{"id":"https://openalex.org/W2027483534","doi":"https://doi.org/10.1158/1078-0432.ccr-14-0983","title":"Clinical Relevance of KRAS -Mutated Subclones Detected with Picodroplet Digital PCR in Advanced Colorectal Cancer Treated with Anti-EGFR Therapy","display_name":"Clinical Relevance of KRAS -Mutated Subclones Detected with Picodroplet Digital PCR in Advanced Colorectal Cancer Treated with Anti-EGFR Therapy","publication_year":2014,"publication_date":"2014-09-24","ids":{"openalex":"https://openalex.org/W2027483534","doi":"https://doi.org/10.1158/1078-0432.ccr-14-0983","mag":"2027483534","pmid":"https://pubmed.ncbi.nlm.nih.gov/25248381"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-14-0983","doi":"https://doi.org/10.1158/1078-0432.ccr-14-0983","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-14-0983","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089818289","display_name":"Pierre Laurent\u2010Puig","orcid":"https://orcid.org/0000-0001-8475-5459","observed_orcids":["https://orcid.org/0000-0001-8475-5459"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210102325","display_name":"H\u00f4pital Europ\u00e9en Georges-Pompidou","ror":"https://ror.org/016vx5156","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102325","https://openalex.org/I4210120235"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Laurent-Puig","raw_affiliation_strings":["1Universit\u00e9 Paris Sorbonne Cit\u00e9; INSERM UMR-S1147; Centre Universitaire des Saints-P\u00e8res, Paris, France","2Departement of Biology, H\u00f4pital Europ\u00e9en Georges Pompidou, AP-HP, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Universit\u00e9 Paris Sorbonne Cit\u00e9; INSERM UMR-S1147; Centre Universitaire des Saints-P\u00e8res, Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"2Departement of Biology, H\u00f4pital Europ\u00e9en Georges Pompidou, AP-HP, Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210102325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022272727","display_name":"Deniz Pekin","orcid":"https://orcid.org/0000-0001-6775-9685","observed_orcids":["https://orcid.org/0000-0001-6775-9685"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Deniz Pekin","raw_affiliation_strings":["1Universit\u00e9 Paris Sorbonne Cit\u00e9; INSERM UMR-S1147; Centre Universitaire des Saints-P\u00e8res, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Universit\u00e9 Paris Sorbonne Cit\u00e9; INSERM UMR-S1147; Centre Universitaire des Saints-P\u00e8res, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103351528","display_name":"Corinne Normand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Corinne Normand","raw_affiliation_strings":["1Universit\u00e9 Paris Sorbonne Cit\u00e9; INSERM UMR-S1147; Centre Universitaire des Saints-P\u00e8res, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Universit\u00e9 Paris Sorbonne Cit\u00e9; INSERM UMR-S1147; Centre Universitaire des Saints-P\u00e8res, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060204545","display_name":"Steve K. Kotsopoulos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steve K. Kotsopoulos","raw_affiliation_strings":["3RainDance Technologies, Billerica, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3RainDance Technologies, Billerica, Massachusetts","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003566457","display_name":"Philippe Nizard","orcid":"https://orcid.org/0000-0002-7880-7029","observed_orcids":["https://orcid.org/0000-0002-7880-7029"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Philippe Nizard","raw_affiliation_strings":["1Universit\u00e9 Paris Sorbonne Cit\u00e9; INSERM UMR-S1147; Centre Universitaire des Saints-P\u00e8res, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Universit\u00e9 Paris Sorbonne Cit\u00e9; INSERM UMR-S1147; Centre Universitaire des Saints-P\u00e8res, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047565328","display_name":"Karla Perez\u2010Toralla","orcid":"https://orcid.org/0000-0003-1980-3068","observed_orcids":["https://orcid.org/0000-0003-1980-3068"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Karla Perez-Toralla","raw_affiliation_strings":["1Universit\u00e9 Paris Sorbonne Cit\u00e9; INSERM UMR-S1147; Centre Universitaire des Saints-P\u00e8res, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Universit\u00e9 Paris Sorbonne Cit\u00e9; INSERM UMR-S1147; Centre Universitaire des Saints-P\u00e8res, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112270671","display_name":"R. Kevin Rowell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rachel Rowell","raw_affiliation_strings":["3RainDance Technologies, Billerica, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3RainDance Technologies, Billerica, Massachusetts","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108671846","display_name":"Jeff Olson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeff Olson","raw_affiliation_strings":["3RainDance Technologies, Billerica, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3RainDance