{"id":"https://openalex.org/W2028083041","doi":"https://doi.org/10.2174/157488709787047558","title":"Treatment of Colorectal Liver Metastases: A Review","display_name":"Treatment of Colorectal Liver Metastases: A Review","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2028083041","doi":"https://doi.org/10.2174/157488709787047558","mag":"2028083041","pmid":"https://pubmed.ncbi.nlm.nih.gov/19149763"},"language":"en","primary_location":{"id":"doi:10.2174/157488709787047558","doi":"https://doi.org/10.2174/157488709787047558","is_oa":false,"landing_page_url":"https://doi.org/10.2174/157488709787047558","pdf_url":null,"source":{"id":"https://openalex.org/S164609936","display_name":"Reviews on Recent Clinical Trials","issn_l":"1574-8871","issn":["1574-8871","1876-1038"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reviews on Recent Clinical Trials","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016173075","display_name":"Marc Van den Eynde","orcid":"https://orcid.org/0000-0002-1405-4785","observed_orcids":["https://orcid.org/0000-0002-1405-4785"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"M. Eynde","raw_affiliation_strings":["Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (U.L.B), Brussels, Belgium. marc.vandeneynde@bordet.be"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles (U.L.B), Brussels, Belgium. marc.vandeneynde@bordet.be","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2801838318"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060058983","display_name":"Alain Hendlisz","orcid":"https://orcid.org/0000-0003-2122-1948","observed_orcids":["https://orcid.org/0000-0003-2122-1948"]},"institutions":[{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"A. Hendlisz","raw_affiliation_strings":["Medical Oncology Clinic, Gastro-enterology Dept., Institut Jules Bordet, Rue Heger-Bordet, 1, Belgium\u20131000 Brussels.,Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Clinic, Gastro-enterology Dept., Institut Jules Bordet, Rue Heger-Bordet, 1, Belgium\u20131000 Brussels.,Belgium","institution_ids":["https://openalex.org/I2801838318"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5060058983"],"corresponding_institution_ids":["https://openalex.org/I2801838318"],"apc_list":null,"apc_paid":null,"fwci":2.8345,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.90672643,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"4","issue":"1","first_page":"56","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8820000290870667},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.8830000162124634},{"id":"https://openalex.org/keywords/liver-resection","display_name":"hepatectomy","score":0.8650000095367432},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.49900001287460327},{"id":"https://openalex.org/keywords/irinotecan","display_name":"irinotecan","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxaliplatin","display_name":"oxaliplatin","score":1.0},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8790000081062317},{"id":"https://openalex.org/keywords/perioperative-chemotherapy","display_name":"perioperative chemotherapy","score":0.7300000190734863},{"id":"https://openalex.org/keywords/tumor-downstaging","display_name":"tumor downstaging","score":0.6610000133514404},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.39899998903274536}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.956676721572876},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.8417085409164429},{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.8055976629257202},{"id":"https://openalex.org/C2779804826","wikidata":"https://www.wikidata.org/wiki/Q45435667","display_name":"Folinic acid","level":4,"score":0.7968548536300659},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7343039512634277},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5882787704467773},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5220617651939392},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5096964836120605},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3311537504196167},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3301406502723694}],"mesh":[{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006499","descriptor_name":"Hepatic Artery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006499","descriptor_name":"Hepatic Artery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006499","descriptor_name":"Hepatic Artery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007261","descriptor_name":"Infusions, Intra-Arterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007261","descriptor_name":"Infusions, Intra-Arterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007261","descriptor_name":"Infusions, Intra-Arterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017115","descriptor_name":"Catheter Ablation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017115","descriptor_name":"Catheter Ablation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017115","descriptor_name":"Catheter Ablation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2174/157488709787047558","doi":"https://doi.org/10.2174/157488709787047558","is_oa":false,"landing_page_url":"https://doi.org/10.2174/157488709787047558","pdf_url":null,"source":{"id":"https://openalex.org/S164609936","display_name":"Reviews on Recent Clinical Trials","issn_l":"1574-8871","issn":["1574-8871","1876-1038"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reviews on Recent Clinical Trials","raw_type":"journal-article"},{"id":"pmid:19149763","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19149763","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reviews