{"id":"https://openalex.org/W2026309239","doi":"https://doi.org/10.1001/jama.285.6.748","title":"Effectiveness of Oseltamivir in Preventing Influenza in Household Contacts A Randomized Controlled Trial","display_name":"Effectiveness of Oseltamivir in Preventing Influenza in Household Contacts A Randomized Controlled Trial","publication_year":2001,"publication_date":"2001-02-14","ids":{"openalex":"https://openalex.org/W2026309239","doi":"https://doi.org/10.1001/jama.285.6.748","mag":"2026309239","pmid":"https://pubmed.ncbi.nlm.nih.gov/11176912"},"language":"en","primary_location":{"id":"doi:10.1001/jama.285.6.748","doi":"https://doi.org/10.1001/jama.285.6.748","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.285.6.748","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014098236","display_name":"Charles Welliver","orcid":"https://orcid.org/0000-0001-8520-3218","observed_orcids":["https://orcid.org/0000-0001-8520-3218"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Robert Welliver","raw_affiliation_strings":["The Medical Building, 327 Mile End Rd, London, England E1 4NS. j.s.oxford@retroscreen.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Medical Building, 327 Mile End Rd, London, England E1 4NS. j.s.oxford@retroscreen.com","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5014098236"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":21.5015,"has_fulltext":false,"cited_by_count":471,"citation_normalized_percentile":{"value":0.99780035,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"285","issue":"6","first_page":"748","last_page":"748"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/influenza","display_name":"influenza","score":0.6539999842643738},{"id":"https://openalex.org/keywords/household-contacts","display_name":"household contacts","score":0.8090000152587891},{"id":"https://openalex.org/keywords/post-exposure-prophylaxis","display_name":"post-exposure prophylaxis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/influenza-transmission","display_name":"influenza transmission","score":0.6019999980926514},{"id":"https://openalex.org/keywords/viral-shedding","display_name":"viral shedding","score":0.7749999761581421},{"id":"https://openalex.org/keywords/protective-efficacy","display_name":"protective efficacy","score":0.7080000042915344},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.4860000014305115},{"id":"https://openalex.org/keywords/influenza-b","display_name":"influenza B","score":0.7200000286102295},{"id":"https://openalex.org/keywords/seroconversion","display_name":"seroconversion","score":0.4790000021457672},{"id":"https://openalex.org/keywords/gastrointestinal-tolerability","display_name":"gastrointestinal tolerance","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C2780374985","wikidata":"https://www.wikidata.org/wiki/Q211509","display_name":"Oseltamivir","level":5,"score":0.9095983505249023},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8690848350524902},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6262476444244385},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5428526401519775},{"id":"https://openalex.org/C12914427","wikidata":"https://www.wikidata.org/wiki/Q7933612","display_name":"Viral shedding","level":3,"score":0.5412724614143372},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4844658374786377},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.48187169432640076},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.4637743830680847},{"id":"https://openalex.org/C2777538117","wikidata":"https://www.wikidata.org/wiki/Q425196","display_name":"Neuraminidase inhibitor","level":5,"score":0.4633849561214447},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4510570764541626},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.43810591101646423},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42075368762016296},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.38145625591278076},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.13801142573356628},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.09886044263839722},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.08138036727905273},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07403066754341125},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000081","descriptor_name":"Acetamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005191","descriptor_name":"Family Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009439","descriptor_name":"Neuraminidase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D009666","descriptor_name":"Nose","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009975","descriptor_name":"Orthomyxoviridae","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010614","descriptor_name":"Pharynx","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D017201","descriptor_name":"Virus Shedding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053139","descriptor_name":"Oseltamivir","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1001/jama.285.6.748","doi":"https://doi.org/10.1001/jama.285.6.748","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.285.6.748","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"journal-article"},{"id":"pmid:11176912","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11176912","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"Clinical Trial"},{"id":"mag:2144872294","doi":null,"is_oa":false,"landing_page_url":"http://static.userland.com/gems/albanymed/flu.