{"id":"https://openalex.org/W2028254185","doi":"https://doi.org/10.1111/aos.12129","title":"Impaired retinal vasodilator responses in prediabetes and type 2 diabetes","display_name":"Impaired retinal vasodilator responses in prediabetes and type 2 diabetes","publication_year":2013,"publication_date":"2013-06-07","ids":{"openalex":"https://openalex.org/W2028254185","doi":"https://doi.org/10.1111/aos.12129","mag":"2028254185","pmid":"https://pubmed.ncbi.nlm.nih.gov/23742315","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3749269"},"language":"en","primary_location":{"id":"doi:10.1111/aos.12129","doi":"https://doi.org/10.1111/aos.12129","is_oa":false,"landing_page_url":"https://doi.org/10.1111/aos.12129","pdf_url":null,"source":{"id":"https://openalex.org/S21165490","display_name":"Acta Ophthalmologica","issn_l":"0001-639X","issn":["0001-639X","1755-375X","1755-3768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Ophthalmologica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3749269","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109077847","display_name":"Mary E. J. Lott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mary E. J. Lott","raw_affiliation_strings":["Heart and Vascular Institute, Penn State Hershey Medical Center, Pennsylvania, USA. mlott@hmc.psu.edu","Heart and Vascular Institute, Penn State Hershey Medical Center, Hershey, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart and Vascular Institute, Penn State Hershey Medical Center, Pennsylvania, USA. mlott@hmc.psu.edu","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]},{"raw_affiliation_string":"Heart and Vascular Institute, Penn State Hershey Medical Center, Hershey, Pennsylvania, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041521971","display_name":"Julia E. Slocomb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia E. Slocomb","raw_affiliation_strings":["Department of Neurology, Penn State Hershey Medical Center, Hershey, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Penn State Hershey Medical Center, Hershey, Pennsylvania, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053290532","display_name":"Vikram Shivkumar","orcid":"https://orcid.org/0000-0003-1658-7881","observed_orcids":["https://orcid.org/0000-0003-1658-7881"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vikram Shivkumar","raw_affiliation_strings":["Department of Neurology, Penn State Hershey Medical Center, Hershey, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Penn State Hershey Medical Center, Hershey, Pennsylvania, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113586561","display_name":"Bruce Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce Smith","raw_affiliation_strings":["Heart and Vascular Institute, Penn State Hershey Medical Center, Hershey, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart and Vascular Institute, Penn State Hershey Medical Center, Hershey, Pennsylvania, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088921492","display_name":"David A. Quillen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Quillen","raw_affiliation_strings":["Department of Ophthalmology, Penn State Hershey Medical Center, Hershey, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Penn State Hershey Medical Center, Hershey, Pennsylvania, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085341405","display_name":"Robert A. Gabbay","orcid":"https://orcid.org/0000-0003-3541-1486","observed_orcids":["https://orcid.org/0000-0003-3541-1486"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Gabbay","raw_affiliation_strings":["Division of Endocrinology, Diabetes and Metabolism, Penn State Hershey Diabetes and Obesity Institute, Penn State College of Medicine, Hershey, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Metabolism, Penn State Hershey Diabetes and Obesity Institute, Penn State College of Medicine, Hershey, Pennsylvania, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005821220","display_name":"Thomas W. Gardner","orcid":"https://orcid.org/0000-0002-5112-5810","observed_orcids":["https://orcid.org/0000-0002-5112-5810"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas W. Gardner","raw_affiliation_strings":["Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078910126","display_name":"Kerstin Bettermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kerstin Bettermann","raw_affiliation_strings":["Department of Neurology, Penn State Hershey Medical Center, Hershey, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Penn State Hershey Medical Center, Hershey, Pennsylvania, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5109077847"],"corresponding_institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":5.8439,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.96110651,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"91","issue":"6","first_page":"e462","last_page":"e469"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.7207000255584717,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.7207000255584717,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.19040000438690186,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.020800000056624413,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prediabetes","display_name":"prediabetes","score":0.8899999856948853},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":1.0},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9259999990463257},{"id":"https://openalex.org/keywords/retinal-artery-diameter","display_name":"retinal