{"id":"https://openalex.org/W2028089759","doi":"https://doi.org/10.1016/j.ydbio.2009.04.017","title":"A reverse genetic screen in the zebrafish identifies crb2b as a regulator of the glomerular filtration barrier","display_name":"A reverse genetic screen in the zebrafish identifies crb2b as a regulator of the glomerular filtration barrier","publication_year":2009,"publication_date":"2009-04-24","ids":{"openalex":"https://openalex.org/W2028089759","doi":"https://doi.org/10.1016/j.ydbio.2009.04.017","mag":"2028089759","pmid":"https://pubmed.ncbi.nlm.nih.gov/19393641"},"language":"en","primary_location":{"id":"doi:10.1016/j.ydbio.2009.04.017","doi":"https://doi.org/10.1016/j.ydbio.2009.04.017","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ydbio.2009.04.017","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0012160609002644/pdf","source":{"id":"https://openalex.org/S136634221","display_name":"Developmental Biology","issn_l":"0012-1606","issn":["0012-1606","1095-564X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.sciencedirect.com/science/article/pii/S0012160609002644/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105460556","display_name":"Lwaki Ebarasi","orcid":"https://orcid.org/0000-0001-7767-196X","observed_orcids":["https://orcid.org/0000-0001-7767-196X"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lwaki Ebarasi","raw_affiliation_strings":["Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles v\u00e4g 2, Plan 4 B1, SE-171 77 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles v\u00e4g 2, Plan 4 B1, SE-171 77 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010803737","display_name":"Liqun He","orcid":"https://orcid.org/0000-0003-2127-7597","observed_orcids":["https://orcid.org/0000-0003-2127-7597"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Liqun He","raw_affiliation_strings":["Laboratory of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019030826","display_name":"Kjell R. Hultenby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Kjell Hultenby","raw_affiliation_strings":["Department of Pathology, Karolinska University Hospital/Huddinge, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Karolinska University Hospital/Huddinge, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103007502","display_name":"Minoru Takemoto","orcid":"https://orcid.org/0000-0002-1623-9919","observed_orcids":["https://orcid.org/0000-0002-1623-9919"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Minoru Takemoto","raw_affiliation_strings":["Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051005847","display_name":"Christer Betsholtz","orcid":"https://orcid.org/0000-0002-8494-971X","observed_orcids":["https://orcid.org/0000-0002-8494-971X"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Christer Betsholtz","raw_affiliation_strings":["Laboratory of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000224317","display_name":"Karl Tryggvason","orcid":"https://orcid.org/0000-0002-0879-3290","observed_orcids":["https://orcid.org/0000-0002-0879-3290","https://orcid.org/0000-0003-1292-9266"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Karl Tryggvason","raw_affiliation_strings":["Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles v\u00e4g 2, Plan 4 B1, SE-171 77 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles v\u00e4g 2, Plan 4 B1, SE-171 77 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108097069","display_name":"\u00c5rindam Majumdar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Arindam Majumdar","raw_affiliation_strings":["Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles v\u00e4g 2, Plan 4 B1, SE-171 77 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles v\u00e4g 2, Plan 4 B1, SE-171 77 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5108097069"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":3.6196,"has_fulltext":true,"cited_by_count":73,"citation_normalized_percentile":{"value":0.92740678,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"334","issue":"1","first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glomerular-filtration-barrier","display_name":"glomerular filtration barrier","score":0.9990000128746033},{"id":"https://openalex.org/keywords/podocytes","display_name":"podocytes","score":0.8669999837875366},{"id":"https://openalex.org/keywords/slit-diaphragm","display_name":"slit diaphragm","score":0.9129999876022339},{"id":"https://openalex.org/keywords/nephrin","display_name":"nephrin","score":0.8100000023841858},{"id":"https://openalex.org/keywords/apicobasal-polarity","display_name":"apical-basal polarity","score":0.8550000190734863},{"id":"https://openalex.org/keywords/epithelial-polarization","display_name":"epithelial polarization","score":0.675000011920929},{"id":"https://openalex.org/keywords/podocyte-differentiation","display_name":"podocyte differentiation","score":0.7490000128746033},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.7099999785423279},{"id":"https://openalex.org/keywords/glomerular-permeability","display_name":"glomerular