{"id":"https://openalex.org/W2026523680","doi":"https://doi.org/10.1186/1471-2350-10-122","title":"Further analysis of previously implicated linkage regions for Alzheimer's disease in affected relative pairs","display_name":"Further analysis of previously implicated linkage regions for Alzheimer's disease in affected relative pairs","publication_year":2009,"publication_date":"2009-12-01","ids":{"openalex":"https://openalex.org/W2026523680","doi":"https://doi.org/10.1186/1471-2350-10-122","mag":"2026523680","pmid":"https://pubmed.ncbi.nlm.nih.gov/19951422","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2791756"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2350-10-122","doi":"https://doi.org/10.1186/1471-2350-10-122","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2350-10-122","pdf_url":"https://bmcmedgenet.biomedcentral.com/counter/pdf/10.1186/1471-2350-10-122","source":{"id":"https://openalex.org/S143585532","display_name":"BMC Medical Genetics","issn_l":"1471-2350","issn":["1471-2350"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","oarl","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedgenet.biomedcentral.com/counter/pdf/10.1186/1471-2350-10-122","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Elin S Blom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Elin S Blom","raw_affiliation_strings":["Section of Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden. elin.blom@pubcare.uu.se","Section of Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden. elin.blom@pubcare.uu.se","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"Section of Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020265276","display_name":"Vilmantas Giedraitis","orcid":"https://orcid.org/0000-0003-3423-2021","observed_orcids":["https://orcid.org/0000-0003-3423-2021"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Vilmantas Giedraitis","raw_affiliation_strings":["Section of Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112282710","display_name":"Sampath Arepalli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sampath Arepalli","raw_affiliation_strings":["Laboratory of Neurogenetics, National Institute of Aging, National Institute of Health, Bethesda, MD, USA","Laboratory of Neurogenetics, National Institute of Aging, National Institute of Health, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurogenetics, National Institute of Aging, National Institute of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"Laboratory of Neurogenetics, National Institute of Aging, National Institute of Health, Bethesda, USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088279659","display_name":"Marian L. Hamshere","orcid":"https://orcid.org/0000-0002-8990-0958","observed_orcids":["https://orcid.org/0000-0002-8990-0958"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marian L Hamshere","raw_affiliation_strings":["Department of Psychological Medicine & Biostatistics and Bioinformatics Unit, Wales School of Medicine, Cardiff University, Cardiff, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychological Medicine & Biostatistics and Bioinformatics Unit, Wales School of Medicine, Cardiff University, Cardiff, UK","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060135876","display_name":"Omanma Adighibe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Omanma Adighibe","raw_affiliation_strings":["Laboratory of Neurogenetics, National Institute of Aging, National Institute of Health, Bethesda, MD, USA","Laboratory of Neurogenetics, National Institute of Aging, National Institute of Health, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurogenetics, National Institute of Aging, National Institute of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"Laboratory of Neurogenetics, National Institute of Aging, National Institute of Health, Bethesda, USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090202716","display_name":"Alison Goate","orcid":"https://orcid.org/0000-0002-0576-2472","observed_orcids":["https://orcid.org/0000-0002-0576-2472","https://orcid.org/0000-0002-2419-1943"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison Goate","raw_affiliation_strings":["Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA","Department of Psychiatry, Washington University School of Medicine, St. Louis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Psychiatry, Washington University School of Medicine, St. Louis, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049840252","display_name":"Julie H. Williams","orcid":"https://orcid.org/0000-0002-4069-0259","observed_orcids":["https://orcid.org/0000-0002-4069-0259"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Julie Williams","raw_affiliation_strings":["Department of Psychological Medicine & Biostatistics and Bioinformatics Unit, Wales School of Medicine, Cardiff University, Cardiff, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychological Medicine & Biostatistics and Bioinformatics Unit, Wales School of Medicine, Cardiff University, Cardiff, UK","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018345023","display_name":"Lars Lannfelt","orcid":"https://orcid.org/0000-0001-9839-659X","observed_orcids":["https://orcid.org/0000-0001-9839-659X"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lars Lannfelt","raw_affiliation_strings":["Section of Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020514779","display_name":"John Hardy","orcid":"https://orcid.org/0000-0002-3122-0423","observed_orcids":["https://orcid.org/0000-0002-3122-0423"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Hardy","raw_affiliation_strings":["Laboratory