{"id":"https://openalex.org/W2027140235","doi":"https://doi.org/10.1002/jor.1100140220","title":"Intraosseous infusion of prostaglandin E2 prevents disuse\u2010induced bone loss in the tibia","display_name":"Intraosseous infusion of prostaglandin E2 prevents disuse\u2010induced bone loss in the tibia","publication_year":1996,"publication_date":"1996-03-01","ids":{"openalex":"https://openalex.org/W2027140235","doi":"https://doi.org/10.1002/jor.1100140220","mag":"2027140235","pmid":"https://pubmed.ncbi.nlm.nih.gov/8648510"},"language":"en","primary_location":{"id":"doi:10.1002/jor.1100140220","doi":"https://doi.org/10.1002/jor.1100140220","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jor.1100140220","pdf_url":null,"source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072683993","display_name":"Robert D. Welch","orcid":"https://orcid.org/0000-0003-0358-2811","observed_orcids":["https://orcid.org/0000-0003-0358-2811"]},"institutions":[{"id":"https://openalex.org/I2802862759","display_name":"Texas Scottish Rite Hospital for Children","ror":"https://ror.org/03gd5jm66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802862759"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R. D. Welch","raw_affiliation_strings":["Research Department, Texas Scottish Rite Hospital for Children, Dallas 75219, USA","Research Department, Texas Scottish Rite Hospital for Children, Dallas, Texas, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Department, Texas Scottish Rite Hospital for Children, Dallas 75219, USA","institution_ids":["https://openalex.org/I2802862759"]},{"raw_affiliation_string":"Research Department, Texas Scottish Rite Hospital for Children, Dallas, Texas, U.S.A","institution_ids":["https://openalex.org/I2802862759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052470978","display_name":"RICHARD B. ASHMAN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802862759","display_name":"Texas Scottish Rite Hospital for Children","ror":"https://ror.org/03gd5jm66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802862759"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. B. Ashman","raw_affiliation_strings":["Research Department, Texas Scottish Rite Hospital for Children, Dallas, Texas, U.S.A","Texas Scottish Rite Hospital for Children"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Department, Texas Scottish Rite Hospital for Children, Dallas, Texas, U.S.A","institution_ids":["https://openalex.org/I2802862759"]},{"raw_affiliation_string":"Texas Scottish Rite Hospital for Children","institution_ids":["https://openalex.org/I2802862759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108584221","display_name":"Kelly Baker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802862759","display_name":"Texas Scottish Rite Hospital for Children","ror":"https://ror.org/03gd5jm66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802862759"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. J. Baker","raw_affiliation_strings":["Research Department, Texas Scottish Rite Hospital for Children, Dallas, Texas, U.S.A","Texas Scottish Rite Hospital for Children"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Department, Texas Scottish Rite Hospital for Children, Dallas, Texas, U.S.A","institution_ids":["https://openalex.org/I2802862759"]},{"raw_affiliation_string":"Texas Scottish Rite Hospital for Children","institution_ids":["https://openalex.org/I2802862759"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104351822","display_name":"Richard H. Browne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802862759","display_name":"Texas Scottish Rite Hospital for Children","ror":"https://ror.org/03gd5jm66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802862759"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. H. Browne","raw_affiliation_strings":["Research Department, Texas Scottish Rite Hospital for Children, Dallas, Texas, U.S.A","Texas Scottish Rite Hospital for Children"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Department, Texas Scottish Rite Hospital for Children, Dallas, Texas, U.S.A","institution_ids":["https://openalex.org/I2802862759"]},{"raw_affiliation_string":"Texas Scottish Rite Hospital for Children","institution_ids":["https://openalex.org/I2802862759"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072683993"],"corresponding_institution_ids":["https://openalex.org/I2802862759"],"apc_list":{"value":3970,"currency":"USD","value_usd":3970},"apc_paid":null,"fwci":0.3787,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.56047984,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"14","issue":"2","first_page":"303","last_page":"310"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.5863999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.5863999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.3181000053882599,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.0478999987244606,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":1.0},{"id":"https://openalex.org/keywords/intraosseous-infusion","display_name":"intraosseous infusion","score":0.8489999771118164},{"id":"https://openalex.org/keywords/skeletal-unloading","display_name":"skeletal unloading","score":0.9110000133514404},{"id":"https://openalex.org/keywords/tibia","display_name":"tibia","score":0.7519999742507935},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.7400000095367432},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.8330000042915344},{"id":"https://openalex.org/keywords/woven-bone","display_name":"woven