{"id":"https://openalex.org/W2027496830","doi":"https://doi.org/10.1002/hep.25599","title":"Noninvasive elastography-based assessment of liver fibrosis progression and prognosis in primary biliary cirrhosis","display_name":"Noninvasive elastography-based assessment of liver fibrosis progression and prognosis in primary biliary cirrhosis","publication_year":2012,"publication_date":"2012-01-23","ids":{"openalex":"https://openalex.org/W2027496830","doi":"https://doi.org/10.1002/hep.25599","mag":"2027496830","pmid":"https://pubmed.ncbi.nlm.nih.gov/22271046"},"language":"en","primary_location":{"id":"doi:10.1002/hep.25599","doi":"https://doi.org/10.1002/hep.25599","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.25599","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.25599","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.25599","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090413862","display_name":"Christophe Corpechot","orcid":"https://orcid.org/0000-0002-7920-9784","observed_orcids":["https://orcid.org/0000-0002-7920-9784"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Christophe Corpechot","raw_affiliation_strings":["Service d'H\u00e9patologie, Centre de r\u00e9f\u00e9rence des Maladies Inflammatoires des Voies Biliaires, H\u00f4pital Saint-Antoine, Assistance Publique-H\u00f4pitaux de Paris (APHP), Paris, France. christophe.corpechot@sat.aphp.fr","Service d'H\u00e9patologie, Centre de r\u00e9f\u00e9rence des Maladies Inflammatoires des Voies Biliaires, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (APHP), Paris, France","UMR_S938, Facult\u00e9 de M\u00e9decine Saint-Antoine, Universit\u00e9 Pierre et Marie Curie (UPMC), Paris, France","fax: 33-1-49-28-21-07"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'H\u00e9patologie, Centre de r\u00e9f\u00e9rence des Maladies Inflammatoires des Voies Biliaires, H\u00f4pital Saint-Antoine, Assistance Publique-H\u00f4pitaux de Paris (APHP), Paris, France. christophe.corpechot@sat.aphp.fr","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]},{"raw_affiliation_string":"Service d'H\u00e9patologie, Centre de r\u00e9f\u00e9rence des Maladies Inflammatoires des Voies Biliaires, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (APHP), Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]},{"raw_affiliation_string":"UMR_S938, Facult\u00e9 de M\u00e9decine Saint-Antoine, Universit\u00e9 Pierre et Marie Curie (UPMC), Paris, France","institution_ids":["https://openalex.org/I4405264447"]},{"raw_affiliation_string":"fax: 33-1-49-28-21-07","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106821635","display_name":"Fabrice Carrat","orcid":"https://orcid.org/0000-0002-8672-7918","observed_orcids":["https://orcid.org/0000-0002-8672-7918"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fabrice Carrat","raw_affiliation_strings":["Unite\u0301 de Sante\u0301 Publique, Ho\u0302pital Saint-Antoine, Assistance Publique\u2013Ho\u0302pitaux de Paris (APHP), Paris, France","Unit\u00e9 de Sant\u00e9 Publique, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (APHP), Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unite\u0301 de Sante\u0301 Publique, Ho\u0302pital Saint-Antoine, Assistance Publique\u2013Ho\u0302pitaux de Paris (APHP), Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]},{"raw_affiliation_string":"Unit\u00e9 de Sant\u00e9 Publique, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (APHP), Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040798107","display_name":"Armelle Poujol\u2010Robert","orcid":"https://orcid.org/0000-0002-6136-6511","observed_orcids":["https://orcid.org/0000-0002-6136-6511"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Armelle Poujol-Robert","raw_affiliation_strings":["Service d'He\u0301patologie, Centre de re\u0301fe\u0301rence des Maladies Inflammatoires des Voies Biliaires, Ho\u0302pital Saint-Antoine, Assistance Publique\u2013Ho\u0302pitaux de Paris (APHP), Paris, France","Service d'H\u00e9patologie, Centre de r\u00e9f\u00e9rence des Maladies Inflammatoires des Voies Biliaires, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (APHP), Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'He\u0301patologie, Centre de re\u0301fe\u0301rence des Maladies Inflammatoires des Voies Biliaires, Ho\u0302pital Saint-Antoine, Assistance Publique\u2013Ho\u0302pitaux de Paris (APHP), Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]},{"raw_affiliation_string":"Service d'H\u00e9patologie, Centre de r\u00e9f\u00e9rence des Maladies Inflammatoires des Voies Biliaires, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (APHP), Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088745824","display_name":"Farid Gaouar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Farid Gaouar","raw_affiliation_strings":["Service d'He\u0301patologie, Centre de re\u0301fe\u0301rence des Maladies Inflammatoires des Voies Biliaires, Ho\u0302pital Saint-Antoine, Assistance Publique\u2013Ho\u0302pitaux de Paris (APHP), Paris, France","Service