{"id":"https://openalex.org/W2026088937","doi":"https://doi.org/10.1002/jcp.1041330406","title":"The stimulation of paracrine and autocrine mitogenic pathways by the platelet-derived growth factor receptor","display_name":"The stimulation of paracrine and autocrine mitogenic pathways by the platelet-derived growth factor receptor","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W2026088937","doi":"https://doi.org/10.1002/jcp.1041330406","mag":"2026088937","pmid":"https://pubmed.ncbi.nlm.nih.gov/2824531"},"language":"en","primary_location":{"id":"doi:10.1002/jcp.1041330406","doi":"https://doi.org/10.1002/jcp.1041330406","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.1041330406","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109941240","display_name":"Lewis T. Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lewis T. Williams","raw_affiliation_strings":["Department of Medicine, Howard Hughes Medical Institute, University of California Medical Center, San Francisco 94143-0724","Department of Medicine and Cardiovascular Research Institute, Howard Hughes Medical Institute, University of California Medical Center, San Francisco, California 94143\u20100724"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Howard Hughes Medical Institute, University of California Medical Center, San Francisco 94143-0724","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I180670191","https://openalex.org/I4210110664"]},{"raw_affiliation_string":"Department of Medicine and Cardiovascular Research Institute, Howard Hughes Medical Institute, University of California Medical Center, San Francisco, California 94143\u20100724","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I180670191","https://openalex.org/I4210110664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110784832","display_name":"Jaime A. Escobedo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaime A. Escobedo","raw_affiliation_strings":["Department of Medicine and Cardiovascular Research Institute, Howard Hughes Medical Institute, University of California Medical Center, San Francisco, California 94143-0724"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Cardiovascular Research Institute, Howard Hughes Medical Institute, University of California Medical Center, San Francisco, California 94143-0724","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I180670191","https://openalex.org/I4210110664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103550127","display_name":"Mark T. Keating","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark T. Keating","raw_affiliation_strings":["Department of Medicine and Cardiovascular Research Institute, Howard Hughes Medical Institute, University of California Medical Center, San Francisco, California 94143-0724"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Cardiovascular Research Institute, Howard Hughes Medical Institute, University of California Medical Center, San Francisco, California 94143-0724","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I180670191","https://openalex.org/I4210110664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026446174","display_name":"Shaun R. Coughlin","orcid":"https://orcid.org/0000-0003-2337-2002","observed_orcids":["https://orcid.org/0000-0003-2337-2002"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaun R. Coughlin","raw_affiliation_strings":["Department of Medicine and Cardiovascular Research Institute, Howard Hughes Medical Institute, University of California Medical Center, San Francisco, California 94143-0724"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Cardiovascular Research Institute, Howard Hughes Medical Institute, University of California Medical Center, San Francisco, California 94143-0724","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I180670191","https://openalex.org/I4210110664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5109941240"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I180670191","https://openalex.org/I4210110664"],"apc_list":{"value":5230,"currency":"USD","value_usd":5230},"apc_paid":null,"fwci":0.2323,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.44795488,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"133","issue":"S5","first_page":"27","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.26980000734329224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.26980000734329224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.19460000097751617,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.13449999690055847,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.9580000042915344},{"id":"https://openalex.org/keywords/pdgf-receptor","display_name":"PDGF receptor","score":0.9919999837875366},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.8939999938011169},{"id":"https://openalex.org/keywords/autocrine-signaling","display_name":"autocrine signaling","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"tyrosine kinase","score":0.8579999804496765},{"id":"https://openalex.org/keywords/receptor-gene-structure","display_name":"receptor gene structure","score":0.7089999914169312},{"id":"https://openalex.org/keywords/receptor-turnover","display_name":"receptor turnover","score":0.5099999904632568},{"id":"https://openalex.org/keywords/phosphatidylinositol-turnover","display_name":"phosphatidylinositol