bone","score":0.9549999833106995},{"id":"https://openalex.org/keywords/mechanical-properties-of-bone","display_name":"bone mechanical properties","score":0.7390000224113464},{"id":"https://openalex.org/keywords/bone-mass-preservation","display_name":"bone mass preservation","score":0.5040000081062317},{"id":"https://openalex.org/keywords/goat-model","display_name":"goat model","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C2777236700","wikidata":"https://www.wikidata.org/wiki/Q178366","display_name":"Tibia","level":2,"score":0.6878266334533691},{"id":"https://openalex.org/C2777198256","wikidata":"https://www.wikidata.org/wiki/Q4860325","display_name":"Prostaglandin E","level":2,"score":0.4700177013874054},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.4536433219909668},{"id":"https://openalex.org/C2777956040","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Prostaglandin E2","level":2,"score":0.44310900568962097},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3999709188938141},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2937830686569214},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2784020006656647}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006041","descriptor_name":"Goats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007103","descriptor_name":"Immobilization","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013977","descriptor_name":"Tibia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017148","descriptor_name":"Infusions, Intraosseous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jor.1100140220","doi":"https://doi.org/10.1002/jor.1100140220","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jor.1100140220","pdf_url":null,"source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},{"id":"pmid:8648510","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8648510","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of orthopaedic research : official publication of the Orthopaedic Research Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1967216371","https://openalex.org/W1970348554","https://openalex.org/W1970955782","https://openalex.org/W1978732627","https://openalex.org/W1984631888","https://openalex.org/W1986032728","https://openalex.org/W1987629029","https://openalex.org/W1990838989","https://openalex.org/W1997473010","https://openalex.org/W2000317189","https://openalex.org/W2003831383","https://openalex.org/W2003890323","https://openalex.org/W2004836911","https://openalex.org/W2006847412","https://openalex.org/W2008521352","https://openalex.org/W2014216696","https://openalex.org/W2018033196","https://openalex.org/W2023987420","https://openalex.org/W2032461382","https://openalex.org/W2033587429","https://openalex.org/W2034039325","https://openalex.org/W2044032085","https://openalex.org/W2054707554","https://openalex.org/W2063971720","https://openalex.org/W2067986741","https://openalex.org/W2070068098","https://openalex.org/W2074637950","https://openalex.org/W2077040449","https://openalex.org/W2079327979","https://openalex.org/W2087378917","https://openalex.org/W2093224917","https://openalex.org/W2093662953","https://openalex.org/W2115971863","https://openalex.org/W2129860620","https://openalex.org/W2291330098","https://openalex.org/W2404739198"],"related_works":["https://openalex.org/W2032461382","https://openalex.org/W2077040449","https://openalex.org/W2044032085","https://openalex.org/W2004836911","https://openalex.org/W1970339612","https://openalex.org/W2078746923","https://openalex.org/W2094677654","https://openalex.org/W2068058981","https://openalex.org/W2075355171","https://openalex.org/W2054759086"],"abstract_inverted_index":{"We":[0],"investigated":[1],"whether":[2],"intraosseous":[3],"injection":[4],"of":[5,18,25,49,85,106,124,160],"prostaglandin":[6,140,165],"E2":[7,39,98,141,166],"would":[8],"preserve":[9],"tibial":[10,73],"bone":[11,89,109,112,130,144,151],"mass":[12],"in":[13,35,70,103],"the":[14,36,71,79,104,122,136,149,157,161,172,176],"skeletally":[15],"unloaded":[16,137,177],"limb":[17,28],"a":[19,100],"large":[20],"animal":[21],"model.":[22],"Skeletal":[23],"unloading":[24,126],"one":[26],"rear":[27],"was":[29,40,153],"produced":[30,99,152],"by":[31],"unilateral":[32],"Achilles":[33],"tenectomy":[34],"goat.":[37],"Prostaglandin":[38,97],"injected":[41],"at":[42,110],"0.5":[43],"or":[44],"1.0":[45,115],"mg":[46,116],"(1":[47],"ml":[48],"volume)":[50],"twice":[51],"daily,":[52],"beginning":[53],"on":[54],"day":[55],"7":[56],"and":[57,87,91,119,127,146,148,178],"continuing":[58],"for":[59,83],"10":[60],"days,":[61],"through":[62],"an":[63],"implant":[64],"that":[65],"had":[66],"been":[67],"surgically":[68],"placed":[69],"proximal":[72],"metaphysis.":[74],"Thirty-five":[75],"days":[76],"after":[77],"surgery,":[78],"tibiae":[80,162],"were":[81],"harvested":[82],"measurement":[84],"static":[86],"dynamic":[88],"parameters":[90],"mechanical":[92],"characteristics":[93],"using":[94],"transmission":[95],"ultrasound.":[96],"dose-dependent":[101],"increase":[102,169],"formation":[105,145],"woven":[107,155],"new":[108,129,150],"all":[111],"envelopes.":[113],"The":[114],"dosage":[117],"prevented":[118],"partially":[120],"reversed":[121],"effects":[123],"skeletal":[125],"added":[128],"(p":[131],"<":[132],"0.05)":[133],"compared":[134,174],"with":[135,164,175],"tibiae.":[138,180],"Because":[139],"increased":[142],"both":[143],"resorption":[147],"primarily":[154],"bone,":[156],"material":[158],"properties":[159],"infused":[163],"did":[167],"not":[168],"significantly":[170],"during":[171],"study":[173],"weight-bearing":[179]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}