{"id":"https://openalex.org/W2027176366","doi":"https://doi.org/10.1371/journal.pone.0099685","title":"Higher Bone Turnover Is Related to Spinal Radiographic Damage and Low Bone Mineral Density in Ankylosing Spondylitis Patients with Active Disease: A Cross-Sectional Analysis","display_name":"Higher Bone Turnover Is Related to Spinal Radiographic Damage and Low Bone Mineral Density in Ankylosing Spondylitis Patients with Active Disease: A Cross-Sectional Analysis","publication_year":2014,"publication_date":"2014-06-11","ids":{"openalex":"https://openalex.org/W2027176366","doi":"https://doi.org/10.1371/journal.pone.0099685","mag":"2027176366","pmid":"https://pubmed.ncbi.nlm.nih.gov/24918782","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4053372"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0099685","doi":"https://doi.org/10.1371/journal.pone.0099685","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0099685","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0099685&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0099685&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046964429","display_name":"Suzanne Arends","orcid":"https://orcid.org/0000-0002-4422-7640","observed_orcids":["https://orcid.org/0000-0002-4422-7640"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]},{"id":"https://openalex.org/I2802652803","display_name":"Medisch Centrum Leeuwarden","ror":"https://ror.org/0283nw634","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802652803","https://openalex.org/I4405259012"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Suzanne Arends","raw_affiliation_strings":["Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Rheumatology, Medical Center Leeuwarden, Leeuwarden, The Netherlands","Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","Rheumatology, Medical Center Leeuwarden, Leeuwarden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Rheumatology, Medical Center Leeuwarden, Leeuwarden, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384","https://openalex.org/I2802652803"]},{"raw_affiliation_string":"Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"Rheumatology, Medical Center Leeuwarden, Leeuwarden, The Netherlands","institution_ids":["https://openalex.org/I2802652803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052491189","display_name":"Anneke J. P. L. Spoorenberg","orcid":"https://orcid.org/0000-0001-8850-8578","observed_orcids":["https://orcid.org/0000-0001-8850-8578"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Anneke Spoorenberg","raw_affiliation_strings":["Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057227498","display_name":"M. Efd\u00e9","orcid":"https://orcid.org/0000-0002-0854-4374","observed_orcids":["https://orcid.org/0000-0002-0854-4374"]},"institutions":[{"id":"https://openalex.org/I2802652803","display_name":"Medisch Centrum Leeuwarden","ror":"https://ror.org/0283nw634","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802652803","https://openalex.org/I4405259012"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Monique Efde","raw_affiliation_strings":["Rheumatology, Medical Center Leeuwarden, Leeuwarden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology, Medical Center Leeuwarden, Leeuwarden, The Netherlands","institution_ids":["https://openalex.org/I2802652803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032738880","display_name":"Reinhard Bos","orcid":"https://orcid.org/0000-0003-1094-5596","observed_orcids":["https://orcid.org/0000-0003-1094-5596"]},"institutions":[{"id":"https://openalex.org/I2802652803","display_name":"Medisch Centrum Leeuwarden","ror":"https://ror.org/0283nw634","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802652803","https://openalex.org/I4405259012"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Reinhard Bos","raw_affiliation_strings":["Rheumatology, Medical Center Leeuwarden, Leeuwarden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology, Medical Center Leeuwarden, Leeuwarden, The Netherlands","institution_ids":["https://openalex.org/I2802652803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056017307","display_name":"M. K. Leijsma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Martha K. Leijsma","raw_affiliation_strings":["Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065705574","display_name":"Hendrika Bootsma","orcid":"https://orcid.org/0000-0001-7126-9785","observed_orcids":["https://orcid.org/0000-0001-7126-9785"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hendrika Bootsma","raw_affiliation_strings":["Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045583556","display_name":"Nic J.G.M. Veeger","orcid":"https://orcid.org/0000-0002-1492-7937","observed_orcids":["https://orcid.org/0000-0002-1492-7937"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Nic J. G. M. Veeger","raw_affiliation_strings":["Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005994370","display_name":"Elisabeth Brouwer","orcid":"https://orcid.org/0000-0002-5652-4423","observed_orcids":["https://orcid.org/0000-0002-5652-4423"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Elisabeth Brouwer","raw_affiliation_strings":["Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028106660","display_name":"Eveline van der Veer","orcid":"https://orcid.org/0000-0002-4825-9981","observed_orcids":["https://orcid.org/0000-0002-4825-9981"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Eveline