{"id":"https://openalex.org/W2027840972","doi":"https://doi.org/10.1038/sj.gt.3302534","title":"Nuclear entry of nonviral vectors","display_name":"Nuclear entry of nonviral vectors","publication_year":2005,"publication_date":"2005-04-28","ids":{"openalex":"https://openalex.org/W2027840972","doi":"https://doi.org/10.1038/sj.gt.3302534","mag":"2027840972","pmid":"https://pubmed.ncbi.nlm.nih.gov/15908994","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4403635"},"language":"en","primary_location":{"id":"doi:10.1038/sj.gt.3302534","doi":"https://doi.org/10.1038/sj.gt.3302534","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.gt.3302534","pdf_url":null,"source":{"id":"https://openalex.org/S65405509","display_name":"Gene Therapy","issn_l":"0969-7128","issn":["0969-7128","1476-5462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Therapy","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4403635","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017939101","display_name":"David A. Dean","orcid":"https://orcid.org/0000-0001-7748-8073","observed_orcids":["https://orcid.org/0000-0001-7748-8073"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D A Dean","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA","Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009557449","display_name":"Donna D. Strong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141570","display_name":"VA Loma Linda Healthcare System","ror":"https://ror.org/03z6z3n38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138663","https://openalex.org/I4210141570"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D D Strong","raw_affiliation_strings":["VA Loma Linda Health Care System, Loma Linda, CA, USA","VA Loma Linda Health Care System, Loma Linda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VA Loma Linda Health Care System, Loma Linda, CA, USA","institution_ids":["https://openalex.org/I4210141570"]},{"raw_affiliation_string":"VA Loma Linda Health Care System, Loma Linda, USA","institution_ids":["https://openalex.org/I4210141570"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038661763","display_name":"Warren E. Zimmer","orcid":"https://orcid.org/0000-0002-0668-6096","observed_orcids":["https://orcid.org/0000-0002-0668-6096"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W E Zimmer","raw_affiliation_strings":["Department of Medical Pharmacology and Toxicology, College of Medicine, Texas A&M University, College Station, TX, USA","Department of Medical Pharmacology and Toxicology, College of Medicine, Texas A&M University, College Station, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Pharmacology and Toxicology, College of Medicine, Texas A&M University, College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Medical Pharmacology and Toxicology, College of Medicine, Texas A&M University, College Station, USA","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":1.4117,"has_fulltext":false,"cited_by_count":330,"citation_normalized_percentile":{"value":0.79777724,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"12","issue":"11","first_page":"881","last_page":"890"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.8295999765396118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.8295999765396118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.14030000567436218,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nonviral-gene-delivery","display_name":"non-viral gene delivery","score":0.8410000205039978},{"id":"https://openalex.org/keywords/nuclear-envelope","display_name":"nuclear envelope","score":0.9570000171661377},{"id":"https://openalex.org/keywords/nondividing-cells","display_name":"non-dividing cells","score":0.902999997138977},{"id":"https://openalex.org/keywords/transfection-efficiency","display_name":"transfection efficiency","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.910503625869751},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.59117591381073},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.57177734375},{"id":"https://openalex.org/C59157529","wikidata":"https://www.wikidata.org/wiki/Q994741","display_name":"Nuclear transport","level":4,"score":0.5600127577781677},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.5186297297477722},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5159947872161865},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.4784645736217499},{"id":"https://openalex.org/C126725582","wikidata":"https://www.wikidata.org/wiki/Q30679","display_name":"Nuclear pore","level":3,"score":0.47449254989624023},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.4432177245616913},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.4281507432460785},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.3829544186592102},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34951257705688477},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3151988983154297},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3031960129737854}],"mesh":[{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009685","descriptor_name":"Nuclear