{"id":"https://openalex.org/W2027816396","doi":"https://doi.org/10.1002/cyto.b.20016","title":"Extra copies of c\u2010myc are more pronounced in nodular melanomas than in superficial spreading melanomas as revealed by fluorescence in situ hybridisation","display_name":"Extra copies of c\u2010myc are more pronounced in nodular melanomas than in superficial spreading melanomas as revealed by fluorescence in situ hybridisation","publication_year":2004,"publication_date":"2004-06-14","ids":{"openalex":"https://openalex.org/W2027816396","doi":"https://doi.org/10.1002/cyto.b.20016","mag":"2027816396","pmid":"https://pubmed.ncbi.nlm.nih.gov/15221868"},"language":"en","primary_location":{"id":"doi:10.1002/cyto.b.20016","doi":"https://doi.org/10.1002/cyto.b.20016","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cyto.b.20016","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.b.20016","source":{"id":"https://openalex.org/S87401112","display_name":"Cytometry Part B Clinical Cytometry","issn_l":"1552-4949","issn":["1552-4949","1552-4957"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytometry Part B: Clinical Cytometry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.b.20016","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089921270","display_name":"Andrea Treszl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132735039","display_name":"University of Debrecen","ror":"https://ror.org/02xf66n48","country_code":"HU","type":"education","lineage":["https://openalex.org/I132735039"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Andrea Treszl","raw_affiliation_strings":["Department of Preventive Medicine, School of Public Health, Medical and Health Science Centre, University of Debrecen, Debrecen, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, School of Public Health, Medical and Health Science Centre, University of Debrecen, Debrecen, Hungary","institution_ids":["https://openalex.org/I132735039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040839445","display_name":"R\u00f3za \u00c1d\u00e1ny","orcid":"https://orcid.org/0000-0002-9679-6669","observed_orcids":["https://orcid.org/0000-0002-9679-6669"]},"institutions":[{"id":"https://openalex.org/I132735039","display_name":"University of Debrecen","ror":"https://ror.org/02xf66n48","country_code":"HU","type":"education","lineage":["https://openalex.org/I132735039"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"R\u00f3za \u00c1d\u00e1ny","raw_affiliation_strings":["Department of Preventive Medicine, School of Public Health, Medical and Health Science Centre, University of Debrecen, Debrecen, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, School of Public Health, Medical and Health Science Centre, University of Debrecen, Debrecen, Hungary","institution_ids":["https://openalex.org/I132735039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013318791","display_name":"Zsuzsa R\u00e1kosy","orcid":"https://orcid.org/0000-0002-9852-1159","observed_orcids":["https://orcid.org/0000-0002-9852-1159"]},"institutions":[{"id":"https://openalex.org/I132735039","display_name":"University of Debrecen","ror":"https://ror.org/02xf66n48","country_code":"HU","type":"education","lineage":["https://openalex.org/I132735039"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Zsuzsa R\u00e1kosy","raw_affiliation_strings":["Department of Preventive Medicine, School of Public Health, Medical and Health Science Centre, University of Debrecen, Debrecen, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, School of Public Health, Medical and Health Science Centre, University of Debrecen, Debrecen, Hungary","institution_ids":["https://openalex.org/I132735039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063441418","display_name":"L\u00e1szl\u00f3 Kardos","orcid":"https://orcid.org/0000-0003-4749-1057","observed_orcids":["https://orcid.org/0000-0003-4749-1057"]},"institutions":[{"id":"https://openalex.org/I132735039","display_name":"University of Debrecen","ror":"https://ror.org/02xf66n48","country_code":"HU","type":"education","lineage":["https://openalex.org/I132735039"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"L\u00e1szl\u00f3 Kardos","raw_affiliation_strings":["Department of Preventive Medicine, School of Public Health, Medical and Health Science Centre, University of Debrecen, Debrecen, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, School of Public Health, Medical and Health Science Centre, University of Debrecen, Debrecen, Hungary","institution_ids":["https://openalex.org/I132735039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009537731","display_name":"\u00c1gnes B\u00e9g\u00e1ny","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132735039","display_name":"University of Debrecen","ror":"https://ror.org/02xf66n48","country_code":"HU","type":"education","lineage":["https://openalex.org/I132735039"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"\u00c1gnes B\u00e9g\u00e1ny","raw_affiliation_strings":["Department of Dermatology, Faculty of Medicine, Medical and Health Science Centre, University of Debrecen, Debrecen, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Faculty of Medicine, Medical and Health Science Centre, University of Debrecen, Debrecen, Hungary","institution_ids":["https://openalex.org/I132735039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031981929","display_name":"Katalin