{"id":"https://openalex.org/W2027612817","doi":"https://doi.org/10.1182/blood-2004-01-0166","title":"Angiostatin is a novel anti-inflammatory factor by inhibiting leukocyte recruitment","display_name":"Angiostatin is a novel anti-inflammatory factor by inhibiting leukocyte recruitment","publication_year":2004,"publication_date":"2004-09-22","ids":{"openalex":"https://openalex.org/W2027612817","doi":"https://doi.org/10.1182/blood-2004-01-0166","mag":"2027612817","pmid":"https://pubmed.ncbi.nlm.nih.gov/15383457"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2004-01-0166","doi":"https://doi.org/10.1182/blood-2004-01-0166","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2004-01-0166","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086672334","display_name":"Triantafyllos Chavakis","orcid":"https://orcid.org/0000-0002-1869-5141","observed_orcids":["https://orcid.org/0000-0002-1869-5141"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]},{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210148371","display_name":"Deutsches Herzzentrum M\u00fcnchen","ror":"https://ror.org/04hbwba26","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I4210148371","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Triantafyllos Chavakis","raw_affiliation_strings":["From the Department of Internal Medicine I, Universita\u0308t, Heidelberg, Germany; the Institute for Biochemistry, Justus-Liebig-Universita\u0308t, Giessen, Germany; the Deutsches Herzzentrum, Technische Universita\u0308t, Mu\u0308nchen, Germany; and the Institute of Theoretical Surgery, Philipps-Universita\u0308t, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine I, Universita\u0308t, Heidelberg, Germany; the Institute for Biochemistry, Justus-Liebig-Universita\u0308t, Giessen, Germany; the Deutsches Herzzentrum, Technische Universita\u0308t, Mu\u0308nchen, Germany; and the Institute of Theoretical Surgery, Philipps-Universita\u0308t, Marburg, Germany","institution_ids":["https://openalex.org/I161103922","https://openalex.org/I200763008","https://openalex.org/I223822909","https://openalex.org/I4210148371","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109186395","display_name":"Athanasios N. Athanasopoulos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]},{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210148371","display_name":"Deutsches Herzzentrum M\u00fcnchen","ror":"https://ror.org/04hbwba26","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I4210148371","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Athanasios Athanasopoulos","raw_affiliation_strings":["From the Department of Internal Medicine I, Universita\u0308t, Heidelberg, Germany; the Institute for Biochemistry, Justus-Liebig-Universita\u0308t, Giessen, Germany; the Deutsches Herzzentrum, Technische Universita\u0308t, Mu\u0308nchen, Germany; and the Institute of Theoretical Surgery, Philipps-Universita\u0308t, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine I, Universita\u0308t, Heidelberg, Germany; the Institute for Biochemistry, Justus-Liebig-Universita\u0308t, Giessen, Germany; the Deutsches Herzzentrum, Technische Universita\u0308t, Mu\u0308nchen, Germany; and the Institute of Theoretical Surgery, Philipps-Universita\u0308t, Marburg, Germany","institution_ids":["https://openalex.org/I161103922","https://openalex.org/I200763008","https://openalex.org/I223822909","https://openalex.org/I4210148371","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022922501","display_name":"Joong-Sup Rhee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]},{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210148371","display_name":"Deutsches Herzzentrum M\u00fcnchen","ror":"https://ror.org/04hbwba26","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I4210148371","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joong-Sup Rhee","raw_affiliation_strings":["From the Department of Internal Medicine I, Universita\u0308t, Heidelberg, Germany; the Institute for Biochemistry, Justus-Liebig-Universita\u0308t, Giessen, Germany; the Deutsches Herzzentrum, Technische Universita\u0308t, Mu\u0308nchen, Germany; and the Institute of Theoretical Surgery, Philipps-Universita\u0308t, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine I, Universita\u0308t, Heidelberg, Germany; the Institute for Biochemistry, Justus-Liebig-Universita\u0308t, Giessen, Germany; the Deutsches Herzzentrum, Technische Universita\u0308t, Mu\u0308nchen, Germany; and