{"id":"https://openalex.org/W2027872608","doi":"https://doi.org/10.1172/jci977","title":"Dietary supplement with vitamin C prevents nitrate tolerance.","display_name":"Dietary supplement with vitamin C prevents nitrate tolerance.","publication_year":1998,"publication_date":"1998-07-01","ids":{"openalex":"https://openalex.org/W2027872608","doi":"https://doi.org/10.1172/jci977","mag":"2027872608","pmid":"https://pubmed.ncbi.nlm.nih.gov/9649558","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/509066"},"language":"en","primary_location":{"id":"doi:10.1172/jci977","doi":"https://doi.org/10.1172/jci977","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci977","pdf_url":"http://www.jci.org/articles/view/977/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/977/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067545097","display_name":"E. Bassenge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"E Bassenge","raw_affiliation_strings":["Institute of Applied Physiology, University of Freiburg, Hermann-Herder-Str 7, D-79104 Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Applied Physiology, University of Freiburg, Hermann-Herder-Str 7, D-79104 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043367046","display_name":"Nelli Fink","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"N Fink","raw_affiliation_strings":["Institute of Applied Physiology, University of Freiburg, Hermann-Herder-Str 7, D-79104 Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Applied Physiology, University of Freiburg, Hermann-Herder-Str 7, D-79104 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113674825","display_name":"Mikhail P. Skatchkov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M Skatchkov","raw_affiliation_strings":["Institute of Applied Physiology, University of Freiburg, Hermann-Herder-Str 7, D-79104 Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Applied Physiology, University of Freiburg, Hermann-Herder-Str 7, D-79104 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067590049","display_name":"Bruno Fink","orcid":"https://orcid.org/0000-0003-1504-5132","observed_orcids":["https://orcid.org/0000-0003-1504-5132"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B Fink","raw_affiliation_strings":["Institute of Applied Physiology, University of Freiburg, Hermann-Herder-Str 7, D-79104 Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Applied Physiology, University of Freiburg, Hermann-Herder-Str 7, D-79104 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I161046081"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":7.9215,"has_fulltext":true,"cited_by_count":139,"citation_normalized_percentile":{"value":0.97956698,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"102","issue":"1","first_page":"67","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitrate-tolerance","display_name":"nitrate tolerance","score":0.9139999747276306},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.7289999723434448},{"id":"https://openalex.org/keywords/vitamin-c-supplementation","display_name":"vitamin C supplementation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/nitroglycerin","display_name":"nitroglycerin","score":0.9129999876022339},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.828000009059906},{"id":"https://openalex.org/keywords/platelet-function","display_name":"platelet function","score":0.5759999752044678},{"id":"https://openalex.org/keywords/orthostatic-blood-pressure","display_name":"orthostatic blood pressure","score":0.7940000295639038},{"id":"https://openalex.org/keywords/pulse-pressure","display_name":"pulse pressure","score":0.6549999713897705},{"id":"https://openalex.org/keywords/vasodilation","display_name":"vasodilation","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C73787029","wikidata":"https://www.wikidata.org/wiki/Q7104929","display_name":"Orthostatic vital signs","level":3,"score":0.7667700052261353},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6833305358886719},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.5714840292930603},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.5184683203697205},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49063482880592346},{"id":"https://openalex.org/C2780022331","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Vitamin C","level":2,"score":0.4894355833530426},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.47505804896354675},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.469252347946167},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.4675876796245575},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.4526885747909546},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42016342282295227},{"id":"https://openalex.org/C17140001","wikidata":"https://www.wikidata.org/wiki/Q1759415","display_name":"Pulse pressure","level":3,"score":0.4137563407421112},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40745267271995544},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40090811252593994}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004361","descriptor_name":"Drug Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005996","descriptor_name":"Nitroglycerin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1172/jci977","doi":"https://doi.org/10.1172/jci977","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci977","pdf_url":"http://www.jci.org/articles/view/977/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:509066","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/509066","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:9649558","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9649558","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Clinical