{"id":"https://openalex.org/W2028085557","doi":"https://doi.org/10.1021/ac9012286","title":"Iron Oxide/Gold Core/Shell Nanoparticles for Ultrasensitive Detection of Carbohydrate\u2212Protein Interactions","display_name":"Iron Oxide/Gold Core/Shell Nanoparticles for Ultrasensitive Detection of Carbohydrate\u2212Protein Interactions","publication_year":2009,"publication_date":"2009-08-18","ids":{"openalex":"https://openalex.org/W2028085557","doi":"https://doi.org/10.1021/ac9012286","mag":"2028085557","pmid":"https://pubmed.ncbi.nlm.nih.gov/19689135"},"language":"en","primary_location":{"id":"doi:10.1021/ac9012286","doi":"https://doi.org/10.1021/ac9012286","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac9012286","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108587580","display_name":"C. Jason Liang","orcid":"https://orcid.org/0000-0002-4832-6590","observed_orcids":["https://orcid.org/0000-0002-4832-6590"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4210087491","display_name":"Genomics Research Center, Academia Sinica","ror":"https://ror.org/002mmyt85","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chi-Hui Liang","raw_affiliation_strings":["The Genomics Research Center, Academia Sinica, Taipei, 115 Taiwan, and Institute of Biochemical Science and Department of Chemistry, National Taiwan University, Taipei, 106 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Genomics Research Center, Academia Sinica, Taipei, 115 Taiwan, and Institute of Biochemical Science and Department of Chemistry, National Taiwan University, Taipei, 106 Taiwan","institution_ids":["https://openalex.org/I16733864","https://openalex.org/I4210087491","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012134103","display_name":"Cheng\u2010Chi Wang","orcid":"https://orcid.org/0000-0002-3009-6571","observed_orcids":["https://orcid.org/0000-0002-3009-6571"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4210087491","display_name":"Genomics Research Center, Academia Sinica","ror":"https://ror.org/002mmyt85","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Cheng-Chi Wang","raw_affiliation_strings":["The Genomics Research Center, Academia Sinica, Taipei, 115 Taiwan, and Institute of Biochemical Science and Department of Chemistry, National Taiwan University, Taipei, 106 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Genomics Research Center, Academia Sinica, Taipei, 115 Taiwan, and Institute of Biochemical Science and Department of Chemistry, National Taiwan University, Taipei, 106 Taiwan","institution_ids":["https://openalex.org/I16733864","https://openalex.org/I4210087491","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101705460","display_name":"Yu-Chen Lin","orcid":"https://orcid.org/0000-0002-0935-4943","observed_orcids":["https://orcid.org/0000-0002-0935-4943"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4210087491","display_name":"Genomics Research Center, Academia Sinica","ror":"https://ror.org/002mmyt85","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Chen Lin","raw_affiliation_strings":["The Genomics Research Center, Academia Sinica, Taipei, 115 Taiwan, and Institute of Biochemical Science and Department of Chemistry, National Taiwan University, Taipei, 106 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Genomics Research Center, Academia Sinica, Taipei, 115 Taiwan, and Institute of Biochemical Science and Department of Chemistry, National Taiwan University, Taipei, 106 Taiwan","institution_ids":["https://openalex.org/I16733864","https://openalex.org/I4210087491","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038091906","display_name":"Chung\u2010Hsuan Chen","orcid":"https://orcid.org/0000-0002-2826-0002","observed_orcids":["https://orcid.org/0000-0002-2826-0002"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4210087491","display_name":"Genomics Research Center, Academia Sinica","ror":"https://ror.org/002mmyt85","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chung-Hsuan Chen","raw_affiliation_strings":["The Genomics Research Center, Academia Sinica, Taipei, 115 Taiwan, and Institute of Biochemical Science and Department of Chemistry, National Taiwan University, Taipei, 106 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Genomics Research Center, Academia Sinica, Taipei, 115 Taiwan, and Institute of Biochemical Science and Department of Chemistry, National Taiwan University, Taipei, 106 Taiwan","institution_ids":["https://openalex.org/I16733864","https://openalex.org/I4210087491","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056753239","display_name":"Chi\u2010Huey Wong","orcid":"https://orcid.org/0000-0002-9961-7865","observed_orcids":["https://orcid.org/0000-0002-9961-7865"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4210087491","display_name":"Genomics Research Center, Academia Sinica","ror":"https://ror.org/002mmyt85","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chi-Huey Wong","raw_affiliation_strings":["The Genomics Research Center, Academia Sinica, Taipei, 115 Taiwan, and Institute of Biochemical Science and Department of Chemistry, National Taiwan University, Taipei, 106 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Genomics Research Center, Academia Sinica, Taipei, 115 Taiwan, and Institute of Biochemical