{"id":"https://openalex.org/W2027110672","doi":"https://doi.org/10.1002/jcb.1982.240180202","title":"Metabolism of Benzo(a)pyrene by Human Epithelial and Fibroblastic Cells: Metabolite Patterns and DNA Adduct Formation","display_name":"Metabolism of Benzo(a)pyrene by Human Epithelial and Fibroblastic Cells: Metabolite Patterns and DNA Adduct Formation","publication_year":1982,"publication_date":"1982-01-01","ids":{"openalex":"https://openalex.org/W2027110672","doi":"https://doi.org/10.1002/jcb.1982.240180202","mag":"2027110672","pmid":"https://pubmed.ncbi.nlm.nih.gov/6279686"},"language":"en","primary_location":{"id":"doi:10.1002/jcb.1982.240180202","doi":"https://doi.org/10.1002/jcb.1982.240180202","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.1982.240180202","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111411255","display_name":"J. C. Bartley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jack Bartley","raw_affiliation_strings":["Peralta Cancer Research Institute, Peralta Hospital, Oakland, California 94609"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peralta Cancer Research Institute, Peralta Hospital, Oakland, California 94609","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111625645","display_name":"James C. Bartholomew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James C. Bartholomew","raw_affiliation_strings":["Melvin Calvin Laboratory, Lawrence Berkeley Laboratory, University of California, Berkeley, California 94720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melvin Calvin Laboratory, Lawrence Berkeley Laboratory, University of California, Berkeley, California 94720","institution_ids":["https://openalex.org/I148283060","https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062141377","display_name":"Martha R. Stampfer","orcid":"https://orcid.org/0000-0002-3801-5086","observed_orcids":["https://orcid.org/0000-0002-3801-5086"]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martha R. Stampfer","raw_affiliation_strings":["Donner Laboratory, Lawrence Berkeley Laboratory, University of California, Berkeley, California 94720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Donner Laboratory, Lawrence Berkeley Laboratory, University of California, Berkeley, California 94720","institution_ids":["https://openalex.org/I148283060","https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5110,"currency":"USD","value_usd":5110},"apc_paid":null,"fwci":1.6604,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.80715706,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"18","issue":"2","first_page":"135","last_page":"148"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.019700000062584877,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.01759999990463257,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzo-a-pyrene","display_name":"benzo[a]pyrene","score":0.9829999804496765},{"id":"https://openalex.org/keywords/dna-adducts","display_name":"DNA adducts","score":0.8130000233650208},{"id":"https://openalex.org/keywords/benzo-a-pyrene-metabolism","display_name":"benzo[a]pyrene metabolism","score":0.8799999952316284},{"id":"https://openalex.org/keywords/mammary-epithelial-cells","display_name":"mammary epithelial cells","score":0.9570000171661377},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.9729999899864197},{"id":"https://openalex.org/keywords/carcinogen-metabolism","display_name":"carcinogen metabolism","score":0.4339999854564667},{"id":"https://openalex.org/keywords/breast-cancer-risk","display_name":"breast cancer risk","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.866385817527771},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.784848690032959},{"id":"https://openalex.org/C2778951431","wikidata":"https://www.wikidata.org/wiki/Q415723","display_name":"Pyrene","level":2,"score":0.7698546648025513},{"id":"https://openalex.org/C2777538855","wikidata":"https://www.wikidata.org/wiki/Q306051","display_name":"Benzo(a)pyrene","level":3,"score":0.7553921937942505},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6415292024612427},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6216476559638977},{"id":"https://openalex.org/C108204754","wikidata":"https://www.wikidata.org/wiki/Q353392","display_name":"Adduct","level":2,"score":0.5996128916740417},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5295729637145996},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5260236859321594},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5169479250907898},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4983792304992676},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