d'H\u00e9patologie, Centre de r\u00e9f\u00e9rence des Maladies Inflammatoires des Voies Biliaires, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (APHP), Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'He\u0301patologie, Centre de re\u0301fe\u0301rence des Maladies Inflammatoires des Voies Biliaires, Ho\u0302pital Saint-Antoine, Assistance Publique\u2013Ho\u0302pitaux de Paris (APHP), Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]},{"raw_affiliation_string":"Service d'H\u00e9patologie, Centre de r\u00e9f\u00e9rence des Maladies Inflammatoires des Voies Biliaires, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (APHP), Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041662580","display_name":"Dominique Wendum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Dominique Wendum","raw_affiliation_strings":["Service d'Anatomie et Cytologie Pathologiques, Ho\u0302pital Saint-Antoine, Assistance Publique\u2013Ho\u0302pitaux de Paris (APHP), Paris, France","Service d'Anatomie et Cytologie Pathologiques, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (APHP), Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'Anatomie et Cytologie Pathologiques, Ho\u0302pital Saint-Antoine, Assistance Publique\u2013Ho\u0302pitaux de Paris (APHP), Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]},{"raw_affiliation_string":"Service d'Anatomie et Cytologie Pathologiques, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (APHP), Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053434760","display_name":"Olivier Chazouill\u00e8res","orcid":"https://orcid.org/0000-0001-6854-8871","observed_orcids":["https://orcid.org/0000-0001-6854-8871"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Chazouill\u00e8res","raw_affiliation_strings":["Service d'He\u0301patologie, Centre de re\u0301fe\u0301rence des Maladies Inflammatoires des Voies Biliaires, Ho\u0302pital Saint-Antoine, Assistance Publique\u2013Ho\u0302pitaux de Paris (APHP), Paris, France","UMR_S938, Faculte\u0301 de Me\u0301decine Saint-Antoine, Universite\u0301 Pierre et Marie Curie (UPMC), Paris, France","Service d'H\u00e9patologie, Centre de r\u00e9f\u00e9rence des Maladies Inflammatoires des Voies Biliaires, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (APHP), Paris, France","UMR_S938, Facult\u00e9 de M\u00e9decine Saint-Antoine, Universit\u00e9 Pierre et Marie Curie (UPMC), Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'He\u0301patologie, Centre de re\u0301fe\u0301rence des Maladies Inflammatoires des Voies Biliaires, Ho\u0302pital Saint-Antoine, Assistance Publique\u2013Ho\u0302pitaux de Paris (APHP), Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]},{"raw_affiliation_string":"UMR_S938, Faculte\u0301 de Me\u0301decine Saint-Antoine, Universite\u0301 Pierre et Marie Curie (UPMC), Paris, France","institution_ids":["https://openalex.org/I4405264447"]},{"raw_affiliation_string":"Service d'H\u00e9patologie, Centre de r\u00e9f\u00e9rence des Maladies Inflammatoires des Voies Biliaires, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (APHP), Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]},{"raw_affiliation_string":"UMR_S938, Facult\u00e9 de M\u00e9decine Saint-Antoine, Universit\u00e9 Pierre et Marie Curie (UPMC), Paris, France","institution_ids":["https://openalex.org/I4405264447"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013728497","display_name":"Raoul Y. Poupon","orcid":"https://orcid.org/0000-0002-2114-7189","observed_orcids":["https://orcid.org/0000-0002-2114-7189"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Raoul Poupon","raw_affiliation_strings":["Service d'He\u0301patologie, Centre de re\u0301fe\u0301rence des Maladies Inflammatoires des Voies Biliaires, Ho\u0302pital Saint-Antoine, Assistance Publique\u2013Ho\u0302pitaux de Paris (APHP), Paris, France","UMR_S938, Faculte\u0301 de Me\u0301decine Saint-Antoine, Universite\u0301 Pierre et Marie Curie (UPMC), Paris, France","Service d'H\u00e9patologie, Centre de r\u00e9f\u00e9rence des Maladies Inflammatoires des Voies Biliaires, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (APHP), Paris, France","UMR_S938, Facult\u00e9 de M\u00e9decine Saint-Antoine, Universit\u00e9 Pierre et Marie Curie (UPMC), Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'He\u0301patologie, Centre de re\u0301fe\u0301rence des Maladies Inflammatoires des Voies Biliaires, Ho\u0302pital Saint-Antoine, Assistance Publique\u2013Ho\u0302pitaux de Paris (APHP), Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]},{"raw_affiliation_string":"UMR_S938, Faculte\u0301 de Me\u0301decine Saint-Antoine, Universite\u0301 Pierre et Marie Curie (UPMC), Paris, France","institution_ids":["https://openalex.org/I4405264447"]},{"raw_affiliation_string":"Service d'H\u00e9patologie, Centre de r\u00e9f\u00e9rence des Maladies Inflammatoires des Voies Biliaires, H\u00f4pital Saint-Antoine, Assistance Publique\u2013H\u00f4pitaux de Paris (APHP), Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]},{"raw_affiliation_string":"UMR_S938, Facult\u00e9 