{"id":"https://openalex.org/W2026323579","doi":"https://doi.org/10.2174/156720506777632835","title":"RNA Therapeutics Directed to the Non Coding Regions of APP mRNA, In Vivo Anti-Amyloid Efficacy of Paroxetine, Erythromycin, and N-acetyl cysteine","display_name":"RNA Therapeutics Directed to the Non Coding Regions of APP mRNA, In Vivo Anti-Amyloid Efficacy of Paroxetine, Erythromycin, and N-acetyl cysteine","publication_year":2006,"publication_date":"2006-06-17","ids":{"openalex":"https://openalex.org/W2026323579","doi":"https://doi.org/10.2174/156720506777632835","mag":"2026323579","pmid":"https://pubmed.ncbi.nlm.nih.gov/16842099"},"language":"en","primary_location":{"id":"doi:10.2174/156720506777632835","doi":"https://doi.org/10.2174/156720506777632835","is_oa":false,"landing_page_url":"https://doi.org/10.2174/156720506777632835","pdf_url":null,"source":{"id":"https://openalex.org/S188438558","display_name":"Current Alzheimer Research","issn_l":"1567-2050","issn":["1567-2050","1875-5828"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Alzheimer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Stephanie Tucker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Tucker","raw_affiliation_strings":["Neurochemistry Laboratory, Division of Psychiatric Neurosciences and Genetics and Aging Research Unit, Massachusetts General Hospital, Boston, MA 02114, USA. Jrogers@partners.org","Neurochemistry Laboratory, Division of Psychiatric Neurosciences and Genetics and Aging Research Unit, Massachusetts General Hospital, Boston, MA 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurochemistry Laboratory, Division of Psychiatric Neurosciences and Genetics and Aging Research Unit, Massachusetts General Hospital, Boston, MA 02114, USA. Jrogers@partners.org","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Neurochemistry Laboratory, Division of Psychiatric Neurosciences and Genetics and Aging Research Unit, Massachusetts General Hospital, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075691205","display_name":"Michelle Ahl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michelle Ahl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023276998","display_name":"Hyun-Hee Cho","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hyun-Hee Cho","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007160886","display_name":"Sanghamitra Bandyopadhyay","orcid":"https://orcid.org/0000-0002-1490-3599","observed_orcids":["https://orcid.org/0000-0002-1490-3599","https://orcid.org/0000-0001-6370-2083"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sanghamitra Bandyopadhyay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055567926","display_name":"Gregory D. Cuny","orcid":"https://orcid.org/0000-0002-3188-4748","observed_orcids":["https://orcid.org/0000-0002-3188-4748"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory Cuny","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038374630","display_name":"Ashley Ian Bush","orcid":"https://orcid.org/0000-0001-8259-9069","observed_orcids":["https://orcid.org/0000-0001-8259-9069"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashley Bush","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045045118","display_name":"Lee E. Goldstein","orcid":"https://orcid.org/0000-0001-8419-9800","observed_orcids":["https://orcid.org/0000-0001-8419-9800"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lee Goldstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014473479","display_name":"David A. Westaway","orcid":"https://orcid.org/0000-0003-1928-4616","observed_orcids":["https://orcid.org/0000-0003-1928-4616"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Westaway","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080825168","display_name":"Xudong Huang","orcid":"https://orcid.org/0000-0002-4811-1901","observed_orcids":["https://orcid.org/0000-0002-4811-1901"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xudong Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5071704528","display_name":"Jack T. Rogers","orcid":"https://orcid.org/0000-0003-1262-8578","observed_orcids":["https://orcid.org/0000-0003-1262-8578"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jack Rogers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4645,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.54750623,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"3","issue":"3","first_page":"221","last_page":"227"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.8050000071525574},{"id":"https://openalex.org/keywords/rna-therapeutics","display_name":"RNA therapeutics","score":0.890999972820282},{"id":"https://openalex.org/keywords/anti-amyloid-drugs","display_name":"anti-amyloid drugs","score":0.7599999904632568},{"id":"https://openalex.org/keywords/paroxetine","display_name":"paroxetine","score":0.8989999890327454},{"id":"https://openalex.org/keywords/erythromycin","display_name":"erythromycin","score":0.9679999947547913},{"id":"https://openalex.org/keywords/macrolides","display_name":"macrolides","score":0.7760000228881836},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.9750000238418579},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.6420000195503235},{"id":"https://openalex.org/keywords/tgcrnd8-mice","display_name":"TgCRND8 