{"id":"https://openalex.org/W2027520173","doi":"https://doi.org/10.1002/jbm.a.10475","title":"Loss of chondroitin 6\u2010sulfate and hyaluronan from failed porcine bioprosthetic valves","display_name":"Loss of chondroitin 6\u2010sulfate and hyaluronan from failed porcine bioprosthetic valves","publication_year":2003,"publication_date":"2003-03-17","ids":{"openalex":"https://openalex.org/W2027520173","doi":"https://doi.org/10.1002/jbm.a.10475","mag":"2027520173","pmid":"https://pubmed.ncbi.nlm.nih.gov/12734820"},"language":"en","primary_location":{"id":"doi:10.1002/jbm.a.10475","doi":"https://doi.org/10.1002/jbm.a.10475","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbm.a.10475","pdf_url":null,"source":{"id":"https://openalex.org/S184573928","display_name":"Journal of Biomedical Materials Research Part A","issn_l":"1549-3296","issn":["1549-3296","1552-4965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research Part A","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044710928","display_name":"Kathryn Jane Grande-Allen","orcid":"https://orcid.org/0000-0003-1533-3767","observed_orcids":["https://orcid.org/0000-0003-1533-3767"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Jane Grande\u2010Allen","raw_affiliation_strings":["Department of Biomedical Engineering, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA","Department of Biomedical Engineering, The Cleveland Clinic Foundation, Cleveland, Ohio 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Department of Biomedical Engineering, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088402770","display_name":"W. John Mako","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. John Mako","raw_affiliation_strings":["Department of Biomedical Engineering, The Cleveland Clinic Foundation, Cleveland, Ohio 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075134729","display_name":"Anthony R. Calabro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Calabro","raw_affiliation_strings":["Department of Biomedical Engineering, The Cleveland Clinic Foundation, Cleveland, Ohio 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100855087","display_name":"Yaling Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yaling Shi","raw_affiliation_strings":["Department of Biomedical Engineering, The Cleveland Clinic Foundation, Cleveland, Ohio 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113632934","display_name":"Norman B. Ratliff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Norman B. Ratliff","raw_affiliation_strings":["Department of Anatomic Pathology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomic Pathology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033486502","display_name":"Ivan Vesel\u00fd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ivan Vesely","raw_affiliation_strings":["Department of Biomedical Engineering, The Cleveland Clinic Foundation, Cleveland, Ohio 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The Cleveland Clinic Foundation, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5033486502"],"corresponding_institution_ids":["https://openalex.org/I1316902750"],"apc_list":{"value":4220,"currency":"USD","value_usd":4220},"apc_paid":null,"fwci":0.8479,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.68207768,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"65A","issue":"2","first_page":"251","last_page":"259"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.7378000020980835,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.7378000020980835,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.14470000565052032,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.06989999860525131,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/valve-failure","display_name":"valve failure","score":0.7129999995231628},{"id":"https://openalex.org/keywords/glycosaminoglycans","display_name":"glycosaminoglycans","score":0.8949999809265137},{"id":"https://openalex.org/keywords/chondroitin-6-sulfate","display_name":"chondroitin-6-sulfate","score":0.9470000267028809},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.9929999709129333},{"id":"https://openalex.org/keywords/versican","display_name":"versican","score":0.8100000023841858},{"id":"https://openalex.org/keywords/decorin","display_name":"decorin","score":0.9760000109672546},{"id":"https://openalex.org/keywords/glutaraldehyde-crosslinking","display_name":"glutaraldehyde crosslinking","score":0.902999997138977},{"id":"https://openalex.org/keywords/explanted-valves","display_name":"explanted valves","score":0.75},{"id":"https://openalex.org/keywords/proteoglycan-degradation","display_name":"proteoglycan degradation","score":0.6759999990463257},{"id":"https://openalex.org/keywords/valve-biomechanics","display_name":"valve biomechanics","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C2779794767","wikidata":"https://www.wikidata.org/wiki/Q18248676","display_name":"Decorin","level":4,"score":0.8531132936477661},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.8350598812103271},{"id":"https://openalex.org/C2778066728","wikidata":"https://www.wikidata.org/wiki/Q2335618","display_name":"Dermatan sulfate","level":4,"score":0.8106639981269836},{"id":"https://openalex.org/C159470946","wikidata":"https://www.wikidata.org/wiki/Q14888030","display_name":"Versican","level":4,"score":0.8075248003005981},{"id":"https://openalex.org/C2779553658","wikidata":"https://www.wikidata.org/wiki/Q408014","display_name":"Chondroitin sulfate","level":3,"score":0.71832275390625},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.6667544841766357},{"id":"https://openalex.org/C2776735749","wikidata":"https://www.wikidata.org/wiki/Q4862650","display_name":"Chondroitin","level":3,"score":0.6121346354484558},{"id":"https://openalex.org/C2777529624","wikidata":"https://www.wikidata.org/wiki/Q416475","display_name":"Glutaraldehyde","level":2,"score":0.5823038816452026},{"id":"https://openalex.org/C2777529286","wikidata":"https://www.wikidata.org/wiki/Q337231","display_name":"Hyaluronic acid","level":2,"score":0.5468899011611938},{"id":"https://openalex.org/C197534660","wikidata":"https://www.wikidata.org/wiki/Q21121862","display_name":"Aggrecan","level":5,"score":0.45433810353279114},{"id":"https://openalex.org/C2778230131","wikidata":"https://www.wikidata.org/wiki/Q2457767","display_name":"Keratan sulfate","level":4,"score":0.42605945467948914},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4191528558731079},{"id":"https://openalex.org/C157890192","wikidata":"https://www.wikidata.org/wiki/Q2561978","display_name":"Explant