Science and Department of Chemistry, National Taiwan University, Taipei, 106 Taiwan","institution_ids":["https://openalex.org/I16733864","https://openalex.org/I4210087491","https://openalex.org/I84653119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073163752","display_name":"Chung\u2010Yi Wu","orcid":"https://orcid.org/0000-0002-5233-4454","observed_orcids":["https://orcid.org/0000-0002-5233-4454"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4210087491","display_name":"Genomics Research Center, Academia Sinica","ror":"https://ror.org/002mmyt85","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chung-Yi Wu","raw_affiliation_strings":["The Genomics Research Center, Academia Sinica, Taipei, 115 Taiwan, and Institute of Biochemical Science and Department of Chemistry, National Taiwan University, Taipei, 106 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Genomics Research Center, Academia Sinica, Taipei, 115 Taiwan, and Institute of Biochemical Science and Department of Chemistry, National Taiwan University, Taipei, 106 Taiwan","institution_ids":["https://openalex.org/I16733864","https://openalex.org/I4210087491","https://openalex.org/I84653119"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5056753239","https://openalex.org/A5073163752"],"corresponding_institution_ids":["https://openalex.org/I16733864","https://openalex.org/I4210087491","https://openalex.org/I84653119"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.1105,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.92786946,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"81","issue":"18","first_page":"7750","last_page":"7756"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.5508000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.5508000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.1607999950647354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10131","display_name":"Gold and Silver Nanoparticles Synthesis and Applications","score":0.15139999985694885,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-carbohydrate-interactions","display_name":"carbohydrate-protein interactions","score":0.9850000143051147},{"id":"https://openalex.org/keywords/mannose-binding-lectin","display_name":"mannose-binding lectin","score":0.7409999966621399},{"id":"https://openalex.org/keywords/concanavalin-a","display_name":"concanavalin A","score":0.9599999785423279},{"id":"https://openalex.org/keywords/ssea-3","display_name":"SSEA-3","score":0.8980000019073486},{"id":"https://openalex.org/keywords/signal-amplification","display_name":"signal amplification","score":0.8149999976158142},{"id":"https://openalex.org/keywords/magnetic-separation","display_name":"magnetic separation","score":0.5139999985694885},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.5},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.868909478187561},{"id":"https://openalex.org/C2778889443","wikidata":"https://www.wikidata.org/wiki/Q6073014","display_name":"Iron oxide nanoparticles","level":3,"score":0.6674870252609253},{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.6200883984565735},{"id":"https://openalex.org/C49853544","wikidata":"https://www.wikidata.org/wiki/Q206229","display_name":"Biomolecule","level":2,"score":0.6006715893745422},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5993165969848633},{"id":"https://openalex.org/C104819515","wikidata":"https://www.wikidata.org/wiki/Q900961","display_name":"Colloidal gold","level":3,"score":0.5666235089302063},{"id":"https://openalex.org/C2780758401","wikidata":"https://www.wikidata.org/wiki/Q408693","display_name":"Lectin","level":2,"score":0.5271399021148682},{"id":"https://openalex.org/C2778977261","wikidata":"https://www.wikidata.org/wiki/Q11358","display_name":"Carbohydrate","level":2,"score":0.5054054260253906},{"id":"https://openalex.org/C2775887612","wikidata":"https://www.wikidata.org/wiki/Q10809118","display_name":"Mannose","level":2,"score":0.50079345703125},{"id":"https://openalex.org/C19869320","wikidata":"https://www.wikidata.org/wiki/Q419277","display_name":"Concanavalin A","level":3,"score":0.48786497116088867},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4690205156803131},{"id":"https://openalex.org/C2777697756","wikidata":"https://www.wikidata.org/wiki/Q721849","display_name":"Iron oxide","level":2,"score":0.45682859420776367},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3976816236972809},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.38862642645835876},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35981810092926025},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.35096949338912964},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.26197725534439087},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09839051961898804},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0961049497127533},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002241","descriptor_name":"Carbohydrates","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002241","descriptor_name":"Carbohydrates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003208","descriptor_name":"Concanavalin A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003208","descriptor_name":"Concanavalin