{"id":"https://openalex.org/W2026414859","doi":"https://doi.org/10.1016/s0013-9351(02)00007-5","title":"In vitro vs in vivo Pb effects on brain protein kinase C activity","display_name":"In vitro vs in vivo Pb effects on brain protein kinase C activity","publication_year":2002,"publication_date":"2002-11-01","ids":{"openalex":"https://openalex.org/W2026414859","doi":"https://doi.org/10.1016/s0013-9351(02)00007-5","mag":"2026414859","pmid":"https://pubmed.ncbi.nlm.nih.gov/12477464"},"language":"en","primary_location":{"id":"doi:10.1016/s0013-9351(02)00007-5","doi":"https://doi.org/10.1016/s0013-9351(02)00007-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0013-9351(02)00007-5","pdf_url":null,"source":{"id":"https://openalex.org/S173943867","display_name":"Environmental Research","issn_l":"0013-9351","issn":["0013-9351","1096-0953"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089896257","display_name":"John D. Cremin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John D Cremin","raw_affiliation_strings":["Department of Environmental Toxicology, University of California, Santa Cruz, CA 95064, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Toxicology, University of California, Santa Cruz, CA 95064, USA","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074940124","display_name":"Donald R. Smith","orcid":"https://orcid.org/0000-0002-4919-1042","observed_orcids":["https://orcid.org/0000-0002-4919-1042"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald R Smith","raw_affiliation_strings":["Department of Environmental Toxicology , University of California , Santa Cruz, CA, 95064, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Toxicology , University of California , Santa Cruz, CA, 95064, USA","institution_ids":["https://openalex.org/I185103710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I185103710"],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":1.4365,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.78165057,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"90","issue":"3","first_page":"191","last_page":"199"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10139","display_name":"Heavy metals in environment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lead-exposure","display_name":"lead exposure","score":0.7929999828338623},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9639999866485596},{"id":"https://openalex.org/keywords/brain","display_name":"brain","score":0.5609999895095825},{"id":"https://openalex.org/keywords/developmental-neurotoxicity","display_name":"developmental neurotoxicity","score":0.8399999737739563},{"id":"https://openalex.org/keywords/frontal-cortex","display_name":"frontal cortex","score":0.9490000009536743},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.855963945388794},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6004208326339722},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.5657444000244141},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.5610449910163879},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5427184104919434},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.45207643508911133},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4261632561683655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3425472676753998},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3288215100765228},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3253352642059326},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31583118438720703},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.27245423197746277},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1607978343963623},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0974530279636383},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007854","descriptor_name":"Lead","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007854","descriptor_name":"Lead","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007854","descriptor_name":"Lead","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020263","descriptor_name":"Lead Poisoning, Nervous System","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D020318","descriptor_name":"Rats, Long-Evans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0013-9351(02)00007-5","doi":"https://doi.org/10.1016/s0013-9351(02)00007-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0013-9351(02)00007-5","pdf_url":null,"source":{"id":"https://openalex.org/S173943867","display_name":"Environmental Research","issn_l":"0013-9351","issn":["0013-9351","1096-0953"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Research","raw_type":"journal-article"},{"id":"pmid:12477464","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12477464","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1510712986","display_name":"BONE PB TOXICITY AND REMOBILIZATION IN RATS","funder_award_id":"R01ES007535","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G7127060103","display_name":"DMSA--EFFICACY IN REDUCING NEUROBEHAVIORAL TOXICITY","funder_award_id":"R01ES007457","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G7743547018","display_name":"SUCCIMER EFFECTS--BRAIN REGION PB &GI PB ABSORPTION","funder_award_id":"F32ES005870","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W105291650","https://openalex.org/W107413778","https://openalex.org/W135855325","https://openalex.org/W221418928","https://openalex.org/W249845531","https://openalex.org/W1041083769","https://openalex.org/W1484757099","https://openalex.org/W1537123837","https://openalex.org/W1675084292","https://openalex.org/W1844691600","https://openalex.org/W1933056516","https://openalex.org/W1985395951","https://openalex.org/W1986391726","https://openalex.org/W1987074935","https://openalex.org/W1997260013","https://openalex.org/W2000284666","https://openalex.org/W2001148956","https://openalex.org/W2004398393","https://openalex.org/W2005175223","https://openalex.org/W2005484002","https://openalex.org/W2008784972","https://openalex.org/W2017788959","https://openalex.org/W2027553165","https://openalex.org/W2028126096","https://openalex.org/W2029525845","https://openalex.org/W2038337382","https://openalex.org/W2039772395","https://openalex.org/W2046975858","https://openalex.org/W2052983072","https://openalex.org/W2055912490","https://openalex.org/W2059588968","https://openalex.org/W2061623771","https://openalex.org/W2069564669","https://openalex.org/W2072776316","https://openalex.org/W2073910850","https://openalex.org/W2100394052","https://openalex.org/W2114664354","https://openalex.org/W2143019190","https://openalex.org/W2151632397","https://openalex.org/W2156160966","https://openalex.org/W2163815564","https://openalex.org/W2167935882","https://openalex.org/W2208810599","https://openalex.org/W2321413400","https://openalex.org/W2409797895","https://openalex.org/W2466724556","https://openalex.org/W2955504961"],"related_works":["https://openalex.org/W1978234265","https://openalex.org/W2156160966","https://openalex.org/W105291650","https://openalex.org/W2386776246","https://openalex.org/W7096672610","https://openalex.org/W2409797895","https://openalex.org/W107413778","https://openalex.org/W2036453654","https://openalex.org/W4246609471","https://openalex.org/W2036388554"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}