{"id":"https://openalex.org/W2028093819","doi":"https://doi.org/10.1021/ic00007a052","title":"Synthetic analog approach to metallobleomycins: possibility of coordination of the carboxamide group of the .beta.-aminoalaninamide moiety of bleomycin to copper in copper(II) bleomycin at physiological pH","display_name":"Synthetic analog approach to metallobleomycins: possibility of coordination of the carboxamide group of the .beta.-aminoalaninamide moiety of bleomycin to copper in copper(II) bleomycin at physiological pH","publication_year":1991,"publication_date":"1991-04-01","ids":{"openalex":"https://openalex.org/W2028093819","doi":"https://doi.org/10.1021/ic00007a052","mag":"2028093819"},"language":"en","primary_location":{"id":"doi:10.1021/ic00007a052","doi":"https://doi.org/10.1021/ic00007a052","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ic00007a052","pdf_url":null,"source":{"id":"https://openalex.org/S171072222","display_name":"Inorganic Chemistry","issn_l":"0020-1669","issn":["0020-1669","1520-510X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inorganic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007799623","display_name":"Larry A. Scheich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Larry A. Scheich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064269183","display_name":"Patricia A. Gosling","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patricia Gosling","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Steven J. Brown","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven J. Brown","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009326683","display_name":"Marilyn M. Olmstead","orcid":"https://orcid.org/0000-0002-6160-1622","observed_orcids":["https://orcid.org/0000-0002-6160-1622"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marilyn M. Olmstead","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5060131715","display_name":"Pradip K. Mascharak","orcid":"https://orcid.org/0000-0002-7044-944X","observed_orcids":["https://orcid.org/0000-0002-7044-944X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pradip K. Mascharak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.8508,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.7666605,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"30","issue":"7","first_page":"1677","last_page":"1680"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.04749999940395355,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11746","display_name":"Inorganic and Organometallic Chemistry","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metallobleomycin","display_name":"metallobleomycin","score":0.9100000262260437},{"id":"https://openalex.org/keywords/bleomycin","display_name":"bleomycin","score":0.8939999938011169},{"id":"https://openalex.org/keywords/copper-coordination","display_name":"copper coordination","score":0.574999988079071},{"id":"https://openalex.org/keywords/synthetic-analogues","display_name":"synthetic analogues","score":0.8169999718666077},{"id":"https://openalex.org/keywords/antitumor-antibiotics","display_name":"antitumor antibiotics","score":0.6629999876022339},{"id":"https://openalex.org/keywords/physiological-ph","display_name":"physiological pH","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9613773226737976},{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.8507039546966553},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.8171448111534119},{"id":"https://openalex.org/C544778455","wikidata":"https://www.wikidata.org/wiki/Q753","display_name":"Copper","level":2,"score":0.8003350496292114},{"id":"https://openalex.org/C2778327999","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Carboxamide","level":2,"score":0.6910204887390137},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.5739638805389404},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5039765238761902},{"id":"https://openalex.org/C2781311116","wikidata":"https://www.wikidata.org/wiki/Q83306","display_name":"Group (periodic table)","level":2,"score":0.42285558581352234},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.3499433398246765},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.17559963464736938},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.08458518981933594},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08403271436691284},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/ic00007a052","doi":"https://doi.org/10.1021/ic00007a052","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ic00007a052","pdf_url":null,"source":{"id":"https://openalex.org/S171072222","display_name":"Inorganic Chemistry","issn_l":"0020-1669","issn":["0020-1669","1520-510X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inorganic Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1971765443","https://openalex.org/W2058879603","https://openalex.org/W1996030457","https://openalex.org/W2952912353","https://openalex.org/W2068503305","https://openalex.org/W1999534519","https://openalex.org/W2093944006","https://openalex.org/W4252982313","https://openalex.org/W2050438088","https://openalex.org/W2402391468"],"abstract_inverted_index":{"ADVERTISEMENT":[0],"RETURN":[1],"TO":[2],"ISSUEPREVArticleNEXTSynthetic":[3],"analog":[4],"approach":[5],"to":[6,21,97,102],"metallobleomycins:":[7],"possibility":[8],"of":[9,11,15,19,75,110,136],"coordination":[10],"the":[12,16,72,103,108,137,148,161,164,169,176,182],"carboxamide":[13],"group":[14],".beta.-aminoalaninamide":[17],"moiety":[18],"bleomycin":[20,25],"copper":[22],"in":[23],"copper(II)":[24],"at":[26,155],"physiological":[27],"pHLarry":[28],"A.":[29],"Scheich,":[30],"Patricia":[31],"Gosling,":[32],"Steven":[33],"J.":[34],"Brown,":[35],"Marilyn":[36],"M.":[37],"Olmstead,":[38],"and":[39,85,90,119,163,180,196,198],"Pradip":[40],"K.":[41],"MascharakCite":[42],"this:":[43],"Inorg.":[44],"Chem.":[45],"1991,":[46],"30,":[47],"7,":[48],"1677\u20131680Publication":[49],"Date":[50],"(Print):April":[51],"1,":[52],"1991Publication":[53],"History":[54],"Published":[55],"online1":[56],"May":[57],"2002Published":[58],"inissue":[59],"1":[60],"April":[61],"1991https://pubs.acs.org/doi/10.1021/ic00007a052https://doi.org/10.1021/ic00007a052research-articleACS":[62],"PublicationsRequest":[63],"reuse":[64],"permissionsArticle":[65],"Views48Altmetric-Citations11LEARN":[66],"ABOUT":[67],"THESE":[68],"METRICSArticle":[69],"Views":[70],"are":[71,94,107],"COUNTER-compliant":[73],"sum":[74],"full":[76],"text":[77],"article":[78,142],"downloads":[79],"since":[80],"November":[81],"2008":[82],"(both":[83],"PDF":[84],"HTML)":[86],"across":[87],"all":[88],"institutions":[89],"individuals.":[91],"These":[92],"metrics":[93],"regularly":[95],"updated":[96,120],"reflect":[98],"usage":[99],"leading":[100],"up":[101],"last":[104],"few":[105],"days.Citations":[106],"number":[109],"other":[111],"articles":[112],"citing":[113],"this":[114],"article,":[115],"calculated":[116],"by":[117],"Crossref":[118,126],"daily.":[121],"Find":[122,172],"more":[123,173],"information":[124,174],"about":[125,160],"citation":[127],"counts.The":[128],"Altmetric":[129,177],"Attention":[130,178],"Score":[131,179],"is":[132,184],"a":[133,140,153],"quantitative":[134],"measure":[135],"attention":[138],"that":[139],"research":[141],"has":[143],"received":[144],"online.":[145],"Clicking":[146],"on":[147,175],"donut":[149],"icon":[150],"will":[151],"load":[152],"page":[154],"altmetric.com":[156],"with":[157,192],"additional":[158],"details":[159],"score":[162,183],"social":[165],"media":[166],"presence":[167],"for":[168],"given":[170],"article.":[171],"how":[181],"calculated.":[185],"Share":[186,201],"Add":[187],"toView":[188],"InAdd":[189],"Full":[190],"Text":[191],"ReferenceAdd":[193],"Description":[194],"ExportRISCitationCitation":[195],"abstractCitation":[197],"referencesMore":[199],"Options":[200],"onFacebookTwitterWechatLinked":[202],"InRedditEmail":[203],"Other":[204],"access":[205],"optionsGet":[206],"e-AlertscloseSupporting":[207],"Info":[208],"(1)\u00bbSupporting":[209],"Information":[210,212],"Supporting":[211],"Get":[213],"e-Alerts":[214]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}