{"id":"https://openalex.org/W2026737645","doi":"https://doi.org/10.1210/en.139.12.5151","title":"Estrogen Receptor- Messenger Ribonucleic Acid Expression in the Pituitary Gland","display_name":"Estrogen Receptor- Messenger Ribonucleic Acid Expression in the Pituitary Gland","publication_year":1998,"publication_date":"1998-12-01","ids":{"openalex":"https://openalex.org/W2026737645","doi":"https://doi.org/10.1210/en.139.12.5151","mag":"2026737645","pmid":"https://pubmed.ncbi.nlm.nih.gov/9832455"},"language":"en","primary_location":{"id":"doi:10.1210/en.139.12.5151","doi":"https://doi.org/10.1210/en.139.12.5151","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.139.12.5151","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110045776","display_name":"Melinda E. Wilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melinda E. Wilson","raw_affiliation_strings":["Program in Molecular Biology (M.E.W., R.J.H.) Loyola University, Stritch School of Medicine, Maywood, Illinois 60153"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Molecular Biology (M.E.W., R.J.H.) Loyola University, Stritch School of Medicine, Maywood, Illinois 60153","institution_ids":["https://openalex.org/I1925986","https://openalex.org/I4210159390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111689433","display_name":"Price Richard H.","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard H., Price","raw_affiliation_strings":["Department of Cell Biology, Neurobiology, and Anatomy (R.H.P., R.J.H.), Loyola University, Stritch School of Medicine, Maywood, Illinois 60153"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Neurobiology, and Anatomy (R.H.P., R.J.H.), Loyola University, Stritch School of Medicine, Maywood, Illinois 60153","institution_ids":["https://openalex.org/I1925986","https://openalex.org/I4210159390"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042132328","display_name":"Robert J. Handa","orcid":"https://orcid.org/0000-0001-9131-2808","observed_orcids":["https://orcid.org/0000-0001-9131-2808"]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Handa","raw_affiliation_strings":["Department of Cell Biology, Neurobiology, and Anatomy (R.H.P., R.J.H.), Loyola University, Stritch School of Medicine, Maywood, Illinois 60153","Program in Molecular Biology (M.E.W., R.J.H.) Loyola University, Stritch School of Medicine, Maywood, Illinois 60153"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Neurobiology, and Anatomy (R.H.P., R.J.H.), Loyola University, Stritch School of Medicine, Maywood, Illinois 60153","institution_ids":["https://openalex.org/I1925986","https://openalex.org/I4210159390"]},{"raw_affiliation_string":"Program in Molecular Biology (M.E.W., R.J.H.) Loyola University, Stritch School of Medicine, Maywood, Illinois 60153","institution_ids":["https://openalex.org/I1925986","https://openalex.org/I4210159390"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":4.5006,"has_fulltext":false,"cited_by_count":80,"citation_normalized_percentile":{"value":0.95206202,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"139","issue":"12","first_page":"5151","last_page":"5156"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-receptor-beta","display_name":"estrogen receptor beta","score":0.9929999709129333},{"id":"https://openalex.org/keywords/anterior-pituitary","display_name":"anterior pituitary","score":0.8320000171661377},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.6639999747276306},{"id":"https://openalex.org/keywords/prepubertal-development","display_name":"prepubertal development","score":0.875},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8619999885559082},{"id":"https://openalex.org/keywords/gonadotrophs","display_name":"gonadotrophs","score":0.9160000085830688},{"id":"https://openalex.org/keywords/lactotrophs","display_name":"lactotrophs","score":0.8830000162124634},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.734000027179718},{"id":"https://openalex.org/keywords/prolactin","display_name":"prolactin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/estrogen-action","display_name":"estrogen action","score":0.5849999785423279},{"id":"https://openalex.org/keywords/pituitary-cell-types","display_name":"pituitary cell types","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7916476130485535},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7624131441116333},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.7013068795204163},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.5463670492172241},{"id":"https://openalex.org/C2779029589","wikidata":"https://www.wikidata.org/wiki/Q356002","display_name":"Anterior pituitary","level":3,"score":0.5190430283546448},{"id":"https://openalex.org/C96307122","wikidata":"https://www.wikidata.org/wiki/Q15329133","display_name":"Estrogen receptor