{"id":"https://openalex.org/W2027436635","doi":"https://doi.org/10.5588/ijtld.10.0485","title":"Distinguishing tuberculosis from Mycobacterium avium complex disease using an interferon-gamma release assay","display_name":"Distinguishing tuberculosis from Mycobacterium avium complex disease using an interferon-gamma release assay","publication_year":2011,"publication_date":"2011-04-11","ids":{"openalex":"https://openalex.org/W2027436635","doi":"https://doi.org/10.5588/ijtld.10.0485","mag":"2027436635","pmid":"https://pubmed.ncbi.nlm.nih.gov/21756514"},"language":"en","primary_location":{"id":"doi:10.5588/ijtld.10.0485","doi":"https://doi.org/10.5588/ijtld.10.0485","is_oa":false,"landing_page_url":"https://doi.org/10.5588/ijtld.10.0485","pdf_url":null,"source":{"id":"https://openalex.org/S124285728","display_name":"The International Journal of Tuberculosis and Lung Disease","issn_l":"1027-3719","issn":["1027-3719","1815-7920","1815-8439"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319960","host_organization_name":"International Union Against Tuberculosis and Lung Disease","host_organization_lineage":["https://openalex.org/P4310319960"],"host_organization_lineage_names":["International Union Against Tuberculosis and Lung Disease"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Tuberculosis and Lung Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5153112516","display_name":"S. W. Ra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]},{"id":"https://openalex.org/I4210136447","display_name":"Ulsan University Hospital","ror":"https://ror.org/03sab2a45","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210136447"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"S. W. Ra","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea","institution_ids":["https://openalex.org/I40542001","https://openalex.org/I4210136447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091548233","display_name":"Jianxin Lyu","orcid":"https://orcid.org/0000-0003-2343-1666","observed_orcids":["https://orcid.org/0000-0003-2343-1666","https://orcid.org/0000-0003-4505-4507","https://orcid.org/0000-0001-9892-6802"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Lyu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103455676","display_name":"C-M. Choi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C-M. Choi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111417293","display_name":"Y-M. Oh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y-M. Oh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068228525","display_name":"Shin\u2010Da Lee","orcid":"https://orcid.org/0000-0002-8393-8349","observed_orcids":["https://orcid.org/0000-0002-8393-8349"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S-D. Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027954533","display_name":"Whitney Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. S. Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013055332","display_name":"D. S. Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. S. Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5074343604","display_name":"Tae Sun Shim","orcid":"https://orcid.org/0000-0001-6653-816X","observed_orcids":["https://orcid.org/0000-0001-6653-816X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. S. Shim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5122,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.81403332,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"15","issue":"5","first_page":"635","last_page":"640"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.7426999807357788,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.7426999807357788,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.25220000743865967,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/mycobacterium-avium-complex","display_name":"Mycobacterium avium complex","score":0.9459999799728394},{"id":"https://openalex.org/keywords/interferon-gamma-release-assay","display_name":"interferon-gamma release assay","score":0.9190000295639038},{"id":"https://openalex.org/keywords/quantiferon-tb-gold","display_name":"QuantiFERON-TB Gold","score":0.9950000047683716},{"id":"https://openalex.org/keywords/quantiferon-tb","display_name":"QuantiFERON-TB","score":0.9160000085830688},{"id":"https://openalex.org/keywords/tuberculin-skin-test","display_name":"tuberculin skin test","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nontuberculous-mycobacterial-lung-disease","display_name":"nontuberculous mycobacterial lung disease","score":0.8429999947547913},{"id":"https://openalex.org/keywords/latent-tuberculosis-infection","display_name":"latent tuberculosis infection","score":0.8669999837875366},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.8259999752044678}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9330353736877441},{"id":"https://openalex.org/C2776763545","wikidata":"https://www.wikidata.org/wiki/Q2893466","display_name":"QuantiFERON","level":5,"score":0.7919380068778992},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.7843931913375854},{"id":"https://openalex.org/C2776247216","wikidata":"https://www.wikidata.org/wiki/Q29505","display_name":"Tuberculin","level":3,"score":0.7458099126815796},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.6971639394760132},{"id":"https://openalex.org/C2780277586","wikidata":"https://www.wikidata.org/wiki/Q6046438","display_name":"Interferon