mice","score":0.8849999904632568},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9409999847412109},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C2780206985","wikidata":"https://www.wikidata.org/wiki/Q213511","display_name":"Erythromycin","level":3,"score":0.6964299082756042},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6813123226165771},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6608034372329712},{"id":"https://openalex.org/C2777828372","wikidata":"https://www.wikidata.org/wiki/Q408471","display_name":"Paroxetine","level":4,"score":0.6549966335296631},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6354678869247437},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.5396776795387268},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.3139057159423828},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.2745969295501709},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2705765962600708},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.21186155080795288},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20333153009414673},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19891592860221863},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17290571331977844},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09862202405929565},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004917","descriptor_name":"Erythromycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004917","descriptor_name":"Erythromycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011500","descriptor_name":"Protein Synthesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011500","descriptor_name":"Protein Synthesis Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015507","descriptor_name":"Drugs, Investigational","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015507","descriptor_name":"Drugs, Investigational","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017374","descriptor_name":"Paroxetine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017374","descriptor_name":"Paroxetine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020121","descriptor_name":"5' Untranslated Regions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020121","descriptor_name":"5' Untranslated Regions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2174/156720506777632835","doi":"https://doi.org/10.2174/156720506777632835","is_oa":false,"landing_page_url":"https://doi.org/10.2174/156720506777632835","pdf_url":null,"source":{"id":"https://openalex.org/S188438558","display_name":"Current Alzheimer Research","issn_l":"1567-2050","issn":["1567-2050","1875-5828"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Alzheimer Research","raw_type":"journal-article"},{"id":"pmid:16842099","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16842099","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Alzheimer research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3911221002","display_name":null,"funder_award_id":"5K01MH002001","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G4069818375","display_name":"BIOMETALS, OXIDATIVE STRESS, AND AB AMYLOIDOSIS","funder_award_id":"5k01mh002001-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5303328785","display_name":"RNA Therapeutics and Abeta Precursor Protein Translation","funder_award_id":"R01AG021081","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2124072274","https://openalex.org/W1988292733","https://openalex.org/W2007642119","https://openalex.org/W2010292436","https://openalex.org/W2038626774","https://openalex.org/W2330931672","https://openalex.org/W1969557433","https://openalex.org/W2795584954","https://openalex.org/W3007084450","https://openalex.org/W2039811312"],"abstract_inverted_index":{"Lead":[0],"compounds":[1,176],"directed":[2],"to":[3,29,56,65,112,145,192,204],"the":[4,8,35,71,108,131,134,206],"5'":[5],"leader":[6],"of":[7,47,54,73,82,133,180,209],"Amyloid":[9],"Precursor":[10],"Protein":[11],"transcript":[12],"(i.e.,":[13],"paroxetine":[14,57,98,210],"(SSRI),":[15],"N-acetyl":[16],"cysteine":[17],"(antioxidant),":[18],"and":[19,61,76,94,123,166,211,219],"erythromycin":[20,62,187,212],"(macrolide":[21],"antibiotic))":[22],"were":[23,50,84,125],"employed":[24],"in":[25,34,120,139],"a":[26,157,195],"pilot":[27],"study":[28],"evaluate":[30],"their":[31],"anti-amyloid":[32,118,161],"efficacy":[33,119],"TgCRND8":[36,146,181],"transgenic":[37],"mouse":[38],"model":[39],"for":[40,102,105,163,170,194,216,221],"Alzheimer's":[41],"Disease":[42],"(AD).":[43],"The":[44,97,168],"relative":[45,64],"levels":[46,72,80],"Abeta":[48,78,83],"peptide":[49,79],"reduced":[51,150],"after":[52],"exposure":[53],"mice":[55,147,182,193],"(N=5),":[58],"NAC":[59,165],"(N=7),":[60],"(N=7)":[63],"matched":[66],"placebo":[67],"counterparts.":[68],"Paroxetine":[69],"limited":[70],"APP":[74,109,135],"holoprotein":[75],"total":[77],"(measurements":[81],"performed":[85],"at":[86],"two":[87],"separate":[88],"sites":[89],"by":[90],"quantitative":[91],"western":[92],"blotting":[93],"ELISA":[95],"assay).":[96],"data":[99,155],"provided":[100,143],"proof-of-concept":[101],"our":[103],"strategy":[104],"further":[106,172,196],"screening":[107],"5'UTR":[110],"target":[111],"identify":[113],"novel":[114],"drugs":[115],"that":[116,128],"exhibit":[117],"vivo.":[121],"Erythromycin":[122,142],"azithromycin":[124],"macrolide":[126],"antibiotics":[127],"markedly":[129],"changed":[130],"cleavage":[132],"C-Terminal":[136],"Fragment":[137],"(CTF)":[138],"SH-SY5Y":[140],"cells.":[141],"orally":[144],"consistently":[148],"(100%)":[149],"brain":[151],"Abeta(1-42)":[152],"levels.":[153],"These":[154],"demonstrated":[156],"highly":[158],"statistically":[159],"significant":[160],"trend":[162],"paroxetine,":[164],"erythromycin.":[167],"potential":[169],"conducting":[171],"studies":[173],"with":[174],"these":[175],"using":[177],"larger":[178],"cohorts":[179],"is":[183],"discussed,":[184],"particularly":[185],"since":[186],"has":[188],"recently":[189],"been":[190],"exposed":[191],"6":[197],"months":[198],"(N=6).":[199],"It":[200],"will":[201],"be":[202],"possible":[203],"employ":[205],"chemical":[207],"structures":[208],"as":[213],"starting":[214],"points":[215],"drug":[217],"design":[218],"development":[220],"AD":[222],"therapeutics.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}