Technologies, Billerica, Massachusetts","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040647849","display_name":"Preethi Srinivasan","orcid":"https://orcid.org/0000-0002-7137-3440","observed_orcids":["https://orcid.org/0000-0002-7137-3440"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Preethi Srinivasan","raw_affiliation_strings":["3RainDance Technologies, Billerica, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3RainDance Technologies, Billerica, Massachusetts","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064362753","display_name":"Delphine Le Corre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Delphine Le Corre","raw_affiliation_strings":["1Universit\u00e9 Paris Sorbonne Cit\u00e9; INSERM UMR-S1147; Centre Universitaire des Saints-P\u00e8res, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Universit\u00e9 Paris Sorbonne Cit\u00e9; INSERM UMR-S1147; Centre Universitaire des Saints-P\u00e8res, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110561477","display_name":"Th\u00e9vy Hor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thevy Hor","raw_affiliation_strings":["1Universit\u00e9 Paris Sorbonne Cit\u00e9; INSERM UMR-S1147; Centre Universitaire des Saints-P\u00e8res, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Universit\u00e9 Paris Sorbonne Cit\u00e9; INSERM UMR-S1147; Centre Universitaire des Saints-P\u00e8res, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074239278","display_name":"Zakaria El Harrak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Zakaria El Harrak","raw_affiliation_strings":["1Universit\u00e9 Paris Sorbonne Cit\u00e9; INSERM UMR-S1147; Centre Universitaire des Saints-P\u00e8res, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Universit\u00e9 Paris Sorbonne Cit\u00e9; INSERM UMR-S1147; Centre Universitaire des Saints-P\u00e8res, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100406125","display_name":"Xinyu Li","orcid":"https://orcid.org/0000-0003-3433-3009","observed_orcids":["https://orcid.org/0000-0003-3433-3009"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xinyu Li","raw_affiliation_strings":["3RainDance Technologies, Billerica, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3RainDance Technologies, Billerica, Massachusetts","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045067310","display_name":"Darren R. Link","orcid":"https://orcid.org/0000-0002-3203-5705","observed_orcids":["https://orcid.org/0000-0002-3203-5705"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Darren R. Link","raw_affiliation_strings":["3RainDance Technologies, Billerica, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3RainDance Technologies, Billerica, Massachusetts","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077000250","display_name":"Olivier Bouch\u00e9","orcid":"https://orcid.org/0000-0002-8284-3743","observed_orcids":["https://orcid.org/0000-0002-8284-3743"]},"institutions":[{"id":"https://openalex.org/I4210105796","display_name":"Centre Hospitalier Universitaire de Reims","ror":"https://ror.org/01jbb3w63","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210105796"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Bouch\u00e9","raw_affiliation_strings":["4Service d'h\u00e9patogastroent\u00e9rologie et de Canc\u00e9rologie Digestive, CHU de Reims, H\u00f4pital Robert-Debr\u00e9, Reims, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Service d'h\u00e9patogastroent\u00e9rologie et de Canc\u00e9rologie Digestive, CHU de Reims, H\u00f4pital Robert-Debr\u00e9, Reims, France","institution_ids":["https://openalex.org/I4210105796"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070179654","display_name":"Jean\u2010Fran\u00e7ois Emile","orcid":"https://orcid.org/0000-0002-6073-4466","observed_orcids":["https://orcid.org/0000-0002-6073-4466"]},"institutions":[{"id":"https://openalex.org/I195731000","display_name":"Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines","ror":"https://ror.org/03mkjjy25","country_code":"FR","type":"education","lineage":["https://openalex.org/I195731000","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210133069","display_name":"H\u00f4pital Ambroise-Par\u00e9","ror":"https://ror.org/03j6rvb05","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210133069"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Fran\u00e7ois Emile","raw_affiliation_strings":["5Department of Pathology, H\u00f4pital Ambroise Par\u00e9, AP-HP, Universit\u00e9 de Versailles St Quentin en Yvelines, Boulogne-Billancourt, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Pathology, H\u00f4pital Ambroise Par\u00e9, AP-HP, Universit\u00e9 de Versailles St Quentin en Yvelines, Boulogne-Billancourt, France","institution_ids":["https://openalex.org/I195731000","https://openalex.org/I4210097159","https://openalex.org/I4210133069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108447623","display_name":"Bruno Landi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210102325","display_name":"H\u00f4pital