artery diameter","score":0.925000011920929},{"id":"https://openalex.org/keywords/flicker-light-stimulation","display_name":"flicker light stimulation","score":0.6809999942779541},{"id":"https://openalex.org/keywords/high-sensitivity-c-reactive-protein","display_name":"high-sensitivity C-reactive protein","score":0.847000002861023},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.921999990940094},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.8360000252723694},{"id":"https://openalex.org/keywords/microvascular-dysfunction","display_name":"microvascular dysfunction","score":0.8330000042915344},{"id":"https://openalex.org/keywords/vascular-risk","display_name":"vascular risk","score":0.8190000057220459}],"concepts":[{"id":"https://openalex.org/C2779668308","wikidata":"https://www.wikidata.org/wiki/Q2087205","display_name":"Prediabetes","level":4,"score":0.9297857284545898},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.707344114780426},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.6940611600875854},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5724296569824219},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5588283538818359},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.5178187489509583},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49309512972831726},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4213455617427826},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3429103493690491},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3388582468032837}],"mesh":[{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006442","descriptor_name":"Glycated Hemoglobin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010775","descriptor_name":"Photic Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011236","descriptor_name":"Prediabetic State","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012171","descriptor_name":"Retinal Vessels","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012171","descriptor_name":"Retinal Vessels","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1111/aos.12129","doi":"https://doi.org/10.1111/aos.12129","is_oa":false,"landing_page_url":"https://doi.org/10.1111/aos.12129","pdf_url":null,"source":{"id":"https://openalex.org/S21165490","display_name":"Acta Ophthalmologica","issn_l":"0001-639X","issn":["0001-639X","1755-375X","1755-3768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Ophthalmologica","raw_type":"journal-article"},{"id":"pmid:23742315","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23742315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta ophthalmologica","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3115823","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3749269","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3749269","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3749269","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Acta Ophthalmol","raw_type":"Text"},{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/99677","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/99677","pdf_url":"https://hdl.handle.net/2027.42/99677","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3115823","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3749269","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1666607560","display_name":"Penn State Clinical and Translational Science Institute","funder_award_id":"UL1TR000127","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3158255397","display_name":null,"funder_award_id":"UL1TR000127","funder_id":"https://openalex.org/F4320310419","funder_display_name":"Pennsylvania State University"},{"id":"https://openalex.org/G3335924918","display_name":"GCRC RELOCATION AND EXPANSION PROJECT","funder_award_id":"C06RR016499","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3537737709","display_name":null,"funder_award_id":"TR000127","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G4039073122","display_name":null,"funder_award_id":"UL TR-000127","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G6884341184","display_name":"Penn State Clinical and Translational Science Institute","funder_award_id":"UL1RR033184","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G9000050448","display_name":null,"funder_award_id":"TR000127","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000865330","display_name":"Michigan Diabetes Research Center (MDRC)","funder_award_id":"P30DK020572","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306811","display_name":"Research to Prevent Blindness","ror":"https://ror.org/04drjs621"},{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320310419","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231"},{"id":"https://openalex.org/F4320310535","display_name":"A. Alfred Taubman Medical Research Institute","ror":"https://ror.org/00jmfr291"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2028254185.pdf","grobid_xml":"https://content.openalex.org/works/W2028254185.