{"id":"https://openalex.org/W2026634733","doi":"https://doi.org/10.1038/ncponc1173","title":"Mechanisms of Disease: survival benefit of temsirolimus validates a role for mTOR in the management of advanced RCC","display_name":"Mechanisms of Disease: survival benefit of temsirolimus validates a role for mTOR in the management of advanced RCC","publication_year":2008,"publication_date":"2008-07-08","ids":{"openalex":"https://openalex.org/W2026634733","doi":"https://doi.org/10.1038/ncponc1173","mag":"2026634733","pmid":"https://pubmed.ncbi.nlm.nih.gov/18607393"},"language":"en","primary_location":{"id":"doi:10.1038/ncponc1173","doi":"https://doi.org/10.1038/ncponc1173","is_oa":false,"landing_page_url":"https://doi.org/10.1038/ncponc1173","pdf_url":null,"source":{"id":"https://openalex.org/S4210176377","display_name":"Nature Clinical Practice Oncology","issn_l":"1743-4254","issn":["1743-4254","1743-4262"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Clinical Practice Oncology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050649350","display_name":"Robert A. Figlin","orcid":"https://orcid.org/0000-0002-6323-6075","observed_orcids":["https://orcid.org/0000-0002-6323-6075"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert A Figlin","raw_affiliation_strings":["Division of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Care Center, Duarte, CA 91010, USA. rfiglin@coh.org","City Of Hope National Medical Center, Duarte, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Care Center, Duarte, CA 91010, USA. rfiglin@coh.org","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"raw_affiliation_string":"City Of Hope National Medical Center, Duarte, United States","institution_ids":["https://openalex.org/I1301076528"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050649350"],"corresponding_institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"],"apc_list":null,"apc_paid":null,"fwci":0.3348,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.26876163,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"5","issue":"10","first_page":"601","last_page":"609"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.6948000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.6948000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.298799991607666,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/temsirolimus","display_name":"temsirolimus","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.7860000133514404},{"id":"https://openalex.org/keywords/advanced-renal-cell-carcinoma","display_name":"advanced renal cell carcinoma","score":0.9150000214576721},{"id":"https://openalex.org/keywords/mtor-inhibitors","display_name":"mTOR inhibitors","score":0.9269999861717224},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8370000123977661},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.671999990940094},{"id":"https://openalex.org/keywords/signaling-pathway-convergence","display_name":"signaling pathway convergence","score":0.6589999794960022},{"id":"https://openalex.org/keywords/cell-cycle-progression","display_name":"cell cycle progression","score":0.7730000019073486},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.7179999947547913},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.6679999828338623},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.5120000243186951}],"concepts":[{"id":"https://openalex.org/C2776820818","wikidata":"https://www.wikidata.org/wiki/Q7699074","display_name":"Temsirolimus","level":5,"score":0.9978483319282532},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.8479849696159363},{"id":"https://openalex.org/C183713625","wikidata":"https://www.wikidata.org/wiki/Q5282002","display_name":"Discovery and development of mTOR inhibitors","level":4,"score":0.634857714176178},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.497160941362381},{"id":"https://openalex.org/C2777921159","wikidata":"https://www.wikidata.org/wiki/Q32089","display_name":"Sirolimus","level":2,"score":0.4971518814563751},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.4968455135822296},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4446316659450531},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.40512073040008545},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3317573070526123},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32391536235809326},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24854737520217896},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.15722882747650146},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/ncponc1173","doi":"https://doi.org/10.1038/ncponc1173","is_oa":false,"landing_page_url":"https://doi.org/10.1038/ncponc1173","pdf_url":null,"source":{"id":"https://openalex.org/S4210176377","display_name":"Nature Clinical Practice Oncology","issn_l":"1743-4254","issn":["1743-4254","1743-4262"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Clinical Practice Oncology","raw_type":"journal-article"},{"id":"pmid:18607393","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18607393","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature clinical practice. Oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","score":0.6100000143051147,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W181471869","https://openalex.org/W1565532031","https://openalex.org/W1885232396","https://openalex.org/W1908619062","https://openalex.org/W1984939867","https://openalex.org/W1988609792","https://openalex.org/W1994001783","https://openalex.org/W1999209934","https://openalex.org/W1999966467","https://openalex.org/W2005942192","https://openalex.org/W2006559495","https://openalex.org/W2013647024","https://openalex.org/W2015407598","https://openalex.org/W2015644147","https://openalex.org/W2025887278","https://openalex.org/W2027795688","https://openalex.org/W2034456120","https://openalex.org/W2034666877","https://openalex.org/W2044645231","https://openalex.org/W2057106513","https://openalex.org/W2075997152","https://openalex.org/W2080679809","https://openalex.org/W2092661658","https://openalex.org/W2095804402","https://openalex.org/W2098176107","https://openalex.org/W2102648794","https://openalex.org/W2112001957","https://openalex.org/W2114438728","https://openalex.org/W2114492564","https://openalex.org/W2120129511","https://openalex.org/W2126022920","https://openalex.org/W2128059625","https://openalex.org/W2129621205","https://openalex.org/W2130883918","https://openalex.org/W2131818083","https://openalex.org/W2132128432","https://openalex.org/W2141825683","https://openalex.org/W2142506125","https://openalex.org/W2143645520","https://openalex.org/W2143782771","https://openalex.org/W2147394591","https://openalex.org/W2147775209","https://openalex.org/W2149456801","https://openalex.org/W2150937214","https://openalex.org/W2152062205","https://openalex.org/W2153867442","https://openalex.org/W2158612356","https://openalex.org/W2160042784","https://openalex.org/W2163583831","https://openalex.org/W2167761137","https://openalex.org/W2171433167","https://openalex.org/W2225154633","https://openalex.org/W2225644272","https://openalex.org/W2240204773","https://openalex.org/W2247806985","https://openalex.org/W2249698993","https://openalex.org/W2254984984","https://openalex.org/W2261812292","https://openalex.org/W2268685596","https://openalex.org/W2274092844","https://openalex.org/W2286186015","https://openalex.org/W2294907521","https://openalex.org/W2301781428","https://openalex.org/W2415680990","https://openalex.org/W2473171778","https://openalex.org/W2517054293","https://openalex.org/W2626632314","https://openalex.org/W3009736595"],"related_works":["https://openalex.org/W2080322619","https://openalex.org/W1997050190","https://openalex.org/W438392113","https://openalex.org/W2086716921","https://openalex.org/W67972648","https://openalex.org/W2054485350","https://openalex.org/W2386631213","https://openalex.org/W169489141","https://openalex.org/W140738955","https://openalex.org/W2588891396"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}