Europ\u00e9en Georges-Pompidou","ror":"https://ror.org/016vx5156","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102325","https://openalex.org/I4210120235"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bruno Landi","raw_affiliation_strings":["6Department of Oncology, H\u00f4pital Europ\u00e9en Georges Pompidou, AP-HP, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Department of Oncology, H\u00f4pital Europ\u00e9en Georges Pompidou, AP-HP, Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210102325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041492973","display_name":"Val\u00e9rie Boige","orcid":"https://orcid.org/0000-0002-7817-4663","observed_orcids":["https://orcid.org/0000-0002-7817-4663"]},"institutions":[{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Val\u00e9rie Boige","raw_affiliation_strings":["7Intitut Gustave Roussy, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Intitut Gustave Roussy, Villejuif, France","institution_ids":["https://openalex.org/I2801843802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071636756","display_name":"J. Brian Hutchison","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Brian Hutchison","raw_affiliation_strings":["3RainDance Technologies, Billerica, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3RainDance Technologies, Billerica, Massachusetts","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040195958","display_name":"Val\u00e9rie Taly","orcid":"https://orcid.org/0000-0002-3116-8602","observed_orcids":["https://orcid.org/0000-0002-3116-8602"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Valerie Taly","raw_affiliation_strings":["1Universit\u00e9 Paris Sorbonne Cit\u00e9; INSERM UMR-S1147; Centre Universitaire des Saints-P\u00e8res, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Universit\u00e9 Paris Sorbonne Cit\u00e9; INSERM UMR-S1147; Centre Universitaire des Saints-P\u00e8res, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":13.7605,"has_fulltext":false,"cited_by_count":166,"citation_normalized_percentile":{"value":0.99416849,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"21","issue":"5","first_page":"1087","last_page":"1097"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.9430000185966492},{"id":"https://openalex.org/keywords/anti-egfr-therapy","display_name":"anti-EGFR therapy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.7960000038146973},{"id":"https://openalex.org/keywords/early-progression","display_name":"early progression","score":0.5120000243186951},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.5989999771118164},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.7900000214576721},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7850000262260437},{"id":"https://openalex.org/keywords/braf-mutation","display_name":"BRAF mutation","score":0.5839999914169312},{"id":"https://openalex.org/keywords/nras-mutation","display_name":"NRAS mutation","score":0.9279999732971191}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.992111325263977},{"id":"https://openalex.org/C48126324","wikidata":"https://www.wikidata.org/wiki/Q5276136","display_name":"Digital polymerase chain reaction","level":4,"score":0.803904116153717},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7489543557167053},{"id":"https://openalex.org/C21790070","wikidata":"https://www.wikidata.org/wiki/Q18030215","display_name":"Neuroblastoma RAS viral oncogene homolog","level":5,"score":0.6841591596603394},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5330438017845154},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5034670233726501},{"id":"https://openalex.org/C2778332735","wikidata":"https://www.wikidata.org/wiki/Q417775","display_name":"Panitumumab","level":5,"score":0.4792742431163788},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4684491455554962},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4588056802749634},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44741666316986084},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4462868571281433},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3256549835205078},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.1748809516429901},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12899479269981384},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10869094729423523}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019233","descriptor_name":"Retreatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1158/1078-0432.ccr-14-0983","doi":"https://doi.org/10.1158/1078-0432.ccr-14-0983","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-14-0983","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:25248381","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25248381","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-02332843v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.archives-ouvertes.fr/hal-02332843","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1078-0432","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:inserm-02299577v1","doi":null,"is_oa":false,"landing_page_url":"https://inserm.hal.science/inserm-02299577","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Cancer