{"id":"https://openalex.org/W2027240807","doi":"https://doi.org/10.1038/sj.cgt.7700475","title":"Immunotherapy for murine K1735 melanoma: Combinatorial use of recombinant adenovirus expressing CD40L and other immunomodulators","display_name":"Immunotherapy for murine K1735 melanoma: Combinatorial use of recombinant adenovirus expressing CD40L and other immunomodulators","publication_year":2002,"publication_date":"2002-06-14","ids":{"openalex":"https://openalex.org/W2027240807","doi":"https://doi.org/10.1038/sj.cgt.7700475","mag":"2027240807","pmid":"https://pubmed.ncbi.nlm.nih.gov/12082460"},"language":"en","primary_location":{"id":"doi:10.1038/sj.cgt.7700475","doi":"https://doi.org/10.1038/sj.cgt.7700475","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.cgt.7700475","pdf_url":null,"source":{"id":"https://openalex.org/S157451995","display_name":"Cancer Gene Therapy","issn_l":"0929-1903","issn":["0929-1903","1476-5500"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Gene Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037303851","display_name":"Isabelle S. Peter","orcid":"https://orcid.org/0000-0003-3685-3147","observed_orcids":["https://orcid.org/0000-0003-3685-3147"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Isabelle Peter","raw_affiliation_strings":["Institute of Molecular Biology, University of Z\u00fcrich, Winterthurerstrasse 190, CH-8057 Z\u00fcrich, Switzerland. hemmi@molbio.unizh.ch","Institute of Molecular Biology, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, University of Z\u00fcrich, Winterthurerstrasse 190, CH-8057 Z\u00fcrich, Switzerland. hemmi@molbio.unizh.ch","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Institute of Molecular Biology, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110423397","display_name":"Michael Nawrath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Michael Nawrath","raw_affiliation_strings":["Institute of Medical Virology, University of Z\u00fcrich, Gloriastrasse 30, Z\u00fcrich, CH-8028, Switzerland","Institute of Medical Virology, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Virology, University of Z\u00fcrich, Gloriastrasse 30, Z\u00fcrich, CH-8028, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Institute of Medical Virology, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047787126","display_name":"Jivko A. Kamarashev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jivko Kamarashev","raw_affiliation_strings":["Department of Dermatology, University Hospital, Gloriastrasse 31, Z\u00fcrich, CH-8091, Switzerland","Department of Dermatology, University Hospital Zurich Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University Hospital, Gloriastrasse 31, Z\u00fcrich, CH-8091, Switzerland","institution_ids":["https://openalex.org/I4210100468"]},{"raw_affiliation_string":"Department of Dermatology, University Hospital Zurich Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031026159","display_name":"Bernhard Odermatt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Bernhard Odermatt","raw_affiliation_strings":["Department of Experimental Immunology, University Hospital, Gloriastrasse 31, Z\u00fcrich, CH-8091, Switzerland","Department of Experimental Immunology, University Hospital, Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Immunology, University Hospital, Gloriastrasse 31, Z\u00fcrich, CH-8091, Switzerland","institution_ids":["https://openalex.org/I4210100468"]},{"raw_affiliation_string":"Department of Experimental Immunology, University Hospital, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051193418","display_name":"Anna Mezzacasa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Anna Mezzacasa","raw_affiliation_strings":["Institute of Molecular Biology, University of Z\u00fcrich, Winterthurerstrasse 190, Z\u00fcrich, CH-8057, Switzerland","Institute of Molecular Biology, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, University of Z\u00fcrich, Winterthurerstrasse 190, Z\u00fcrich, CH-8057, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Institute of Molecular Biology, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028387254","display_name":"Silvio Hemmi","orcid":"https://orcid.org/0000-0002-4238-2217","observed_orcids":["https://orcid.org/0000-0002-4238-2217"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Silvio Hemmi","raw_affiliation_strings":["Institute of Molecular Biology, University of Z\u00fcrich, Winterthurerstrasse 190, Z\u00fcrich, CH-8057, Switzerland","Institute of Molecular Biology, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, University of Z\u00fcrich, Winterthurerstrasse 190, Z\u00fcrich, CH-8057, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Institute of Molecular Biology, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028387254"],"corresponding_institution_ids":["https://openalex.org/I202697423"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":0.7668,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.69205845,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"9","issue":"7","first_page":"597","last_page":"605"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recombinant-adenovirus","display_name":"recombinant adenovirus","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cd40-ligand","display_name":"CD40 ligand","score":0.9860000014305115},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.8920000195503235},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.996999979019165},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7099999785423279},{"id":"https://openalex.org/keywords/cancer-vaccination","display_name":"cancer vaccination","score":0.6620000004768372},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.6039999723434448},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9480000138282776},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.6909999847412109},{"id":"https://openalex.org/keywords/survival-time","display_name":"survival time","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.7402414679527283},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7031934857368469},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6388214230537415},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.6237359046936035},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5764225125312805},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.526906430721283},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.5227891802787781},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.49604305624961853},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49245819449424744},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4505208730697632},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.25807738304138184},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.18269577622413635},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06198325753211975},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.04992839694023132}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019444","descriptor_name":"Vaccines, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023201","descriptor_name":"CD40 Ligand","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/sj.cgt.7700475","doi":"https://doi.org/10.1038/sj.cgt.7700475","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.cgt.7700475","pdf_url":null,"source":{"id":"https://openalex.org/S157451995","display_name":"Cancer Gene Therapy","issn_l":"0929-1903","issn":["0929-1903","1476-5500"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Gene Therapy","raw_type":"journal-article"},{"id":"pmid:12082460","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12082460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer gene therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.550000011920929}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320318087","display_name":"Kanton Z\u00fcrich","ror":"https://ror.org/00cdteb39"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1561485846","https://openalex.org/W1583796784","https://openalex.org/W1592760947","https://openalex.org/W1593640213","https://openalex.org/W1661544713","https://openalex.org/W1876800744","https://openalex.org/W1963576366","https://openalex.org/W1970114554","https://openalex.org/W1971090459","https://openalex.org/W1978416272","https://openalex.org/W1990668606","https://openalex.org/W1991148746","https://openalex.org/W2000428575","https://openalex.org/W2002143278","https://openalex.org/W2004281948","https://openalex.org/W2010050763","https://openalex.org/W2019546595","https://openalex.org/W2026642783","https://openalex.org/W2050862468","https://openalex.org/W2058661677","https://openalex.org/W2059557084","https://openalex.org/W2063495860","https://openalex.org/W2068776651","https://openalex.org/W2092312916","https://openalex.org/W2095516763","https://openalex.org/W2109913659","https://openalex.org/W2114458218","https://openalex.org/W2149641471","https://openalex.org/W2155229523","https://openalex.org/W2322389503","https://openalex.org/W2334454364","https://openalex.org/W2345971816"],"related_works":["https://openalex.org/W2606213698","https://openalex.org/W2053248202","https://openalex.org/W2002143278","https://openalex.org/W2112148623","https://openalex.org/W2383342274","https://openalex.org/W2348801359","https://openalex.org/W2898339120","https://openalex.org/W2359923451","https://openalex.org/W3210867078","https://openalex.org/W2315356527"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}