29563987255096436},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09907501935958862},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.05004650354385376}],"mesh":[{"descriptor_ui":"D001564","descriptor_name":"Benzo(a)pyrene","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001564","descriptor_name":"Benzo(a)pyrene","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001564","descriptor_name":"Benzo(a)pyrene","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001580","descriptor_name":"Benzopyrenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001580","descriptor_name":"Benzopyrenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001580","descriptor_name":"Benzopyrenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcb.1982.240180202","doi":"https://doi.org/10.1002/jcb.1982.240180202","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.1982.240180202","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},{"id":"pmid:6279686","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6279686","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8100000023841858,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W329060596","https://openalex.org/W1488998471","https://openalex.org/W1509148122","https://openalex.org/W1512177890","https://openalex.org/W1526832509","https://openalex.org/W1545388843","https://openalex.org/W1562777547","https://openalex.org/W1576609341","https://openalex.org/W1586514445","https://openalex.org/W1893474114","https://openalex.org/W1963735070","https://openalex.org/W1974648730","https://openalex.org/W1978154354","https://openalex.org/W1980697583","https://openalex.org/W1992882061","https://openalex.org/W1993557939","https://openalex.org/W2003391824","https://openalex.org/W2016076553","https://openalex.org/W2020873813","https://openalex.org/W2021432690","https://openalex.org/W2023313487","https://openalex.org/W2027825341","https://openalex.org/W2033672933","https://openalex.org/W2035986872","https://openalex.org/W2038457576","https://openalex.org/W2038728166","https://openalex.org/W2054815209","https://openalex.org/W2056775945","https://openalex.org/W2061352113","https://openalex.org/W2084422301","https://openalex.org/W2092890634","https://openalex.org/W2093684972","https://openalex.org/W2102096958","https://openalex.org/W2130597755","https://openalex.org/W2144484820","https://openalex.org/W2243300209","https://openalex.org/W2291313881","https://openalex.org/W2292020733","https://openalex.org/W2344078688","https://openalex.org/W2412884239","https://openalex.org/W3145402682","https://openalex.org/W4299503307"],"related_works":["https://openalex.org/W2027825341","https://openalex.org/W2017265243","https://openalex.org/W2014658034","https://openalex.org/W2046283121","https://openalex.org/W1824702621","https://openalex.org/W2080535537","https://openalex.org/W1507061234","https://openalex.org/W2132399066","https://openalex.org/W2065921964","https://openalex.org/W2147688474"],"abstract_inverted_index":{"We":[0],"demonstrate":[1],"in":[2,48,57,114,139,145],"cell":[3],"culture":[4],"that":[5,130],"mammary":[6],"epithelial":[7,53,78,107],"cells":[8,54,79,108],"from":[9,37,60,68,106],"normal":[10],"human":[11],"breast":[12,143],"specimens":[13,64],"metabolize":[14],"benzo(a)pyrene":[15,123],"(BaP)":[16],"and":[17,28,43,65,98,119],"form":[18],"adducts":[19,116],"with":[20,52,66,111],"the":[21,38,49,77,89,112,120,140],"bases":[22],"of":[23,32,62,70,76,82,85,101,122,142],"their":[24],"DNA":[25,118],"more":[26],"readily":[27],"at":[29],"lower":[30],"concentrations":[31],"BaP":[33,41],"than":[34],"do":[35],"fibroblasts":[36,67,94],"same":[39,50],"specimens.":[40,72],"metabolism":[42],"adduct":[44],"formation":[45,84],"was":[46,80,109],"determined":[47],"incubations":[51],"grown":[55],"out":[56],"early":[58],"passage":[59],"each":[61],"three":[63],"one":[69],"these":[71],"The":[73,103],"metabolite":[74,104],"pattern":[75,105],"indicative":[81],"preferential":[83],"7,":[86],"8-dihydrodiol-9,":[87],"10-dihydroepoxybenzo(a)pyrene":[88],"ultimate":[90],"carcinogen.":[91],"In":[92],"contrast,":[93],"formed":[95],"mainly":[96],"mono-":[97],"dihydroxide":[99],"derivatives":[100],"BaP.":[102],"compatible":[110],"ease":[113],"which":[115],"between":[117],"diolepoxide":[121],"were":[124],"formed.":[125],"These":[126],"results":[127],"provide":[128],"evidence":[129],"chemical":[131],"carcinogens":[132],"should":[133],"be":[134],"considered":[135],"as":[136],"possible":[137],"factors":[138],"induction":[141],"cancer":[144],"women.":[146]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2016-06-24T00:00:00"}