{"id":"https://openalex.org/W2027163003","doi":"https://doi.org/10.1038/sj.onc.1203694","title":"Activation of the insulin-like growth factor II transcription by aflatoxin B1 induced p53 mutant 249 is caused by activation of transcription complexes; implications for a gain-of-function during the formation of hepatocellular carcinoma","display_name":"Activation of the insulin-like growth factor II transcription by aflatoxin B1 induced p53 mutant 249 is caused by activation of transcription complexes; implications for a gain-of-function during the formation of hepatocellular carcinoma","publication_year":2000,"publication_date":"2000-07-28","ids":{"openalex":"https://openalex.org/W2027163003","doi":"https://doi.org/10.1038/sj.onc.1203694","mag":"2027163003","pmid":"https://pubmed.ncbi.nlm.nih.gov/10949925"},"language":"en","primary_location":{"id":"doi:10.1038/sj.onc.1203694","doi":"https://doi.org/10.1038/sj.onc.1203694","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.onc.1203694","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1038/sj.onc.1203694","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050102857","display_name":"Young Ik Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young Ik Lee","raw_affiliation_strings":["Bioscience Research Division, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon","Bioscience Research Division, Liver Cell Signal Transduction Research Unit, Korea Research Institute of Bioscience and Biotechnology, Yusong, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioscience Research Division, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon","institution_ids":["https://openalex.org/I73616290"]},{"raw_affiliation_string":"Bioscience Research Division, Liver Cell Signal Transduction Research Unit, Korea Research Institute of Bioscience and Biotechnology, Yusong, Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036102916","display_name":"Sook Lee","orcid":"https://orcid.org/0000-0002-8451-8573","observed_orcids":["https://orcid.org/0000-0002-8451-8573"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sook Lee","raw_affiliation_strings":["Bioscience Research Division, Liver Cell Signal Transduction Research Unit, Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusong, 305-600, Taejon, Korea","Bioscience Research Division, Liver Cell Signal Transduction Research Unit, Korea Research Institute of Bioscience and Biotechnology, Yusong, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioscience Research Division, Liver Cell Signal Transduction Research Unit, Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusong, 305-600, Taejon, Korea","institution_ids":["https://openalex.org/I73616290"]},{"raw_affiliation_string":"Bioscience Research Division, Liver Cell Signal Transduction Research Unit, Korea Research Institute of Bioscience and Biotechnology, Yusong, Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Gokul C Das","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90436673","display_name":"The University of Texas Health Science Center at Tyler","ror":"https://ror.org/01sps7q28","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I90436673"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gokul C Das","raw_affiliation_strings":["Department of Molecular Biology, The University of Texas Health Center, Tyler, 75710-2003, Texas, TX, USA","Department of Molecular Biology, The University of Texas Health Center, Tyler, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, The University of Texas Health Center, Tyler, 75710-2003, Texas, TX, USA","institution_ids":["https://openalex.org/I90436673"]},{"raw_affiliation_string":"Department of Molecular Biology, The University of Texas Health Center, Tyler, USA","institution_ids":["https://openalex.org/I90436673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109139008","display_name":"Ui Sun Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ui Sun Park","raw_affiliation_strings":["Bioscience Research Division, Liver Cell Signal Transduction Research Unit, Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusong, 305-600, Taejon, Korea","Bioscience Research Division, Liver Cell Signal Transduction Research Unit, Korea Research Institute of Bioscience and Biotechnology, Yusong, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioscience Research Division, Liver Cell Signal Transduction Research Unit, Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusong, 305-600, Taejon, Korea","institution_ids":["https://openalex.org/I73616290"]},{"raw_affiliation_string":"Bioscience Research Division, Liver Cell Signal Transduction Research Unit, Korea Research Institute of Bioscience and Biotechnology, Yusong, Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078406599","display_name":"Sook Mi Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sook Mi Park","raw_affiliation_strings":["Bioscience Research Division, Liver Cell Signal Transduction Research Unit, Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusong, 305-600, Taejon, Korea","Bioscience Research Division, Liver Cell Signal Transduction Research