{"id":"https://openalex.org/W20276093","doi":null,"title":"Agonist and antagonist protect sulfhydrals in the binding site of the D-1 dopamine receptor","display_name":"Agonist and antagonist protect sulfhydrals in the binding site of the D-1 dopamine receptor","publication_year":1986,"publication_date":"1986-05-01","ids":{"openalex":"https://openalex.org/W20276093","mag":"20276093"},"language":"en","primary_location":{"id":"mag:20276093","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/scitech/biblio/5220250-agonist-antagonist-protect-sulfhydrals-binding-site-dopamine-receptor","pdf_url":null,"source":{"id":"https://openalex.org/S4306510388","display_name":"Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026807389","display_name":"A Sidhu","orcid":"https://orcid.org/0009-0005-5352-3248","observed_orcids":["https://orcid.org/0009-0005-5352-3248"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Sidhu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-5352-3248","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001203681","display_name":"John W. Kebabian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John W. Kebabian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5087034581","display_name":"Peter H. Fishman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter H. Fishman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00156955,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopamine-d1-receptor","display_name":"dopamine D1 receptor","score":0.9229999780654907},{"id":"https://openalex.org/keywords/sulfhydryl-groups","display_name":"sulfhydryl groups","score":0.9259999990463257},{"id":"https://openalex.org/keywords/n-ethylmaleimide","display_name":"N-ethylmaleimide","score":0.9399999976158142},{"id":"https://openalex.org/keywords/ligand-binding-site","display_name":"ligand binding sites","score":0.878000020980835},{"id":"https://openalex.org/keywords/receptor-inactivation","display_name":"receptor inactivation","score":0.7210000157356262},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.8109999895095825},{"id":"https://openalex.org/keywords/g-proteins","display_name":"G proteins","score":0.7160000205039978},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.8579999804496765},{"id":"https://openalex.org/keywords/radioligand-binding-affinity","display_name":"radioligand binding affinity","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.8315114974975586},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6653926968574524},{"id":"https://openalex.org/C86811712","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Competitive antagonist","level":4,"score":0.6238865852355957},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5771350860595703},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5682482719421387},{"id":"https://openalex.org/C67847695","wikidata":"https://www.wikidata.org/wiki/Q626478","display_name":"Radioligand","level":3,"score":0.5296694040298462},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.5211077332496643},{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.5088139176368713},{"id":"https://openalex.org/C58732023","wikidata":"https://www.wikidata.org/wiki/Q770260","display_name":"Partial agonist","level":4,"score":0.5072616934776306},{"id":"https://openalex.org/C2780069284","wikidata":"https://www.wikidata.org/wiki/Q5198121","display_name":"Cyclase","level":3,"score":0.49769166111946106},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.48238053917884827},{"id":"https://openalex.org/C160262196","wikidata":"https://www.wikidata.org/wiki/Q5376331","display_name":"Endogenous agonist","level":5,"score":0.4552236795425415},{"id":"https://openalex.org/C2778539182","wikidata":"https://www.wikidata.org/wiki/Q4693408","display_name":"Agonist-antagonist","level":4,"score":0.4396202564239502},{"id":"https://openalex.org/C120750228","wikidata":"https://www.wikidata.org/wiki/Q2035393","display_name":"Dopamine receptor D1","level":4,"score":0.4004228115081787},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34534478187561035},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25371670722961426},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10095870494842529},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05922645330429077}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:20276093","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/scitech/biblio/5220250-agonist-antagonist-protect-sulfhydrals-binding-site-dopamine-receptor","pdf_url":null,"source":{"id":"https://openalex.org/S4306510388","display_name":"Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2065219516","https://openalex.org/W2033069615","https://openalex.org/W1991876876","https://openalex.org/W2022274582","https://openalex.org/W1989094128","https://openalex.org/W1982309568","https://openalex.org/W2004201567","https://openalex.org/W2002090685","https://openalex.org/W1566901974","https://openalex.org/W2431931004"],"abstract_inverted_index":{"An":[0],"iodinated":[1],"compound":[2],"(/sup":[3],"125/I)-SCH":[4],"23982":[5],"(8-iodo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol)":[6],"has":[7],"been":[8],"characterized":[9],"as":[10],"a":[11,42,55,70,97,105,156],"specific,":[12],"high":[13,126],"affinity":[14,127],"(Kd":[15],"=":[16],"0.7":[17],"nM)":[18],"ligand":[19,26,188],"for":[20,86],"the":[21,30,109,116,122,133,145,173,184,187],"D-1":[22,31,98,174],"dopamine":[23,175],"receptor.":[24],"The":[25,48,80,124,169],"binding":[27,60,65,110,189],"site":[28],"of":[29,59,64,88,137,142,144,148,159,186],"receptor":[32,74,176],"in":[33,41,73,77,104,132],"rat":[34],"striatum":[35],"was":[36,50,118,130,155],"inactivated":[37],"by":[38,95,114],"N-ethylmaleimide":[39],"(NEM)":[40],"time":[43],"and":[44,52,76,91,161],"concentration":[45],"dependent":[46,107],"manner.":[47],"inactivation":[49,113,143],"rapid":[51],"irreversible":[53],"with":[54],"70%":[56],"net":[57],"loss":[58,158],"sites.":[61],"Scatchard":[62],"analysis":[63],"to":[66],"NEM-treated":[67],"tissue":[68],"showed":[69],"decrease":[71],"both":[72,89],"number":[75],"radioligand":[78],"affinity.":[79],"remaining":[81],"receptors":[82],"retained":[83],"their":[84],"selectivity":[85],"stereoisomers":[87],"agonist":[90,100,117,125],"antagonist.":[92,123],"Receptor":[93],"occupancy":[94],"either":[96],"specific":[99],"or":[101,135,182],"antagonist":[102],"protected":[103],"dose":[106],"manner":[108],"sites":[111],"from":[112],"NEM;":[115],"more":[119],"effective":[120],"than":[121],"site,":[128],"however,":[129],"abolished":[131],"absence":[134],"presence":[136],"protective":[138],"compound,":[139],"presumably":[140],"because":[141],"GTP-binding":[146],"component":[147],"adenylate":[149,163],"cyclase.":[150],"In":[151],"this":[152],"regard,":[153],"there":[154],"total":[157],"agonist-":[160],"forskolin-stimulated":[162],"cyclase":[164],"activity":[165],"after":[166],"NEM":[167],"treatment.":[168],"authors":[170],"conclude":[171],"that":[172],"contains":[177],"NEM-sensitive":[178],"sulfhydral":[179],"group(s)":[180],"at":[181],"near":[183],"vicinity":[185],"site.":[190]},"counts_by_year":[],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2016-06-24T00:00:00"}
