{"id":"https://openalex.org/W2028114522","doi":"https://doi.org/10.1155/2012/715049","title":"Impairment and Differential Expression of PR3 and MPO on Peripheral Myelomonocytic Cells with Endothelial Properties in Granulomatosis with Polyangiitis","display_name":"Impairment and Differential Expression of PR3 and MPO on Peripheral Myelomonocytic Cells with Endothelial Properties in Granulomatosis with Polyangiitis","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2028114522","doi":"https://doi.org/10.1155/2012/715049","mag":"2028114522","pmid":"https://pubmed.ncbi.nlm.nih.gov/22792461","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3390043"},"language":"en","primary_location":{"id":"doi:10.1155/2012/715049","doi":"https://doi.org/10.1155/2012/715049","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/715049","pdf_url":"https://downloads.hindawi.com/journals/ijn/2012/715049.pdf","source":{"id":"https://openalex.org/S120416549","display_name":"International Journal of Nephrology","issn_l":"2090-214X","issn":["2090-214X","2090-2158"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://downloads.hindawi.com/journals/ijn/2012/715049.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035843496","display_name":"Susann A. Patschan","orcid":"https://orcid.org/0000-0002-2286-7356","observed_orcids":["https://orcid.org/0000-0002-2286-7356"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Susann Patschan","raw_affiliation_strings":["Department of Nephrology and Rheumatology, University Medical Center G\u00f6ttingen, 37075 G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Rheumatology, University Medical Center G\u00f6ttingen, 37075 G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081945237","display_name":"Daniel Patschan","orcid":"https://orcid.org/0000-0002-6914-5254","observed_orcids":["https://orcid.org/0000-0002-6914-5254","https://orcid.org/0000-0002-5232-9540"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel Patschan","raw_affiliation_strings":["Department of Nephrology and Rheumatology, University Medical Center G\u00f6ttingen, 37075 G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Rheumatology, University Medical Center G\u00f6ttingen, 37075 G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063476138","display_name":"Elvira Henze","orcid":"https://orcid.org/0000-0002-1621-907X","observed_orcids":["https://orcid.org/0000-0002-1621-907X"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Elvira Henze","raw_affiliation_strings":["Department of Nephrology and Rheumatology, University Medical Center G\u00f6ttingen, 37075 G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Rheumatology, University Medical Center G\u00f6ttingen, 37075 G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013358717","display_name":"Sabine Blaschke","orcid":"https://orcid.org/0000-0001-8800-7554","observed_orcids":["https://orcid.org/0000-0001-8800-7554"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabine Blaschke","raw_affiliation_strings":["Department of Nephrology and Rheumatology, University Medical Center G\u00f6ttingen, 37075 G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Rheumatology, University Medical Center G\u00f6ttingen, 37075 G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033162310","display_name":"Johannes T. Wessels","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johannes T. Wessels","raw_affiliation_strings":["Core Facility \u201cMolecular & Optical Live Cell Imaging (MOLCI)\u201d, University Medical Center G\u00f6ttingen, 37075 G\u00f6ttingen, Germany","Department of Nephrology and Rheumatology, University Medical Center G\u00f6ttingen, 37075 G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Facility \u201cMolecular & Optical Live Cell Imaging (MOLCI)\u201d, University Medical Center G\u00f6ttingen, 37075 G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730"]},{"raw_affiliation_string":"Department of Nephrology and Rheumatology, University Medical Center G\u00f6ttingen, 37075 G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112395966","display_name":"Gerhard Anton Muller","orcid":"https://orcid.org/0000-0001-9889-1638","observed_orcids":["https://orcid.org/0000-0001-9889-1638"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerhard Anton M\u00fcller","raw_affiliation_strings":["Department of Nephrology and Rheumatology, University Medical Center G\u00f6ttingen, 37075 G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Rheumatology, University Medical Center G\u00f6ttingen, 37075 G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035843496"],"corresponding_institution_ids":["https://openalex.org/I4210116730"],"apc_list":{"value":1000,"currency":"USD","value_usd":1000},"apc_paid":{"value":561,"currency":"EUR","value_usd":605},"fwci":0.2001,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.58217063,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"2012","issue":null,"first_page":"1","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/granulomatosis-with-polyangiitis","display_name":"granulomatosis with polyangiitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/microscopic-polyangiitis","display_name":"microscopic polyangiitis","score":1.0},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.7670000195503235},{"id":"https://openalex.org/keywords/proteinase-3","display_name":"proteinase 3","score":0.8299999833106995},{"id":"https://openalex.org/keywords/endothelial-progenitor-cells","display_name":"endothelial progenitor cells","score":0.6620000004768372},{"id":"https://openalex.org/keywords/myelomonocytic-cells","display_name":"myelomonocytic cells","score":0.8560000061988831},{"id":"https://openalex.org/keywords/flk-1","display_name":"Flk-1","score":0.8140000104904175},{"id":"https://openalex.org/keywords/angiopoietin-1","display_name":"angiopoietin-1","score":0.9480000138282776},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8289999961853027},{"id":"https://openalex.org/keywords/anca-associated-vasculitis","display_name":"ANCA-associated vasculitis","score":0.7760000228881836},{"id":"https://openalex.org/keywords/neovascularization","display_name":"neovascularization","score":0.8399999737739563},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7045400142669678},{"id":"https://openalex.org/C2781229154","wikidata":"https://www.wikidata.org/wiki/Q1161568","display_name":"Granulomatosis with polyangiitis","level":4,"score":0.6400608420372009},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6202254295349121},{"id":"https://openalex.org/C2778910314","wikidata":"https://www.wikidata.org/wiki/Q1934069","display_name":"Microscopic polyangiitis","level":4,"score":0.5093051195144653},{"id":"https://openalex.org/C24040308","wikidata":"https://www.wikidata.org/wiki/Q574727","display_name":"Anti-neutrophil cytoplasmic antibody","level":4,"score":0.4820297956466675},{"id":"https://openalex.org/C21194631","wikidata":"https://www.wikidata.org/wiki/Q2113501","display_name":"Proteinase 3","level":4,"score":0.46963024139404297},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.465863972902298},{"id":"https://openalex.org/C2776015282","wikidata":"https://www.wikidata.org/wiki/Q644318","display_name":"Vasculitis","level":3,"score":0.4190669655799866},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4164387583732605},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40639394521713257},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.29699406027793884},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.11135292053222656}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.1155/2012/715049","doi":"https://doi.org/10.1155/2012/715049","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/715049","pdf_url":"https://downloads.hindawi.com/journals/ijn/2012/715049.pdf","source":{"id":"https://openalex.org/S120416549","display_name":"International Journal of Nephrology","issn_l":"2090-214X","issn":["2090-214X","2090-2158"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nephrology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2399833","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3390043","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3390043","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3390043","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Nephrol","raw_type":"Text"},{"id":"pmid:22792461","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22792461","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of nephrology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.773.7008","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.773.7008","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/90/a5/IJN2012-715049.PMC3390043.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:638864a72445446388d2c3cc73d7589a","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/638864a72445446388d2c3cc73d7589a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Nephrology, Vol 2012 (2012)","raw_type":"article"},{"id":"pmh:oai:goescholar:1/7718","doi":null,"is_oa":true,"landing_page_url":"http://resolver.sub.uni-goettingen.de/purl?gs-1/7718","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journalArticle"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/60445","doi":null,"is_oa":true,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gs-1/7718","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal_article"}],"best_oa_location":{"id":"doi:10.1155/2012/715049","doi":"https://doi.org/10.1155/2012/715049","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/715049","pdf_url":"https://downloads.hindawi.com/journals/ijn/2012/715049.pdf","source":{"id":"https://openalex.org/S120416549","display_name":"International Journal of Nephrology","issn_l":"2090-214X","issn":["2090-214X","2090-2158"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nephrology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2028114522.pdf","grobid_xml":"https://content.openalex.org/works/W2028114522.