{"id":"https://openalex.org/W2027995367","doi":"https://doi.org/10.1111/ajo.12131","title":"Subclinical hypothyroidism as a risk factor for placental abruption: Evidence from a low\u2010risk primigravid population","display_name":"Subclinical hypothyroidism as a risk factor for placental abruption: Evidence from a low\u2010risk primigravid population","publication_year":2013,"publication_date":"2013-10-01","ids":{"openalex":"https://openalex.org/W2027995367","doi":"https://doi.org/10.1111/ajo.12131","mag":"2027995367","pmid":"https://pubmed.ncbi.nlm.nih.gov/24111733"},"language":"en","primary_location":{"id":"doi:10.1111/ajo.12131","doi":"https://doi.org/10.1111/ajo.12131","is_oa":false,"landing_page_url":"https://doi.org/10.1111/ajo.12131","pdf_url":null,"source":{"id":"https://openalex.org/S104741914","display_name":"Australian and New Zealand Journal of Obstetrics and Gynaecology","issn_l":"0004-8666","issn":["0004-8666","1479-828X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Australian and New Zealand Journal of Obstetrics and Gynaecology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076137001","display_name":"Fionnuala Breathnach","orcid":"https://orcid.org/0000-0002-2966-6987","observed_orcids":["https://orcid.org/0000-0002-2966-6987"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Fionnuala M. Breathnach","raw_affiliation_strings":["Department of Obstetrics and Gynaecology Royal College of Surgeons in Ireland Dublin Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology Royal College of Surgeons in Ireland Dublin Ireland","institution_ids":["https://openalex.org/I142762351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002556022","display_name":"Jennifer Catherine Donnelly","orcid":"https://orcid.org/0000-0003-0267-9339","observed_orcids":["https://orcid.org/0000-0003-0267-9339"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Jennifer Donnelly","raw_affiliation_strings":["Department of Obstetrics and Gynaecology Royal College of Surgeons in Ireland Dublin Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology Royal College of Surgeons in Ireland Dublin Ireland","institution_ids":["https://openalex.org/I142762351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090594221","display_name":"Sharon M Cooley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799298456","display_name":"Rotunda Hospital","ror":"https://ror.org/05t4vgv93","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2799298456"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Sharon M. Cooley","raw_affiliation_strings":["Department of Obstetrics and Gynaecology Rotunda Hospital Dublin Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology Rotunda Hospital Dublin Ireland","institution_ids":["https://openalex.org/I2799298456"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074065777","display_name":"Michael Patrick Geary","orcid":"https://orcid.org/0000-0002-7387-3385","observed_orcids":["https://orcid.org/0000-0002-7387-3385"]},"institutions":[{"id":"https://openalex.org/I2799298456","display_name":"Rotunda Hospital","ror":"https://ror.org/05t4vgv93","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2799298456"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Michael Geary","raw_affiliation_strings":["Department of Obstetrics and Gynaecology Rotunda Hospital Dublin Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology Rotunda Hospital Dublin Ireland","institution_ids":["https://openalex.org/I2799298456"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030836937","display_name":"Fergal Desmond Malone","orcid":"https://orcid.org/0009-0003-4313-4594","observed_orcids":["https://orcid.org/0009-0003-4313-4594"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Fergal D. Malone","raw_affiliation_strings":["Department of Obstetrics and Gynaecology Royal College of Surgeons in Ireland Dublin Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology Royal College of Surgeons in Ireland Dublin