A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005290","descriptor_name":"Ferric Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006046","descriptor_name":"Gold","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053768","descriptor_name":"Metal Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/ac9012286","doi":"https://doi.org/10.1021/ac9012286","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac9012286","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:19689135","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19689135","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321041","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W128706905","https://openalex.org/W1966169673","https://openalex.org/W1966836615","https://openalex.org/W1968153092","https://openalex.org/W1968196198","https://openalex.org/W1971428641","https://openalex.org/W1972754463","https://openalex.org/W1977686192","https://openalex.org/W1981382191","https://openalex.org/W1992272938","https://openalex.org/W2003131503","https://openalex.org/W2012338624","https://openalex.org/W2017469968","https://openalex.org/W2022147450","https://openalex.org/W2023269042","https://openalex.org/W2029662794","https://openalex.org/W2030701775","https://openalex.org/W2031119996","https://openalex.org/W2035256873","https://openalex.org/W2037356551","https://openalex.org/W2040172043","https://openalex.org/W2040711070","https://openalex.org/W2042650834","https://openalex.org/W2043680485","https://openalex.org/W2045589130","https://openalex.org/W2057993402","https://openalex.org/W2059939467","https://openalex.org/W2065445969","https://openalex.org/W2067071334","https://openalex.org/W2076697448","https://openalex.org/W2076975212","https://openalex.org/W2078820160","https://openalex.org/W2078954120","https://openalex.org/W2083260383","https://openalex.org/W2086754387","https://openalex.org/W2092602198","https://openalex.org/W2101908398","https://openalex.org/W2126818937","https://openalex.org/W2130592661","https://openalex.org/W2131848203","https://openalex.org/W2141720376","https://openalex.org/W2159941442","https://openalex.org/W2163523761","https://openalex.org/W2165426251","https://openalex.org/W2170347395","https://openalex.org/W2170473509","https://openalex.org/W3014059151","https://openalex.org/W3140098542","https://openalex.org/W4211014836","https://openalex.org/W4235614422"],"related_works":["https://openalex.org/W2042650834","https://openalex.org/W7017790422","https://openalex.org/W2022170072","https://openalex.org/W2070167792","https://openalex.org/W2801720975","https://openalex.org/W2150551587","https://openalex.org/W2108525441","https://openalex.org/W1489154593","https://openalex.org/W1824503206","https://openalex.org/W2163346503"],"abstract_inverted_index":{"Changes":[0],"in":[1,201],"the":[2,97,188],"expression":[3,15],"of":[4,31,35,85,113,170,186,190],"cell":[5],"surface":[6,157],"glycan":[7],"are":[8],"often":[9],"associated":[10],"with":[11,60,125,138,177],"malignant":[12],"metastasis.":[13],"The":[14,103],"level":[16,200],"may":[17],"be":[18,40],"dramatically":[19],"enhanced":[20],"during":[21],"tumor":[22],"progression.":[23],"A":[24,66],"highly":[25],"sensitive":[26],"assay":[27,196],"that":[28],"is":[29,64,69],"capable":[30],"detecting":[32],"low":[33,101],"levels":[34],"cancer-associated":[36],"carbohydrate":[37,202],"antigens":[38],"can":[39],"a":[41,80,107,126,133,139,178],"powerful":[42],"tool":[43],"for":[44,111,165],"early":[45],"diagnosis.":[46],"In":[47],"this":[48,147],"work,":[49],"an":[50,83,191],"ultrasensitive":[51],"glycans":[52],"array":[53,84],"using":[54],"iron":[55,192],"oxide/gold":[56,193],"core/shell":[57,194],"nanoparticles":[58],"conjugated":[59],"antibodies":[61,78],"or":[62,77],"proteins":[63,76],"developed.":[65],"magnetic":[67],"field":[68],"applied":[70],"to":[71,82,92,95,145,154,198],"quickly":[72],"bring":[73],"nanoparticle":[74],"labeled":[75],"from":[79],"solution":[81],"carbohydrates":[86,98],"immobilized":[87],"on":[88,183],"glass":[89],"slides":[90],"and":[91,123,132,161,167,172],"help":[93],"them":[94],"encounter":[96],"at":[99],"very":[100],"concentration.":[102],"gold":[104],"shell":[105],"provides":[106],"well":[108],"established":[109],"platform":[110],"conjugation":[112],"biomolecules.":[114],"Well-defined":[115],"recognition":[116],"systems,":[117],"namely,":[118],"mannose":[119,127],"derivatives":[120],"(Man1,":[121],"Man4,":[122],"Man9)":[124],"binding":[128,163],"lectin":[129],"(Concanavalin":[130],"A)":[131],"stage-specific":[134],"embryonic":[135],"antigens-3":[136],"(SSEA-3)":[137],"monoclonal":[140],"antibody":[141],"(anti-SSEA-3)":[142],"were":[143,152],"chosen":[144],"establish":[146],"detection":[148],"tool.":[149],"Array":[150],"systems":[151],"conducted":[153],"determine":[155],"their":[156,162],"dissociation":[158],"constant":[159],"(K(D,surface))":[160],"specificity":[164],"qualitative":[166],"quantitative":[168],"analysis":[169],"carbohydrate-protein":[171],"carbohydrate-antibody":[173],"interactions.":[174],"When":[175],"coupled":[176],"signal":[179],"amplification":[180],"method":[181],"based":[182],"nanoparticle-promoted":[184],"reduction":[185],"silver,":[187],"sensitivity":[189],"nanoparticle-based":[195],"reached":[197],"subattomole":[199],"detection.":[203]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}