Research, 2015, 21 (5), pp.1087-1097. &#x27E8;10.1158/1078-0432.CCR-14-0983&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3029061067","display_name":"Diagnostic Digital","funder_award_id":"ANR-10-NANB-0002","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G6139691929","display_name":"Nanophotonics Based Optical Trapping","funder_award_id":"ANR-10-NANO-0002","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1653677725","https://openalex.org/W1969105160","https://openalex.org/W1975493557","https://openalex.org/W1988955440","https://openalex.org/W1991518159","https://openalex.org/W1997860952","https://openalex.org/W1999250974","https://openalex.org/W2015438948","https://openalex.org/W2026125236","https://openalex.org/W2037977739","https://openalex.org/W2040928840","https://openalex.org/W2060142575","https://openalex.org/W2062109911","https://openalex.org/W2064543601","https://openalex.org/W2066356996","https://openalex.org/W2083086303","https://openalex.org/W2085633477","https://openalex.org/W2089135124","https://openalex.org/W2093798509","https://openalex.org/W2096504879","https://openalex.org/W2098223440","https://openalex.org/W2100008522","https://openalex.org/W2106787323","https://openalex.org/W2113559596","https://openalex.org/W2116731538","https://openalex.org/W2120490763","https://openalex.org/W2125229905","https://openalex.org/W2128059540","https://openalex.org/W2135672185","https://openalex.org/W2138713106","https://openalex.org/W2143670514","https://openalex.org/W2145927385","https://openalex.org/W2146437121","https://openalex.org/W2151606724","https://openalex.org/W2168213749","https://openalex.org/W2579829632","https://openalex.org/W3021124747"],"related_works":["https://openalex.org/W2625123081","https://openalex.org/W2314682804","https://openalex.org/W1555993565","https://openalex.org/W2474267498","https://openalex.org/W1815214772","https://openalex.org/W2909200349","https://openalex.org/W2031413186","https://openalex.org/W2889961516","https://openalex.org/W1513630408","https://openalex.org/W2413380883"],"abstract_inverted_index":{"PURPOSE:":[0],"KRAS":[1,100,140,147,193,204],"mutations":[2,141],"are":[3],"predictive":[4],"of":[5,18,37,59,130,153,176,191],"nonresponse":[6],"to":[7,50,74,119,127,228],"anti-EGFR":[8,94,163,234],"therapies":[9],"in":[10,142],"metastatic":[11],"colorectal":[12],"cancer":[13],"(mCRC).":[14],"However,":[15],"only":[16],"50%":[17],"nonmutated":[19],"patients":[20,60,90,133,211],"benefit":[21,232],"from":[22,233],"them.":[23],"KRAS-mutated":[24,84,121,135,154,177,215,222],"subclonal":[25],"populations":[26],"nondetectable":[27],"by":[28,93,149,157],"conventional":[29],"methods":[30],"have":[31,195],"been":[32],"suggested":[33],"as":[34,146],"the":[35,120,128,131,174],"cause":[36],"early":[38],"progression.":[39],"Molecular":[40],"analysis":[41],"technology":[42],"with":[43,61,70,107,134,162,181,187,202,212,214,220],"high":[44],"sensitivity":[45],"and":[46,66,82,105,112,184,198],"precision":[47],"is":[48],"required":[49],"test":[51],"this":[52],"hypothesis.":[53],"EXPERIMENTAL":[54],"DESIGN:":[55],"From":[56],"two":[57],"cohorts":[58],"mCRC,":[62],"136":[63],"KRAS,":[64],"NRAS,":[65],"BRAF":[67,102],"wild-type":[68,148,203],"tumors":[69,85],"sufficient":[71],"tumor":[72],"material":[73],"perform":[75],"highly":[76],"sensitive":[77],"picodroplet":[78],"digital":[79],"PCR":[80],"(dPCR)":[81],"41":[83,132],"were":[86,91,116],"selected.":[87],"All":[88],"these":[89],"treated":[92],"therapy.":[95],"dPCR":[96,137,158],"was":[97,159,179],"used":[98],"for":[99],"or":[101,226],"mutation":[103],"screening":[104],"compared":[106],"qPCR.":[108,150],"Progression-free":[109],"survival":[110,114],"(PFS)":[111],"overall":[113],"(OS)":[115],"analyzed":[117],"according":[118],"allele":[122,155,178,194],"fraction.":[123],"RESULTS:":[124],"In":[125,170],"addition":[126],"confirmation":[129],"tumors,":[136],"also":[138],"identified":[139],"22":[143],"samples":[144],"considered":[145],"The":[151],"fraction":[152,175,224],"quantified":[156],"inversely":[160],"correlated":[161],"therapy":[164],"response":[165],"rate":[166],"(P":[167],"<":[168],"0.001).":[169],"a":[171,221,231],"Cox":[172],"model,":[173],"associated":[180],"worse":[182],"PFS":[183,197],"OS.":[185],"Patients":[186],"less":[188],"than":[189,200],"1%":[190],"mutant":[192],"similar":[196],"OS":[199],"those":[201,219],"tumors.":[205],"CONCLUSIONS:":[206],"This":[207],"study":[208],"suggests":[209],"that":[210],"mCRC":[213],"subclones":[216,223],"(at":[217],"least":[218],"lower":[225],"equal":[227],"1%)":[229],"had":[230],"therapies.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":26},{"year":2016,"cited_by_count":32},{"year":2015,"cited_by_count":24},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