permeability","score":0.796999990940094},{"id":"https://openalex.org/keywords/rapgef2","display_name":"RAPGEF2","score":0.9639999866485596},{"id":"https://openalex.org/keywords/reverse-genetic-screen","display_name":"reverse genetic screen","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.8462426066398621},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.819832444190979},{"id":"https://openalex.org/C3018201436","wikidata":"https://www.wikidata.org/wiki/Q138912","display_name":"Slit diaphragm","level":5,"score":0.79587322473526},{"id":"https://openalex.org/C2780819817","wikidata":"https://www.wikidata.org/wiki/Q909653","display_name":"Nephrin","level":5,"score":0.766686201095581},{"id":"https://openalex.org/C2777146197","wikidata":"https://www.wikidata.org/wiki/Q138912","display_name":"Podocyte","level":4,"score":0.7485454678535461},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6348415613174438},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5824474096298218},{"id":"https://openalex.org/C31697123","wikidata":"https://www.wikidata.org/wiki/Q2656768","display_name":"Pronephros","level":4,"score":0.5220610499382019},{"id":"https://openalex.org/C207177822","wikidata":"https://www.wikidata.org/wiki/Q5050812","display_name":"Genetic screen","level":4,"score":0.4704388976097107},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3823484182357788},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.327415406703949},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2943589687347412},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.19714030623435974},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.18903303146362305}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050199","descriptor_name":"Podocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D050199","descriptor_name":"Podocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050199","descriptor_name":"Podocytes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ydbio.2009.04.017","doi":"https://doi.org/10.1016/j.ydbio.2009.04.017","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ydbio.2009.04.017","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0012160609002644/pdf","source":{"id":"https://openalex.org/S136634221","display_name":"Developmental Biology","issn_l":"0012-1606","issn":["0012-1606","1095-564X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Biology","raw_type":"journal-article"},{"id":"pmid:19393641","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19393641","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.ydbio.2009.04.017","doi":"https://doi.org/10.1016/j.ydbio.2009.04.017","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ydbio.2009.04.017","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0012160609002644/pdf","source":{"id":"https://openalex.org/S136634221","display_name":"Developmental Biology","issn_l":"0012-1606","issn":["0012-1606","1095-564X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322327","display_name":"Knut och Alice Wallenbergs Stiftelse","ror":"https://ror.org/004hzzk67"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2028089759.pdf","grobid_xml":"https://content.openalex.org/works/W2028089759.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W7980726","https://openalex.org/W1535846504","https://openalex.org/W1555420746","https://openalex.org/W1556198965","https://openalex.org/W1964442895","https://openalex.org/W1966032423","https://openalex.org/W1974229450","https://openalex.org/W1980398528","https://openalex.org/W1980670800","https://openalex.org/W1998756807","https://openalex.org/W2011614193","https://openalex.org/W2019907052","https://openalex.org/W2027097760","https://openalex.org/W2033848557","https://openalex.org/W2039537505","https://openalex.org/W2041703199","https://openalex.org/W2043982544","https://openalex.org/W2048501294","https://openalex.org/W2069177997","https://openalex.org/W2072846146","https://openalex.org/W2073606372","https://openalex.org/W2075321187","https://openalex.org/W2077970848","https://openalex.org/W2078298967","https://openalex.org/W2083971326","https://openalex.org/W2087296674","https://openalex.org/W2092088744","https://openalex.org/W2104088479","https://openalex.org/W2105388550","https://openalex.org/W2105535336","https://openalex.org/W2114889093","https://openalex.org/W2119711419","https://openalex.org/W2121977177","https://openalex.org/W2129416468","https://openalex.org/W2132619856","https://openalex.org/W2133862855","https://openalex.org/W2134378274","https://openalex.org/W2135679847","https://openalex.org/W2147850775","https://openalex.org/W2153534186","https://openalex.org/W2167103757","https://openalex.org/W2168287443","https://openalex.org/W2171145836","https://openalex.org/W2171316490","https://openalex.org/W4210988776"],"related_works":["https://openalex.org/W2167127947","https://openalex.org/W7014907983","https://openalex.org/W3133495938","https://openalex.org/W2073606372","https://openalex.org/W2241269383","https://openalex.org/W2167103757","https://openalex.org/W1667692994","https://openalex.org/W1988571905","https://openalex.org/W4383710365","https://openalex.org/W2766826061"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}