turnover","score":0.9279999732971191},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9010000228881836},{"id":"https://openalex.org/keywords/c-fos","display_name":"c-fos","score":0.9850000143051147}],"concepts":[{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.8877444863319397},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.8127202987670898},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6772453784942627},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.6762427091598511},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5702240467071533},{"id":"https://openalex.org/C2781294074","wikidata":"https://www.wikidata.org/wiki/Q22327352","display_name":"Platelet-derived growth factor","level":5,"score":0.5285885334014893},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.524543821811676},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.4967249035835266},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4897756576538086},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.4851244390010834},{"id":"https://openalex.org/C79186569","wikidata":"https://www.wikidata.org/wiki/Q14897880","display_name":"Tropomyosin receptor kinase C","level":5,"score":0.4215906858444214},{"id":"https://openalex.org/C26375932","wikidata":"https://www.wikidata.org/wiki/Q118226","display_name":"Growth factor receptor","level":3,"score":0.4208185374736786},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37995386123657227},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22956708073616028}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013268","descriptor_name":"Stimulation, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017479","descriptor_name":"Receptors, Platelet-Derived Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcp.1041330406","doi":"https://doi.org/10.1002/jcp.1041330406","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.1041330406","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"pmid:2824531","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2824531","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular physiology. Supplement","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6537734785","display_name":"VASCULAR RECEPTORS FOR PLATELET-DERIVED GROWTH FACTOR","funder_award_id":"R01HL032898","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1480178458","https://openalex.org/W1495653195","https://openalex.org/W1515935875","https://openalex.org/W1570617743","https://openalex.org/W1964822816","https://openalex.org/W1964846497","https://openalex.org/W1965001673","https://openalex.org/W1967925725","https://openalex.org/W1982020713","https://openalex.org/W1983688599","https://openalex.org/W1983861608","https://openalex.org/W2002513158","https://openalex.org/W2003124778","https://openalex.org/W2013012981","https://openalex.org/W2014477576","https://openalex.org/W2021253208","https://openalex.org/W2025529909","https://openalex.org/W2038595692","https://openalex.org/W2068953892","https://openalex.org/W2153885659","https://openalex.org/W2164515753"],"related_works":["https://openalex.org/W2086862958","https://openalex.org/W2423093050","https://openalex.org/W1553223526","https://openalex.org/W2075447348","https://openalex.org/W2085579708","https://openalex.org/W1781314548","https://openalex.org/W1996728737","https://openalex.org/W4300525779","https://openalex.org/W2955564784","https://openalex.org/W1611838331"],"abstract_inverted_index":{"Platelet-derived":[0],"growth":[1],"factor":[2],"(PDGF)":[3],"and":[4,12,34,68,117,123,162],"PDGF-like":[5],"polypeptides":[6],"stimulate":[7],"cell":[8,66],"proliferation":[9],"through":[10,56],"paracrine":[11],"autocrine":[13],"pathways.":[14],"Each":[15],"of":[16,81,101,115,120,155,158],"these":[17],"pathways":[18],"is":[19,42,54,62,69],"mediated":[20],"by":[21,74,173],"the":[22,29,65,76,97,102,105,121,156,166,169],"PDGF":[23,144],"receptor.":[24,103],"Recently,":[25,130],"cDNA":[26,134],"clones":[27],"for":[28],"receptor":[30,37,77,86,133,160],"have":[31,126],"been":[32,128,137],"isolated":[33],"sequenced.":[35],"The":[36,50,85],"gene":[38],"on":[39],"chromosome":[40],"5":[41],"transcribed":[43],"into":[44],"a":[45,79,131],"single":[46],"5.2":[47],"kb":[48],"mRNA.":[49],"translated":[51],"product,":[52],"which":[53],"processed":[55],"at":[57,64],"least":[58],"one":[59],"identifiable":[60],"precursor,":[61],"expressed":[63,138],"surface":[67],"rapidly":[70],"degraded.":[71],"When":[72],"activated":[73],"PDGF,":[75],"mediates":[78],"group":[80],"diverse":[82],"intracellular":[83,170],"reactions.":[84],"domains":[87,106,161],"that":[88,107,141],"mediate":[89,108],"tyrosine":[90],"kinase":[91],"activity":[92],"can":[93],"be":[94],"identified":[95],"in":[96,139],"amino":[98],"acid":[99],"sequence":[100],"However,":[104],"other":[109],"PDGF-stimulated":[110],"responses,":[111],"such":[112],"as":[113],"turnover":[114],"phosphatidylinositol":[116],"enhanced":[118],"expression":[119,147],"c-myc":[122],"c-fos":[124],"genes,":[125],"not":[127],"determined.":[129],"full-length":[132],"clone":[135],"has":[136],"cells":[140],"normally":[142],"lack":[143],"receptors.":[145],"This":[146],"system":[148],"should":[149,163],"provide":[150],"an":[151],"approach":[152],"to":[153],"studies":[154],"function":[157],"specific":[159],"help":[164],"determine":[165],"relationship":[167],"among":[168],"reactions":[171],"stimulated":[172],"PDGF.":[174]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
