{"id":"https://openalex.org/W2028090214","doi":"https://doi.org/10.1038/bcj.2011.5","title":"Human glioblastoma cells exposed to long-term hypoxia and nutrient starvation stimulated induction of secondary T-cell leukemia in mice","display_name":"Human glioblastoma cells exposed to long-term hypoxia and nutrient starvation stimulated induction of secondary T-cell leukemia in mice","publication_year":2011,"publication_date":"2011-02-25","ids":{"openalex":"https://openalex.org/W2028090214","doi":"https://doi.org/10.1038/bcj.2011.5","mag":"2028090214","pmid":"https://pubmed.ncbi.nlm.nih.gov/22829112","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3255269"},"language":"en","primary_location":{"id":"doi:10.1038/bcj.2011.5","doi":"https://doi.org/10.1038/bcj.2011.5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bcj.2011.5","pdf_url":"https://www.nature.com/articles/bcj20115.pdf","source":{"id":"https://openalex.org/S2496263508","display_name":"Blood Cancer Journal","issn_l":"2044-5385","issn":["2044-5385"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Cancer Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/bcj20115.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017406759","display_name":"Tsuyoshi Osawa","orcid":"https://orcid.org/0000-0002-9479-6665","observed_orcids":["https://orcid.org/0000-0002-9479-6665"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Osawa","raw_affiliation_strings":["Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Yushima, Tokyo, Japan","Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Yushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Yushima, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Yushima, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005474653","display_name":"Rikuhei Tsuchida","orcid":"https://orcid.org/0000-0003-2274-7917","observed_orcids":["https://orcid.org/0000-0003-2274-7917"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"R Tsuchida","raw_affiliation_strings":["Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Yushima, Tokyo, Japan","Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Yushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Yushima, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Yushima, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080610198","display_name":"Masashi Muramatsu","orcid":"https://orcid.org/0000-0001-6048-1529","observed_orcids":["https://orcid.org/0000-0001-6048-1529"]},"institutions":[{"id":"https://openalex.org/I4210160102","display_name":"National Center for Geriatrics and Gerontology","ror":"https://ror.org/05h0rw812","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210160102"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Muramatsu","raw_affiliation_strings":["Laboratory of Genomics and Proteomics, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan","Laboratory of Genomics and Proteomics, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Genomics and Proteomics, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan","institution_ids":["https://openalex.org/I4210160102"]},{"raw_affiliation_string":"Laboratory of Genomics and Proteomics, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Japan","institution_ids":["https://openalex.org/I4210160102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067475959","display_name":"Yasuhito Yuasa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Yuasa","raw_affiliation_strings":["Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Yushima, Tokyo, Japan","Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Yushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Yushima, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Yushima, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058213173","display_name":"Masabumi Shibuya","orcid":"https://orcid.org/0000-0002-8277-8400","observed_orcids":["https://orcid.org/0000-0002-8277-8400"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I156649623","display_name":"Jobu University","ror":"https://ror.org/022b6b871","country_code":"JP","type":"education","lineage":["https://openalex.org/I156649623"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"M Shibuya","raw_affiliation_strings":["Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Yushima, Tokyo, Japan","Department of Research and Education, Jobu University, Isesaki, Gunma, Japan","Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Yushima, Japan","Department of Research and Education, Jobu University, Isesaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Yushima, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Department of Research and Education, Jobu University, Isesaki, Gunma, Japan","institution_ids":["https://openalex.org/I156649623"]},{"raw_affiliation_string":"Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Yushima, Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Department of Research and Education, Jobu University, Isesaki, Japan","institution_ids":["https://openalex.org/I156649623"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5058213173"],"corresponding_institution_ids":["https://openalex.org/I125602781","https://openalex.org/I156649623"],"apc_list":{"value":5290,"currency":"USD","value_usd":5290},"apc_paid":{"value":5290,"currency":"USD","value_usd":5290},"fwci":0.3899,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.59461212,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"1","issue":"2","first_page":"e6","last_page":"e6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.774399995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.774399995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.06319999694824219,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.04740000143647194,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9509999752044678},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8569999933242798},{"id":"https://openalex.org/keywords/nutrient-starvation","display_name":"nutrient deprivation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.7390000224113464},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.7289999723434448},{"id":"https://openalex.org/keywords/vegfr-tyrosine-kinase-inhibitors","display_name":"VEGFR inhibitors","score":0.9120000004768372},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.9729999899864197},{"id":"https://openalex.org/keywords/sorafenib","display_name":"sorafenib","score":0.7360000014305115},{"id":"https://openalex.org/keywords/sunitinib","display_name":"sunitinib","score":0.9810000061988831},{"id":"https://openalex.org/keywords/xenografts","display_name":"xenografts","score":0.6690000295639038},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8289999961853027},{"id":"https://openalex.org/keywords/leukemogenesis","display_name":"leukemogenesis","score":0.6230000257492065},{"id":"https://openalex.org/keywords/distant-metastasis","display_name":"distant