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W35781219","https://openalex.org/W1968649551","https://openalex.org/W1977001646","https://openalex.org/W1980921512","https://openalex.org/W1983496107","https://openalex.org/W1984351174","https://openalex.org/W1987202143","https://openalex.org/W1993921230","https://openalex.org/W1994417887","https://openalex.org/W1994653065","https://openalex.org/W2006467965","https://openalex.org/W2009014858","https://openalex.org/W2016622896","https://openalex.org/W2020158942","https://openalex.org/W2027458734","https://openalex.org/W2028823817","https://openalex.org/W2032604509","https://openalex.org/W2034671535","https://openalex.org/W2034888646","https://openalex.org/W2039117216","https://openalex.org/W2041245457","https://openalex.org/W2043421666","https://openalex.org/W2053290690","https://openalex.org/W2053561784","https://openalex.org/W2077187401","https://openalex.org/W2081985889","https://openalex.org/W2084102521","https://openalex.org/W2088704086","https://openalex.org/W2093515582","https://openalex.org/W2107297886","https://openalex.org/W2109181258","https://openalex.org/W2115776356","https://openalex.org/W2115786792","https://openalex.org/W2117358073","https://openalex.org/W2117899424","https://openalex.org/W2118479818","https://openalex.org/W2121378461","https://openalex.org/W2121602880","https://openalex.org/W2125921569","https://openalex.org/W2126119724","https://openalex.org/W2126327417","https://openalex.org/W2127389619","https://openalex.org/W2135386376","https://openalex.org/W2138753856","https://openalex.org/W2144684988","https://openalex.org/W2145053304","https://openalex.org/W2149886744","https://openalex.org/W2164418602","https://openalex.org/W2165373379","https://openalex.org/W2167788046","https://openalex.org/W2167826190","https://openalex.org/W2169278125","https://openalex.org/W2171750720","https://openalex.org/W2273152624","https://openalex.org/W2596624061","https://openalex.org/W4240304626","https://openalex.org/W4242003139","https://openalex.org/W4244017022"],"related_works":["https://openalex.org/W4251188503","https://openalex.org/W2557522688","https://openalex.org/W2288896819","https://openalex.org/W7074227130","https://openalex.org/W2247128353","https://openalex.org/W2948549271","https://openalex.org/W2981902322","https://openalex.org/W2140127003","https://openalex.org/W2020158942","https://openalex.org/W2089104992"],"abstract_inverted_index":{"PURPOSE:":[0],"In":[1],"diabetes,":[2],"endothelial":[3],"dysfunction":[4,29],"and":[5,18,35,57,78,81,128,135,164,184,219],"subsequent":[6],"structural":[7],"damage":[8],"to":[9,14,44,97,143,245],"blood":[10,124],"vessels":[11],"can":[12],"lead":[13],"heart":[15],"attacks,":[16],"retinopathy":[17],"strokes.":[19],"However,":[20],"it":[21],"is":[22],"unclear":[23],"whether":[24,46],"prediabetic":[25,154,174,218],"subjects":[26,155,160,175,180,186],"exhibit":[27],"microvascular":[28],"indicating":[30],"early":[31,52,247],"stages":[32],"of":[33,40,63,119,201,235],"arteriosclerosis":[34],"vascular":[36,248],"risk.":[37,249],"The":[38],"purpose":[39],"this":[41],"study":[42],"was":[43,121,215],"examine":[45],"retinal":[47,99,140,198,208],"reactivity":[48,214],"may":[49,58,240],"be":[50,59,241],"impaired":[51,216],"in":[53,103,123,139,197,217,224],"the":[54,93,144],"hyperglycaemic":[55],"continuum":[56],"associated":[60,205,232],"with":[61,67,149,206,226,233],"markers":[62],"inflammation.":[64],"METHODS:":[65],"Individuals":[66],"prediabetes":[68],"(n":[69,75,86],"=":[70,76,87,170,191],"22),":[71],"type":[72,220],"2":[73,221],"diabetes":[74],"25)":[77],"healthy":[79,150],"age":[80],"body":[82],"composition":[83],"matched":[84],"controls":[85,151,165],"19)":[88],"were":[89,195,203],"studied.":[90],"We":[91],"used":[92],"Dynamic":[94],"Vessel":[95],"Analyzer":[96],"assess":[98,246],"vasoreactivity":[100,238],"(percentage":[101],"change":[102],"vessel":[104,209],"diameter)":[105],"during":[106],"a":[107,117,242],"flickering":[108,145],"light":[109,146],"stimulation.":[110],"Fasting":[111],"highly":[112],"sensitive":[113,243],"c-reactive":[114],"protein":[115],"(hs-CRP),":[116],"marker":[118],"inflammation,":[120],"measured":[122],"plasma.":[125],"RESULTS:":[126],"Prediabetic":[127],"diabetic":[129,159,179,222],"individuals":[130,223],"had":[131],"attenuated":[132],"peak":[133],"vasodilator":[134],"relative":[136,172],"amplitude":[137],"changes":[138],"vein":[141],"diameters":[142],"stimulus":[147],"compared":[148],"(peak":[152],"dilation:":[153],"3.3":[156,161],"\u00b1":[157,162,167,177,182,188],"1.8%,":[158],"2.1%":[163],"5.6":[166],"2.6%,":[168],"p":[169,190],"0.001;":[171],"amplitude:":[173],"4.3":[176],"2.2%,":[178],"5.0":[181],"2.6%":[183],"control":[185],"7.2":[187],"3.2%,":[189],"0.003).":[192],"Similar":[193],"findings":[194],"observed":[196],"arteries.":[199],"Levels":[200],"hs-CRP":[202],"not":[204,231],"either":[207],"response":[210],"parameters.":[211],"CONCLUSION:":[212],"Retinal":[213,237],"parallel":[225],"reduced":[227],"insulin":[228],"sensitivity":[229],"but":[230],"levels":[234],"hs-CRP.":[236],"measurements":[239],"tool":[244]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}