Trial"},{"id":"pmh:oai:freidok.uni-freiburg.de:19318","doi":null,"is_oa":false,"landing_page_url":"https://freidok.uni-freiburg.de/data/19318","pdf_url":null,"source":{"id":"https://openalex.org/S4306401057","display_name":"FreiDok plus (Universit\u00e4tsbibliothek Freiburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161046081","host_organization_name":"University of Freiburg","host_organization_lineage":["https://openalex.org/I161046081"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Investigation. - 102, 1 (1998) , 67-71, ISSN: 0021-9738","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1172/jci977","doi":"https://doi.org/10.1172/jci977","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci977","pdf_url":"http://www.jci.org/articles/view/977/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320323555","display_name":"Deutsche Herzstiftung","ror":"https://ror.org/02hq6wv21"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2027872608.pdf","grobid_xml":"https://content.openalex.org/works/W2027872608.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W963753019","https://openalex.org/W1512367461","https://openalex.org/W1512889873","https://openalex.org/W1963495254","https://openalex.org/W1975974235","https://openalex.org/W1976555160","https://openalex.org/W1977597523","https://openalex.org/W1981988093","https://openalex.org/W1987700050","https://openalex.org/W1989291137","https://openalex.org/W1990949779","https://openalex.org/W1996024251","https://openalex.org/W1998672217","https://openalex.org/W2008165932","https://openalex.org/W2029463317","https://openalex.org/W2032181779","https://openalex.org/W2035199836","https://openalex.org/W2035433779","https://openalex.org/W2043169578","https://openalex.org/W2052075519","https://openalex.org/W2056411968","https://openalex.org/W2057294252","https://openalex.org/W2059407166","https://openalex.org/W2064166699","https://openalex.org/W2081143505","https://openalex.org/W2081394289","https://openalex.org/W2084304010","https://openalex.org/W2084486613","https://openalex.org/W2091198858","https://openalex.org/W2121723655","https://openalex.org/W2141260882","https://openalex.org/W2169872077","https://openalex.org/W2313837936","https://openalex.org/W2322907210","https://openalex.org/W2329819503","https://openalex.org/W2440605766"],"related_works":["https://openalex.org/W2317215688","https://openalex.org/W2017248509","https://openalex.org/W2334009346","https://openalex.org/W2318174104","https://openalex.org/W2145682776","https://openalex.org/W2086853009","https://openalex.org/W7126996067","https://openalex.org/W2329819503","https://openalex.org/W2411310937","https://openalex.org/W2094766094"],"abstract_inverted_index":{"Enhanced":[0],"formation":[1],"of":[2,16,25,40,95,102,121,130,147,157,172,175,199,208],"superoxide":[3],"radicals":[4],"has":[5],"been":[6],"proposed":[7],"to":[8],"play":[9],"a":[10,118],"major":[11],"role":[12],"in":[13,19,44,54,76,80,90,125,139,162,165,210],"the":[14,23,81,105,122,136,140,145,155,158,173],"development":[15,49],"nitrate":[17],"tolerance":[18,164,195],"humans.":[20,211],"We":[21],"tested":[22],"effects":[24,34],"vitamin":[26],"C":[27],"(Vit-C)":[28],"supplementation":[29,190],"on":[30],"glyceroltrinitrate":[31],"(GTN)-induced":[32],"hemodynamic":[33],"during":[35,204],"3-d":[36],"nonintermittent":[37,206],"transdermal":[38],"administration":[39,207],"GTN":[41,84,133,209],"(0.4":[42],"mg/h)":[43],"nine":[45],"healthy":[46],"subjects.":[47,83],"Tolerance":[48],"was":[50,117,150,179],"monitored":[51],"by":[52,152,170,182],"changes":[53,138],"arterial":[55,91],"pressure,":[56,60,143],"dicrotic":[57,96],"digital":[58],"pulse":[59],"and":[61,110,132,144,196],"heart":[62],"rate.":[63],"Studies":[64],"with":[65,191],"GTN,":[66,104],"Vit-C,":[67],"or":[68],"GTN/Vit-C":[69],"were":[70,168],"successively":[71],"carried":[72],"out":[73],"at":[74],"random":[75],"three":[77],"different":[78],"series":[79],"same":[82],"treatment":[85],"caused":[86],"an":[87],"immediate":[88],"rise":[89,146],"conductivity":[92],"(a/b":[93],"ratio":[94,107,149],"pulse),":[97],"but":[98],"within":[99],"2":[100],"d":[101],"initiating":[103],"a/b":[106,148],"progressively":[108],"decreased":[109],"reached":[111],"basal":[112],"levels.":[113],"In":[114],"addition,":[115],"there":[116],"progressive":[119],"loss":[120],"orthostatic":[123,141],"decrease":[124],"blood":[126,142],"pressure.":[127],"However,":[128],"coadministration":[129],"Vit-C":[131,183,192],"fully":[134],"maintained":[135],"GTN-induced":[137],"augmented":[151],"310%":[153],"for":[154],"duration":[156],"test":[159],"period.":[160],"Changes":[161],"vascular":[163,194],"GTN-treated":[166],"subjects":[167],"paralleled":[169],"upregulation":[171,198],"activity":[174,203],"isolated":[176],"platelets,":[177],"which":[178],"also":[180],"reversed":[181],"administration.":[184],"These":[185],"findings":[186],"demonstrate":[187],"that":[188],"dietary":[189],"eliminates":[193],"concomitant":[197],"ex":[200],"vivo-washed":[201],"platelet":[202],"long-term":[205]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}