the Institute of Theoretical Surgery, Philipps-Universita\u0308t, Marburg, Germany","institution_ids":["https://openalex.org/I161103922","https://openalex.org/I200763008","https://openalex.org/I223822909","https://openalex.org/I4210148371","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027838810","display_name":"Valeria V. Orlova","orcid":"https://orcid.org/0000-0002-1169-2802","observed_orcids":["https://orcid.org/0000-0002-1169-2802"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]},{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210148371","display_name":"Deutsches Herzzentrum M\u00fcnchen","ror":"https://ror.org/04hbwba26","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I4210148371","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Valeria Orlova","raw_affiliation_strings":["From the Department of Internal Medicine I, Universita\u0308t, Heidelberg, Germany; the Institute for Biochemistry, Justus-Liebig-Universita\u0308t, Giessen, Germany; the Deutsches Herzzentrum, Technische Universita\u0308t, Mu\u0308nchen, Germany; and the Institute of Theoretical Surgery, Philipps-Universita\u0308t, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine I, Universita\u0308t, Heidelberg, Germany; the Institute for Biochemistry, Justus-Liebig-Universita\u0308t, Giessen, Germany; the Deutsches Herzzentrum, Technische Universita\u0308t, Mu\u0308nchen, Germany; and the Institute of Theoretical Surgery, Philipps-Universita\u0308t, Marburg, Germany","institution_ids":["https://openalex.org/I161103922","https://openalex.org/I200763008","https://openalex.org/I223822909","https://openalex.org/I4210148371","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052443095","display_name":"Thomas Schmidt-W\u00f6ll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]},{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210148371","display_name":"Deutsches Herzzentrum M\u00fcnchen","ror":"https://ror.org/04hbwba26","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I4210148371","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Schmidt-Wo\u0308ll","raw_affiliation_strings":["From the Department of Internal Medicine I, Universita\u0308t, Heidelberg, Germany; the Institute for Biochemistry, Justus-Liebig-Universita\u0308t, Giessen, Germany; the Deutsches Herzzentrum, Technische Universita\u0308t, Mu\u0308nchen, Germany; and the Institute of Theoretical Surgery, Philipps-Universita\u0308t, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine I, Universita\u0308t, Heidelberg, Germany; the Institute for Biochemistry, Justus-Liebig-Universita\u0308t, Giessen, Germany; the Deutsches Herzzentrum, Technische Universita\u0308t, Mu\u0308nchen, Germany; and the Institute of Theoretical Surgery, Philipps-Universita\u0308t, Marburg, Germany","institution_ids":["https://openalex.org/I161103922","https://openalex.org/I200763008","https://openalex.org/I223822909","https://openalex.org/I4210148371","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065997689","display_name":"Angelika Bierhaus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]},{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210148371","display_name":"Deutsches Herzzentrum M\u00fcnchen","ror":"https://ror.org/04hbwba26","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I4210148371","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Angelika Bierhaus","raw_affiliation_strings":["From the Department of Internal Medicine I, Universita\u0308t, Heidelberg, Germany; the Institute for Biochemistry, Justus-Liebig-Universita\u0308t, Giessen, Germany; the Deutsches Herzzentrum, Technische Universita\u0308t, Mu\u0308nchen, Germany; and the Institute of Theoretical Surgery, Philipps-Universita\u0308t, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine I, Universita\u0308t, Heidelberg, Germany; the Institute for Biochemistry, Justus-Liebig-Universita\u0308t, Giessen, Germany; the Deutsches Herzzentrum, Technische Universita\u0308t, Mu\u0308nchen, Germany; and the Institute of Theoretical Surgery, Philipps-Universita\u0308t, Marburg, Germany","institution_ids":["https://openalex.org/I161103922","https://openalex.org/I200763008","https://openalex.org/I223822909","https://openalex.org/I4210148371","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111635076","display_name":"Andreas E. May","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]},{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210148371","display_name":"Deutsches