of Neurogenetics, National Institute of Aging, National Institute of Health, Bethesda, MD, USA","Laboratory of Neurogenetics, National Institute of Aging, National Institute of Health, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurogenetics, National Institute of Aging, National Institute of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"Laboratory of Neurogenetics, National Institute of Aging, National Institute of Health, Bethesda, USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046652694","display_name":"Fabienne Wavrant\u2010De Vri\u00e8ze","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fabienne Wavrant-De Vri\u00e8ze","raw_affiliation_strings":["Laboratory of Neurogenetics, National Institute of Aging, National Institute of Health, Bethesda, MD, USA","Laboratory of Neurogenetics, National Institute of Aging, National Institute of Health, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurogenetics, National Institute of Aging, National Institute of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"Laboratory of Neurogenetics, National Institute of Aging, National Institute of Health, Bethesda, USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110150669","display_name":"Anna Glaser","orcid":"https://orcid.org/0000-0003-2221-9161","observed_orcids":["https://orcid.org/0000-0003-2221-9161"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Anna Glaser","raw_affiliation_strings":["Section of Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5110150669"],"corresponding_institution_ids":["https://openalex.org/I123387679"],"apc_list":{"value":2380,"currency":"USD","value_usd":2380},"apc_paid":{"value":2380,"currency":"USD","value_usd":2380},"fwci":0.6305,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.71041558,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"10","issue":"1","first_page":"122","last_page":"122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.029100000858306885,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/affected-relative-pairs","display_name":"affected relative pairs","score":0.871999979019165},{"id":"https://openalex.org/keywords/genetic-linkage","display_name":"genetic linkage","score":0.8820000290870667},{"id":"https://openalex.org/keywords/chromosome-19q13","display_name":"chromosome 19q13","score":0.8519999980926514},{"id":"https://openalex.org/keywords/susceptibility-genes","display_name":"susceptibility genes","score":0.6340000033378601},{"id":"https://openalex.org/keywords/linkage-region","display_name":"linkage region","score":0.3140000104904175}],"concepts":[{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7404277324676514},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.6786938905715942},{"id":"https://openalex.org/C142870003","wikidata":"https://www.wikidata.org/wiki/Q843863","display_name":"Genetic linkage","level":3,"score":0.6617685556411743},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6460211277008057},{"id":"https://openalex.org/C31266012","wikidata":"https://www.wikidata.org/wiki/Q6554340","display_name":"Linkage (software)","level":3,"score":0.5775337219238281},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.5662176609039307},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.5149170160293579},{"id":"https://openalex.org/C2910560014","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genome Scan","level":5,"score":0.4489542245864868},{"id":"https://openalex.org/C163588314","wikidata":"https://www.wikidata.org/wiki/Q742870","display_name":"Chromosome 16","level":4,"score":0.4162501096725464},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35415446758270264},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.14654752612113953},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.1296585202217102}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018895","descriptor_name":"Microsatellite Repeats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/1471-2350-10-122","doi":"https://doi.org/10.1186/1471-2350-10-122","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2350-10-122","pdf_url":"https://bmcmedgenet.biomedcentral.com/counter/pdf/10.1186/1471-2350-10-122","source":{"id":"https://openalex.org/S143585532","display_name":"BMC Medical Genetics","issn_l":"1471-2350","issn":["1471-2350"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","oarl","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Genetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2791756","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2791756","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Med Genet","raw_type":"Text"},{"id":"pmid:19951422","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19951422","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical genetics","raw_type":"Journal Article"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:28493","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/28493/1/Blom%201471-2350-10-122.pdf","pdf_url":"https://orca.cardiff.ac.uk/id/eprint/28493/1/Blom%201471-2350-10-122.