{"id":"https://openalex.org/W2025984548","doi":"https://doi.org/10.1056/nejm197708182970701","title":"Healing of Duodenal Ulcer with an Antacid Regimen","display_name":"Healing of Duodenal Ulcer with an Antacid Regimen","publication_year":1977,"publication_date":"1977-08-18","ids":{"openalex":"https://openalex.org/W2025984548","doi":"https://doi.org/10.1056/nejm197708182970701","mag":"2025984548","pmid":"https://pubmed.ncbi.nlm.nih.gov/876324"},"language":"en","primary_location":{"id":"doi:10.1056/nejm197708182970701","doi":"https://doi.org/10.1056/nejm197708182970701","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm197708182970701","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Walter L. Peterson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Walter L. Peterson","raw_affiliation_strings":["University of California at Los Angeles"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at Los Angeles","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048271289","display_name":"Richard A.L. Sturdevant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard A. L. Sturdevant","raw_affiliation_strings":["University of California at Los Angeles"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at Los Angeles","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Harold D. Frankl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harold D. Frankl","raw_affiliation_strings":["University of California at Los Angeles"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at Los Angeles","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016664830","display_name":"Charles T. Richardson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles T. Richardson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Jon I. Isenberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jon I. Isenberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002463388","display_name":"JANET DIXON ELASHOFF","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janet D. Elashoff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053087351","display_name":"James Q. Sones","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Q. Sones","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072069097","display_name":"Robert A. Gross","orcid":"https://orcid.org/0000-0003-4258-3913","observed_orcids":["https://orcid.org/0000-0003-4258-3913"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert A. Gross","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005028574","display_name":"Richard W. McCallum","orcid":"https://orcid.org/0000-0002-6652-8049","observed_orcids":["https://orcid.org/0000-0002-6652-8049"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard W. McCallum","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5009994411","display_name":"John S. Fordtran","orcid":"https://orcid.org/0000-0002-2049-9879","observed_orcids":["https://orcid.org/0000-0002-2049-9879"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John S. Fordtran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":43.1031,"has_fulltext":false,"cited_by_count":336,"citation_normalized_percentile":{"value":0.99938589,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"297","issue":"7","first_page":"341","last_page":"345"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.062300000339746475,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.029500000178813934,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/duodenal-ulcer","display_name":"duodenal ulcer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ulcer-healing","display_name":"ulcer healing","score":0.871999979019165},{"id":"https://openalex.org/keywords/antacids","display_name":"antacids","score":0.8389999866485596},{"id":"https://openalex.org/keywords/placebo-controlled-comparison","display_name":"placebo comparison","score":0.6499999761581421},{"id":"https://openalex.org/keywords/ulcer-symptoms","display_name":"ulcer symptoms","score":0.8289999961853027},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C2780590083","wikidata":"https://www.wikidata.org/wiki/Q274083","display_name":"Antacid","level":2,"score":0.9824703335762024},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9205770492553711},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.8746792674064636},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.8315460681915283},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5810365676879883},{"id":"https://openalex.org/C2993747882","wikidata":"https://www.wikidata.org/wiki/Q172941","display_name":"Duodenal ulcer","level":2,"score":0.5648217797279358},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5604944229125977},{"id":"https://openalex.org/C2778814440","wikidata":"https://www.wikidata.org/wiki/Q2742649","display_name":"Antidiarrhoeal","level":3,"score":0.42791539430618286},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3666903078556061},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.04083043336868286},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2778229996","wikidata":"https://www.wikidata.org/wiki/Q337492","display_name":"Castor oil","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000536","descriptor_name":"Aluminum Hydroxide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000536","descriptor_name":"Aluminum Hydroxide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000863","descriptor_name":"Antacids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000863","descriptor_name":"Antacids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004381","descriptor_name":"Duodenal Ulcer","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D004381","descriptor_name":"Duodenal Ulcer","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004386","descriptor_name":"Duodenum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004724","descriptor_name":"Endoscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012828","descriptor_name":"Silicones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012828","descriptor_name":"Silicones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D013607","descriptor_name":"Tablets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejm197708182970701","doi":"https://doi.org/10.1056/nejm197708182970701","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm197708182970701","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:876324","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/876324","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1987097139","https://openalex.org/W1987603452","https://openalex.org/W1988336805","https://openalex.org/W1994855621","https://openalex.org/W1998795924","https://openalex.org/W2073586907","https://openalex.org/W2077319005","https://openalex.org/W2110615630","https://openalex.org/W2124057260","https://openalex.org/W2334499353","https://openalex.org/W2336764248","https://openalex.org/W2341314610","https://openalex.org/W4231124136"],"related_works":["https://openalex.org/W1983154953","https://openalex.org/W2411103448","https://openalex.org/W2057604514","https://openalex.org/W2003881864","https://openalex.org/W2148540304","https://openalex.org/W2419302224","https://openalex.org/W2089173762","https://openalex.org/W2070695256","https://openalex.org/W2048150275","https://openalex.org/W2030869293"],"abstract_inverted_index":{"To":[0],"determine":[1],"whether":[2],"a":[3,23,30,83,129],"large-dose":[4,130],"antacid":[5,60,122,131],"regimen":[6,31,61,123,132],"is":[7],"effective":[8,65],"in":[9,40,68],"promoting":[10],"healing":[11,135],"of":[12,42,50,75,86,90,95,108,120,136],"duodenal":[13,20,137],"ulcer,":[14],"74":[15],"patients":[16,54,97],"with":[17,32],"endoscopically":[18],"proved":[19],"ulcer":[21,37,70,92],"completed":[22],"28-day":[24],"double-blind":[25],"clinical":[26],"trial":[27],"comparing":[28],"such":[29],"an":[33,91],"inert":[34],"placebo.":[35],"The":[36,59],"healed":[38],"completely":[39],"28":[41],"the":[43,51,78,121,134],"36":[44],"antacid-treated":[45],"as":[46],"compared":[47],"to":[48,104],"17":[49],"38":[52],"placebo-treated":[53,96],"(P":[55,110],"less":[56,102],"than":[57,66,106],"0.005).":[58],"was":[62,82],"not":[63],"more":[64],"placebo":[67],"relieving":[69],"symptoms.":[71],"Presence":[72],"or":[73,88],"absence":[74,89],"symptoms":[76],"during":[77],"fourth":[79],"treatment":[80],"week":[81],"poor":[84],"predictor":[85],"presence":[87],"crater.":[93],"Ulcers":[94],"who":[98],"smoked":[99],"cigarettes":[100],"were":[101,124],"likely":[103],"heal":[105],"those":[107],"nonsmokers":[109],"=":[111],"0.03).":[112],"Except":[113],"for":[114],"mild":[115],"diarrhea,":[116],"no":[117],"side":[118],"effects":[119],"observed.":[125],"We":[126],"conclude":[127],"that":[128],"hastens":[133],"ulcer.":[138]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