van der Veer","raw_affiliation_strings":["Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5046964429"],"corresponding_institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384","https://openalex.org/I2802652803"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.5002,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.87324985,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"9","issue":"6","first_page":"e99685","last_page":"e99685"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11030","display_name":"Scoliosis diagnosis and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ankylosing-spondylitis","display_name":"ankylosing spondylitis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/bone-turnover-markers","display_name":"bone turnover markers","score":0.9869999885559082},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.7950000166893005},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/c-terminal-telopeptide-of-type-i-collagen","display_name":"C-terminal telopeptide of type I collagen","score":0.7379999756813049},{"id":"https://openalex.org/keywords/bone-specific-alkaline-phosphatase","display_name":"bone-specific alkaline phosphatase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/osteopenia","display_name":"osteopenia","score":0.8360000252723694},{"id":"https://openalex.org/keywords/syndesmophytes","display_name":"syndesmophytes","score":0.8450000286102295},{"id":"https://openalex.org/keywords/active-disease","display_name":"active disease","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9187920093536377},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.7595455050468445},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.6921619772911072},{"id":"https://openalex.org/C2777402515","wikidata":"https://www.wikidata.org/wiki/Q52849","display_name":"Ankylosing spondylitis","level":2,"score":0.5757037997245789},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5399596095085144},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.5350858569145203},{"id":"https://openalex.org/C2775854910","wikidata":"https://www.wikidata.org/wiki/Q4844892","display_name":"Femoral neck","level":3,"score":0.495705246925354},{"id":"https://openalex.org/C64348721","wikidata":"https://www.wikidata.org/wiki/Q7247456","display_name":"Procollagen peptidase","level":2,"score":0.47000035643577576},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.40607213973999023},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.37399083375930786},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.34966349601745605}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008159","descriptor_name":"Lumbar Vertebrae","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008159","descriptor_name":"Lumbar Vertebrae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011347","descriptor_name":"Procollagen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011832","descriptor_name":"Radiation Injuries","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011832","descriptor_name":"Radiation Injuries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013167","descriptor_name":"Spondylitis, Ankylosing","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D013167","descriptor_name":"Spondylitis, Ankylosing","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D024042","descriptor_name":"Collagen Type I","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0099685","doi":"https://doi.org/10.1371/journal.pone.0099685","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0099685","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0099685&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmid:24918782","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24918782","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4053372","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4053372/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:pure.rug.nl:openaire/876dce68-9d70-4422-9bfa-3531cd9bad29","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/876dce68-9d70-4422-9bfa-3531cd9bad29","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arends, S, Spoorenberg, A, Efde, M, Bos, R, Leijsma, M K, Bootsma, H, Veeger, N J G M, Brouwer, E & van der Veer, E 2014, 'Higher bone turnover is related to spinal radiographic damage and low bone mineral density in ankylosing spondylitis patients with active disease : a cross-sectional analysis', PLoS ONE, vol. 9, no. 6, e0099685. https://doi.org/10.1371/journal.pone.0099685","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.781.4170","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.781.4170","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/f2/f8/pone.0099685.PMC4053372.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:6fe27c016d314519b962e74d8f43565b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6fe27c016d314519b962e74d8f43565b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 6, p e99685 (2014)","raw_type":"article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/876dce68-9d70-4422-9bfa-3531cd9bad29","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/876dce68-9d70-4422-9bfa-3531cd9bad29","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, 9(6):e0099685. PUBLIC LIBRARY SCIENCE","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0099685","doi":"https://doi.org/10.1371/journal.pone.0099685","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0099685","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0099685&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2027176366.pdf","grobid_xml":"https://content.openalex.org/works/W2027176366.