de M\u00e9decine Saint-Antoine, Universit\u00e9 Pierre et Marie Curie (UPMC), Paris, France","institution_ids":["https://openalex.org/I4405264447"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5090413862"],"corresponding_institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210102928","https://openalex.org/I4405264447"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":12.3678,"has_fulltext":true,"cited_by_count":357,"citation_normalized_percentile":{"value":0.99138132,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"56","issue":"1","first_page":"198","last_page":"208"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.7387999892234802,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.7387999892234802,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.23019999265670776,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-biliary-cholangitis","display_name":"primary biliary cirrhosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/transient-elastography","display_name":"transient elastography","score":0.8519999980926514},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9279999732971191},{"id":"https://openalex.org/keywords/liver-stiffness","display_name":"liver stiffness","score":0.9459999799728394},{"id":"https://openalex.org/keywords/fibrosis-staging","display_name":"fibrosis staging","score":0.6909999847412109},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.7450000047683716},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.5519999861717224},{"id":"https://openalex.org/keywords/ursodeoxycholic-acid","display_name":"ursodeoxycholic acid","score":0.9120000004768372},{"id":"https://openalex.org/keywords/hepatic-decompensation","display_name":"hepatic decompensation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/noninvasive-fibrosis-markers","display_name":"non-invasive fibrosis markers","score":0.6880000233650208},{"id":"https://openalex.org/keywords/metavir-score","display_name":"METAVIR score","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7606028914451599},{"id":"https://openalex.org/C2780366471","wikidata":"https://www.wikidata.org/wiki/Q1072420","display_name":"Primary biliary cirrhosis","level":2,"score":0.7261761426925659},{"id":"https://openalex.org/C2777690781","wikidata":"https://www.wikidata.org/wiki/Q1324974","display_name":"Elastography","level":3,"score":0.6066418290138245},{"id":"https://openalex.org/C2780826214","wikidata":"https://www.wikidata.org/wiki/Q1324974","display_name":"Transient elastography","level":4,"score":0.5980836749076843},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.5684010982513428},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5230808854103088},{"id":"https://openalex.org/C2994217296","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Liver fibrosis","level":3,"score":0.5098899602890015},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4923757314682007},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4869883954524994},{"id":"https://openalex.org/C2994419564","wikidata":"https://www.wikidata.org/wiki/Q1072420","display_name":"Biliary cirrhosis","level":4,"score":0.4428616762161255},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3805064558982849},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.36837178468704224},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.11815395951271057},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.05198350548744202},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001707","descriptor_name":"Biopsy, Needle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008105","descriptor_name":"Liver Cirrhosis, Biliary","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008105","descriptor_name":"Liver Cirrhosis, Biliary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008111","descriptor_name":"Liver Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008991","descriptor_name":"Monitoring, Physiologic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016001","descriptor_name":"Confidence Intervals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054459","descriptor_name":"Elasticity Imaging Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/hep.25599","doi":"https://doi.org/10.1002/hep.25599","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.25599","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.25599","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:22271046","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22271046","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1002/hep.25599","doi":"https://doi.org/10.1002/hep.25599","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.25599","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.25599","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2027496830.pdf","grobid_xml":"https://content.openalex.org/works/W2027496830.