Herzzentrum M\u00fcnchen","ror":"https://ror.org/04hbwba26","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I4210148371","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas E. May","raw_affiliation_strings":["From the Department of Internal Medicine I, Universita\u0308t, Heidelberg, Germany; the Institute for Biochemistry, Justus-Liebig-Universita\u0308t, Giessen, Germany; the Deutsches Herzzentrum, Technische Universita\u0308t, Mu\u0308nchen, Germany; and the Institute of Theoretical Surgery, Philipps-Universita\u0308t, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine I, Universita\u0308t, Heidelberg, Germany; the Institute for Biochemistry, Justus-Liebig-Universita\u0308t, Giessen, Germany; the Deutsches Herzzentrum, Technische Universita\u0308t, Mu\u0308nchen, Germany; and the Institute of Theoretical Surgery, Philipps-Universita\u0308t, Marburg, Germany","institution_ids":["https://openalex.org/I161103922","https://openalex.org/I200763008","https://openalex.org/I223822909","https://openalex.org/I4210148371","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101935942","display_name":"\u0130. \u00c7eli\u0307k","orcid":"https://orcid.org/0000-0003-3709-2511","observed_orcids":["https://orcid.org/0000-0003-3709-2511"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]},{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210148371","display_name":"Deutsches Herzzentrum M\u00fcnchen","ror":"https://ror.org/04hbwba26","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I4210148371","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ilhan Celik","raw_affiliation_strings":["From the Department of Internal Medicine I, Universita\u0308t, Heidelberg, Germany; the Institute for Biochemistry, Justus-Liebig-Universita\u0308t, Giessen, Germany; the Deutsches Herzzentrum, Technische Universita\u0308t, Mu\u0308nchen, Germany; and the Institute of Theoretical Surgery, Philipps-Universita\u0308t, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine I, Universita\u0308t, Heidelberg, Germany; the Institute for Biochemistry, Justus-Liebig-Universita\u0308t, Giessen, Germany; the Deutsches Herzzentrum, Technische Universita\u0308t, Mu\u0308nchen, Germany; and the Institute of Theoretical Surgery, Philipps-Universita\u0308t, Marburg, Germany","institution_ids":["https://openalex.org/I161103922","https://openalex.org/I200763008","https://openalex.org/I223822909","https://openalex.org/I4210148371","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067599146","display_name":"Peter P. Nawroth","orcid":"https://orcid.org/0000-0002-6134-7804","observed_orcids":["https://orcid.org/0000-0002-6134-7804"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]},{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210148371","display_name":"Deutsches Herzzentrum M\u00fcnchen","ror":"https://ror.org/04hbwba26","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I4210148371","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter P. Nawroth","raw_affiliation_strings":["From the Department of Internal Medicine I, Universita\u0308t, Heidelberg, Germany; the Institute for Biochemistry, Justus-Liebig-Universita\u0308t, Giessen, Germany; the Deutsches Herzzentrum, Technische Universita\u0308t, Mu\u0308nchen, Germany; and the Institute of Theoretical Surgery, Philipps-Universita\u0308t, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine I, Universita\u0308t, Heidelberg, Germany; the Institute for Biochemistry, Justus-Liebig-Universita\u0308t, Giessen, Germany; the Deutsches Herzzentrum, Technische Universita\u0308t, Mu\u0308nchen, Germany; and the Institute of Theoretical Surgery, Philipps-Universita\u0308t, Marburg, Germany","institution_ids":["https://openalex.org/I161103922","https://openalex.org/I200763008","https://openalex.org/I223822909","https://openalex.org/I4210148371","https://openalex.org/I62916508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105839599","display_name":"Klaus T. Preissner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]},{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210148371","display_name":"Deutsches Herzzentrum M\u00fcnchen","ror":"https://ror.org/04hbwba26","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I4210148371","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Klaus T. Preissner","raw_affiliation_strings":["From the Department of Internal Medicine I, Universita\u0308t, Heidelberg, Germany; the Institute for