on recent clinical trials","raw_type":"Journal Article"},{"id":"pmh:oai:dial.uclouvain.be:boreal:193398","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2078.1/193398","pdf_url":null,"source":{"id":"https://openalex.org/S4306401974","display_name":"DIAL (Catholic University of Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Reviews on Recent Clinical Trials, Vol. 4, p. 56-62 (2009)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/164949","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/164949","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Reviews on Recent Clinical Trials, 4 (1","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7200000286102295}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W19092580","https://openalex.org/W31513995","https://openalex.org/W63885587","https://openalex.org/W137975989","https://openalex.org/W1491010061","https://openalex.org/W1782669727","https://openalex.org/W1835268604","https://openalex.org/W1961040537","https://openalex.org/W1976445376","https://openalex.org/W1979423262","https://openalex.org/W1985941484","https://openalex.org/W1989175303","https://openalex.org/W1998966672","https://openalex.org/W2000180049","https://openalex.org/W2001663715","https://openalex.org/W2013807550","https://openalex.org/W2016726396","https://openalex.org/W2022086436","https://openalex.org/W2031358641","https://openalex.org/W2035454562","https://openalex.org/W2045066689","https://openalex.org/W2051224942","https://openalex.org/W2066390717","https://openalex.org/W2067482493","https://openalex.org/W2068670884","https://openalex.org/W2070833957","https://openalex.org/W2073016557","https://openalex.org/W2080577931","https://openalex.org/W2082009481","https://openalex.org/W2085070000","https://openalex.org/W2087923534","https://openalex.org/W2096563748","https://openalex.org/W2101789374","https://openalex.org/W2104256009","https://openalex.org/W2104614485","https://openalex.org/W2105613824","https://openalex.org/W2106845199","https://openalex.org/W2108585052","https://openalex.org/W2109498035","https://openalex.org/W2114817289","https://openalex.org/W2114857812","https://openalex.org/W2121368761","https://openalex.org/W2122378536","https://openalex.org/W2124515527","https://openalex.org/W2128447158","https://openalex.org/W2133399075","https://openalex.org/W2134920919","https://openalex.org/W2135423900","https://openalex.org/W2136055188","https://openalex.org/W2138235363","https://openalex.org/W2142564546","https://openalex.org/W2143007780","https://openalex.org/W2154143304","https://openalex.org/W2155854000","https://openalex.org/W2157769714","https://openalex.org/W2162313061","https://openalex.org/W2170486320","https://openalex.org/W2171680834","https://openalex.org/W2227477053","https://openalex.org/W2275743056","https://openalex.org/W2314927739","https://openalex.org/W2316178638","https://openalex.org/W2410220635","https://openalex.org/W2414965874","https://openalex.org/W2472159473","https://openalex.org/W2573659293","https://openalex.org/W2604975714","https://openalex.org/W4232330952"],"related_works":["https://openalex.org/W2010429874","https://openalex.org/W1999159801","https://openalex.org/W2577979650","https://openalex.org/W131030860","https://openalex.org/W2811271347","https://openalex.org/W2080692829","https://openalex.org/W2104256009","https://openalex.org/W2042150224","https://openalex.org/W2058385450","https://openalex.org/W2465617904"],"abstract_inverted_index":{"Liver":[0],"metastases":[1,95,159],"from":[2],"colorectal":[3,32],"cancer":[4],"(CRC)":[5],"have":[6,47,79],"a":[7],"poor":[8],"prognosis.":[9],"Despite":[10],"recent":[11,165],"advances":[12],"in":[13,142],"the":[14,24,58,84,121,150,153,162,170],"management":[15],"of":[16,37,152,164,173],"advanced":[17],"disease":[18,50],"with":[19,31,39,68,111],"chemotherapy,":[20],"liver":[21,33,49,103,119,158],"resection":[22,104],"remains":[23],"only":[25],"hope":[26],"for":[27,29,115,123,136,156],"cure":[28],"patients":[30,38],"metastases.":[34],"Approximately":[35],"15%":[36],"stage":[40],"IV":[41],"CRC":[42,157],"referred":[43],"to":[44,52,82,87,96,168],"specialist":[45],"centers":[46],"metastatic":[48],"deemed":[51],"be":[53,97],"resectable":[54,137],"at":[55],"presentation.":[56],"Over":[57],"last":[59],"five":[60],"years,":[61],"combination":[62],"chemotherapeutic":[63],"regimens,":[64],"namely":[65],"5-fluorouracil/folinic":[66],"acid":[67],"irinotecan":[69],"or":[70],"oxaliplatin":[71],"and,":[72,160],"more":[73],"recently,":[74],"integrating":[75],"targeted":[76],"monoclonal":[77],"antibodies,":[78],"been":[80],"shown":[81],"downsize":[83],"tumour":[85],"burden":[86],"an":[88],"extent":[89],"that":[90],"sometimes":[91],"allows":[92],"initially":[93],"unresectable":[94],"excised.":[98],"Five-year":[99],"survival":[100],"rates":[101],"following":[102],"range":[105],"between":[106],"25%":[107],"and":[108,113],"55%":[109],"compared":[110],"0%":[112],"5%":[114],"non-operated":[116],"patients.":[117],"Beyond":[118],"resection,":[120],"rationale":[122],"\"pseudo-adjuvant\"":[124],"chemotherapy":[125,135],"lacks":[126],"scientific":[127],"evidence,":[128],"despite":[129],"some":[130],"promising":[131],"data.":[132],"However,":[133],"perioperative":[134],"lesions":[138],"is":[139],"gaining":[140],"ground":[141],"current":[143],"practice.":[144],"In":[145],"this":[146],"article":[147],"we":[148],"review":[149],"state":[151],"art":[154],"treatment":[155],"considering":[161],"results":[163],"trials,":[166],"try":[167],"determine":[169],"appropriate":[171],"role":[172],"chemotherapy.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}