Envelope","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1038/sj.gt.3302534","doi":"https://doi.org/10.1038/sj.gt.3302534","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.gt.3302534","pdf_url":null,"source":{"id":"https://openalex.org/S65405509","display_name":"Gene Therapy","issn_l":"0969-7128","issn":["0969-7128","1476-5462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Therapy","raw_type":"journal-article"},{"id":"pmid:15908994","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15908994","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene therapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4403635","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4403635","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Gene Ther","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4403635","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4403635","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Gene Ther","raw_type":"Text"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3918680077","display_name":"Pathophysiology of Acute Lung Injury","funder_award_id":"P01HL071643","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6125590448","display_name":"Vascular smooth muscle specific gene therapy vectors","funder_award_id":"R01HL059956","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7585886887","display_name":"Prostate Epithelial Cell-Specific Gene Regulation","funder_award_id":"R01CA095608","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":86,"referenced_works":["https://openalex.org/W45084834","https://openalex.org/W90997337","https://openalex.org/W1508758974","https://openalex.org/W1549673200","https://openalex.org/W1573783643","https://openalex.org/W1587940136","https://openalex.org/W1649138245","https://openalex.org/W1918993292","https://openalex.org/W1972183902","https://openalex.org/W1973911001","https://openalex.org/W1974248986","https://openalex.org/W1974724939","https://openalex.org/W1975844162","https://openalex.org/W1977502221","https://openalex.org/W1977712028","https://openalex.org/W1978372522","https://openalex.org/W1978638754","https://openalex.org/W1992155709","https://openalex.org/W1994131234","https://openalex.org/W1994294376","https://openalex.org/W1994915896","https://openalex.org/W1996775795","https://openalex.org/W1998113813","https://openalex.org/W1998908425","https://openalex.org/W2001986771","https://openalex.org/W2003340286","https://openalex.org/W2003702457","https://openalex.org/W2013544239","https://openalex.org/W2013960353","https://openalex.org/W2014639173","https://openalex.org/W2014825046","https://openalex.org/W2015748683","https://openalex.org/W2016647855","https://openalex.org/W2018081816","https://openalex.org/W2018822301","https://openalex.org/W2023227076","https://openalex.org/W2023842478","https://openalex.org/W2033906494","https://openalex.org/W2034922635","https://openalex.org/W2036509457","https://openalex.org/W2039316428","https://openalex.org/W2055574063","https://openalex.org/W2056022116","https://openalex.org/W2056315093","https://openalex.org/W2059322023","https://openalex.org/W2059973210","https://openalex.org/W2061032107","https://openalex.org/W2061312545","https://openalex.org/W2061555550","https://openalex.org/W2063864338","https://openalex.org/W2064126464","https://openalex.org/W2064633836","https://openalex.org/W2068218887","https://openalex.org/W2068350301","https://openalex.org/W2068370931","https://openalex.org/W2072578546","https://openalex.org/W2074870430","https://openalex.org/W2075149057","https://openalex.org/W2078988079","https://openalex.org/W2081076598","https://openalex.org/W2083145577","https://openalex.org/W2086274688","https://openalex.org/W2087893222","https://openalex.org/W2089021854","https://openalex.org/W2090214004","https://openalex.org/W2105007068","https://openalex.org/W2107826964","https://openalex.org/W2122849093","https://openalex.org/W2125940088","https://openalex.org/W2128953116","https://openalex.org/W2134934522","https://openalex.org/W2139763819","https://openalex.org/W2143566830","https://openalex.org/W2154464726","https://openalex.org/W2168837119","https://openalex.org/W2186321860","https://openalex.org/W2272235377","https://openalex.org/W2315550967","https://openalex.org/W2316964745","https://openalex.org/W2325056821","https://openalex.org/W2325089333","https://openalex.org/W2333539510","https://openalex.org/W2419498198","https://openalex.org/W2464657768","https://openalex.org/W2472531854","https://openalex.org/W4241694659"],"related_works":["https://openalex.org/W2048284285","https://openalex.org/W2084327544","https://openalex.org/W2048310708","https://openalex.org/W2139257010","https://openalex.org/W2095971796","https://openalex.org/W2053447722","https://openalex.org/W4230915619","https://openalex.org/W2014328495","https://openalex.org/W2035404640","https://openalex.org/W2057545740"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":56},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
