{"id":"https://openalex.org/W2026237387","doi":"https://doi.org/10.1016/s0954-6111(11)70023-3","title":"Applying clinical outcome variables to appropriate aerosolized antibiotics for the treatment of patients with cystic fibrosis","display_name":"Applying clinical outcome variables to appropriate aerosolized antibiotics for the treatment of patients with cystic fibrosis","publication_year":2011,"publication_date":"2011-12-01","ids":{"openalex":"https://openalex.org/W2026237387","doi":"https://doi.org/10.1016/s0954-6111(11)70023-3","mag":"2026237387","pmid":"https://pubmed.ncbi.nlm.nih.gov/22208544"},"language":"en","primary_location":{"id":"doi:10.1016/s0954-6111(11)70023-3","doi":"https://doi.org/10.1016/s0954-6111(11)70023-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0954-6111(11)70023-3","pdf_url":"https://doi.org/10.1016/s0954-6111(11)70023-3","source":{"id":"https://openalex.org/S71995303","display_name":"Respiratory Medicine","issn_l":"0954-6111","issn":["0954-6111","1532-3064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/s0954-6111(11)70023-3","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018376808","display_name":"Donald R. VanDevanter","orcid":"https://orcid.org/0000-0002-5727-8164","observed_orcids":["https://orcid.org/0000-0002-5727-8164"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald R. VanDevanter","raw_affiliation_strings":["Case Western Reserve University School of Medicine, Cleveland, OH, USA. enigmaster@comcast.net","Case Western Reserve University School of Medicine, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University School of Medicine, Cleveland, OH, USA. enigmaster@comcast.net","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Case Western Reserve University School of Medicine, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015555168","display_name":"Manfred Ballmann","orcid":"https://orcid.org/0000-0003-4480-1312","observed_orcids":["https://orcid.org/0000-0003-4480-1312"]},"institutions":[{"id":"https://openalex.org/I2799784675","display_name":"University Hospitals of the Ruhr-University of Bochum","ror":"https://ror.org/03zcpvf19","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675"]},{"id":"https://openalex.org/I4210152922","display_name":"LWL-Universit\u00e4tsklinikum Bochum","ror":"https://ror.org/04nkkrh90","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210130751","https://openalex.org/I4210152922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Manfred Ballmann","raw_affiliation_strings":["Klinikum der Ruhr-Universit\u00e4t , D-44791 Bochum , Germany","Klinikum der Ruhr-Universitat, D-44791 Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinikum der Ruhr-Universit\u00e4t , D-44791 Bochum , Germany","institution_ids":["https://openalex.org/I2799784675"]},{"raw_affiliation_string":"Klinikum der Ruhr-Universitat, D-44791 Bochum, Germany","institution_ids":["https://openalex.org/I2799784675","https://openalex.org/I4210152922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005915390","display_name":"Patrick A. Flume","orcid":"https://orcid.org/0000-0002-1560-6879","observed_orcids":["https://orcid.org/0000-0002-1560-6879"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick A. Flume","raw_affiliation_strings":["Departments of Medicine and Pediatrics, Medical University of South Carolina, Charleston, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Pediatrics, Medical University of South Carolina, Charleston, SC, USA","institution_ids":["https://openalex.org/I153297377"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":null,"fwci":1.3596,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.82479631,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"105","issue":null,"first_page":"S18","last_page":"S23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":1.0},{"id":"https://openalex.org/keywords/inhaled-antibiotics","display_name":"inhaled antibiotics","score":0.8820000290870667},{"id":"https://openalex.org/keywords/aerosolized-antibiotics","display_name":"aerosolized antibiotics","score":0.9399999976158142},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9290000200271606},{"id":"https://openalex.org/keywords/chronic-lung-infection","display_name":"chronic lung infection","score":0.7919999957084656},{"id":"https://openalex.org/keywords/pulmonary-exacerbations","display_name":"pulmonary exacerbations","score":0.800000011920929},{"id":"https://openalex.org/keywords/lung-function","display_name":"lung function","score":0.9369999766349792},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9496369361877441},{"id":"https://openalex.org/C2776938444","wikidata":"https://www.wikidata.org/wiki/Q178194","display_name":"Cystic fibrosis","level":2,"score":0.7464092969894409},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.7251959443092346},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.7166682481765747},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.46919959783554077},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.45430901646614075},{"id":"https://openalex.org/C2778974779","wikidata":"https://www.wikidata.org/wiki/Q1758380","display_name":"Tobramycin","level":4,"score":0.45137515664100647},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.42054125666618347},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35266080498695374},{"id":"https://openalex.org/C2775832221","wikidata":"https://www.wikidata.org/wiki/Q422482","display_name":"Gentamicin","level":3,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000336","descriptor_name":"Aerosols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D012129","descriptor_name":"Respiratory Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0954-6111(11)70023-3","doi":"https://doi.org/10.1016/s0954-6111(11)70023-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0954-6111(11)70023-3","pdf_url":"https://doi.org/10.1016/s0954-6111(11)70023-3","source":{"id":"https://openalex.org/S71995303","display_name":"Respiratory Medicine","issn_l":"0954-6111","issn":["0954-6111","1532-3064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Medicine","raw_type":"journal-article"},{"id":"pmid:22208544","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22208544","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0954-6111(11)70023-3","doi":"https://doi.org/10.1016/s0954-6111(11)70023-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0954-6111(11)70023-3","pdf_url":"https://doi.org/10.1016/s0954-6111(11)70023-3","source":{"id":"https://openalex.org/S71995303","display_name":"Respiratory Medicine","issn_l":"0954-6111","issn":["0954-6111","1532-3064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2026237387.pdf","grobid_xml":"https://content.openalex.org/works/W2026237387.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W29861392","https://openalex.org/W1966242444","https://openalex.org/W1975379303","https://openalex.org/W1989841457","https://openalex.org/W1990987230","https://openalex.org/W1996245529","https://openalex.org/W1999011569","https://openalex.org/W2004189684","https://openalex.org/W2010268034","https://openalex.org/W2018392439","https://openalex.org/W2026100561","https://openalex.org/W2032940647","https://openalex.org/W2034489516","https://openalex.org/W2050102384","https://openalex.org/W2052521716","https://openalex.org/W2053189420","https://openalex.org/W2061431879","https://openalex.org/W2069648171","https://openalex.org/W2070458418","https://openalex.org/W2075069205","https://openalex.org/W2089215286","https://openalex.org/W2097072748","https://openalex.org/W2110828250","https://openalex.org/W2113263701","https://openalex.org/W2114243674","https://openalex.org/W2132707658","https://openalex.org/W2133361303","https://openalex.org/W2142418276","https://openalex.org/W2149520619","https://openalex.org/W2149906284","https://openalex.org/W2151174404","https://openalex.org/W2157320660","https://openalex.org/W2161621810","https://openalex.org/W2163575531","https://openalex.org/W2165028346","https://openalex.org/W2317332612","https://openalex.org/W2326999967","https://openalex.org/W2336210752"],"related_works":["https://openalex.org/W2111439678","https://openalex.org/W7097713982","https://openalex.org/W2400095514","https://openalex.org/W1911569221","https://openalex.org/W4289261210","https://openalex.org/W4250975860","https://openalex.org/W4309001067","https://openalex.org/W3139047428","https://openalex.org/W4363673302","https://openalex.org/W2171125771"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}