{"id":"https://openalex.org/W2026871305","doi":"https://doi.org/10.1016/0091-6749(91)90326-j","title":"Effect of low-dose methotrexate on the disposition of glucocorticoids and theophylline","display_name":"Effect of low-dose methotrexate on the disposition of glucocorticoids and theophylline","publication_year":1991,"publication_date":"1991-08-01","ids":{"openalex":"https://openalex.org/W2026871305","doi":"https://doi.org/10.1016/0091-6749(91)90326-j","mag":"2026871305","pmid":"https://pubmed.ncbi.nlm.nih.gov/1880318"},"language":"en","primary_location":{"id":"doi:10.1016/0091-6749(91)90326-j","doi":"https://doi.org/10.1016/0091-6749(91)90326-j","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0091-6749(91)90326-j","pdf_url":null,"source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045046884","display_name":"Anne M. Glynn-Barnhart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]},{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne M. Glynn-Barnhart","raw_affiliation_strings":["Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206","From the Departments of Pediatrics, Medicine, and Pharmacology, University of Colorado Health Sciences Center, Denver, Colo., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206","institution_ids":["https://openalex.org/I3019586173"]},{"raw_affiliation_string":"From the Departments of Pediatrics, Medicine, and Pharmacology, University of Colorado Health Sciences Center, Denver, Colo., USA","institution_ids":["https://openalex.org/I4210087413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111909523","display_name":"SERPIL C. ERZURUM","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Serpil C. Erzurum","raw_affiliation_strings":["From the Departments of Pediatrics, Medicine, and Pharmacology, University of Colorado Health Sciences Center, Denver, Colo., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pediatrics, Medicine, and Pharmacology, University of Colorado Health Sciences Center, Denver, Colo., USA","institution_ids":["https://openalex.org/I4210087413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103404398","display_name":"Jonathan A. Leff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan A. Leff","raw_affiliation_strings":["From the Departments of Pediatrics, Medicine, and Pharmacology, University of Colorado Health Sciences Center, Denver, Colo., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pediatrics, Medicine, and Pharmacology, University of Colorado Health Sciences Center, Denver, Colo., USA","institution_ids":["https://openalex.org/I4210087413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033749081","display_name":"Richard J. Martin","orcid":"https://orcid.org/0000-0003-2422-1847","observed_orcids":["https://orcid.org/0000-0003-2422-1847"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard J. Martin","raw_affiliation_strings":["From the Departments of Pediatrics, Medicine, and Pharmacology, University of Colorado Health Sciences Center, Denver, Colo., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pediatrics, Medicine, and Pharmacology, University of Colorado Health Sciences Center, Denver, Colo., USA","institution_ids":["https://openalex.org/I4210087413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067640359","display_name":"Judith Evans Cochran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judith Evans Cochran","raw_affiliation_strings":["From the Departments of Pediatrics, Medicine, and Pharmacology, University of Colorado Health Sciences Center, Denver, Colo., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pediatrics, Medicine, and Pharmacology, University of Colorado Health Sciences Center, Denver, Colo., USA","institution_ids":["https://openalex.org/I4210087413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002248529","display_name":"Gary R. Cott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary R. Cott","raw_affiliation_strings":["From the Departments of Pediatrics, Medicine, and Pharmacology, University of Colorado Health Sciences Center, Denver, Colo., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pediatrics, Medicine, and Pharmacology, University of Colorado Health Sciences Center, Denver, Colo., USA","institution_ids":["https://openalex.org/I4210087413"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033765434","display_name":"Stanley James Szefler","orcid":"https://orcid.org/0000-0002-6911-3199","observed_orcids":["https://orcid.org/0000-0002-6911-3199"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanley J. Szefler","raw_affiliation_strings":["From the Departments of Pediatrics, Medicine, and Pharmacology, University of Colorado Health Sciences Center, Denver, Colo., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pediatrics, Medicine, and Pharmacology, University of Colorado Health Sciences Center, Denver, Colo., USA","institution_ids":["https://openalex.org/I4210087413"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4900,"currency":"USD","value_usd":4900},"apc_paid":null,"fwci":1.0048,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.69770617,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"88","issue":"2","first_page":"180","last_page":"186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9125999808311462,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9125999808311462,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.061799999326467514,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/low-dose-methotrexate","display_name":"low-dose methotrexate","score":0.9240000247955322},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.8569999933242798},{"id":"https://openalex.org/keywords/theophylline","display_name":"theophylline","score":0.9909999966621399},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7910000085830688},{"id":"https://openalex.org/keywords/theophylline-clearance","display_name":"theophylline clearance","score":0.8479999899864197},{"id":"https://openalex.org/keywords/prednisolone","display_name":"prednisolone","score":0.9549999833106995},{"id":"https://openalex.org/keywords/methylprednisolone","display_name":"methylprednisolone","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.968999981880188},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.5929999947547913},{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C2778095195","wikidata":"https://www.wikidata.org/wiki/Q407308","display_name":"Theophylline","level":2,"score":0.9453052282333374},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.789760172367096},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.672520101070404},{"id":"https://openalex.org/C2781018748","wikidata":"https://www.wikidata.org/wiki/Q927234","display_name":"Bronchodilator","level":3,"score":0.6357948184013367},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6192640066146851},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5235209465026855},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.4937325417995453},{"id":"https://openalex.org/C2776715498","wikidata":"https://www.wikidata.org/wiki/Q11426176","display_name":"Prednisolone","level":2,"score":0.4816262125968933},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4208020567893982},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.4140598773956299},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3553975224494934},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0091-6749(91)90326-j","doi":"https://doi.org/10.1016/0091-6749(91)90326-j","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0091-6749(91)90326-j","pdf_url":null,"source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},{"id":"pmid:1880318","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1880318","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of allergy and clinical immunology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W435647448","https://openalex.org/W1942211023","https://openalex.org/W1974065253","https://openalex.org/W1988659691","https://openalex.org/W1996007417","https://openalex.org/W2017480851","https://openalex.org/W2019902007","https://openalex.org/W2021007931","https://openalex.org/W2031327941","https://openalex.org/W2053048391","https://openalex.org/W2055977308","https://openalex.org/W2077042832","https://openalex.org/W2080314044","https://openalex.org/W2131658103","https://openalex.org/W2297243234","https://openalex.org/W2333773266","https://openalex.org/W2338849636","https://openalex.org/W2415800613"],"related_works":["https://openalex.org/W2168501933","https://openalex.org/W2041253602","https://openalex.org/W2398508343","https://openalex.org/W1965199980","https://openalex.org/W2061098320","https://openalex.org/W2032390903","https://openalex.org/W1605859621","https://openalex.org/W2399356565","https://openalex.org/W2077615019","https://openalex.org/W1977485975"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}