culture","level":3,"score":0.41328707337379456},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40975791215896606},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4038519859313965},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3268798887729645},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2957218885421753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2295805811882019},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.21522459387779236},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.20547068119049072},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.19752290844917297},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13232377171516418},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12468701601028442},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.08336707949638367},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.07945114374160767},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001705","descriptor_name":"Bioprosthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002809","descriptor_name":"Chondroitin Sulfates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004586","descriptor_name":"Electrophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006025","descriptor_name":"Glycosaminoglycans","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006025","descriptor_name":"Glycosaminoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006025","descriptor_name":"Glycosaminoglycans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008422","descriptor_name":"Materials Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011475","descriptor_name":"Prosthesis Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jbm.a.10475","doi":"https://doi.org/10.1002/jbm.a.10475","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbm.a.10475","pdf_url":null,"source":{"id":"https://openalex.org/S184573928","display_name":"Journal of Biomedical Materials Research Part A","issn_l":"1549-3296","issn":["1549-3296","1552-4965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research Part A","raw_type":"journal-article"},{"id":"pmid:12734820","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12734820","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedical materials research. Part A","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","score":0.8700000047683716,"display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W74697958","https://openalex.org/W1484388118","https://openalex.org/W1521949639","https://openalex.org/W1529402584","https://openalex.org/W1605041458","https://openalex.org/W1818229232","https://openalex.org/W1970824706","https://openalex.org/W1976566500","https://openalex.org/W1977693892","https://openalex.org/W1979271427","https://openalex.org/W1984400276","https://openalex.org/W1990658941","https://openalex.org/W1997806115","https://openalex.org/W1998828425","https://openalex.org/W2004249100","https://openalex.org/W2021309957","https://openalex.org/W2049721055","https://openalex.org/W2060315576","https://openalex.org/W2060624663","https://openalex.org/W2061216264","https://openalex.org/W2065309296","https://openalex.org/W2066703545","https://openalex.org/W2069438408","https://openalex.org/W2072029917","https://openalex.org/W2089147035","https://openalex.org/W2110114807","https://openalex.org/W2124573683","https://openalex.org/W2153179983","https://openalex.org/W2160251803","https://openalex.org/W2164461910","https://openalex.org/W2307428509","https://openalex.org/W2425422282","https://openalex.org/W4211041099"],"related_works":["https://openalex.org/W3214689500","https://openalex.org/W2008905610","https://openalex.org/W2067190474","https://openalex.org/W2440613352","https://openalex.org/W27779954","https://openalex.org/W2413278927","https://openalex.org/W1966450095","https://openalex.org/W1986733889","https://openalex.org/W4387563741","https://openalex.org/W3009347741"],"abstract_inverted_index":{"Explanted":[0],"porcine":[1,40],"bioprosthetic":[2,27],"valves":[3,28],"have":[4],"a":[5,51],"thinned":[6,175],"spongiosa,":[7],"partially":[8],"because":[9],"of":[10,14,21,88,98,112,164,180,192],"an":[11],"overall":[12],"loss":[13,163],"glycosaminoglycans":[15],"(GAGs).":[16],"We":[17],"measured":[18],"the":[19,61,89,135,151,174,190,193],"concentrations":[20],"specific":[22],"GAG":[23,63,67,91,119,130],"classes":[24,92],"in":[25,69,134,150,195],"explanted":[26],"(n":[29],"=":[30],"14,":[31],"implanted":[32],"12.0":[33],"+/-":[34,73],"4.7":[35],"years)":[36],"compared":[37],"with":[38,44,173],"glutaraldehyde-fixed":[39],"controls.":[41,82,95],"After":[42],"extraction":[43],"NaOH,":[45],"GAGs":[46],"were":[47,102],"analyzed":[48],"using":[49],"either":[50],"hexuronic":[52],"acid":[53],"assay":[54],"or":[55],"fluorophore-assisted":[56],"carbohydrate":[57],"electrophoresis":[58],"to":[59,94,106,110,127],"quantify":[60],"individual":[62],"classes.":[64],"The":[65,96,116,162,177],"total":[66,113],"concentration":[68],"explants":[70],"was":[71,121],"198":[72],"95":[74],"pmol/mg":[75],"wet":[76],"weight-93%":[77],"less":[78],"than":[79],"freshly":[80],"fixed":[81],"Explants":[83],"also":[84],"contained":[85],"altered":[86],"proportions":[87,97],"different":[90],"relative":[93],"hyaluronan":[99],"and":[100,108,153,166,184],"chondroitin/dermatan-6-sulfate":[101],"reduced":[103],"from":[104,125],"39":[105],"7%":[107],"34":[109],"18%":[111],"GAGs,":[114],"respectively.":[115],"predominant":[117],"explant":[118],"class":[120],"chondroitin/dermatan-4-sulfate":[122],"(proportion":[123],"elevated":[124],"14":[126],"70%).":[128],"This":[129],"is":[131,140,147,158,171],"commonly":[132,148],"found":[133,149],"collagen-associated":[136],"proteoglycan":[137,155],"decorin,":[138],"which":[139,157],"likely":[141,159],"well":[142],"crosslinked":[143],"by":[144],"glutaraldehyde.":[145],"Chondroitin-6-sulfate":[146],"water-":[152],"hyaluronan-binding":[154],"versican,":[156],"poorly":[160],"crosslinked.":[161],"versican":[165],"its":[167],"associated":[168],"water-binding":[169],"capacity":[170],"consistent":[172],"spongiosa.":[176],"resultant":[178],"compromise":[179],"hydration,":[181],"compressive":[182],"resistance,":[183],"viscoelasticity":[185],"may":[186],"be":[187],"responsible":[188],"for":[189],"deterioration":[191],"bioprosthesis":[194],"vivo.":[196]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
