{"id":"https://openalex.org/W2026251237","doi":"https://doi.org/10.1073/pnas.1218581109","title":"Shape change in the receptor for gliding motility in Plasmodium sporozoites","display_name":"Shape change in the receptor for gliding motility in Plasmodium sporozoites","publication_year":2012,"publication_date":"2012-12-11","ids":{"openalex":"https://openalex.org/W2026251237","doi":"https://doi.org/10.1073/pnas.1218581109","mag":"2026251237","pmid":"https://pubmed.ncbi.nlm.nih.gov/23236185","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3535621"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1218581109","doi":"https://doi.org/10.1073/pnas.1218581109","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1218581109","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3535621","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037732408","display_name":"Gaojie Song","orcid":"https://orcid.org/0000-0002-7787-6452","observed_orcids":["https://orcid.org/0000-0002-7787-6452"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gaojie Song","raw_affiliation_strings":["Immune Disease Institute, Program in Cellular and Molecular Medicine, Children\u2019s Hospital Boston, MA 02115; and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immune Disease Institute, Program in Cellular and Molecular Medicine, Children\u2019s Hospital Boston, MA 02115; and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078998694","display_name":"Adem C. Koksal","orcid":"https://orcid.org/0000-0002-3163-7421","observed_orcids":["https://orcid.org/0000-0002-3163-7421"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adem C. Koksal","raw_affiliation_strings":["Immune Disease Institute, Program in Cellular and Molecular Medicine, Children\u2019s Hospital Boston, MA 02115; and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immune Disease Institute, Program in Cellular and Molecular Medicine, Children\u2019s Hospital Boston, MA 02115; and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025363376","display_name":"Chafen Lu","orcid":"https://orcid.org/0000-0002-3954-4836","observed_orcids":["https://orcid.org/0000-0002-3954-4836"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chafen Lu","raw_affiliation_strings":["Immune Disease Institute, Program in Cellular and Molecular Medicine, Children\u2019s Hospital Boston, MA 02115; and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immune Disease Institute, Program in Cellular and Molecular Medicine, Children\u2019s Hospital Boston, MA 02115; and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003615852","display_name":"Timothy A. Springer","orcid":"https://orcid.org/0000-0001-6627-2904","observed_orcids":["https://orcid.org/0000-0001-6627-2904"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy A. Springer","raw_affiliation_strings":["Immune Disease Institute, Program in Cellular and Molecular Medicine, Children\u2019s Hospital Boston, MA 02115; and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immune Disease Institute, Program in Cellular and Molecular Medicine, Children\u2019s Hospital Boston, MA 02115; and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.6286,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.94563123,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"109","issue":"52","first_page":"21420","last_page":"21425"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium-sporozoites","display_name":"Plasmodium sporozoites","score":0.902999997138977},{"id":"https://openalex.org/keywords/gliding-motility","display_name":"gliding motility","score":0.9470000267028809},{"id":"https://openalex.org/keywords/von-willebrand-factor-type-a-domain","display_name":"von Willebrand factor type A domain","score":0.8619999885559082},{"id":"https://openalex.org/keywords/protein-conformational-change","display_name":"protein conformational change","score":0.7680000066757202},{"id":"https://openalex.org/keywords/magnesium-binding","display_name":"magnesium binding","score":0.5230000019073486},{"id":"https://openalex.org/keywords/disulfide-bonds","display_name":"disulfide bonds","score":0.5889999866485596},{"id":"https://openalex.org/keywords/sporozoite-vaccine","display_name":"sporozoite vaccine","score":0.656000018119812},{"id":"https://openalex.org/keywords/plasmodium-vivax","display_name":"Plasmodium vivax","score":0.875},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9330000281333923},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.595684826374054},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.5563817024230957},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.5140289068222046},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.5025045871734619},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.4882981777191162},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.45247095823287964},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4456923305988312},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.43060046434402466},{"id":"https://openalex.org/C64745115","wikidata":"https://www.wikidata.org/wiki/Q618561","display_name":"Gliding motility","level":3,"score":0.4239477515220642},{"id":"https://openalex.org/C53195969","wikidata":"https://www.wikidata.org/wiki/Q5470213","display_name":"Formins","level":5,"score":0.4115604758262634},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.38559943437576294},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.3847261071205139},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3248157501220703},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.22194531559944153},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18157857656478882},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.10492455959320068},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09119993448257446},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009068","descriptor_name":"Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010961","descriptor_name":"Plasmodium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034101","descriptor_name":"Sporozoites","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.1218581109","doi":"https://doi.org/10.1073/pnas.1218581109","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1218581109","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2685016","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3535621","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3535621","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3535621","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:23236185","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23236185","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2685016","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3535621","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1068622613","display_name":"Structural