Biochemistry, Justus-Liebig-Universita\u0308t, Giessen, Germany; the Deutsches Herzzentrum, Technische Universita\u0308t, Mu\u0308nchen, Germany; and the Institute of Theoretical Surgery, Philipps-Universita\u0308t, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine I, Universita\u0308t, Heidelberg, Germany; the Institute for Biochemistry, Justus-Liebig-Universita\u0308t, Giessen, Germany; the Deutsches Herzzentrum, Technische Universita\u0308t, Mu\u0308nchen, Germany; and the Institute of Theoretical Surgery, Philipps-Universita\u0308t, Marburg, Germany","institution_ids":["https://openalex.org/I161103922","https://openalex.org/I200763008","https://openalex.org/I223822909","https://openalex.org/I4210148371","https://openalex.org/I62916508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":3.3807,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":{"value":0.91302597,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"105","issue":"3","first_page":"1036","last_page":"1043"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.8179000020027161,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.8179000020027161,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.15330000221729279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiostatin","display_name":"angiostatin","score":1.0},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.7450000047683716},{"id":"https://openalex.org/keywords/leukocyte-recruitment","display_name":"leukocyte recruitment","score":0.949999988079071},{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.5299999713897705},{"id":"https://openalex.org/keywords/beta2-integrins","display_name":"beta2 integrins","score":0.9850000143051147},{"id":"https://openalex.org/keywords/mac-1","display_name":"Mac-1","score":0.9079999923706055},{"id":"https://openalex.org/keywords/lfa-1","display_name":"LFA-1","score":0.9110000133514404},{"id":"https://openalex.org/keywords/leukocyte-adhesion","display_name":"leukocyte adhesion","score":0.8349999785423279},{"id":"https://openalex.org/keywords/neutrophil-transmigration","display_name":"neutrophil transmigration","score":0.8029999732971191},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8029999732971191},{"id":"https://openalex.org/keywords/tissue-factor","display_name":"tissue factor","score":0.9890000224113464},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.9110000133514404},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.6520000100135803},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.42100000381469727}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5654782652854919},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46130305528640747},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4603848457336426}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010538","descriptor_name":"Peritonitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020014","descriptor_name":"K562 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D043168","descriptor_name":"Angiostatins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood-2004-01-0166","doi":"https://doi.org/10.1182/blood-2004-01-0166","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2004-01-0166","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:15383457","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15383457","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"pmh:oai:opus-zb.helmholtz-muenchen.de:43637","doi":null,"is_oa":false,"landing_page_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=43637","pdf_url":null,"source":{"id":"https://openalex.org/S4377196115","display_name":"Site cant be reached","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Blood 105, 1036-1043 (2005)","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W141774154","https://openalex.org/W200640348","https://openalex.org/W336219641","https://openalex.org/W1498287490","https://openalex.org/W1538447709","https://openalex.org/W1574172480","https://openalex.org/W1597610606","https://openalex.org/W1639658090","https://openalex.org/W1830089244","https://openalex.org/W1842892140","https://openalex.org/W1942494087","https://openalex.org/W1963776052","https://openalex.org/W1968673560","https://openalex.org/W1970258936","https://openalex.org/W1970483666","https://openalex.org/W1977451666","https://openalex.org/W1978080764","https://openalex.org/W1984352482","https://openalex.org/W1984464853","https://openalex.org/W1984649993","https://openalex.org/W1992434978","https