gamma release assay","level":5,"score":0.6592787504196167},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5090770125389099},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5073572993278503},{"id":"https://openalex.org/C2780639635","wikidata":"https://www.wikidata.org/wiki/Q4888238","display_name":"Tuberculosis diagnosis","level":4,"score":0.4966939091682434},{"id":"https://openalex.org/C2779806340","wikidata":"https://www.wikidata.org/wiki/Q4254929","display_name":"Latent tuberculosis","level":4,"score":0.47865521907806396},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.4691285789012909},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41445720195770264},{"id":"https://openalex.org/C3020380090","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon \u03b3","level":4,"score":0.41261428594589233},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15235069394111633},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.14266231656074524}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014374","descriptor_name":"Tuberculin Test","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015269","descriptor_name":"Mycobacterium avium Complex","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015269","descriptor_name":"Mycobacterium avium Complex","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D015270","descriptor_name":"Mycobacterium avium-intracellulare Infection","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015270","descriptor_name":"Mycobacterium avium-intracellulare Infection","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.5588/ijtld.10.0485","doi":"https://doi.org/10.5588/ijtld.10.0485","is_oa":false,"landing_page_url":"https://doi.org/10.5588/ijtld.10.0485","pdf_url":null,"source":{"id":"https://openalex.org/S124285728","display_name":"The International Journal of Tuberculosis and Lung Disease","issn_l":"1027-3719","issn":["1027-3719","1815-7920","1815-8439"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319960","host_organization_name":"International Union Against Tuberculosis and Lung Disease","host_organization_lineage":["https://openalex.org/P4310319960"],"host_organization_lineage_names":["International Union Against Tuberculosis and Lung Disease"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Tuberculosis and Lung Disease","raw_type":"journal-article"},{"id":"pmid:21756514","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21756514","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2125086684","https://openalex.org/W2136938785","https://openalex.org/W4778613","https://openalex.org/W2154239844","https://openalex.org/W1598734066","https://openalex.org/W1912449410","https://openalex.org/W2021841518","https://openalex.org/W7095704051","https://openalex.org/W2272498267","https://openalex.org/W3034155227"],"abstract_inverted_index":{"SETTING:":[0],"The":[1,113,142],"QuantiFERON-TB":[2,31],"Gold":[3],"(QFT-G)":[4],"test":[5,72],"can":[6],"be":[7],"used":[8,47],"to":[9,74],"distinguish":[10],"between":[11,167],"tuberculosis":[12],"(TB)":[13],"and":[14,66,68,106,122,132,136,138,150,162,170],"non-tuberculous":[15],"mycobacterial":[16],"disease,":[17],"but":[18],"a":[19,27,39,49,178],"high":[20],"background":[21],"TB":[22,76,86,105,121,169,175],"infection":[23,176],"rate":[24],"may":[25],"pose":[26],"problem.":[28],"Although":[29],"the":[30,34,55,69,92,127,160],"(QFT)":[32],"test,":[33,37],"first-generation":[35],"QFT-G":[36,65,135],"employs":[38],"non-specific":[40],"PPD":[41],"antigen,":[42],"avium":[43,79],"sensitin":[44],"is":[45],"also":[46],"as":[48],"stimulating":[50],"antigen.":[51],"OBJECTIVE:":[52],"To":[53],"evaluate":[54],"utility":[56],"of":[57,95,120,124,146],"these":[58,96],"two":[59],"interferon":[60],"gamma":[61],"release":[62],"assays":[63],"(IGRAs),":[64],"QFT,":[67],"tuberculin":[70],"skin":[71],"(TST),":[73],"differentiate":[75],"from":[77],"Mycobacterium":[78],"complex":[80],"(MAC)":[81],"disease":[82,172],"in":[83,99,118,152,177],"an":[84],"intermediate":[85],"burden":[87],"country.":[88],"METHODS:":[89],"We":[90],"compared":[91],"diagnostic":[93],"performance":[94],"three":[97,143],"tests":[98,144],"38":[100],"prospectively":[101],"enrolled":[102],"patients":[103],"with":[104,108],"40":[107],"MAC":[109,125,171],"lung":[110],"disease.":[111],"RESULTS:":[112],"TST":[114,161],"yielded":[115],"positive":[116],"results":[117],"70.6%":[119],"47.5%":[123],"patients;":[126],"proportions":[128],"were":[129,145],"respectively":[130],"89.5%":[131],"34.3%":[133],"for":[134,140],"86.8%":[137],"35.3%":[139],"QFT.":[141],"similar":[147],"accuracy,":[148],"sensitivity":[149],"specificity":[151],"diagnosing":[153],"TB.":[154],"CONCLUSION:":[155],"Our":[156],"findings":[157],"indicate":[158],"that":[159],"IGRAs":[163],"could":[164],"not":[165],"discriminate":[166],"active":[168],"or":[173],"latent":[174],"TB-endemic":[179],"area.":[180]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