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1587549087","https://openalex.org/W1593355446","https://openalex.org/W1958319776","https://openalex.org/W1963598216","https://openalex.org/W1969562548","https://openalex.org/W1985442918","https://openalex.org/W1994968614","https://openalex.org/W1997865776","https://openalex.org/W1997884202","https://openalex.org/W2010358777","https://openalex.org/W2019951467","https://openalex.org/W2023270047","https://openalex.org/W2027862649","https://openalex.org/W2028798921","https://openalex.org/W2037788436","https://openalex.org/W2039586762","https://openalex.org/W2056147648","https://openalex.org/W2058865320","https://openalex.org/W2059953419","https://openalex.org/W2063975050","https://openalex.org/W2064387090","https://openalex.org/W2075774005","https://openalex.org/W2094174828","https://openalex.org/W2094639617","https://openalex.org/W2111191397","https://openalex.org/W2112759780","https://openalex.org/W2122612551","https://openalex.org/W2123805246","https://openalex.org/W2141861294","https://openalex.org/W2153174384","https://openalex.org/W2328176404","https://openalex.org/W2786456523","https://openalex.org/W2797563284","https://openalex.org/W4295008070"],"related_works":["https://openalex.org/W1988029992","https://openalex.org/W2551637709","https://openalex.org/W3088744978","https://openalex.org/W2077348069","https://openalex.org/W1593355446","https://openalex.org/W4366779049","https://openalex.org/W4405899235","https://openalex.org/W4415559659","https://openalex.org/W7054818246","https://openalex.org/W1991255592"],"abstract_inverted_index":{"UNLABELLED:":[0],"The":[1],"development":[2],"of":[3,18,24,33,41,57,62,70,79,86,104,161,179,217,227,244,250,278,285],"liver":[4,42,105,228,230,251,260,279],"fibrosis":[5,43,64,109,252],"markers":[6,137,249],"in":[7,37,48,66,82,107,152,192,211,253,264,273,281],"primary":[8],"biliary":[9],"cirrhosis":[10],"(PBC)":[11],"is":[12,242,283],"needed":[13],"to":[14,92,135],"facilitate":[15],"the":[16,22,30,38,60,162,172,245],"assessment":[17],"its":[19],"progression":[20,47,177,191],"and":[21,45,117,123,131,149,187],"effectiveness":[23],"new":[25],"therapies.":[26],"Here,":[27],"we":[28],"investigated":[29],"potential":[31],"usefulness":[32],"transient":[34],"elastography":[35],"(TE)":[36],"noninvasive":[39],"evaluation":[40],"stage":[44],"disease":[46],"PBC.":[49,254],"We":[50],"performed,":[51],"first,":[52],"a":[53,67,75,83,201,256],"prospective":[54],"performance":[55,130],"analysis":[56,78],"TE":[58,127,241],"for":[59,90],"diagnosis":[61],"METAVIR":[63],"stages":[65,110],"diagnostic":[68],"cohort":[69,85,164],"103":[71],"patients":[72,88,96,193,274],"and,":[73],"second,":[74],"retrospective":[76],"longitudinal":[77],"repeated":[80],"examinations":[81],"monitoring":[84,163],"150":[87],"followed-up":[89],"up":[91],"5":[93],"years.":[94],"All":[95],"were":[97,119],"treated":[98],"with":[99,194,222,275],"ursodeoxycholic":[100],"acid.":[101],"Diagnostic":[102],"thresholds":[103],"stiffness":[106,261,280],"discriminating":[108],"\u2265":[111,113,115],"F1,":[112],"F2,":[114,196],"F3,":[116],"=F4":[118],"7.1,":[120],"8.8,":[121],"10.7,":[122],"16.9":[124],"kPa,":[125],"respectively.":[126],"showed":[128,171],"high":[129],"was":[132,220],"significantly":[133,271],"superior":[134],"biochemical":[136],"(e.g.,":[138],"aspartate":[139],"aminotransferase":[140,147],"[AST]/platelet":[141],"ratio,":[142,148],"FIB-4,":[143],"hyaluronic":[144],"acid,":[145],"AST/alanine":[146],"Mayo":[150],"score)":[151],"diagnosing":[153],"significant":[154,190,202],"fibrosis,":[155,157],"severe":[156],"or":[158,197,232],"cirrhosis.":[159,276],"Analysis":[160],"data":[165],"set":[166],"using":[167],"generalized":[168],"linear":[169],"models":[170],"following:":[173],"(1)":[174],"an":[175,223],"overall":[176],"rate":[178],"0.48":[180],"\u00b1":[181,205],"0.21":[182],"kPa/year":[183,219],"(P":[184,234],"=":[185],"0.02)":[186],"(2)":[188],"no":[189],"F0-F1,":[195],"F3":[198],"stages,":[199],"but":[200],"increase":[203],"(4.06":[204],"0.72":[206],"kPa/year;":[207],"P":[208],"<":[209,235],"0.0001)":[210],"cirrhotic":[212],"patients.":[213],"A":[214],"cut-off":[215],"value":[216],"2.1":[218],"associated":[221],"8.4-fold":[224],"increased":[225],"risk":[226],"decompensations,":[229],"transplantations,":[231],"deaths":[233],"0.0001,":[236],"Cox":[237],"regression":[238],"analysis).":[239],"CONCLUSION:":[240],"one":[243],"best":[246],"current":[247],"surrogate":[248],"Over":[255],"5-year":[257],"period,":[258],"on-treatment":[259],"appears":[262],"stable":[263],"most":[265],"noncirrhotic":[266],"PBC":[267,282],"patients,":[268],"whereas":[269],"it":[270],"increases":[272],"Progression":[277],"predictive":[284],"poor":[286],"outcome.":[287]},"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":24},{"year":2024,"cited_by_count":25},{"year":2023,"cited_by_count":26},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":35},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":30},{"year":2018,"cited_by_count":32},{"year":2017,"cited_by_count":26},{"year":2016,"cited_by_count":25},{"year":2015,"cited_by_count":34},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}