://openalex.org/W1995827857","https://openalex.org/W2003775813","https://openalex.org/W2005971799","https://openalex.org/W2013730613","https://openalex.org/W2032637425","https://openalex.org/W2035591620","https://openalex.org/W2036443538","https://openalex.org/W2040470926","https://openalex.org/W2043297474","https://openalex.org/W2062880732","https://openalex.org/W2063595903","https://openalex.org/W2072928113","https://openalex.org/W2099675490","https://openalex.org/W2100363932","https://openalex.org/W2106780768","https://openalex.org/W2113369935","https://openalex.org/W2115272551","https://openalex.org/W2117783767","https://openalex.org/W2121300516","https://openalex.org/W2126267641","https://openalex.org/W2129962589","https://openalex.org/W2130927569","https://openalex.org/W2146672236","https://openalex.org/W2149958200","https://openalex.org/W2166473887","https://openalex.org/W2171231906","https://openalex.org/W2290936009","https://openalex.org/W2331176038","https://openalex.org/W2396494606","https://openalex.org/W2396519825","https://openalex.org/W4214835361","https://openalex.org/W4250888565","https://openalex.org/W6903602003"],"related_works":["https://openalex.org/W7097668512","https://openalex.org/W2149958200","https://openalex.org/W2109691458","https://openalex.org/W2029557709","https://openalex.org/W2003775813","https://openalex.org/W4205109618","https://openalex.org/W3174551540","https://openalex.org/W2029196838","https://openalex.org/W2023907053","https://openalex.org/W1942935820"],"abstract_inverted_index":{"Angiogenesis":[0],"and":[1,11,43,68,77,88,104,113,181,204],"inflammation":[2],"are":[3,27],"closely":[4],"related":[5],"biologic":[6],"processes":[7,232],"in":[8,20,124,133,176,233],"wound":[9,190],"healing":[10,191,199],"the":[12,24,49,65,114,122,129,146,157,185,194,198,220],"responses":[13],"to":[14,109,228],"vascular":[15,169],"injury":[16],"as":[17,19,116,118,154,156,212],"well":[18,117,155],"cardiovascular":[21],"diseases;":[22],"however,":[23],"molecular":[25],"connections":[26],"poorly":[28],"defined.":[29],"In":[30,80,135],"particular,":[31,81],"it":[32],"is":[33],"yet":[34],"unclear":[35],"whether":[36],"endogenous":[37,50],"factors":[38],"can":[39],"regulate":[40],"both":[41],"angiogenesis":[42,51],"inflammation.":[44],"Here,":[45],"we":[46],"show":[47],"that":[48],"inhibitor,":[52],"angiostatin":[53,127,142,172,209,227],"(containing":[54],"kringle":[55,70,86],"domains":[56],"1-4":[57],"of":[58,107,145,160,166,189,197,207,226],"plasminogen),":[59],"serves":[60],"an":[61,213],"anti-inflammatory":[62],"role,":[63],"since":[64],"kringles":[66],"1-3":[67],"its":[69,138],"4":[71,87],"directly":[72],"interact":[73],"with":[74,140],"leukocyte":[75,93],"beta1-":[76,103],"beta2-integrins,":[78],"respectively.":[79],"a":[82,163],"specific":[83],"interaction":[84,139],"between":[85],"alphaMbeta2-integrin":[89],"(Mac-1)":[90],"but":[91],"not":[92],"function":[94],"antigen":[95],"1":[96],"(LFA-1)":[97],"was":[98,210],"identified.":[99],"Angiostatin":[100],"thereby":[101],"inhibited":[102],"beta2-integrin-mediated":[105],"adhesion":[106],"leukocytes":[108],"extracellular":[110],"matrix":[111],"proteins":[112],"endothelium":[115,123],"their":[119],"transmigration":[120],"through":[121,137],"vitro.":[125],"Moreover,":[126],"blocked":[128],"peritonitis-induced":[130],"neutrophil":[131],"emigration":[132],"vivo.":[134],"addition,":[136],"Mac-1,":[141],"reduced":[143],"activation":[144],"proinflammatory":[147],"transcription":[148],"factor":[149,151],"nuclear":[150],"kappaB":[152],"(NFkappaB),":[153],"NFkappaB-related":[158],"expression":[159],"tissue":[161],"factor,":[162],"potent":[164],"initiator":[165],"hemostasis":[167],"following":[168,178,186],"injury.":[170],"Finally,":[171],"forms":[173],"were":[174,182],"generated":[175],"vivo":[177],"skin":[179],"injury/inflammation":[180],"detectable":[183],"during":[184],"entire":[187],"period":[188],"peaking":[192],"at":[193],"terminal":[195],"phase":[196],"process.":[200],"Taken":[201],"together,":[202],"over":[203],"above":[205],"inhibition":[206],"neovascularization,":[208],"identified":[211],"antiadhesive/anti-inflammatory":[214],"substance.":[215],"These":[216],"observations":[217],"could":[218],"provide":[219],"basis":[221],"for":[222],"new":[223],"therapeutic":[224],"applications":[225],"target":[229],"chronic":[230],"inflammatory":[231],"different":[234],"pathologic":[235],"situations.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
