{"id":"https://openalex.org/W2026316716","doi":"https://doi.org/10.3109/03008207.2013.822865","title":"The expanded collagen VI family: new chains and new questions","display_name":"The expanded collagen VI family: new chains and new questions","publication_year":2013,"publication_date":"2013-07-19","ids":{"openalex":"https://openalex.org/W2026316716","doi":"https://doi.org/10.3109/03008207.2013.822865","mag":"2026316716","pmid":"https://pubmed.ncbi.nlm.nih.gov/23869615","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5248970"},"language":"en","primary_location":{"id":"doi:10.3109/03008207.2013.822865","doi":"https://doi.org/10.3109/03008207.2013.822865","is_oa":false,"landing_page_url":"https://doi.org/10.3109/03008207.2013.822865","pdf_url":null,"source":{"id":"https://openalex.org/S3113591","display_name":"Connective Tissue Research","issn_l":"0300-8207","issn":["0300-8207","1026-7433","1607-8438"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Connective Tissue Research","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5248970","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jamie Fitzgerald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jamie Fitzgerald","raw_affiliation_strings":["Departments of Orthopaedics and Rehabilitation","Molecular and Medical Genetics, Oregon Health and Science University\nPortland, OR 97239USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Orthopaedics and Rehabilitation","institution_ids":[]},{"raw_affiliation_string":"Molecular and Medical Genetics, Oregon Health and Science University\nPortland, OR 97239USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109417139","display_name":"Paul K. Holden","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Holden","raw_affiliation_strings":["Departments of Orthopaedics and Rehabilitation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Orthopaedics and Rehabilitation","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047983303","display_name":"Uwe J. Hansen","orcid":"https://orcid.org/0000-0001-8519-8228","observed_orcids":["https://orcid.org/0000-0001-8519-8228"]},"institutions":[{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Uwe Hansen","raw_affiliation_strings":["Institute for Physiological Chemistry and Pathobiochemistry, University Hospital of Muenster 48129 MuensterGermany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Physiological Chemistry and Pathobiochemistry, University Hospital of Muenster 48129 MuensterGermany","institution_ids":["https://openalex.org/I4210103666"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I165690674"],"apc_list":null,"apc_paid":null,"fwci":0.6974,"has_fulltext":false,"cited_by_count":94,"citation_normalized_percentile":{"value":0.57295374,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"54","issue":"6","first_page":"345","last_page":"350"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.6898999810218811,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.6898999810218811,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.1949000060558319,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":0.0333000011742115,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/collagen-vi","display_name":"collagen VI","score":1.0},{"id":"https://openalex.org/keywords/col6a6","display_name":"COL6A6","score":1.0},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.6809999942779541},{"id":"https://openalex.org/keywords/microfibrils","display_name":"microfibrils","score":0.902999997138977},{"id":"https://openalex.org/keywords/basement-membrane","display_name":"basement membrane","score":0.6869999766349792},{"id":"https://openalex.org/keywords/congenital-muscular-dystrophy","display_name":"congenital muscular dystrophy","score":0.9750000238418579},{"id":"https://openalex.org/keywords/connective-tissue","display_name":"connective tissue","score":0.6309999823570251},{"id":"https://openalex.org/keywords/genetic-loci","display_name":"genetic loci","score":0.33500000834465027},{"id":"https://openalex.org/keywords/chromosome-3q","display_name":"chromosome 3q","score":0.6119999885559082},{"id":"https://openalex.org/keywords/chromosome-9","display_name":"chromosome 9","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C2778873089","wikidata":"https://www.wikidata.org/wiki/Q3281418","display_name":"Collagen VI","level":3,"score":0.8706046342849731},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7036739587783813},{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.5871540904045105},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5706192255020142},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5152366757392883},{"id":"https://openalex.org/C2780105995","wikidata":"https://www.wikidata.org/wiki/Q232358","display_name":"Tendon","level":2,"score":0.4524180293083191},{"id":"https://openalex.org/C38008103","wikidata":"https://www.wikidata.org/wiki/Q5145884","display_name":"Collagen, type I, alpha 1","level":3,"score":0.4423671364784241},{"id":"https://openalex.org/C518705261","wikidata":"https://www.wikidata.org/wiki/Q25615","display_name":"Connective tissue","level":2,"score":0.41581061482429504},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41143739223480225},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33456289768218994},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3241438865661621},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30085229873657227},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.256252646446228}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002875","descriptor_name":"Chromosomes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024142","descriptor_name":"Collagen