{"id":"https://openalex.org/W2028112873","doi":"https://doi.org/10.1016/j.bpj.2008.12.083","title":"Unfolding, refolding and proteolysis of the von Willebrand Factor A2 domain under tensile force","display_name":"Unfolding, refolding and proteolysis of the von Willebrand Factor A2 domain under tensile force","publication_year":2009,"publication_date":"2009-02-01","ids":{"openalex":"https://openalex.org/W2028112873","doi":"https://doi.org/10.1016/j.bpj.2008.12.083","mag":"2028112873"},"language":"en","primary_location":{"id":"doi:10.1016/j.bpj.2008.12.083","doi":"https://doi.org/10.1016/j.bpj.2008.12.083","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2008.12.083","pdf_url":"http://www.cell.com/article/S0006349508002099/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0006349508002099/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088269023","display_name":"Xiao Hui Zhang","orcid":"https://orcid.org/0000-0002-8778-595X","observed_orcids":["https://orcid.org/0000-0002-8778-595X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Xiaohui Zhang","raw_affiliation_strings":["Immune Disease Institute, Harvard Medical School, Boston, MA, USA","Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immune Disease Institute, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072823909","display_name":"Kenneth Halvorsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4387153050","display_name":"Rowland Institute at Harvard","ror":"https://ror.org/03eta9142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I136199984","https://openalex.org/I4387153050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth Halvorsen","raw_affiliation_strings":["Rowland Institute at Harvard, Harvard University, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rowland Institute at Harvard, Harvard University, Cambridge, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4387153050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003644127","display_name":"Wesley P. Wong","orcid":"https://orcid.org/0000-0001-7398-546X","observed_orcids":["https://orcid.org/0000-0001-7398-546X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4387153050","display_name":"Rowland Institute at Harvard","ror":"https://ror.org/03eta9142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I136199984","https://openalex.org/I4387153050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wesley P. Wong","raw_affiliation_strings":["Rowland Institute at Harvard, Harvard University, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rowland Institute at Harvard, Harvard University, Cambridge, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4387153050"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003615852","display_name":"Timothy A. Springer","orcid":"https://orcid.org/0000-0001-6627-2904","observed_orcids":["https://orcid.org/0000-0001-6627-2904"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy A. Springer","raw_affiliation_strings":["Immune Disease Institute, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immune Disease Institute, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15138943,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"96","issue":"3","first_page":"37a","last_page":"37a"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.7710000276565552,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.7710000276565552,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.08699999749660492,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.06769999861717224,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.984000027179718},{"id":"https://openalex.org/keywords/a2-domain","display_name":"A2 domain","score":0.8669999837875366},{"id":"https://openalex.org/keywords/adamts13","display_name":"ADAMTS13","score":0.8610000014305115},{"id":"https://openalex.org/keywords/tensile-force","display_name":"tensile force","score":0.7739999890327454},{"id":"https://openalex.org/keywords/protein-unfolding","display_name":"protein unfolding","score":0.8759999871253967},{"id":"https://openalex.org/keywords/protein-refolding","display_name":"protein refolding","score":0.9700000286102295},{"id":"https://openalex.org/keywords/conformational-change","display_name":"conformational change","score":0.703000009059906},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C2780921031","wikidata":"https://www.wikidata.org/wiki/Q14873945","display_name":"ADAMTS13","level":4,"score":0.8267757296562195},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.724774956703186},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7139889001846313},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.66999751329422},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6332864761352539},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.4992501735687256},{"id":"https://openalex.org/C112950240","wikidata":"https://www.wikidata.org/wiki/Q76005","display_name":"Ultimate tensile strength","level":2,"score":0.4844343960285187},{"id":"https://openalex.org/C87282627","wikidata":"https://www.wikidata.org/wiki/Q3623657","display_name":"Scissile bond","level":4,"score":0.4489646255970001},{"id":"https://openalex.org/C33947775","wikidata":"https://www.wikidata.org/wiki/Q271439","display_name":"Elongation","level":3,"score":0.437865287065506},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.41524338722229004},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.337998628616333},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.26948684453964233},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20346400141716003},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.19446280598640442},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19260090589523315},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09423947334289551},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.07521852850914001},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.07056906819343567},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bpj.2008.12.083","doi":"https://doi.org/10.1016/j.bpj.2008.12.083","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2008.12.083","pdf_url":"http://www.cell.com/article/S0006349508002099/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.bpj.2008.12.083","doi":"https://doi.org/10.1016/j.bpj.2008.12.083","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2008.12.083","pdf_url":"http://www.cell.com/article/S0006349508002099/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2028112873.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2097894057","https://openalex.org/W2151187602","https://openalex.org/W1963641813","https://openalex.org/W3212116415","https://openalex.org/W2037554469","https://openalex.org/W4415146987","https://openalex.org/W2085435652","https://openalex.org/W2989575954","https://openalex.org/W2530347956","https://openalex.org/W1964738009"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}