{"id":"https://openalex.org/W202741840","doi":null,"title":"Human relaxin. In vitro response of human and pig myometrium.","display_name":"Human relaxin. In vitro response of human and pig myometrium.","publication_year":1991,"publication_date":"1991-09-01","ids":{"openalex":"https://openalex.org/W202741840","mag":"202741840","pmid":"https://pubmed.ncbi.nlm.nih.gov/1774723"},"language":"en","primary_location":{"id":"pmid:1774723","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1774723","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of reproductive medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007232294","display_name":"Alastair H. MacLennan","orcid":"https://orcid.org/0000-0002-4464-5236","observed_orcids":["https://orcid.org/0000-0002-4464-5236"]},"institutions":[{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"A H MacLennan","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, University of Adelaide, South Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, University of Adelaide, South Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111862200","display_name":"P. A. Grant","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Grant","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7707,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.81413713,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"36","issue":"9","first_page":"630","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12715","display_name":"Pregnancy-related medical research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12715","display_name":"Pregnancy-related medical research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11290","display_name":"Preterm Birth and Chorioamnionitis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/relaxin","display_name":"relaxin","score":0.8230000138282776},{"id":"https://openalex.org/keywords/myometrium","display_name":"myometrium","score":0.7269999980926514},{"id":"https://openalex.org/keywords/uterine-contractility","display_name":"uterine contractility","score":0.7870000004768372},{"id":"https://openalex.org/keywords/species-specificity","display_name":"species specificity","score":0.7129999995231628},{"id":"https://openalex.org/keywords/oxytocin","display_name":"oxytocin","score":0.6890000104904175},{"id":"https://openalex.org/keywords/prostaglandin-f2alpha","display_name":"prostaglandin F2alpha","score":0.9340000152587891},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.9639999866485596},{"id":"https://openalex.org/keywords/estrogen-priming","display_name":"estrogen priming","score":0.9380000233650208}],"concepts":[{"id":"https://openalex.org/C2777121736","wikidata":"https://www.wikidata.org/wiki/Q24773888","display_name":"Relaxin","level":3,"score":0.9815662503242493},{"id":"https://openalex.org/C2778164554","wikidata":"https://www.wikidata.org/wiki/Q2562472","display_name":"Myometrium","level":3,"score":0.9285163879394531},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7430012226104736},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7282444834709167},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.5681715607643127},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5266656279563904},{"id":"https://openalex.org/C2776176026","wikidata":"https://www.wikidata.org/wiki/Q169960","display_name":"Oxytocin","level":2,"score":0.4978163242340088},{"id":"https://openalex.org/C2779066055","wikidata":"https://www.wikidata.org/wiki/Q9612","display_name":"Uterus","level":2,"score":0.4671840965747833},{"id":"https://openalex.org/C2776766599","wikidata":"https://www.wikidata.org/wiki/Q1751296","display_name":"Uterine contraction","level":3,"score":0.45996031165122986},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.41904908418655396},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.1628226935863495}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009215","descriptor_name":"Myometrium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010121","descriptor_name":"Oxytocin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012065","descriptor_name":"Relaxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014590","descriptor_name":"Uterine Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015237","descriptor_name":"Dinoprost","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1774723","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1774723","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of reproductive medicine","raw_type":"Journal Article"},{"id":"mag:202741840","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1774723","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2416220565","https://openalex.org/W2427957541","https://openalex.org/W2418551377","https://openalex.org/W18081750","https://openalex.org/W2022651656","https://openalex.org/W1497807858","https://openalex.org/W2119231737","https://openalex.org/W2095512730","https://openalex.org/W2125200790","https://openalex.org/W2474870874"],"abstract_inverted_index":{"Human":[0,187],"myometrial":[1,20,33,169,200],"strips":[2,21],"were":[3,24,98],"excised":[4],"at":[5,38,59,117],"hysterectomy":[6],"and":[7,10,91,164],"cesarean":[8],"section":[9],"allowed":[11],"to":[12,62,120,156],"contract":[13],"spontaneously":[14],"in":[15,35,76,89,94,196,202],"a":[16,39,86,193],"water":[17],"bath.":[18],"Porcine":[19],"from":[22],"midpregnancy":[23],"also":[25],"collected.":[26],"Recombinant":[27],"human":[28,45,57,68,71,78,115,143,149,152,165],"relaxin":[29,46,69,106,126,141,150,166,188],"completely":[30],"inhibited":[31],"spontaneous":[32,130],"activity":[34,170,201],"the":[36,123,138,157,173,180,184,197,203],"pig":[37],"concentration":[40,124],"of":[41,50,67,125,140,148,161,199],"0.6":[42],"micrograms/mL,":[43],"but":[44,182],"had":[47,107,128],"much":[48],"less":[49],"an":[51],"effect":[52,55,66,81,110,147],"or":[53,102,114],"no":[54,108],"on":[56,70,111,142,151,167],"myometrium":[58,72,116,153],"concentrations":[60],"up":[61,119],"7.5":[63],"micrograms/mL.":[64],"Any":[65],"was":[73,82],"seen":[74],"only":[75],"estrogen-primed":[77],"tissues;":[79],"that":[80,127,172],"never":[83],"greater":[84],"than":[85],"5%":[87],"reduction":[88,93],"amplitude":[90],"50%":[92],"frequency.":[95],"When":[96],"contractions":[97],"stimulated":[99],"with":[100,133,179,183],"oxytocin":[101],"prostaglandin":[103],"F2":[104],"alpha,":[105],"inhibitory":[109,159],"either":[112],"porcine":[113,163,168],"doses":[118],"eight":[121],"times":[122],"attenuated":[129],"contractions.":[131],"Pretreatment":[132],"progesterone":[134],"did":[135],"not":[136,177,191],"enhance":[137],"action":[139,160],"myometrium.":[144],"The":[145],"limited":[146],"as":[154],"compared":[155],"marked":[158],"both":[162],"suggests":[171],"species":[174],"specificity":[175],"does":[176],"lie":[178],"relaxins":[181],"target":[185],"tissues.":[186],"H2":[189],"might":[190],"play":[192],"major":[194],"role":[195],"control":[198],"human.":[204]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}