Ireland","institution_ids":["https://openalex.org/I142762351"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5076137001"],"corresponding_institution_ids":["https://openalex.org/I142762351"],"apc_list":{"value":3920,"currency":"USD","value_usd":3920},"apc_paid":null,"fwci":2.3598,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.88812359,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"53","issue":"6","first_page":"553","last_page":"560"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subclinical-hypothyroidism","display_name":"subclinical hypothyroidism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/placental-abruption","display_name":"placental abruption","score":0.9789999723434448},{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone","display_name":"thyroid-stimulating hormone","score":0.7409999966621399},{"id":"https://openalex.org/keywords/anti-thyroid-peroxidase-antibodies","display_name":"thyroid peroxidase antibodies","score":0.8949999809265137},{"id":"https://openalex.org/keywords/anti-thyroglobulin-antibodies","display_name":"thyroglobulin antibodies","score":0.9980000257492065},{"id":"https://openalex.org/keywords/thyroid-autoantibodies","display_name":"thyroid autoantibodies","score":0.7239999771118164},{"id":"https://openalex.org/keywords/primigravida","display_name":"primigravida","score":0.746999979019165},{"id":"https://openalex.org/keywords/low-risk-pregnancy","display_name":"low-risk pregnancy","score":0.7870000004768372},{"id":"https://openalex.org/keywords/antenatal-thyroid-screening","display_name":"antenatal thyroid screening","score":0.9089999794960022},{"id":"https://openalex.org/keywords/obstetric-outcomes","display_name":"obstetric outcomes","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9070991277694702},{"id":"https://openalex.org/C2779225303","wikidata":"https://www.wikidata.org/wiki/Q388113","display_name":"Placental abruption","level":4,"score":0.7995477914810181},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.7935616970062256},{"id":"https://openalex.org/C2777195454","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Euthyroid","level":3,"score":0.7261118292808533},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.6477253437042236},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5871919989585876},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5264604687690735},{"id":"https://openalex.org/C180650514","wikidata":"https://www.wikidata.org/wiki/Q419502","display_name":"Thyroid peroxidase","level":3,"score":0.5009663105010986},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.42840176820755005},{"id":"https://openalex.org/C2780176905","wikidata":"https://www.wikidata.org/wiki/Q6673122","display_name":"Thyroid disease","level":3,"score":0.4163912534713745},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.39914751052856445},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.3371920585632324},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.33527857065200806},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3049018383026123},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.18289250135421753},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000037","descriptor_name":"Abruptio Placentae","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000037","descriptor_name":"Abruptio Placentae","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D007453","descriptor_name":"Iodide Peroxidase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013954","descriptor_name":"Thyroglobulin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020073","descriptor_name":"Gravidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058070","descriptor_name":"Asymptomatic Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/ajo.12131","doi":"https://doi.org/10.1111/ajo.12131","is_oa":false,"landing_page_url":"https://doi.org/10.1111/ajo.12131","pdf_url":null,"source":{"id":"https://openalex.org/S104741914","display_name":"Australian and New Zealand Journal of Obstetrics and Gynaecology","issn_l":"0004-8666","issn":["0004-8666","1479-828X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Australian and New Zealand Journal of Obstetrics and Gynaecology","raw_type":"journal-article"},{"id":"pmid:24111733","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24111733","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Australian & New Zealand journal of obstetrics & gynaecology","raw_type":"Journal