beta","level":5,"score":0.5178992748260498},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5059115290641785},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.4822548031806946},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.47033625841140747},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4599311649799347},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.458322674036026},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.37433093786239624},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21145355701446533},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15391555428504944},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.06855127215385437},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/en.139.12.5151","doi":"https://doi.org/10.1210/en.139.12.5151","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.139.12.5151","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"doi:10.1210/endo.139.12.6354","doi":"https://doi.org/10.1210/endo.139.12.6354","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.139.12.6354","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:9832455","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9832455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2054664428","display_name":"TESTOSTERONE AND ETHANOL WITHDRAWAL NEUROTOXICITY","funder_award_id":"F31AA005461","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G4962159605","display_name":"FETAL ALCOHOL AND FEMALE REPRODUCTIVE DEVELOPMENT","funder_award_id":"F31AA005395","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1538903611","https://openalex.org/W1963894875","https://openalex.org/W1965563883","https://openalex.org/W1973809455","https://openalex.org/W1979097052","https://openalex.org/W1986785111","https://openalex.org/W1992388070","https://openalex.org/W1996680175","https://openalex.org/W2007889656","https://openalex.org/W2010452157","https://openalex.org/W2024215106","https://openalex.org/W2032980756","https://openalex.org/W2037350042","https://openalex.org/W2039628906","https://openalex.org/W2068781432","https://openalex.org/W2071792035","https://openalex.org/W2073353512","https://openalex.org/W2073883348","https://openalex.org/W2074316110","https://openalex.org/W2077260452","https://openalex.org/W2092049238","https://openalex.org/W2113439270","https://openalex.org/W2115537559","https://openalex.org/W2117645526","https://openalex.org/W2130372414","https://openalex.org/W2130623234","https://openalex.org/W2145865543","https://openalex.org/W2408824914","https://openalex.org/W2435237898"],"related_works":["https://openalex.org/W4249940261","https://openalex.org/W7100469022","https://openalex.org/W145362554","https://openalex.org/W2080487349","https://openalex.org/W2010206469","https://openalex.org/W4255302211","https://openalex.org/W4248101807","https://openalex.org/W1980498491","https://openalex.org/W2068285229","https://openalex.org/W2098708143"],"abstract_inverted_index":{"Estrogen":[0],"plays":[1],"a":[2,35,193],"key":[3],"role":[4],"in":[5,25,57,69,91,96,127,131,148,157,180,213,257,262,281,294],"the":[6,26,46,62,149,158,243,263,275,288],"regulation":[7],"of":[8,14,41,48,64,87,109,116,151,160,197,233,242,278,291],"many":[9,175],"pituitary":[10,29,65],"hormones.":[11],"The":[12],"presence":[13],"estrogen":[15,279,292],"receptor-beta":[16],"(ER":[17],"beta)":[18],"messenger":[19],"RNA":[20],"(mRNA)":[21],"has":[22,50],"been":[23,51],"demonstrated":[24],"adult":[27,70,92,132,144],"anterior":[28,264],"by":[30],"RT-PCR":[31],"to":[32,53],"be":[33,287],"at":[34],"level":[36,150,196],"much":[37,105],"greater":[38,106,126,195],"than":[39,85,107,130],"that":[40,78,86,121,141,190,270],"ER":[42,66,79,88,100,110,122,152,163,198,208,217,238,247,258,271,284],"beta":[43,67,80,101,123,153,164,199,209,218,248,259,272,285],"mRNA.":[44,112,165,249],"Because":[45],"number":[47,159],"ERs":[49],"shown":[52],"change":[54],"during":[55],"development,":[56],"this":[58],"study":[59],"we":[60,76,211],"examined":[61],"distribution":[63],"mRNA":[68,81,90,102,124,154,200,219,260],"and":[71,143,187,254],"prepubertal":[72,97,128,142,185,228],"rats.":[73],"Using":[74],"RT-PCR,":[75],"confirmed":[77,140],"expression":[82,261],"is":[83,125,273],"less":[84],"alpha":[89,111],"females.":[93],"In":[94,166,227],"contrast,":[95],"female":[98],"pituitaries,":[99,118,170,229],"levels":[103],"are":[104],"those":[108],"Film":[113],"densitometric":[114],"analysis":[115],"whole":[117],"similarly":[119],"showed":[120,189],"pituitaries":[129,145],"pituitaries.":[133],"However,":[134],"after":[135],"emulsion":[136],"autoradiography,":[137],"cell":[138,205],"counts":[139],"differ,":[146],"not":[147,274],"expression,":[155],"but":[156],"cells":[161,176,235,245],"expressing":[162],"postnatal":[167],"day":[168],"15":[169],"there":[171],"were":[172],"twice":[173],"as":[174,179],"per":[177],"mm2":[178],"adults.":[181],"A":[182],"comparison":[183],"between":[184],"males":[186],"females":[188,191],"exhibited":[192],"2-fold":[194],"expression.":[201],"To":[202],"determine":[203],"which":[204],"types":[206],"express":[207,237],"mRNA,":[210],"performed":[212],"situ":[214],"hybridization":[215],"for":[216,223],"coupled":[220],"with":[221],"immunohistochemistry":[222],"FSH":[224],"or":[225],"PRL.":[226],"84.5":[230],"+/-":[231],"2.3%":[232],"FSH-immunoreactive":[234],"also":[236],"beta.":[239],"Nearly":[240],"all":[241],"PRL-immunoreactive":[244],"lacked":[246],"These":[250],"data":[251,268],"demonstrate":[252],"sex-":[253],"age-related":[255],"differences":[256],"pituitary.":[265],"Furthermore,":[266],"these":[267],"suggest":[269],"specific":[276],"mediator":[277,290],"action":[280,293],"lactotrophs,":[282],"whereas":[283],"may":[286],"prime":[289],"FSH-containing":[295],"gonadotrophs.":[296]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}