Gilde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119956","display_name":"National Institute of Oncology","ror":"https://ror.org/02kjgsq44","country_code":"HU","type":"healthcare","lineage":["https://openalex.org/I4210119956"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Katalin Gilde","raw_affiliation_strings":["Department of Dermatology, National Institute of Oncology, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, National Institute of Oncology, Budapest, Hungary","institution_ids":["https://openalex.org/I4210119956"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041695793","display_name":"Margit Bal\u00e1zs","orcid":"https://orcid.org/0000-0002-4246-2321","observed_orcids":["https://orcid.org/0000-0002-4246-2321"]},"institutions":[{"id":"https://openalex.org/I132735039","display_name":"University of Debrecen","ror":"https://ror.org/02xf66n48","country_code":"HU","type":"education","lineage":["https://openalex.org/I132735039"]}],"countries":["HU"],"is_corresponding":true,"raw_author_name":"Margit Bal\u00e1zs","raw_affiliation_strings":["Department of Preventive Medicine, School of Public Health, Medical and Health Science Centre, University of Debrecen, Debrecen, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, School of Public Health, Medical and Health Science Centre, University of Debrecen, Debrecen, Hungary","institution_ids":["https://openalex.org/I132735039"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5041695793"],"corresponding_institution_ids":["https://openalex.org/I132735039"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":1.4703,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.81056694,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"60B","issue":"1","first_page":"37","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.8859999775886536},{"id":"https://openalex.org/keywords/gene-amplification","display_name":"gene amplification","score":0.8949999809265137},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.8360000252723694},{"id":"https://openalex.org/keywords/nodular-melanoma","display_name":"nodular melanoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/superficial-spreading-melanoma","display_name":"superficial spreading melanoma","score":1.0},{"id":"https://openalex.org/keywords/melanoma-subtypes","display_name":"melanoma subtypes","score":0.8500000238418579},{"id":"https://openalex.org/keywords/melanoma-metastasis","display_name":"melanoma metastasis","score":0.843999981880188},{"id":"https://openalex.org/keywords/aneuploidy","display_name":"aneuploidy","score":0.8840000033378601},{"id":"https://openalex.org/keywords/centromeric-probes","display_name":"centromeric probes","score":0.5490000247955322},{"id":"https://openalex.org/keywords/invasive-potential","display_name":"invasive potential","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.7967069149017334},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6642193794250488},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.6092819571495056},{"id":"https://openalex.org/C3018290483","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridisation","level":3,"score":0.589657723903656},{"id":"https://openalex.org/C2777542201","wikidata":"https://www.wikidata.org/wiki/Q1336182","display_name":"Fluorescence in situ hybridization","level":4,"score":0.5475566983222961},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5331823825836182},{"id":"https://openalex.org/C2780667408","wikidata":"https://www.wikidata.org/wiki/Q7643331","display_name":"Superficial spreading melanoma","level":3,"score":0.5296399593353271},{"id":"https://openalex.org/C55548728","wikidata":"https://www.wikidata.org/wiki/Q1465102","display_name":"Gene dosage","level":4,"score":0.4746052622795105},{"id":"https://openalex.org/C143191323","wikidata":"https://www.wikidata.org/wiki/Q118406","display_name":"Ploidy","level":3,"score":0.4467400908470154},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4437122344970703},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.431792676448822},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19312360882759094},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.18301039934158325},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.13089382648468018},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10824704170227051}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002503","descriptor_name":"Centromere","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011003","descriptor_name":"Ploidies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/cyto.b.20016","doi":"https://doi.org/10.1002/cyto.b.20016","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cyto.b.20016","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.b.20016","source":{"id":"https://openalex.org/S87401112","display_name":"Cytometry Part B Clinical Cytometry","issn_l":"1552-4949","issn":["1552-4949","1552-4957"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytometry Part B: Clinical Cytometry","raw_type":"journal-article"},{"id":"pmid:15221868","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15221868","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytometry. Part B, Clinical cytometry","raw_type":"Journal Article"},{"id":"pmh:oai:ganymedesd.lib.unideb.hu:2437/159662","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2437/159662","pdf_url":null,"source":{"id":"https://openalex.org/S4306402089","display_name":"University