from":[116,192,284,290],"mammary":[118,400],"fat":[119,401],"pads":[120],"obese":[122,126,173,180,211,217,285,318],"+/+":[124,182,219],"+/\u2212":[127,175,213],"mice.":[128,292],"Using":[129],"qPCR":[131],"array,":[132],"we":[133],"measured":[134],"expression":[136,224,390],"85":[138],"related":[140],"stress":[143,377,416],"screened":[145],"for":[146,297,446],"transcripts":[147],"were":[149,261,272,294],"altered":[150],"at":[152],"least":[153],"2":[154],"fold.":[155],"Expression":[156],"gene":[159],"thioredoxin-interacting":[160],"protein":[161],"(TXNIP)":[162],"almost":[166,204],"30":[167],"fold":[168,206],"MFP":[170,209],"sedentary,":[172,179],"mice":[176,183,191,214,220],"compared":[177,215,320],"(n=3).":[184],"validated":[186],"finding":[188],"using":[189],"6":[190],"each":[193],"group":[194],"found":[196],"Txnip":[198],"significantly":[201],"3":[205],"(p<0.001).":[221],"Interestingly,":[222],"TXNIP":[223,254,340,347,389,408],"response":[228,424],"high":[230,373],"glucose":[231],"flux,":[232],"can":[233],"mediate":[234],"apoptosis":[235],"ROS,":[239],"lost":[242],"many":[244],"cancers,":[245],"including":[246],"breast.":[247],"To":[248],"further":[249],"elucidate":[250],"function":[252],"cells,":[258,407],"MCF-7":[259],"cells":[260,322],"stably":[262],"transfected":[263,305],"shRNA":[265,308],"targeting":[266],"TXNIP,":[267],"p53,":[268],"or":[269,287,327,341],"both.":[270],"Cells":[271,293,304],"incubated":[273,316,323],"overnight":[274],"either":[276],"serum-free":[277],"media":[278],"(SFM),":[279],"2%":[280,282,288,328],"FBS,":[281],"serum":[283,289,319],"mice,":[286],"control":[291,307,329],"then":[295],"assayed":[296],"ROS":[298,314,334,356,362,410],"production,":[299],"DNA":[300,379,427],"damage,":[301,380],"apoptosis.":[303,387],"exhibited":[309],"7-fold":[311],"increase":[312,354,360],"when":[315],"SFM,":[325],"2%FBS,":[326],"serum.":[330],"Increased":[331],"production":[332,363],"abrogated":[336],"knockdown":[338,344],"p53.":[342],"However,":[343],"resulted":[350],"35-fold":[353],"levels.":[357],"The":[358],"significant":[359],"intense":[367],"nuclear":[368],"H2AX":[369],"immunufluorescent":[370],"staining.":[371],"Despite":[372],"levels":[374,411],"there":[381],"25%":[384],"reduction":[385],"Conclusion:":[388],"p53-deficiency":[396],"mouse":[399],"pad.":[402],"In":[403],"human":[404],"regulates":[409],"reduces":[413],"chronic":[414],"mediating":[421],"an":[422],"apoptotic":[423],"excessive":[426],"damage.":[428],"Citation":[429],"Format:":[430],"{Authors}.":[431],"{Abstract":[432],"title}":[433],"[abstract].":[434],"In:":[435],"Proceedings":[436],"103rd":[439],"Annual":[440],"Meeting":[441],"American":[444],"Association":[445],"Cancer":[447,458],"Research;":[448],"2012":[449],"Mar":[450],"31-Apr":[451],"4;":[452],"Chicago,":[453],"IL.":[454],"Philadelphia":[455],"(PA):":[456],"AACR;":[457],"Res":[459],"2012;72(8":[460],"Suppl):Abstract":[461],"nr":[462],"2070.":[463],"doi:1538-7445.AM2012-2070":[464]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}