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:digitalcommons.wustl.edu:open_access_pubs-1290","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wustl.edu/open_access_pubs/282","pdf_url":"https://digitalcommons.wustl.edu/open_access_pubs/282","source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:0c92539b56d5422a9435dcd051687410","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/0c92539b56d5422a9435dcd051687410","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Genetics, Vol 10, Iss 1, p 122 (2009)","raw_type":"article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1359057","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1359057/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC MEDICAL GENETICS , 10 (ARTN 122) (2009)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1186/1471-2350-10-122","doi":"https://doi.org/10.1186/1471-2350-10-122","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2350-10-122","pdf_url":"https://bmcmedgenet.biomedcentral.com/counter/pdf/10.1186/1471-2350-10-122","source":{"id":"https://openalex.org/S143585532","display_name":"BMC Medical Genetics","issn_l":"1471-2350","issn":["1471-2350"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","oarl","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1074658981","display_name":"ETIOLOGIC HETEROGENEITY IN FAMILIAL ALZHEIMERS DISEASE","funder_award_id":"U01MH046373","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G144593012","display_name":null,"funder_award_id":"AG 16208","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G364899994","display_name":null,"funder_award_id":"AG 08724","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3844713901","display_name":"DIAGNOSTIC CENTERS FOR PSYCHIATRIC LINKAGE STUDIES","funder_award_id":"U01MH046290","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G7352717633","display_name":"DEMENTIA IN SWEDISH TWINS","funder_award_id":"R01AG008724","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8106843359","display_name":"GENOMIC SEARCH FOR SUSCEPTIBILITY TO ALZHEIMER DISEASE","funder_award_id":"R01AG016208","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8641987243","display_name":"GENETIC STUDIES OF ALZHEIMERS DISEASE","funder_award_id":"U01MH046281","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G9000916178","display_name":"National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)","funder_award_id":"U24AG021886","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G915114362","display_name":null,"funder_award_id":"R01 AG08724","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320319841","display_name":"Alzheimer's Research Trust","ror":"https://ror.org/02ymzm013"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2026523680.pdf","grobid_xml":"https://content.openalex.org/works/W2026523680.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1539826184","https://openalex.org/W1964867688","https://openalex.org/W1966741769","https://openalex.org/W1976741643","https://openalex.org/W1984508337","https://openalex.org/W1996807233","https://openalex.org/W1999887312","https://openalex.org/W2009056478","https://openalex.org/W2012733162","https://openalex.org/W2017581860","https://openalex.org/W2036173741","https://openalex.org/W2036362108","https://openalex.org/W2046209489","https://openalex.org/W2058723245","https://openalex.org/W2066874799","https://openalex.org/W2067153744","https://openalex.org/W2083633251","https://openalex.org/W2085276148","https://openalex.org/W2116314953","https://openalex.org/W2116391847","https://openalex.org/W2121286926","https://openalex.org/W2127334295","https://openalex.org/W2134448489","https://openalex.org/W2134783591","https://openalex.org/W2145492845","https://openalex.org/W2154441086","https://openalex.org/W2156220037","https://openalex.org/W2159824577","https://openalex.org/W2166966137","https://openalex.org/W2170643232"],"related_works":["https://openalex.org/W2171857394","https://openalex.org/W2036173741","https://openalex.org/W2085276148","https://openalex.org/W7099079469","https://openalex.org/W3022113159","https://openalex.org/W2154441086","https://openalex.org/W2049642770","https://openalex.org/W1602655991","https://openalex.org/W2009056478","https://openalex.org/W2097200253"],"abstract_inverted_index":{"BACKGROUND:":[0],"Genome-wide":[1],"linkage":[2,43,72,92,110,118],"studies":[3],"for":[4,15],"Alzheimer's":[5,145],"disease":[6],"have":[7,24,70],"implicated":[8,82],"several":[9],"chromosomal":[10,140],"regions":[11],"as":[12,103],"potential":[13],"loci":[14],"susceptibility":[16],"genes.":[17],"METHODS:":[18],"In":[19,61],"the":[20,34,37,84,98,106,116,120,138],"present":[21,129],"study,":[22],"we":[23,69],"combined":[25],"a":[26,41],"selection":[27],"of":[28,66],"affected":[29],"relative":[30],"pairs":[31],"(ARPs)":[32],"from":[33,56],"UK":[35],"and":[36,58,80],"USA":[38],"included":[39],"in":[40,83,119],"previous":[42,85,121],"study":[44],"by":[45],"Myers":[46],"et":[47],"al.":[48],"(Am":[49],"J":[50],"Med":[51],"Genet,":[52],"2002),":[53],"with":[54],"ARPs":[55],"Sweden":[57],"Washington":[59],"University.":[60],"this":[62],"total":[63],"sample":[64],"collection":[65],"397":[67],"ARPs,":[68],"analyzed":[71],"to":[73,93,97,105,111,144],"chromosomes":[74],"1,":[75],"9,":[76],"10,":[77],"12,":[78],"19":[79],"21,":[81],"scan.":[86,108],"RESULTS:":[87],"The":[88,128],"analysis":[89],"revealed":[90],"that":[91,135],"chromosome":[94,112],"19q13":[95,136],"close":[96],"APOE":[99],"locus":[100],"increased":[101],"considerably":[102],"compared":[104],"earlier":[107],"However,":[109],"10q21,":[113],"which":[114],"provided":[115],"strongest":[117],"scan":[122],"could":[123],"not":[124],"be":[125],"detected.":[126],"CONCLUSION:":[127],"investigation":[130],"provides":[131],"yet":[132],"further":[133],"evidence":[134],"is":[137],"only":[139],"region":[141],"consistently":[142],"linked":[143],"disease.":[146]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}