{"id":"https://openalex.org/W2026030739","doi":"https://doi.org/10.1001/archinternmed.2009.314","title":"Going Off-label Without Venturing Off-Course","display_name":"Going Off-label Without Venturing Off-Course","publication_year":2009,"publication_date":"2009-10-26","ids":{"openalex":"https://openalex.org/W2026030739","doi":"https://doi.org/10.1001/archinternmed.2009.314","mag":"2026030739","pmid":"https://pubmed.ncbi.nlm.nih.gov/19858430"},"language":"en","primary_location":{"id":"doi:10.1001/archinternmed.2009.314","doi":"https://doi.org/10.1001/archinternmed.2009.314","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archinternmed.2009.314","pdf_url":null,"source":{"id":"https://openalex.org/S4210206803","display_name":"Archives of Internal Medicine","issn_l":"0003-9926","issn":["0003-9926","0730-188X","1538-3679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001385550","display_name":"Emily A. Largent","orcid":"https://orcid.org/0000-0002-7536-5077","observed_orcids":["https://orcid.org/0000-0002-7536-5077"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Emily A. Largent","raw_affiliation_strings":["Clinical Center Department of Ethics, National Institutes of Health, Bethesda, MD 20892-1156, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Center Department of Ethics, National Institutes of Health, Bethesda, MD 20892-1156, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001385550"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"],"apc_list":null,"apc_paid":null,"fwci":14.5935,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":{"value":0.9871502,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"169","issue":"19","first_page":"1745","last_page":"1745"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11649","display_name":"Pharmaceutical industry and healthcare","score":0.8583999872207642,"subfield":{"id":"https://openalex.org/subfields/2910","display_name":"Issues, ethics and legal aspects"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11649","display_name":"Pharmaceutical industry and healthcare","score":0.8583999872207642,"subfield":{"id":"https://openalex.org/subfields/2910","display_name":"Issues, ethics and legal aspects"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.06400000303983688,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11792","display_name":"Pharmaceutical Economics and Policy","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/off-label-drug-use","display_name":"off-label drug use","score":0.972000002861023},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.6909999847412109},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.3490000069141388}],"concepts":[{"id":"https://openalex.org/C2777552389","wikidata":"https://www.wikidata.org/wiki/Q1962728","display_name":"Course (navigation)","level":2,"score":0.5601088404655457},{"id":"https://openalex.org/C143177785","wikidata":"https://www.wikidata.org/wiki/Q5172437","display_name":"Corporate venture capital","level":3,"score":0.5453119277954102},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.432917058467865},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3626328110694885},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.22975438833236694},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1697980761528015},{"id":"https://openalex.org/C84309077","wikidata":"https://www.wikidata.org/wiki/Q3908516","display_name":"Entrepreneurship","level":2,"score":0.10382169485092163},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003142","descriptor_name":"Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004348","descriptor_name":"Drug Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007258","descriptor_name":"Informed Consent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010818","descriptor_name":"Practice Patterns, Physicians'","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D010818","descriptor_name":"Practice Patterns, Physicians'","qualifier_ui":"Q000941","qualifier_name":"ethics","is_major_topic":true},{"descriptor_ui":"D011307","descriptor_name":"Drug Prescriptions","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014486","descriptor_name":"United States Food and Drug Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016527","descriptor_name":"Drug Costs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019317","descriptor_name":"Evidence-Based Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026690","descriptor_name":"Ethics, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1001/archinternmed.2009.314","doi":"https://doi.org/10.1001/archinternmed.2009.314","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archinternmed.2009.314","pdf_url":null,"source":{"id":"https://openalex.org/S4210206803","display_name":"Archives of Internal Medicine","issn_l":"0003-9926","issn":["0003-9926","0730-188X","1538-3679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:19858430","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19858430","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of internal medicine","raw_type":"Journal Article"},{"id":"pmh:oai:repository.library.georgetown.edu:10822/1026539","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10822/1026539","pdf_url":null,"source":{"id":"https://openalex.org/S4306402467","display_name":"DigitalGeorgetown (Georgetown University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210145449","host_organization_name":"Center for Security and Emerging Technology","host_organization_lineage":["https://openalex.org/I4210145449"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eweb:327692","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W162686037","https://openalex.org/W1972855023","https://openalex.org/W1997101969","https://openalex.org/W2033172977","https://openalex.org/W2051168294","https://openalex.org/W2062139442","https://openalex.org/W2065314593","https://openalex.org/W2103928570","https://openalex.org/W2121191306","https://openalex.org/W2121487587","https://openalex.org/W2128380434"],"related_works":["https://openalex.org/W2411328967","https://openalex.org/W4250532368","https://openalex.org/W2007290275","https://openalex.org/W4417056097","https://openalex.org/W2042453869","https://openalex.org/W2551567640","https://openalex.org/W1597092343","https://openalex.org/W2032998139","https://openalex.org/W1960566199","https://openalex.org/W1555470627"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}