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W117467031","https://openalex.org/W1269121966","https://openalex.org/W1550111394","https://openalex.org/W1591583811","https://openalex.org/W1966609065","https://openalex.org/W1970185437","https://openalex.org/W1980180037","https://openalex.org/W1985047685","https://openalex.org/W1985365252","https://openalex.org/W1986932186","https://openalex.org/W1986991023","https://openalex.org/W1987273686","https://openalex.org/W1992584670","https://openalex.org/W1998863675","https://openalex.org/W1999420207","https://openalex.org/W2001727723","https://openalex.org/W2007431915","https://openalex.org/W2012579226","https://openalex.org/W2017148424","https://openalex.org/W2029798707","https://openalex.org/W2037298492","https://openalex.org/W2041574862","https://openalex.org/W2042116568","https://openalex.org/W2050717533","https://openalex.org/W2053704719","https://openalex.org/W2064999867","https://openalex.org/W2072681889","https://openalex.org/W2075643680","https://openalex.org/W2084753601","https://openalex.org/W2095561182","https://openalex.org/W2098084886","https://openalex.org/W2098414385","https://openalex.org/W2098743872","https://openalex.org/W2099240764","https://openalex.org/W2102670544","https://openalex.org/W2104726137","https://openalex.org/W2107483871","https://openalex.org/W2120194682","https://openalex.org/W2145639716","https://openalex.org/W2150662590","https://openalex.org/W2157405158","https://openalex.org/W2158398090","https://openalex.org/W2160389457","https://openalex.org/W2165492938","https://openalex.org/W2167220033","https://openalex.org/W2169011242","https://openalex.org/W2171650049","https://openalex.org/W2171950933","https://openalex.org/W2411557239","https://openalex.org/W2416590109","https://openalex.org/W2419083838","https://openalex.org/W4298356939","https://openalex.org/W4298880977"],"related_works":["https://openalex.org/W7095841961","https://openalex.org/W3193494511","https://openalex.org/W4294218853","https://openalex.org/W2939518427","https://openalex.org/W4214937029","https://openalex.org/W2031191344","https://openalex.org/W4321200475","https://openalex.org/W7034698401","https://openalex.org/W2539204893","https://openalex.org/W764022910"],"abstract_inverted_index":{"Background.":[0],"Granulomatosis":[1],"with":[2,41,114],"polyangiitis":[3,7],"(GPA)":[4],"and":[5,19,30,81,102,107,119,126,143,156,231],"microscopic":[6],"(MPA)":[8],"are":[9,56],"autoimmune-mediated":[10],"diseases":[11,55],"characterized":[12,57],"by":[13,58,149,160,169],"vasculitic":[14],"inflammation":[15],"of":[16,33,36,88,98,154,173,188,214,227],"respiratory":[17],"tract":[18],"kidneys.":[20],"Clinical":[21],"observations":[22],"indicated":[23],"a":[24,137,232],"strong":[25],"association":[26],"between":[27,219],"disease":[28],"activity":[29,97,131],"serum":[31,171],"levels":[32,153,172],"certain":[34],"types":[35],"autoantibodies":[37],"(antineutrophil":[38],"cytoplasm":[39],"antibodies":[40],"cytoplasmic":[42],"[cANCA":[43],"in":[44,50,76,110,117,175,192,204,209,237,240],"GPA]":[45],"or":[46],"perinuclear":[47],"[pAN":[48],"CA":[49],"MPA]":[51],"immunofluorescence).":[52],"Pathologically,":[53],"both":[54,79],"severe":[59],"microvascular":[60],"endothelial":[61,65,115],"cell":[62],"damage.":[63],"Early":[64],"outgrowth":[66],"cells":[67,113,146,191],"(eEOCs)":[68],"have":[69],"been":[70],"shown":[71],"to":[72,93,104,180],"be":[73],"critically":[74],"involved":[75],"neovascularization":[77],"under":[78],"physiological":[80],"pathological":[82],"condition.":[83],"Objectives.":[84],"The":[85],"principal":[86],"aims":[87],"our":[89],"study":[90],"were":[91,134,147,158,196],"(i)":[92],"analyze":[94],"the":[95,99,185,193,220,228],"regenerative":[96,130],"eEOC":[100,166,229],"system":[101,230],"(ii)":[103],"determine":[105],"mPR3":[106],"MPO":[108,215],"expression":[109,200],"myelo":[111],"monocytic":[112],"characteristics":[116],"GPA":[118,125,176],"MPA":[120,128],"patients.":[121],"Methods.":[122],"In":[123,183],"27":[124],"10":[127],"patients,":[129],"blood-derived":[132],"eEOCs":[133],"analyzed":[135],"using":[136],"culture-forming":[138],"assay.":[139],"Flk-1(+),":[140],"CD133(+)/Flk-1(+),":[141],"mPR3(+),":[142],"Flk-1(+)/mPR3(+)":[144],"myelomonocytic":[145,190,211],"quantified":[148],"FACS":[150],"analysis.":[151],"Serum":[152],"Angiopoietin-1":[155,174],"TNF-\u03b1":[157],"measured":[159],"ELISA.":[161],"Results.":[162],"We":[163],"found":[164],"reduced":[165],"regeneration,":[167],"accompanied":[168],"lower":[170],"patients":[177,241],"as":[178,206,208],"compared":[179],"healthy":[181],"controls.":[182],"addition,":[184],"total":[186,205],"numbers":[187],"Flk-1(+)":[189,210],"peripheral":[194],"circulation":[195],"decreased.":[197],"Membrane":[198],"PR3":[199,236],"was":[201,216],"significantly":[202],"higher":[203],"well":[207],"cells.":[212],"Expression":[213],"not":[217],"different":[218],"groups.":[221],"Conclusions.":[222],"These":[223],"data":[224],"suggest":[225],"impairment":[226],"possible":[233],"role":[234],"for":[235],"this":[238],"process":[239],"suffering":[242],"from":[243],"GPA.":[244]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