Vaccinology of the Malaria Sporozoite Surface Sheath","funder_award_id":"R01AI095686","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3201085063","display_name":null,"funder_award_id":"AI095686","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6594250107","display_name":"Structural Vaccinology of the Malaria Sporozoite Surface Sheath","funder_award_id":"R56AI095686","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320338284","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1972300275","https://openalex.org/W1972470306","https://openalex.org/W1973230865","https://openalex.org/W1981284849","https://openalex.org/W1983764955","https://openalex.org/W1987060667","https://openalex.org/W2015784069","https://openalex.org/W2018858007","https://openalex.org/W2021528981","https://openalex.org/W2024411676","https://openalex.org/W2026757666","https://openalex.org/W2031364054","https://openalex.org/W2039132575","https://openalex.org/W2039440389","https://openalex.org/W2050429474","https://openalex.org/W2062121087","https://openalex.org/W2062888678","https://openalex.org/W2065795429","https://openalex.org/W2069455668","https://openalex.org/W2074857354","https://openalex.org/W2083100745","https://openalex.org/W2083803997","https://openalex.org/W2084969272","https://openalex.org/W2086588775","https://openalex.org/W2087650666","https://openalex.org/W2089625435","https://openalex.org/W2093238184","https://openalex.org/W2094725247","https://openalex.org/W2096025413","https://openalex.org/W2096686175","https://openalex.org/W2099015185","https://openalex.org/W2099095285","https://openalex.org/W2103740565","https://openalex.org/W2108476551","https://openalex.org/W2112226676","https://openalex.org/W2113301165","https://openalex.org/W2114622716","https://openalex.org/W2116590074","https://openalex.org/W2119132855","https://openalex.org/W2122339645","https://openalex.org/W2130373733","https://openalex.org/W2131903471","https://openalex.org/W2133698011","https://openalex.org/W2143304554","https://openalex.org/W2144081223","https://openalex.org/W2144998676","https://openalex.org/W2146080841","https://openalex.org/W2158202876","https://openalex.org/W2160696686","https://openalex.org/W2168908538","https://openalex.org/W2170877356","https://openalex.org/W2171797964","https://openalex.org/W2180229411","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W4380291619","https://openalex.org/W2022077448","https://openalex.org/W2096686175","https://openalex.org/W2060403328","https://openalex.org/W2015186773","https://openalex.org/W2900227853","https://openalex.org/W2112393852","https://openalex.org/W2140417128","https://openalex.org/W2127552172","https://openalex.org/W2015784069"],"abstract_inverted_index":{"Sporozoite":[0],"gliding":[1],"motility":[2,48,215,229],"and":[3,7,27,41,56,62,74,77,135,149,178,191,230],"invasion":[4],"of":[5,109,145,160,217,226,233],"mosquito":[6],"vertebrate":[8],"host":[9],"cells":[10],"in":[11,34,65,89,95,104,165],"malaria":[12],"is":[13,99,143],"mediated":[14],"by":[15,204,212],"thrombospondin":[16,28],"repeat":[17,31],"anonymous":[18],"protein":[19],"(TRAP).":[20],"Tandem":[21],"von":[22],"Willebrand":[23],"factor":[24],"A":[25],"(VWA)":[26],"type":[29],"I":[30,111],"(TSR)":[32],"domains":[33,43,58,71,193],"TRAP":[35,69],"connect":[36],"through":[37],"proline-rich":[38],"stalk,":[39],"transmembrane,":[40],"cytoplasmic":[42],"to":[44,101,151,170],"the":[45,54,96,105,125,152,161,171,213,218],"parasite":[46,228],"actin-dependent":[47],"apparatus.":[49],"We":[50],"crystallized":[51],"fragments":[52],"containing":[53],"VWA":[55,70,115,127,153,163],"TSR":[57,121,137,179,192],"from":[59],"Plasmodium":[60,63],"vivax":[61],"falciparum":[64],"different":[66],"crystal":[67],"lattices.":[68],"adopt":[72,194],"closed":[73,114,162],"open":[75,97,106,126,172],"conformations,":[76],"bind":[78],"a":[79,83,119,166,183,195,209],"Mg(2+)":[80],"ion":[81,93],"at":[82,182],"metal":[84],"ion-dependent":[85],"adhesion":[86],"site":[87],"implicated":[88],"ligand":[90],"binding.":[91],"Metal":[92],"coordination":[94],"state":[98,108],"identical":[100],"that":[102,155,200],"seen":[103],"high-affinity":[107],"integrin":[110],"domains.":[112],"The":[113,139,174,186],"conformation":[116,128],"associates":[117],"with":[118,130],"disordered":[120],"domain.":[122,138],"In":[123],"contrast,":[124],"crystallizes":[129],"an":[131],"extensible":[132,140,175,188],"\u03b2":[133,141,176,189],"ribbon":[134,142,177],"ordered":[136],"composed":[144],"disulfide-bonded":[146],"segments":[147],"N-":[148],"C-terminal":[150],"domain":[154,164,180],"are":[156],"largely":[157],"drawn":[158],"out":[159],"15":[167],"\u00c5":[168],"movement":[169],"conformation.":[173],"overlap":[181],"conserved":[184],"interface.":[185],"VWA,":[187],"ribbon,":[190],"highly":[196],"elongated":[197],"overall":[198],"orientation":[199],"would":[201],"be":[202],"stabilized":[203],"tensile":[205],"force":[206],"exerted":[207],"across":[208],"ligand-receptor":[210],"complex":[211],"actin":[214],"apparatus":[216],"sporozoite.":[219],"Our":[220],"results":[221],"provide":[222],"insights":[223],"into":[224],"regulation":[225],"\"stick-and-slip\"":[227],"for":[231],"development":[232],"sporozoite":[234],"subunit":[235],"vaccines.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}