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W17997704","https://openalex.org/W179140423","https://openalex.org/W1621490964","https://openalex.org/W1881321933","https://openalex.org/W1963988339","https://openalex.org/W1965690582","https://openalex.org/W1966756689","https://openalex.org/W1969914594","https://openalex.org/W1990748933","https://openalex.org/W2005779589","https://openalex.org/W2021009204","https://openalex.org/W2031388203","https://openalex.org/W2035645263","https://openalex.org/W2040326818","https://openalex.org/W2045283500","https://openalex.org/W2054797852","https://openalex.org/W2056097377","https://openalex.org/W2077615804","https://openalex.org/W2091085064","https://openalex.org/W2093478907","https://openalex.org/W2099145274","https://openalex.org/W2100137363","https://openalex.org/W2100496294","https://openalex.org/W2103778140","https://openalex.org/W2103874459","https://openalex.org/W2105602722","https://openalex.org/W2110086427","https://openalex.org/W2113148706","https://openalex.org/W2140309296","https://openalex.org/W2153830154","https://openalex.org/W2157881774","https://openalex.org/W2162319272","https://openalex.org/W2163493960","https://openalex.org/W2168887963","https://openalex.org/W2341897292","https://openalex.org/W3135506742","https://openalex.org/W3150777031","https://openalex.org/W4210974969"],"related_works":["https://openalex.org/W2104232642","https://openalex.org/W2405310971","https://openalex.org/W2955419479","https://openalex.org/W2153830154","https://openalex.org/W1963988339","https://openalex.org/W1983812102","https://openalex.org/W2968972737","https://openalex.org/W2017288888","https://openalex.org/W7097617859","https://openalex.org/W2087843698"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Ankylosing":[1],"spondylitis":[2],"(AS)":[3],"is":[4],"characterized":[5],"by":[6,98],"excessive":[7],"bone":[8,11,21,30,57,65,93],"formation":[9,66],"and":[10,29,64,89,165,183,193,221,241,259,270],"loss.":[12],"Our":[13],"aim":[14],"was":[15,121,132,285],"to":[16,81,103,228,271,295],"investigate":[17],"the":[18,46,84,145,229,279],"association":[19],"of":[20,45,56,60,112,116,125,231,268,281,300],"turnover":[22],"markers":[23,55],"(BTM)":[24],"with":[25,37,148,177,199,209,245,257,278,288],"spinal":[26],"radiographic":[27,128],"damage":[28],"mineral":[31],"density":[32],"(BMD)":[33],"in":[34,243,254,310],"AS":[35,43,49,106,255],"patients":[36,147,187,208,256],"active":[38,258],"disease.":[39],"METHODS:":[40],"201":[41],"consecutive":[42],"outpatients":[44],"Groningen":[47],"Leeuwarden":[48],"(GLAS)":[50],"cohort":[51],"were":[52,76,79,96],"included.":[53],"Serum":[54],"resorption":[58],"(C-telopeptides":[59],"type-I":[61,68],"collagen,":[62],"sCTX)":[63],"(procollagen":[67],"N-terminal":[69],"peptide,":[70],"PINP;":[71],"bone-specific":[72],"alkaline":[73],"phosphatase,":[74],"BALP)":[75],"measured.":[77],"Z-scores":[78,185],"used":[80],"correct":[82],"for":[83,217,307],"normal":[85,210],"influence":[86],"that":[87,264,297],"age":[88],"gender":[90],"have":[91],"on":[92],"turnover.":[94],"Radiographs":[95],"scored":[97],"two":[99,119],"independent":[100],"readers":[101],"according":[102],"modified":[104],"Stoke":[105],"Spinal":[107],"Score":[108],"(mSASSS).":[109],"The":[110],"presence":[111,230,280],"complete":[113,149,156,282],"bridging":[114,178,189,237,242],"(ankylosis":[115],"at":[117],"least":[118],"vertebrae)":[120],"considered":[122],"as":[123,134,304],"measure":[124],"more":[126],"advanced":[127],"damage.":[129],"Low":[130],"BMD":[131,139,201,211,233,247],"defined":[133],"lumbar":[135],"spine":[136],"and/or":[137],"hip":[138],"Z-score":[140,206,224],"\u2264":[141],"-1.":[142],"RESULTS:":[143],"Of":[144],"151":[146],"data,":[150],"52":[151],"(34%)":[152],"had":[153,160,168,173,179,202],"\u2265":[154,161],"1":[155,162],"bridge,":[157],"49":[158],"(33%)":[159,167],"syndesmophyte":[163],"(non-bridging),":[164],"50":[166],"no":[169],"syndesmophytes.":[170],"66":[171],"(44%)":[172],"low":[174,200,232,246,289],"BMD.":[175,290],"Patients":[176,198],"significantly":[180,203,226],"higher":[181,204,265],"sCTX":[182,205,223,284,301],"PINP":[184],"than":[186,207],"without":[188],"(0.43":[190],"vs.":[191,195,213],"-0.55":[192],"0.55":[194],"0.04,":[196],"respectively).":[197],"(-0.08":[212],"-0.61).":[214],"After":[215],"correcting":[216],"gender,":[218],"symptom":[219],"duration,":[220],"CRP,":[222],"remained":[225],"related":[227],"alone":[234,238],"(OR:":[235,239,248],"1.60),":[236],"1.82),":[240],"combination":[244],"2.26).":[249],"CONCLUSIONS:":[250],"This":[251],"cross-sectional":[252],"study":[253],"relatively":[260],"long-standing":[261],"disease":[262],"demonstrated":[263],"serum":[266,298],"levels":[267,299],"sCTX,":[269],"a":[272],"lesser":[273],"extent":[274],"PINP,":[275],"are":[276,293],"associated":[277,287],"bridging.":[283],"also":[286],"Longitudinal":[291],"studies":[292],"needed":[294],"confirm":[296],"can":[302],"serve":[303],"objective":[305],"marker":[306],"bone-related":[308],"outcome":[309],"AS.":[311]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}