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:2279704543","doi":null,"is_oa":false,"landing_page_url":"http://en.journals.sid.ir/ViewPaper.aspx?ID=73959","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W67087141","https://openalex.org/W264898042","https://openalex.org/W1548704164","https://openalex.org/W1960753282","https://openalex.org/W1979083332","https://openalex.org/W2003926950","https://openalex.org/W2004554957","https://openalex.org/W2027368298","https://openalex.org/W2042633745","https://openalex.org/W2046938649","https://openalex.org/W2047562582","https://openalex.org/W2055986785","https://openalex.org/W2060920861","https://openalex.org/W2072658090","https://openalex.org/W2080927210","https://openalex.org/W2082883881","https://openalex.org/W2094397596","https://openalex.org/W2095804377","https://openalex.org/W2126383827","https://openalex.org/W2130060383","https://openalex.org/W2130441728","https://openalex.org/W2145230724","https://openalex.org/W2150348390","https://openalex.org/W2152301816","https://openalex.org/W2153531642","https://openalex.org/W2164343098","https://openalex.org/W2316425515"],"related_works":["https://openalex.org/W2016310165","https://openalex.org/W7095712880","https://openalex.org/W2127390470","https://openalex.org/W2105612216","https://openalex.org/W2117512155","https://openalex.org/W2165375890","https://openalex.org/W2614881755","https://openalex.org/W2337212536","https://openalex.org/W2281725702","https://openalex.org/W4212944113"],"abstract_inverted_index":{"CONTEXT:":[0],"Influenza":[1],"virus":[2,159,255],"is":[3],"easily":[4],"spread":[5,23,38],"among":[6],"the":[7,27,32,66,133,190,263],"household":[8,19,42,85,105],"contacts":[9,20,43,86,94,100,148,185,218,243,302],"of":[10,16,24,34,39,44,68,77,90,95,111,129,149,158,186,194,219,227,303],"an":[11,187],"infected":[12],"person,":[13],"and":[14,63,83,163,179,209,281,313],"prevention":[15],"influenza":[17,25,40,81,146,198,307],"in":[18,26,36,60,132,147,153,161,172,242,278],"can":[21],"control":[22],"community.":[28],"OBJECTIVE:":[29],"To":[30],"investigate":[31],"efficacy":[33,193,233,249],"oseltamivir":[35,112,195,222,258,279],"preventing":[37],"to":[41,107,262],"influenza-infected":[45,304],"index":[46],"cases":[47],"(ICs).":[48],"DESIGN":[49],"AND":[50],"SETTING:":[51],"Randomized,":[52],"double-blind,":[53],"placebo-controlled":[54],"study":[55],"conducted":[56],"at":[57],"76":[58],"centers":[59],"North":[61],"America":[62],"Europe":[64],"during":[65],"winter":[67],"1998-1999.":[69],"PARTICIPANTS:":[70],"Three":[71],"hundred":[72],"seventy-seven":[73],"ICs,":[74,151,221],"163":[75],"(43%)":[76],"whom":[78],"had":[79],"laboratory-confirmed":[80],"infection,":[82],"955":[84],"(aged":[87],">/=12":[88],"years)":[89],"all":[91,220],"ICs":[92,136],"(415":[93],"influenza-positive":[96,150,188],"ICs).":[97],"INTERVENTIONS:":[98],"Household":[99],"were":[101,273],"randomly":[102],"assigned":[103],"by":[104,156],"cluster":[106],"take":[108],"75":[109,293],"mg":[110,294],"(n":[113,118],"=":[114,119],"493)":[115],"or":[116,166,169],"placebo":[117,282],"462)":[120],"once":[121,295],"daily":[122,296],"for":[123,201,211,297],"7":[124,298],"days":[125],"within":[126,311],"48":[127],"hours":[128],"symptom":[130],"onset":[131],"IC.":[134],"The":[135],"did":[137],"not":[138],"receive":[139],"antiviral":[140],"treatment.":[141],"MAIN":[142],"OUTCOME":[143],"MEASURE:":[144],"Clinical":[145],"confirmed":[152],"a":[154,167],"laboratory":[155],"detection":[157],"shedding":[160,239],"nose":[162],"throat":[164],"swabs":[165],"4-fold":[168],"greater":[170],"increase":[171],"influenza-specific":[173],"serum":[174,181],"antibody":[175],"titer":[176],"between":[177],"baseline":[178],"convalescent":[180],"samples.":[182],"RESULTS:":[183],"In":[184,217,286],"IC,":[189],"overall":[191],"protective":[192,232,248],"against":[196,306],"clinical":[197,228],"was":[199,240,267,314],"89%":[200,231],"individuals":[202],"(95%":[203,213,234,250],"confidence":[204],"interval":[205],"[CI],":[206],"67%-97%;":[207],"P<.001)":[208],"84%":[210,247],"households":[212],"CI,":[214,235,251],"49%-95%;":[215],"P<.001).":[216,237,253],"also":[223],"significantly":[224],"reduced":[225],"incidence":[226],"influenza,":[229],"with":[230,246,275,291],"71%-96%;":[236],"Viral":[238],"inhibited":[241],"taking":[244],"oseltamivir,":[245,292],"57%-95%;":[252],"All":[254],"isolates":[256],"from":[257],"recipients":[259],"retained":[260],"sensitivity":[261],"active":[264],"metabolite.":[265],"Oseltamivir":[266],"well":[268,315],"tolerated;":[269],"gastrointestinal":[270],"tract":[271],"effects":[272],"reported":[274],"similar":[276],"frequency":[277],"(9.3%)":[280],"(7.2%)":[283],"recipients.":[284],"CONCLUSION:":[285],"our":[287],"sample,":[288],"postexposure":[289],"prophylaxis":[290],"days,":[299],"protected":[300],"close":[301],"persons":[305],"illness,":[308],"prevented":[309],"outbreaks":[310],"households,":[312],"tolerated.":[316]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":26}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
