{"id":"https://openalex.org/W2028019272","doi":"https://doi.org/10.4161/cbt.4.4.1620","title":"Augmentation of antitumor effects of p53 Gene therapy by combination with HDAC inhibitor","display_name":"Augmentation of antitumor effects of p53 Gene therapy by combination with HDAC inhibitor","publication_year":2005,"publication_date":"2005-04-01","ids":{"openalex":"https://openalex.org/W2028019272","doi":"https://doi.org/10.4161/cbt.4.4.1620","mag":"2028019272","pmid":"https://pubmed.ncbi.nlm.nih.gov/15846102"},"language":"en","primary_location":{"id":"doi:10.4161/cbt.4.4.1620","doi":"https://doi.org/10.4161/cbt.4.4.1620","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cbt.4.4.1620","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.4.4.1620?needAccess=true&role=button","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology & Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.4.4.1620?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008694549","display_name":"Rishu Takimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rishu Takimoto","raw_affiliation_strings":["Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103049153","display_name":"Junji Kato","orcid":"https://orcid.org/0000-0002-7367-8344","observed_orcids":["https://orcid.org/0000-0002-7367-8344"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junji Kato","raw_affiliation_strings":["Fourth Department of Internal Medicine ; Sapporo Medical University School of Medicine ; Sapporo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine ; Sapporo Medical University School of Medicine ; Sapporo , Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103643279","display_name":"Takeshi Terui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Terui","raw_affiliation_strings":["Fourth Department of Internal Medicine ; Sapporo Medical University School of Medicine ; Sapporo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine ; Sapporo Medical University School of Medicine ; Sapporo , Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111701162","display_name":"Koichi Takada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichi Takada","raw_affiliation_strings":["Fourth Department of Internal Medicine ; Sapporo Medical University School of Medicine ; Sapporo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine ; Sapporo Medical University School of Medicine ; Sapporo , Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065394835","display_name":"Ganji Kuroiwa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ganji Kuroiwa","raw_affiliation_strings":["Fourth Department of Internal Medicine ; Sapporo Medical University School of Medicine ; Sapporo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine ; Sapporo Medical University School of Medicine ; Sapporo , Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061851713","display_name":"Jing Wu","orcid":"https://orcid.org/0000-0001-7735-0349","observed_orcids":["https://orcid.org/0000-0001-7735-0349"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jing Wu","raw_affiliation_strings":["Fourth Department of Internal Medicine ; Sapporo Medical University School of Medicine ; Sapporo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine ; Sapporo Medical University School of Medicine ; Sapporo , Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024753283","display_name":"Hiroyuki Ohnuma","orcid":"https://orcid.org/0000-0002-4350-6971","observed_orcids":["https://orcid.org/0000-0002-4350-6971"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIroyuki Ohnuma","raw_affiliation_strings":["Fourth Department of Internal Medicine ; Sapporo Medical University School of Medicine ; Sapporo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine ; Sapporo Medical University School of Medicine ; Sapporo , Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070643359","display_name":"Daisuke Takahari","orcid":"https://orcid.org/0000-0002-2492-6014","observed_orcids":["https://orcid.org/0000-0002-2492-6014"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daisuke Takahari","raw_affiliation_strings":["Fourth Department of Internal Medicine ; Sapporo Medical University School of Medicine ; Sapporo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine ; Sapporo Medical University School of Medicine ; Sapporo , Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074930047","display_name":"Masayoshi Kobune","orcid":"https://orcid.org/0000-0003-3828-8444","observed_orcids":["https://orcid.org/0000-0003-3828-8444"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayoshi Kobune","raw_affiliation_strings":["Fourth Department of Internal Medicine ; Sapporo Medical University School of Medicine ; Sapporo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine ; Sapporo Medical University School of Medicine ; Sapporo , Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021158752","display_name":"Yasushi Sato","orcid":"https://orcid.org/0000-0002-6776-4609","observed_orcids":["https://orcid.org/0000-0002-6776-4609","https://orcid.org/0000-0003-0446-8017"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasushi Sato","raw_affiliation_strings":["Fourth Department of Internal Medicine ; Sapporo Medical University School of Medicine ; Sapporo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine ; Sapporo Medical University School of Medicine ; Sapporo , Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030298726","display_name":"Tetsuji Takayama","orcid":"https://orcid.org/0000-0002-0175-1573","observed_orcids":["https://orcid.org/0000-0002-0175-1573"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuji Takayama","raw_affiliation_strings":["Fourth Department of Internal Medicine ; Sapporo Medical University School of Medicine ; Sapporo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine ; Sapporo Medical University School of Medicine ; Sapporo , Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090634106","display_name":"Takuya Matsunaga","orcid":"https://orcid.org/0000-0001-7813-5982","observed_orcids":["https://orcid.org/0000-0001-7813-5982"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuya Matsunaga","raw_affiliation_strings":["Fourth Department of Internal Medicine ; Sapporo Medical University School of Medicine ; Sapporo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine ; Sapporo Medical University School of Medicine ; Sapporo , Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105903935","display_name":"Yoshiro Niistu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yoshiro Niistu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5105903935"],"corresponding_institution_ids":[],"apc_list":{"value":2710,"currency":"EUR","value_usd":2970},"apc_paid":null,"fwci":5.8582,"has_fulltext":true,"cited_by_count":68,"citation_normalized_percentile":{"value":0.96845882,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"4","issue":"4","first_page":"427","last_page":"434"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.36059999465942383,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.36059999465942383,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.3449999988079071,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.2831999957561493,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53-gene-therapy","display_name":"p53 gene therapy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9010000228881836},{"id":"https://openalex.org/keywords/sodium-butyrate","display_name":"sodium butyrate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.8510000109672546},{"id":"https://openalex.org/keywords/coxsackie-adenovirus-receptor","display_name":"coxsackievirus and adenovirus receptor","score":0.9150000214576721},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5630000233650208},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.8080000281333923},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6449999809265137},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.652999997138977},{"id":"https://openalex.org/keywords/xenograft-tumor-regression","display_name":"xenograft tumor regression","score":0.6259999871253967},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6348292231559753},{"id":"https://openalex.org/C2778942008","wikidata":"https://www.wikidata.org/wiki/Q305004","display_name":"Sodium butyrate","level":3,"score":0.5898008346557617},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5102202892303467},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5072023868560791},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4470495879650116},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4416186809539795},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.43598994612693787},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.42837584018707275},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.41611573100090027},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3961010277271271},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3422331213951111},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.25813984870910645},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.232255220413208},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22381412982940674},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002087","descriptor_name":"Butyrates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.4161/cbt.4.4.1620","doi":"https://doi.org/10.4161/cbt.4.4.1620","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cbt.4.4.1620","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.4.4.1620?needAccess=true&role=button","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology & Therapy","raw_type":"journal-article"},{"id":"pmid:15846102","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15846102","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer biology & therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4161/cbt.4.4.1620","doi":"https://doi.org/10.4161/cbt.4.4.1620","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cbt.4.4.1620","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.4.4.1620?needAccess=true&role=button","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology & Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2028019272.pdf","grobid_xml":"https://content.openalex.org/works/W2028019272.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2189073461","https://openalex.org/W2097017461","https://openalex.org/W1755993224","https://openalex.org/W1996497067","https://openalex.org/W2590563457","https://openalex.org/W276995005","https://openalex.org/W2047029503","https://openalex.org/W2077594056","https://openalex.org/W2049819449","https://openalex.org/W2142823751"],"abstract_inverted_index":{"We":[0,116,140],"have":[1],"previously":[2],"shown":[3,291],"that":[4,51,235,265],"the":[5,10,54,63,82,199,225,233,247,263],"HDAC":[6],"inhibitors":[7],"(HDACI)":[8],"activate":[9],"p53":[11,36,91,253,298],"molecule":[12],"through":[13],"acetylation":[14],"of":[15,53,62,85,122,130,147,155,168,174,180,204,273,297],"320":[16],"and":[17,23,25,33,58,108,149,157,282],"373":[18],"lysine":[19],"residues,":[20],"upregulate":[21],"PIG3":[22],"NOXA":[24],"induce":[26],"apoptosis":[27],"in":[28,65,113,137,178,221,243,280],"cancer":[29,66,105],"cells":[30,67,106,111,207,284],"expressing":[31],"wild":[32,89],"pseudo-wild":[34],"type":[35,90],"genes":[37],"(Terui":[38],"T,":[39],"et":[40],"al.":[41],"Cancer":[42],"Res":[43],"2003;":[44],"63:8948-54).":[45],"It":[46],"has":[47],"also":[48],"been":[49],"reported":[50],"expression":[52,121,133],"Coxsackie":[55,123],"adenovirus":[56,64,124],"receptor":[57],"subsequent":[59],"transfection":[60],"efficiency":[61],"were":[68,218],"enhanced":[69],"by":[70,134,238,262,277],"HDACI":[71],"treatment.":[72],"In":[73],"this":[74,185],"study,":[75],"we":[76],"extended":[77],"these":[78],"observations":[79],"to":[80,232,292],"explore":[81],"combination":[83,186,200,226,248],"effect":[84,164],"adenoviral":[86],"vector":[87],"carrying":[88],"(Ad-p53)":[92],"gene":[93,254,299],"therapy":[94,300],"with":[95,126,152,184,188,198,211,224,246,252,286],"a":[96,159,171,212,229],"HDACI,":[97],"sodium":[98],"butyrate":[99],"(SB),":[100],"on":[101],"xenografted":[102],"human":[103],"gastric":[104],"(KATO-III)":[107],"hepatocellular":[109],"carcinoma":[110],"(HuH7)":[112],"nude":[114],"mice.":[115],"first":[117],"confirmed":[118],"an":[119,127,271,294],"increased":[120],"receptors":[125],"associated":[128],"increment":[129],"transgene":[131],"(X-gal)":[132],"SB":[135,156,256,278,289],"treatment":[136,190,279],"KATO-III":[138,148,281],"cells.":[139],"then":[141],"injected":[142],"Ad-p53":[143],"into":[144],"subcutaneous":[145],"tumors":[146,175,222,244],"HuH7":[150,283],"combined":[151],"intraperitoneal":[153],"administration":[154],"found":[158],"significantly":[160],"higher":[161,202],"growth":[162],"suppressive":[163],"than":[165,208,227,249],"single":[166,189,213],"treatments":[167],"each.":[169],"Even":[170],"complete":[172],"regression":[173,193],"was":[176,194,241,259,275,290],"observed":[177],"three":[179],"five":[181],"mice":[182],"treated":[183,197,210,223,245,251],"while":[187],"no":[191],"tumor":[192],"observed.":[195],"Tumors":[196],"showed":[201],"numbers":[203],"TUNEL":[205],"positive":[206],"those":[209,250],"modality.":[214],"Moreover,":[215],"necrotic":[216],"changes":[217],"more":[219],"evident":[220],"separately,":[228],"compatible":[230],"finding":[231,264],"observation":[234],"vascularity":[236],"revealed":[237],"CD34":[239],"staining":[240],"poorer":[242],"or":[255],"alone.":[257],"This":[258],"further":[260],"supported":[261],"BAI-1":[266],"(brain":[267],"specific":[268],"angiogenesis":[269],"inhibitor-1),":[270],"inhibitor":[272],"vascularization,":[274],"induced":[276],"transfected":[285],"Ad-p53.":[287],"Thus":[288],"be":[293],"efficient":[295],"potentiator":[296],"for":[301],"cancer.":[302]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}