of Debrecen Electronic Archive (University of Debrecen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132735039","host_organization_name":"University of Debrecen","host_organization_lineage":["https://openalex.org/I132735039"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"foly\u00f3iratcikk"}],"best_oa_location":{"id":"doi:10.1002/cyto.b.20016","doi":"https://doi.org/10.1002/cyto.b.20016","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cyto.b.20016","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.b.20016","source":{"id":"https://openalex.org/S87401112","display_name":"Cytometry Part B Clinical Cytometry","issn_l":"1552-4949","issn":["1552-4949","1552-4957"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytometry Part B: Clinical Cytometry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G7672182509","display_name":null,"funder_award_id":"OTKA T 032587","funder_id":"https://openalex.org/F4320321994","funder_display_name":"Hungarian Scientific Research Fund"}],"funders":[{"id":"https://openalex.org/F4320321994","display_name":"Hungarian Scientific Research Fund","ror":"https://ror.org/00v349e63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2027816396.pdf","grobid_xml":"https://content.openalex.org/works/W2027816396.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W165982523","https://openalex.org/W333351152","https://openalex.org/W1516721515","https://openalex.org/W1523901812","https://openalex.org/W1561412137","https://openalex.org/W1910168157","https://openalex.org/W1919139351","https://openalex.org/W1966155757","https://openalex.org/W1973728202","https://openalex.org/W1980794013","https://openalex.org/W1987832176","https://openalex.org/W1998538610","https://openalex.org/W2004902290","https://openalex.org/W2012685443","https://openalex.org/W2013977169","https://openalex.org/W2014897269","https://openalex.org/W2027499645","https://openalex.org/W2038737598","https://openalex.org/W2039493732","https://openalex.org/W2041139141","https://openalex.org/W2042386318","https://openalex.org/W2049971450","https://openalex.org/W2061255915","https://openalex.org/W2076614293","https://openalex.org/W2077224617","https://openalex.org/W2078958377","https://openalex.org/W2085071454","https://openalex.org/W2094939250","https://openalex.org/W2095901867","https://openalex.org/W2117344370","https://openalex.org/W2131365547","https://openalex.org/W2133714934","https://openalex.org/W2147330111","https://openalex.org/W2156858528","https://openalex.org/W2300340713","https://openalex.org/W2396347398","https://openalex.org/W2410538479"],"related_works":["https://openalex.org/W1973728202","https://openalex.org/W2002235770","https://openalex.org/W1980794013","https://openalex.org/W2465881965","https://openalex.org/W126036965","https://openalex.org/W1919139351","https://openalex.org/W2396347398","https://openalex.org/W2078502275","https://openalex.org/W2249714089","https://openalex.org/W1561412137"],"abstract_inverted_index":{"BACKGROUND:":[0],"Amplification":[1],"of":[2,18,22,31,53,97,117,126,187,194,212],"c-myc":[3,45,68,122,170,196],"is":[4],"a":[5,12,16],"common":[6],"genetic":[7],"alteration":[8],"and":[9,69,86,180],"associated":[10,182],"with":[11,56,183],"poor":[13],"prognosis":[14],"in":[15,28,49,62,140,151,161,175,198,209,218],"variety":[17],"cancers.":[19],"Extra":[20],"copies":[21],"the":[23,44,91,118,176,184,188,195,210,219],"gene":[24,130,197],"have":[25,39],"been":[26,40],"found":[27],"large":[29],"numbers":[30],"melanoma":[32,178],"metastases,":[33],"but":[34],"only":[35,124,150,162],"few":[36],"primary":[37,54],"tumours":[38,106],"studied.":[41],"We":[42],"investigated":[43],"copy":[46,94,171],"number":[47,95,172],"alterations":[48,173],"two":[50,177],"different":[51,57,99],"subtypes":[52,179],"melanomas":[55,79,84],"biological":[58],"behaviours.":[59],"METHODS:":[60],"Fluorescence":[61],"situ":[63],"hybridisation":[64],"was":[65,101,137,148,157],"performed":[66],"using":[67],"centromeric":[70],"8":[71],"(C8)":[72],"probes":[73],"on":[74],"68":[75],"lesions":[76,200],"(28":[77],"nodular":[78],"[NMs],":[80],"26":[81],"superficial":[82],"spreading":[83],"[SSMs],":[85],"14":[87],"metastases).":[88],"To":[89],"assess":[90],"ploidy":[92],"pattern,":[93],"distribution":[96],"seven":[98],"chromosomes":[100],"also":[102],"investigated.":[103],"RESULTS:":[104],"All":[105],"showed":[107,128],"aneuploid":[108],"populations":[109],"for":[110],"at":[111],"least":[112],"three":[113],"chromosomes.":[114],"Whereas":[115],"61%":[116],"NMs":[119,141],"exhibited":[120],"extra":[121],"copies,":[123],"27%":[125],"SSMs":[127],"increased":[129],"dosage.":[131],"The":[132,190],"c-myc/C8":[133,155],"ratio":[134,156],"exceeding":[135],"1.5":[136,160],"significantly":[138],"higher":[139,158],"(P":[142],"=":[143],"0.01).":[144],"High":[145],"level":[146],"amplification":[147,193],"seen":[149],"NMs.":[152],"An":[153],"elevated":[154],"than":[159,217],"four":[163],"metastases.":[164],"CONCLUSION:":[165],"Our":[166],"data":[167],"show":[168],"that":[169,202],"differ":[174],"are":[181],"advanced":[185],"stage":[186],"disease.":[189],"less":[191],"frequent":[192],"metastatic":[199,220],"indicates":[201],"it":[203],"may":[204],"play":[205],"an":[206,213],"important":[207],"role":[208],"development":[211],"invasive":[214],"potential":[215],"rather":[216],"process.":[221]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}