Unit, Korea Research Institute of Bioscience and Biotechnology, Yusong, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioscience Research Division, Liver Cell Signal Transduction Research Unit, Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusong, 305-600, Taejon, Korea","institution_ids":["https://openalex.org/I73616290"]},{"raw_affiliation_string":"Bioscience Research Division, Liver Cell Signal Transduction Research Unit, Korea Research Institute of Bioscience and Biotechnology, Yusong, Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111671980","display_name":"Yoon Ik Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yoon Ik Lee","raw_affiliation_strings":["Bioscience Research Division, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon","Bioscience Research Division, Liver Cell Signal Transduction Research Unit, Korea Research Institute of Bioscience and Biotechnology, Yusong, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioscience Research Division, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon","institution_ids":["https://openalex.org/I73616290"]},{"raw_affiliation_string":"Bioscience Research Division, Liver Cell Signal Transduction Research Unit, Korea Research Institute of Bioscience and Biotechnology, Yusong, Korea","institution_ids":["https://openalex.org/I73616290"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5990,"currency":"USD","value_usd":5990},"apc_paid":{"value":5990,"currency":"USD","value_usd":5990},"fwci":4.3329,"has_fulltext":false,"cited_by_count":94,"citation_normalized_percentile":{"value":0.94675087,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"19","issue":"33","first_page":"3717","last_page":"3726"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aflatoxin-b1","display_name":"aflatoxin B1","score":0.9660000205039978},{"id":"https://openalex.org/keywords/igf-ii","display_name":"insulin-like growth factor II","score":0.9580000042915344},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9359999895095825},{"id":"https://openalex.org/keywords/sp1","display_name":"Sp1","score":0.7120000123977661},{"id":"https://openalex.org/keywords/tata-binding-protein","display_name":"TATA-binding protein","score":0.9580000042915344},{"id":"https://openalex.org/keywords/transcription-factor-binding","display_name":"transcription factor binding","score":0.8040000200271606},{"id":"https://openalex.org/keywords/sp1-phosphorylation","display_name":"Sp1 phosphorylation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/hbv-x-protein","display_name":"HBV X protein","score":0.5899999737739563},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.878000020980835},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7860000133514404},{"id":"https://openalex.org/keywords/gain-of-function-mutations","display_name":"gain-of-function mutations","score":0.8259999752044678},{"id":"https://openalex.org/keywords/hepatocyte-transformation","display_name":"hepatocyte transformation","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8322752714157104},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.689070463180542},{"id":"https://openalex.org/C57467964","wikidata":"https://www.wikidata.org/wiki/Q14888082","display_name":"Sp1 transcription factor","level":5,"score":0.66344153881073},{"id":"https://openalex.org/C191163429","wikidata":"https://www.wikidata.org/wiki/Q20970205","display_name":"Sp3 transcription factor","level":5,"score":0.603000283241272},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5512559413909912},{"id":"https://openalex.org/C144825837","wikidata":"https://www.wikidata.org/wiki/Q2316030","display_name":"General transcription factor","level":5,"score":0.5268705487251282},{"id":"https://openalex.org/C146027311","wikidata":"https://www.wikidata.org/wiki/Q18031820","display_name":"TAF2","level":5,"score":0.5239983797073364},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5177213549613953},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.5088920593261719},{"id":"https://openalex.org/C132376346","wikidata":"https://www.wikidata.org/wiki/Q7315962","display_name":"Response element","level":5,"score":0.47194260358810425},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4462258219718933},{"id":"https://openalex.org/C105208137","wikidata":"https://www.wikidata.org/wiki/Q425812","display_name":"Transcription factor II B","level":5,"score":0.4383103847503662},{"id":"https://openalex.org/C20291555","wikidata":"https://www.wikidata.org/wiki/Q4677462","display_name":"Activating transcription factor 2","level":5,"score":0.42602166533470154},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4050554633140564},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26471906900405884},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.24485623836517334},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13258641958236694},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.1185932457447052},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006511","descriptor_name":"Hepatitis B Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007335","descriptor_name":"Insulin-Like