Article"},{"id":"pmh:oai:www.lenus.ie:10147/326285","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10147/326285","pdf_url":null,"source":{"id":"https://openalex.org/S4306401756","display_name":"Lenus, The Irish Health Repository (Dr Steevens Hospital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320313911","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1975368188","https://openalex.org/W2009905473","https://openalex.org/W2016236854","https://openalex.org/W2039786614","https://openalex.org/W2046792534","https://openalex.org/W2065009448","https://openalex.org/W2079693765","https://openalex.org/W2081220240","https://openalex.org/W2087122887","https://openalex.org/W2096524107","https://openalex.org/W2107474740","https://openalex.org/W2122237405","https://openalex.org/W2124173888","https://openalex.org/W2136228387","https://openalex.org/W2148883945","https://openalex.org/W2154116297","https://openalex.org/W2157641854","https://openalex.org/W2160955295","https://openalex.org/W2314414681","https://openalex.org/W2334882251","https://openalex.org/W2336104393","https://openalex.org/W2530107877","https://openalex.org/W4297972022"],"related_works":["https://openalex.org/W1980435794","https://openalex.org/W2074611593","https://openalex.org/W2160955295","https://openalex.org/W1565518967","https://openalex.org/W2524994686","https://openalex.org/W3122993811","https://openalex.org/W2537312416","https://openalex.org/W2600058976","https://openalex.org/W2592443621","https://openalex.org/W1973174215"],"abstract_inverted_index":{"BACKGROUND:":[0],"Subclinical":[1,197],"thyroid":[2,62,228],"hypofunction":[3],"in":[4,16,39,66,86,175,213],"pregnancy":[5],"has":[6],"been":[7],"shown":[8],"to":[9,45,220],"have":[10],"an":[11],"association":[12,48],"with":[13,49,90,103,121,127,163,187,205],"neurodevelopmental":[14],"delay":[15],"the":[17,33,67,82,87,100,118,176,221],"offspring.":[18],"It":[19],"is":[20],"unclear":[21],"whether":[22],"obstetric":[23,50],"factors":[24],"may":[25],"account":[26],"for":[27,77,84,139,154,223,226],"this":[28,214],"observation.":[29],"AIMS:":[30],"To":[31],"establish":[32],"prevalence":[34,144],"of":[35,135,145,178,210],"subclinical":[36,91],"hypothyroidism":[37,92,198],"(SCH)":[38],"a":[40,104,122],"low-risk":[41,216],"primigravid":[42,59],"population":[43,217],"and":[44,57,72,133,193,199],"explore":[46],"its":[47],"sequelae.":[51],"MATERIALS":[52],"AND":[53],"METHODS:":[54],"Nine":[55],"hundred":[56],"fifty-three":[58],"women":[60,79],"had":[61],"hormone":[63,94],"indices":[64],"analysed":[65],"early":[68],"second":[69,119],"trimester.":[70],"Delivery":[71],"neonatal":[73],"outcomes":[74],"were":[75,125,137],"available":[76],"904":[78],"who":[80],"met":[81],"criteria":[83],"inclusion":[85],"study.":[88],"Women":[89],"(thyroid-stimulating":[93],"(TSH)":[95],"values":[96],"at":[97,115],"or":[98,109,116,147,158,181],"above":[99],"98th":[101],"percentile":[102,120],"normal":[105],"free":[106],"thyroxine":[107],"(fT4))":[108],"isolated":[110,148,182,200],"maternal":[111,149,183,201],"hypothyroxinaemia":[112,150,184,202],"(fT4":[113],"level":[114],"below":[117],"normal-range":[123],"TSH)":[124],"compared":[126,186],"biochemically":[128],"euthyroid":[129,188],"controls.":[130],"Chi-squared":[131],"test":[132],"analysis":[134],"variance":[136],"used":[138],"statistical":[140],"analysis.":[141],"RESULTS:":[142],"The":[143,208],"SCH":[146,164,180],"was":[151,171],"4%.":[152],"Positivity":[153],"antithyroid":[155],"peroxidase":[156],"(TPO)":[157],"antithyroglobulin":[159],"(ATG)":[160],"antibodies":[161],"correlated":[162],"status":[165],"(P":[166,190],"=":[167,191],"0.02).":[168],"Placental":[169],"abruption":[170],"observed":[172],"more":[173],"commonly":[174],"setting":[177],"either":[179],"when":[185],"controls":[189],"0.02":[192],"0.04,":[194],"respectively).":[195],"CONCLUSIONS:":[196],"are":[203],"associated":[204],"placental":[206],"abruption.":[207],"observation":[209],"these":[211],"effects":[212],"healthy":[215],"lends":[218],"weight":[219],"case":[222],"antenatal":[224],"screening":[225],"diminished":[227],"reserve.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":24},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}