Type VI","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024142","descriptor_name":"Collagen Type VI","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024142","descriptor_name":"Collagen Type VI","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3109/03008207.2013.822865","doi":"https://doi.org/10.3109/03008207.2013.822865","is_oa":false,"landing_page_url":"https://doi.org/10.3109/03008207.2013.822865","pdf_url":null,"source":{"id":"https://openalex.org/S3113591","display_name":"Connective Tissue Research","issn_l":"0300-8207","issn":["0300-8207","1026-7433","1607-8438"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Connective Tissue Research","raw_type":"journal-article"},{"id":"pmid:23869615","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23869615","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Connective tissue research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5248970","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5248970","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Connect Tissue Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5248970","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5248970","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Connect Tissue Res","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G131613461","display_name":"Three new collagen VI genes; COL6A4, COL6A5 and COL6A6","funder_award_id":"R01AR055957","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W92534390","https://openalex.org/W1482127541","https://openalex.org/W1608938564","https://openalex.org/W1965435311","https://openalex.org/W1970778492","https://openalex.org/W1975437957","https://openalex.org/W1978421647","https://openalex.org/W2000191164","https://openalex.org/W2002226831","https://openalex.org/W2003305541","https://openalex.org/W2010555821","https://openalex.org/W2013717602","https://openalex.org/W2021212400","https://openalex.org/W2029301550","https://openalex.org/W2032022637","https://openalex.org/W2039694476","https://openalex.org/W2042445363","https://openalex.org/W2045499302","https://openalex.org/W2055389201","https://openalex.org/W2055490078","https://openalex.org/W2055948319","https://openalex.org/W2068694666","https://openalex.org/W2072576191","https://openalex.org/W2074592121","https://openalex.org/W2078399898","https://openalex.org/W2084591484","https://openalex.org/W2103838657","https://openalex.org/W2114447697","https://openalex.org/W2115523644","https://openalex.org/W2121280649","https://openalex.org/W2127790326","https://openalex.org/W2130036778","https://openalex.org/W2136043670","https://openalex.org/W2141573080","https://openalex.org/W2156509251","https://openalex.org/W2159009641","https://openalex.org/W2160075959","https://openalex.org/W2168037575","https://openalex.org/W2168782470","https://openalex.org/W2223764435","https://openalex.org/W2401079384","https://openalex.org/W2426763187","https://openalex.org/W3190095640"],"related_works":["https://openalex.org/W2045499302","https://openalex.org/W1666982048","https://openalex.org/W1970778492","https://openalex.org/W2028436839","https://openalex.org/W2055389201","https://openalex.org/W1970199379","https://openalex.org/W2086250226","https://openalex.org/W2238722478","https://openalex.org/W2072030041","https://openalex.org/W2741114495"],"abstract_inverted_index":{"Collagen":[0],"VI":[1,39,68,108],"is":[2,40,46],"a":[3,114],"component":[4],"of":[5,9,37,53,161,163],"the":[6,50,76,131,136,146,158,164],"extracellular":[7],"matrix":[8,52],"almost":[10],"all":[11],"connective":[12],"tissues,":[13],"including":[14],"cartilage,":[15],"bone,":[16],"tendon,":[17],"muscles":[18],"and":[19,25,55,72,79,93,123,143,149],"cornea,":[20],"where":[21],"it":[22,45],"forms":[23],"abundant":[24,48],"structurally":[26],"unique":[27],"microfibrils":[28],"organized":[29],"into":[30],"different":[31],"suprastructural":[32],"assemblies.":[33],"The":[34],"precise":[35],"role":[36,94],"collagen":[38,67,107],"not":[41],"clearly":[42],"defined":[43],"although":[44],"most":[47],"in":[49,58,95,111,121,126],"interstitial":[51],"tissues":[54],"often":[56],"found":[57],"close":[59],"association":[60],"with":[61],"basement":[62],"membranes.":[63],"Three":[64],"genetically":[65],"distinct":[66],"chains,":[69,151],"\u03b11(VI),":[70],"\u03b12(VI)":[71],"\u03b13(VI),":[73],"encoded":[74],"by":[75],"COL6A1.":[77],"COL6A2":[78],"COL6A3":[80],"genes,":[81],"were":[82,128,139],"first":[83],"described":[84],"more":[85],"than":[86],"20":[87],"years":[88],"ago.":[89],"Their":[90],"molecular":[91],"assembly":[92],"congenital":[96],"muscular":[97],"dystrophy":[98],"has":[99],"been":[100],"broadly":[101],"characterized.":[102],"In":[103],"2008,":[104],"three":[105,165],"additional":[106],"genes":[109,138],"arrayed":[110],"tandem":[112],"at":[113],"single":[115],"gene":[116],"locus":[117],"on":[118,157],"chromosome":[119,124],"3q":[120],"humans,":[122],"9":[125],"mice,":[127],"described.":[129],"Following":[130],"naming":[132],"scheme":[133],"for":[134],"collagens":[135],"new":[137,166],"designated":[140],"COL6A4.":[141],"COL6A5":[142],"COL6A6":[144],"encoding":[145],"\u03b14(VI),":[147],"\u03b15(VI)":[148],"\u03b16(VI)":[150],"respectively.":[152],"This":[153],"review":[154],"will":[155],"focus":[156],"current":[159],"state":[160],"knowledge":[162],"chains.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}