Growth Factor II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016329","descriptor_name":"Sp1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016604","descriptor_name":"Aflatoxin B1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035181","descriptor_name":"TATA-Box Binding Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054334","descriptor_name":"Viral Regulatory and Accessory Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/sj.onc.1203694","doi":"https://doi.org/10.1038/sj.onc.1203694","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.onc.1203694","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},{"id":"pmid:10949925","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10949925","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},{"id":"pmh:oai:http://repository.kribb.re.kr:8080/:201005/5107","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/201005/5107","pdf_url":null,"source":{"id":"https://openalex.org/S4406922719","display_name":"KRIBB Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"/dspace/upload/original/2970.pdf","raw_type":"Article"},{"id":"pmh:oai:https://repository.kribb.re.kr:201005/5107","doi":null,"is_oa":false,"landing_page_url":"https://repository.kribb.re.kr/handle/201005/5107","pdf_url":null,"source":{"id":"https://openalex.org/S4406922719","display_name":"KRIBB Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"/dspace/upload/original/2970.pdf","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1038/sj.onc.1203694","doi":"https://doi.org/10.1038/sj.onc.1203694","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.onc.1203694","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1484177930","https://openalex.org/W1552426876","https://openalex.org/W1903324674","https://openalex.org/W1952468142","https://openalex.org/W1973368924","https://openalex.org/W1986676942","https://openalex.org/W1992052038","https://openalex.org/W1993475388","https://openalex.org/W1995966539","https://openalex.org/W2001663882","https://openalex.org/W2030573603","https://openalex.org/W2035794058","https://openalex.org/W2043912950","https://openalex.org/W2043964688","https://openalex.org/W2052472936","https://openalex.org/W2054506280","https://openalex.org/W2065386716","https://openalex.org/W2080719579","https://openalex.org/W2081075932","https://openalex.org/W2097767970","https://openalex.org/W2127380756","https://openalex.org/W2144206181","https://openalex.org/W2148107077","https://openalex.org/W2161080071","https://openalex.org/W2171798719","https://openalex.org/W2320182093","https://openalex.org/W2405173083","https://openalex.org/W2509077705","https://openalex.org/W2510403669","https://openalex.org/W4244681600"],"related_works":["https://openalex.org/W7007889071","https://openalex.org/W2128882591","https://openalex.org/W1973368924","https://openalex.org/W1991715856","https://openalex.org/W2008699332","https://openalex.org/W1501108160","https://openalex.org/W1964501820","https://openalex.org/W1990926444","https://openalex.org/W2375240883","https://openalex.org/W1996053010"],"abstract_inverted_index":{"Aflatoxin":[0],"B1":[1],"(AFB1)":[2],"induced":[3,176],"mutation":[4],"of":[5,18,45,48,67,82,108,123,129,140,145,155,167],"the":[6,16,42,49,74,80,114,132,138,153,161,165],"p53":[7,58,64,119],"gene":[8],"at":[9],"codon":[10],"249":[11],"(p53mt249)":[12],"is":[13],"critical":[14],"during":[15],"formation":[17,81],"hepatocellular":[19],"carcinoma":[20],"(HCC)":[21],"following":[22],"hepatitis":[23],"B":[24],"virus":[25],"(HBV)":[26],"infection.":[27],"p53mt249":[28,60,78,97,126,170],"markedly":[29],"increases":[30],"insulin-like":[31],"growth":[32],"factor":[33,51,100,111],"II":[34],"(IGF-II)":[35],"transcription":[36,50,68,99,110],"largely":[37],"from":[38],"promoter":[39,116],"4,":[40],"accumulating":[41],"fetal":[43],"form":[44],"IGF-II.":[46],"Modulation":[47],"binding":[52,66,112],"to":[53,174],"IGF-II":[54,146],"P4":[55,75,115],"by":[56,131,169,177],"wild-type":[57,118],"and":[59,71,91,94,135],"was":[61,172],"identified.":[62],"Wild-type":[63],"inhibited":[65],"factors":[69],"Sp1":[70,101],"TBP":[72],"on":[73,113],"promoter,":[76],"while":[77,117],"enhanced":[79,86,143],"transcriptional":[83],"complexes":[84],"through":[85,142],"DNA-protein":[87],"(Sp1":[88,93],"or":[89],"TBP)":[90,95],"protein-protein":[92],"interactions.":[96],"stimulates":[98],"phosphorylation":[102],"which":[103,171],"might":[104],"be":[105,175],"a":[106,149,178],"cause":[107],"increased":[109],"does":[120],"not.":[121],"Transfection":[122],"hepatocytes":[124],"with":[125],"impaired":[127],"induction":[128],"apoptosis":[130,141],"HBV-X":[133],"protein":[134],"TNF-alpha.":[136],"Therefore,":[137],"blocking":[139],"production":[144],"should":[147],"provide":[148],"favorable":[150],"opportunity":[151],"for":[152,164],"selection":[154],"transformed":[156],"hepatocytes.":[157],"These":[158],"results":[159],"explain":[160],"molecular":[162],"basis":[163],"genesis":[166],"HCC":[168],"found":[173],"potent":[179],"mutagen,":[180],"AFB1.":[181]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