metastasis","score":0.656000018119812},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.7008749842643738},{"id":"https://openalex.org/C2780606744","wikidata":"https://www.wikidata.org/wiki/Q853930","display_name":"Starvation","level":2,"score":0.6657830476760864},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.6594293117523193},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4853619337081909},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.48258721828460693},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.4820176362991333},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46600016951560974},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36747950315475464},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27550208568573},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19212782382965088},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1301516592502594},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.11896106600761414},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/bcj.2011.5","doi":"https://doi.org/10.1038/bcj.2011.5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bcj.2011.5","pdf_url":"https://www.nature.com/articles/bcj20115.pdf","source":{"id":"https://openalex.org/S2496263508","display_name":"Blood Cancer Journal","issn_l":"2044-5385","issn":["2044-5385"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Cancer Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2263195","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3255269","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3255269","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3255269","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Cancer J","raw_type":"Text"},{"id":"pmid:22829112","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22829112","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood cancer journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/bcj.2011.5","doi":"https://doi.org/10.1038/bcj.2011.5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bcj.2011.5","pdf_url":"https://www.nature.com/articles/bcj20115.pdf","source":{"id":"https://openalex.org/S2496263508","display_name":"Blood Cancer Journal","issn_l":"2044-5385","issn":["2044-5385"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Cancer Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1568240861","display_name":"Gastric cancer: a mouse model and epigenetic statuses of blood in mice and humans","funder_award_id":"23300342","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2904992889","display_name":"Targeting cancer cells resistant to hypoxia and nutrient starvation to improve anti-cancer therapy","funder_award_id":"23701047","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6023230560","display_name":"Signaling mechanism of tumor angiogenesis.","funder_award_id":"17014020","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320324799","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2028090214.pdf","grobid_xml":"https://content.openalex.org/works/W2028090214.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1496109170","https://openalex.org/W2002424169","https://openalex.org/W2053221827","https://openalex.org/W2061366514","https://openalex.org/W2067009147","https://openalex.org/W2072297806","https://openalex.org/W2084740377","https://openalex.org/W2090739244","https://openalex.org/W2140088548","https://openalex.org/W2140201170"],"related_works":["https://openalex.org/W7097966464","https://openalex.org/W2159948826","https://openalex.org/W1811896390","https://openalex.org/W2074496815","https://openalex.org/W1537447319","https://openalex.org/W2488801043","https://openalex.org/W2326749252","https://openalex.org/W2586490694","https://openalex.org/W2587171270","https://openalex.org/W1519299662"],"abstract_inverted_index":{"Secondary":[0],"leukemia":[1,38],"occurs":[2],"long":[3],"after":[4,41],"remission":[5],"of":[6,13,21,35,44,49,82,96,106,134,183,227],"the":[7,19,103,110,175,228],"primary":[8,46,176],"tumor":[9,185,188,221,229],"with":[10,59,142,163,168],"a":[11,86,180,213,225],"history":[12],"chemo":[14,50],"and":[15,51,75,91,99,129,137,145,190,200,209],"radiation":[16],"therapy;":[17],"however,":[18],"mechanism":[20,226],"secondary":[22,36],"leukemogenesis":[23],"is":[24],"not":[25],"fully":[26],"understood.":[27],"1":[28],"In":[29,156],"this":[30,219],"study,":[31],"we":[32],"demonstrate":[33],"cases":[34],"T-cell":[37],"in":[39,57,112,115,166,212],"mice":[40],"complete":[42],"regression":[43],"xenograft":[45],"glioblastoma":[47],"independent":[48],"radiotherapy.":[52],"Recently,":[53],"antiangiogenic":[54,232],"therapy,":[55],"often":[56],"combination":[58,167],"conventional":[60],"chemotherapy,":[61],"has":[62],"been":[63,149],"clinically":[64],"validated":[65],"for":[66],"solid":[67],"tumors.":[68],"2":[69],"Vascular":[70],"endothelial":[71],"growth":[72],"factors":[73],"(VEGFs)":[74],"their":[76],"receptors":[77],"(VEGFRs)":[78],"are":[79],"major":[80],"regulators":[81],"angiogenesis;":[83],"3":[84],"indeed,":[85],"monoclonal":[87],"anti-VEGF":[88,135,164],"antibody":[89,136,165],"(bevacizumab)":[90],"small":[92],"molecular":[93],"weight":[94],"inhibitors":[95,140],"VEGFRs":[97],"(sorafenib":[98],"sunitinib)":[100],"have":[101,148],"improved":[102],"therapeutic":[104],"indexes":[105],"advanced":[107],"malignancies,":[108],"including":[109,187],"increase":[111],"disease-free":[113],"survival":[114],"breast":[116],"cancer,":[117,119],"colorectal":[118],"non-small":[120],"cell":[121,125],"lung":[122],"carcinoma,":[123,126],"renal":[124],"hepatocellular":[127],"carcinoma":[128],"glioblastoma.":[130],"However,":[131],"antitumor":[132],"effect":[133],"VEGF":[138],"receptor":[139],"concomitant":[141],"increased":[143,205],"invasiveness,":[144],"distant":[146,184,210],"metastasis":[147,211],"reported":[150,196],"using":[151],"preclinical":[152],"cancer":[153,215],"models.":[154],"4":[155],"addition,":[157],"high-grade":[158],"glioma":[159],"patients":[160],"following":[161,231],"treatments":[162],"irinotecan":[169],"demonstrated":[170],"an":[171],"effective":[172],"response":[173],"by":[174],"tumor,":[177],"but":[178],"also":[179],"high":[181],"rate":[182],"progression":[186],"infiltration":[189],"vascular":[191],"co-option.":[192],"5":[193],"We":[194],"previously":[195],"that":[197,218],"long-term":[198],"hypoxia":[199],"nutrient":[201],"starvation":[202],"double-deprivation":[203],"cycles":[204],"cellular":[206],"migration,":[207],"invasion":[208],"murine":[214],"model,":[216],"suggesting":[217],"extreme":[220],"microenvironment":[222],"could":[223],"be":[224],"aggressiveness":[230],"therapy.":[233],"6":[234]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
